Clinical trials: Artery Disease, Peripheral
Intermittent Claudication, Metabolic Syndrome X
Prevalence of Metabolic Syndrome in Patients With Intermittent Claudication
Metabolic syndrome, a group of cardiovascular risk factors related to insulin resistance, is a major determinant of cardiovascular mortality. Intermittent claudication is a symptom of an early stage of atherosclerosis.
- Trial name
- NCT00946868
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- University of Sao Paulo
Diabetic Peripheral Neuropathy
Exploratory Study of the Efficacy of Standard of Care Revascularization of the Lower Extremity
The purpose of this study is to evaluate the efficacy of the standard of care revascularization of the lower extremity with the addition of revascularization of the lateral plantar artery and anterior pedal loop of the foot as…
- Trial name
- NCT04720170
- Testing
- Revascularization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Diabetes and Glandular Disease Clinic
Peripheral Arterial Disease
Post-Market Study of ZENFLEX Pro Stent for Femoropopliteal Artery Lesions
This is a prospective, multi-center, single-arm post-market study evaluating the safety and effectiveness of the ZENFLEX Pro™ Drug-eluting Stent in treating femoropopliteal artery stenosis or occlusion.
- Trial name
- NCT07049120
- Testing
- ZENFLEX Pro™ Peripheral Drug-eluting Stent System
- Where
- Poland
- Volunteers
- 153 people
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Peripheral Arterial Disease
Local or Systemic Effects: Mechanisms Related to Arm Crank Exercise - Comparison Between Individuals With and Without PAD
INTRODUCTION: Exercise with an arm ergometer (EB) overcomes the main barrier to physical exercise in patients with Peripheral Artery Disease (PAD), leg pain during walking.
- Trial name
- NCT06828172
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Peripheral Arterial Disease, Critical Limb Ischemia
ACPs in Severe PAD/CLI by Direct Intramuscular Injection
Study title: A Study of Blood-Borne Autologous Angiogenic Cell Precursors Therapy in Patients with Critical Limb Ischemia ( ACPs-CLI ) Principle Investigator: Assoc.Prof. Pramook Mutirangura,M.D.
- Trial name
- NCT00523731
- Testing
- Angiogenic Cell Precursors (ACPs) or Vescell TM
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- TheraVitae Ltd.
Peripheral Arterial Disease, Atherosclerosis Obliterans
Comparison of 3 Ultrasonic Techniques for Measuring the Systolic Pressure Index
Continuous Doppler ankle brachial index (ABI) is the gold standard for screening and monitoring of peripheral arterial disease (PAD) but is no longer carried out in clinical practice.
- Conditions
- Peripheral Arterial Disease, Atherosclerosis Obliterans, Atherosclerosis Right Leg, Atherosclerosis Left Leg
- Trial name
- ABIPULSE (NCT04440072)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Osteoarthritis, Cardiovascular Disease
Risk Factor Control Before Orthopedic Surgery
This trial is designed to determine the best preoperative management strategy for patients undergoing orthopedic surgery.
- Trial name
- OPTMIZE-OS (NCT01837069)
- Testing
- Metoprolol, Lisinopril, Atorvastatin
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- NYU Langone Health
Peripheral Artery Disease
Clinical Implications of Peripheral Plaque Morphology
Peripheral Artery Disease involves a buildup of fatty deposits (plaque) within blood vessels that can restrict blood flow. Patients who have PAD and claudication (pain in legs during exercise due to poor blood circulation) may be…
- Trial name
- NCT00578422
- Testing
- Ivus (Intravascular Ultrasound) of Amputation Specimens, IVUS (Intravascular Ultrasound)
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- The Cleveland Clinic
Peripheral Arterial Diseases, Intermittent Claudication
Lower Extremity Peripheral Arterial Disease and Exercise Ischemia
Lower extremity peripheral arterial disease (LEPAD) is a highly prevalent chronic disease. Cardiovascular mortality of LEPAD patients at five years ranges between 18 to 30%.
- Trial name
- CLASH (NCT02041169)
- Testing
- Subsequent walking performance
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Rennes University Hospital
Atherosclerosis, Arteriosclerosis
BIOLUX P-I First in Man Study
A prospective, multi-centre, randomized controlled, First in Man study to assess the safety and performance of the coated Passeo-18 Lux Paclitaxel releasing PTA Balloon Catheter vs.
- Conditions
- Atherosclerosis, Arteriosclerosis, Vascular Disease, Peripheral Artery Disease
- Trial name
- NCT01221610
- Testing
- Passeo-18 Lux DRB, Standard PTA (POBA)
- Where
- 5 sites in Austria, Germany
- Volunteers
- 60 people
- Sponsor
- Biotronik AG
Peripheral Vascular Disease
GORE VIABAHN® Versus Plain Old Balloon Angioplasty (POBA) for Superficial Femoral Artery (SFA) In-Stent Restenosis
This is a prospective, randomized, multi-center study recruiting patients with an in-stent restenosis in the superficial femoral artery. The safety and efficacity of the Viabahn endoprosthesis (W.L.
