Clinical trials: Artery Injury
Myocardial Infarction, Acute, Myocardial Infarction With Nonobstructive Coronary Arteries
Stratified Medicine of Eplerenone in Acute Myocardial Infarction or Injury and no Obstructive Coronary Arteries.
Patients with heart attack or heart injury are tested (angiogram) for blockages in their arteries. Patients may develop heart problems caused by damage to small (microvascular) blood vessels.
- Conditions
- Myocardial Infarction, Acute, Myocardial Infarction With Nonobstructive Coronary Arteries, Myocardial Injury
- Trial name
- StratMedMINOCA (NCT05198791)
- Testing
- Stratified medicine - Microvascular dysfunction and eplerenone therapy, tablets, Stratification and standard care
- Where
- 2 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- NHS National Waiting Times Centre Board
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
Carotid Artery Injury, Vertebral Artery Injury
Anticoagulation in Blunt Cerebrovascular Injuries
Originally thought to be a rare occurrence, BCVI are now diagnosed in approximately 1% of blunt trauma patients. Initially BCVI were thought to have unavoidable devastating neurologic outcomes.
- Trial name
- NCT00494156
- Testing
- heparin, aspirin and clopidogrel
- Where
- United States
- Sponsor
- C. Clay Cothren, MD
Cancer, Myocardial Infarction
NORVIT and WENBIT - Long-term Follow-up
Two large homocysteine-lowering B-vitamin intervention trials have been performed in Norway during the period 1998 to 2005, NORVIT and WENBIT.
- Conditions
- Cancer, Myocardial Infarction, Cerebrovascular Stroke
- Trial name
- NORVITWENBIT (NCT00671346)
- Where
- 2 sites in Norway
- Volunteers
- 6,839 people
- Sponsor
- Haukeland University Hospital
Acute Kidney Injury, Renal Artery Blood Flow
Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance
To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical…
- Conditions
- Acute Kidney Injury, Renal Artery Blood Flow, Renal Venous Return, Renal Microcirculation
- Trial name
- NCT06090773
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College Hospital
Kidney Failure, Acute
Effect of Erythropoietin (EPO) in Kidney After Cardiac Surgery
The purpose of this study is to determine whether erythropoietin is effective in preventing acute kidney dysfunction after coronary artery bypass grafting surgery.
- Trial name
- EPO-CABG (NCT00654992)
- Testing
- Erythropoietin-Beta, Normal Saline
- Where
- South Korea
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Chronic Subdural Hematoma
Intra-Arterial Bevacizumab as an Adjunct to Middle Meningeal Artery Embolization for Chronic Subdural Hematoma
This is a Phase 1, open-label, single-center, dose-escalation study evaluating the safety and tolerability of intra-arterial bevacizumab (IA-BEV) given as an adjunct to middle meningeal artery embolization (MMAE) in adults with…
- Trial name
- SAFER-MMAE (NCT07729098)
- Testing
- Bevacizumab (intra-arterial)
- Volunteers
- 18 people
- Sponsor
- Dheeraj Gandhi
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Coronary Syndrome, Acute, Myocardial Infarction
Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation
People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample.
- Conditions
- Coronary Syndrome, Acute, Myocardial Infarction, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- DanRUSH (NCT07727135)
- Testing
- 0/3-hour high-sensitivity cardiac troponin algorithm, 0/1-hour high-sensitivity cardiac troponin algorithm
- Where
- 11 sites in Denmark
- Volunteers
- 28,000 people
- Sponsor
- Herlev and Gentofte Hospital
Cardiac Valve Disease, Coronary Artery Disease
The Val-CARD Trial
The Val-CARD trial aims to answer the question: "Does the drug sodium valproate reduce complications affecting the heart and kidneys in patients having heart operations?" Sodium valproate is a drug commonly used in the treatment…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Organ Failure, Multiple
- Trial name
- Val-CARD (NCT03825250)
- Testing
- Sodium Valproate
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Leicester
Coronary Artery Disease, Coronary Artery Bypass Grafting
Extensive BITA Grafting in the Canary Islands: an IPTW Analysis
Coronary artery bypass grafting (CABG) remains the preferred revascularization strategy for patients with complex multivessel coronary artery disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Myocardial Revascularization
- Trial name
- BITA-SURV (NCT07796750)
- Where
- Spain
- Volunteers
- 666 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Arterial Stiffness, Renin Angiotensin Aldosterone System
RAAS and Arterial Stiffness in SCI
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.