- Trial name
- RELINE (NCT01108861)
- Testing
- GORE VIABAHN® Endoprosthesis, Plain old balloon angioplasty
- Where
- 6 sites in Belgium, Germany
- Volunteers
- 100 people
- Sponsor
- Flanders Medical Research Program
Peripheral Arterial Disease
BIO REsponse Adapted Combination Therapy Pilot Study
Both drug-coated balloon and stents have been used for a number of years to treat subjects with Peripheral Artery Disease (PAD) and are recognized as very good treatment methods.
- Trial name
- NCT03547986
- Testing
- Duplex Ultrasound (DUS), IVUS with Intraarterial pressure measurement (IAP) if needed
- Where
- 15 sites in Australia, Austria and 4 more
- Volunteers
- 150 people
- Sponsor
- Biotronik AG
Peripheral Vascular Diseases, Peripheral Arterial Disease
Calf Muscle Perfusion in Patients With Intermittent Claudication by Non-invasive MSOT
The objective of the proposed study is to define independent parameters for the diagnostic assessment of the perfusion situation of the calf muscle based on multispectral optoacoustic tomography (MSOT) in a cross-sectional…
- Conditions
- Peripheral Vascular Diseases, Peripheral Arterial Disease, Intermittent Claudication
- Trial name
- MSOT_IC (NCT05373927)
- Testing
- Multispectral Optoacoustic Tomography (MSOT)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ulrich Rother
Erectile Dysfunction, Lower Urinary Tract Symptoms
Imaging and Interventional Study for Erectile Dysfunction and Lower Urinary Tract Symptoms
Erectile dysfunction is highly prevalent as men grow older. Among the various causes of erectile dysfunction, it has been shown that pelvic arterial insufficiency plays a very important role.
- Conditions
- Erectile Dysfunction, Lower Urinary Tract Symptoms, Peripheral Arterial Disease
- Trial name
- PERFECT (NCT02178761)
- Testing
- drug-eluting balloon, biodegradable vascular scaffold stent, Apex™ PTCA Dilatation Catheter
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Peripheral Arterial Disease
Investigating a Model for Acute Ischemic Pain in Humans
The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies.
- Trial name
- NCT02192242
- Testing
- acute ischemic pain
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Atherosclerosis, Lower Extremity Ischemia
Comparison of Prosthetic Femoropopliteal Bypass Versus Viabahn Endoprosthesis for Treatment of Symptomatic Femoral Artery Occlusion
A retrospective review with four year followup on patients that had previously been enrolled in a study to evaluate blockages in the lower legs.
- Conditions
- Atherosclerosis, Lower Extremity Ischemia, Claudication, Rest Pain
- Trial name
- NCT00962897
- Testing
- Femoral-popliteal bypass, Stent-graft placement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Texas Vascular Associates
Postoperative Complications, Cardiovascular Diseases
General Versus Regional Anesthesia in Peripheral Arterial Surgery
This multicenter, prospective, randomized clinical trial aims to compare the effects of spinal (neuraxial) anesthesia with spontaneous ventilation versus general anesthesia with mechanical ventilation on the incidence of…
- Trial name
- GENERA (NCT06953128)
- Testing
- Spinal Anesthesia, General Anesthesia
- Where
- Brazil
- Volunteers
- 594 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Claudication, Intermittent, Peripheral Arterial Disease
REmotely Supervised Exercise Therapy Trial 2
Supervised exercise for intermittent claudication is a first line therapy for peripheral arterial disease, as recommended by the National Institute for Health and Clinical Excellence and the European Society for Vascular Surgery.
- Trial name
- RESET2 (NCT04925219)
- Testing
- Remotely supervised exercise programme, Self-directed exercise
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Message-based Rehabilitation for Peripheral Artery Disease Patients
Effectiveness of Text Message-based Rehabilitation Program for Patients With Peripheral Artery Disease
Background: Many patients with peripheral artery disease are unable to achieve healthy lifestyle after revascularization. There is evidence that rehabilitation program could result in decreased re-admission, reduced…
- Trial name
- NCT03640767
- Testing
- Message-based lifestyle intervention
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 160 people
- Sponsor
- Caritas Institute of Higher Education
Peripheral Arterial Disease
DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions
The objective of this study is to evaluate the immediate and long-term (up to 12 months) safety and effectiveness of primary stenting with the Protégé Everflex+ stent system for the treatment of superficial femoral artery (SFA)…
- Trial name
- DURABILITY+ (NCT01412463)
- Testing
- stent placement
- Where
- 3 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Flanders Medical Research Program
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