- Conditions
- Arterial Stiffness, Renin Angiotensin Aldosterone System, Orthostatic Hypotension, Spinal Cord Injury
- Trial name
- NCT04510974
- Testing
- Spinal Cord Injury
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Myocardial Ischemia, Ischemic Reperfusion Injury
Remote Ischemic Preconditioning in Elective Percutaneous Interventions
Myocardial injury occurs after percutaneous coronary intervention due to micro emboli, ischemia-reperfusion injury or side branch occlusion.
- Trial name
- NCT02581618
- Testing
- remote ischemic preconditioning
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Trakya University
Hemorrhage, Vascular Injury
A Transparent Elasticized Adhesive Occlusive Compression Bandage for Use as an Arterial Tourniquet
This cross-over study of twenty five (anticipated) healthy human subjects will utilize two active control devices, and two different widths of the investigational device.
- Trial name
- NCT02592655
- Testing
- Pneumatic Tourniquet, One Windlass Tourniquet, Two Windlass Tourniquets
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Marcus Migura
Subdural Hematoma, Chronic
Endovascular vs Conservative Treatment in Patients With Chronic Subdural Hematomas and Mild Symptoms
Embotrial-1 is an Italian multicenter prospective randomized clinical trial with open-label treatment and blinded outcome assessment (PROBE) to assess the superiority of MMA embolization compared to conservative treatment.
- Trial name
- NCT06274580
- Testing
- embolization of the middle meningeal artery
- Volunteers
- 300 people
- Sponsor
- Ospedale Policlinico San Martino
Coronary Artery Disease, Valvular Heart Disease
Application of Remote Ischemic Preconditioning in Patients Undergoing Open Heart Surgeries
Strategies for myocardial protection during open heart surgeries are desired. Several experimental studies have shown beneficial effects of remote ischemic preconditioning (RIPC).
- Trial name
- NCT01906918
- Testing
- IRPC, Remote preconditioning
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Campinas, Brazil
Atrial Fibrillation, Acute Kidney Injury
Autonomic State, Cardiovascular Control and Outcomes in Coronary Surgery
Characterization of the perioperative autonomic nervous system state, cardiovascular and cerebrovascular control and microcirculation in order to predict postoperative atrial fibrillation and acute kidney injury in patients…
- Trial name
- NCT03169608
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Policlinico S. Donato
Coronary Artery Disease, Angina
Ivabradine and Post-revascularisation Microcirculatory Dysfunction
The aim of the study is to test whether, in patients with angina and flow limiting epicardial coronary artery disease, pre-treatment with Ivabradine, as opposed to beta blockers, will reduce post percutaneous coronary…
- Trial name
- MICRO-PCI (NCT02507050)
- Testing
- Ivabradine
- Where
- United Kingdom
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA
This is a prospective, multi-center, open-label, randomized controlled study in which subjects can receive standard of care (SOC) alone or SOC and TRUFILL n-BCA MMA embolization for the treatment of chronic subdural hematomas…
- Trial name
- MEMBRANE (NCT04816591)
- Testing
- Experimental: Interventional Cohort: TRUFILL n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System, Standard of Care Surgery, Experimental: Interventional Cohort: TRUFILL n-BCA Liquid Embolic System
- Where
- 33 sites in United States, China
- Volunteers
- 376 people
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Cardiogenic Shock, Acute Kidney Injury
Accelerated vs. Standard Continuous Renal Replacement Therapy for Patients With Cardiogenic Shock Undergoing Veno-arterial ExtraCorporeal Membrane Oxygenator
This study was designed to compare the safety and efficacy of early continuous renal replacement therapy with standard continuous renal replacement therapy in the presence of acute kidney injury (stage 2 or greater acute kidney…
- Trial name
- REDUCE-ECMO (NCT06696235)
- Testing
- Early initiation of continuous renal replacement therapy, Standard initiation of continuous renal replacement therapy
- Where
- 2 sites in South Korea
- Volunteers
- 408 people
- Sponsor
- Samsung Medical Center