Clinical trials: Artery Stenosis
Ischemic Stroke
External Counterpulsation Therapy for Severe Steno-occlusive Intracranial Stenosis
Intracranial stenosis is prevalent among Asians and constitute a common cause of cerebral ischemia. While the best medical therapy carries stroke recurrence rates in access of 10% per year, intracranial stenting was associated…
- Trial name
- NCT03921827
- Testing
- Enhance External Counterpulsation Therapy
- Where
- Singapore
- Volunteers
- 130 people
- Sponsor
- National University of Singapore
Ischemic Heart Disease, Coronary Artery Stenosis
Trial to Assess the Everolimus-Eluting Coronary Stent System (PROMUS Element) for Coronary Revascularization
The PROMUS Element™ clinical trial (PLATINUM-PLUS) consists of a randomized controlled trial (RCT) in the European Union (EU) which will enroll approximately 2980 subjects (2:1 randomization PROMUS Element™: Xience™ Prime) in a…
- Trial name
- PLATINUM+ (NCT01342822)
- Testing
- Angioplasty (PROMUS Element™, and Xience™ Prime stent)
- Where
- 50 sites in France, Germany and 6 more
- Volunteers
- 2,980 people
- Sponsor
- European Cardiovascular Research Center
Vertebrobasilar Insufficiency
Prospective Evaluation of Safety and Efficacy Vertebral Drug-eluting Stent System
The purpose of this study is to evaluate the safety and efficacy of Firehorus vertebral artery rapamycin-target-eluting stent system (hereinafter referred to as Firehorus) in treatment of symptomatic vertebral artery stenosis.
- Trial name
- PESS (NCT02328781)
- Testing
- Drug-eluting stent
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Zhongrong Miao
Coronary Artery Disease, Cardiac Valve Insufficiency
Study on the Clinical Performance of Steelex® Sternum Set for Sternal Closure
The study is designed as a retrospective, international, multi-center cohort study to evaluate Steelex® Sternum Set for sternum closure.
- Conditions
- Coronary Artery Disease, Cardiac Valve Insufficiency, Aortic Valve Stenosis
- Trial name
- STERCCAS (NCT05439395)
- Testing
- Sternum Closure after Cardiac Surgery
- Where
- 2 sites in Germany, Spain
- Volunteers
- 229 people
- Sponsor
- Aesculap AG
Carotid Artery Stenosis
Prospective Single Arm CAS - ROADSAVER Study
Approximately 2000 patients eligible for elective treatment with a Carotid Stent according to hospital routine practice in centers across Europe will be enrolled in the study.
- Trial name
- ROADSAVER (NCT03504228)
- Testing
- Roadsaver
- Where
- 57 sites in Belgium, Czechia and 11 more
- Volunteers
- 1,967 people
- Sponsor
- Terumo Europe N.V.
Carotid Stenosis, Coronary Stenosis
Coronary Angiography Before Elective Carotid Endarterectomy in Patients With Asymptomatic Coronary Artery Disease
The purpose of this study is to evaluate the potential benefit of systematic preoperative coronary angiography followed by selective coronary artery revascularization on the incidence of myocardial infarction (MI) in patients…
- Trial name
- CACEA (NCT02260453)
- Testing
- Preoperative coronary angiography, Standard cardiac workup
- Volunteers
- 426 people
- Sponsor
- University of Roma La Sapienza
Femoral Artery Stenosis, Popliteal Artery Stenosis
Lutonix Drug Coated Balloon for Treatment of Femoropopliteal Arteries in United States Females (CONFIRM)
The post approval study will enroll US female patients presenting with claudication or ischemic rest pain and an angiographically significant lesion in the superficial femoral or popliteal artery.
- Conditions
- Femoral Artery Stenosis, Popliteal Artery Stenosis, Femoral Artery Occlusion, Popliteal Artery Occlusion
- Trial name
- CONFIRM (NCT02813577)
- Testing
- Lutonix® 035 Drug Coated Balloon PTA Catheter
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- C. R. Bard
Peripheral Artery Disease, Peripheral Artery Stenosis
The THOR IDE Study
The goal of this clinical trial is to test the Thor system in adult (≥ 18 year old) patients with de novo (new, never treated) calcified lesions in infrainguinal (leg) arteries (peripheral artery disease or PAD).
- Conditions
- Peripheral Artery Disease, Peripheral Artery Stenosis, Peripheral Artery Calcification, PAD
- Trial name
- THOR (NCT05916950)
- Testing
- Thor laser atherectomy
- Where
- 29 sites in United States
- Volunteers
- 155 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Coronary Artery Disease
Fast Assessment of STenosis Severity- FASTII Study
The Multicenter FAST (Fast Assessment of STenosis severity) study is a prospective observational multicenter study designed to evaluate the diagnostic accuracy of offline 3D-QCA based FFR, using CAAS Workstation (Pie Medical…
- Trial name
- FASTII (NCT03791320)
- Testing
- Vessel Fractional Flow Reserve
- Where
- 6 sites in United States, France and 4 more
- Volunteers
- 330 people
- Sponsor
- Erasmus Medical Center
Carotid Artery Stenosis
High Dose Atorvastatin for Preventing Periprocedural Ischemic Brain Damage During Carotid Artery Stenting
The purpose is to test whether a short-term, high-dose atorvastatin treatment (80mg once a daily (QD) from 3 days before to 3 days after CAS, then 20 mg QD until 30 days after CAS) is superior to conventional-dose atorvastatin…
- Trial name
- PICAS (NCT03079115)
- Testing
- High-dose Atorvastatin, Conventional-dose Atorvastatin
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Beijing Hospital
End-stage Renal Disease
Evaluation of the Radial Artery Deviation And Reimplantation Technique for Primary Hemodialysis Access Creation
The Radial Artery Deviation And Reimplantation (RADAR) technique is a new approach for the construction of hemodialysis arteriovenous fistula.
- Trial name
- RADAR (NCT02728817)
- Testing
- End-cephalic vein to side-radial artery fistula creation, RADAR fistula creation
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Coronary Arterial Disease (CAD), Restenosis, Coronary
Restrospective Analysis of MACE in Patients Treated With Drug-elluting Balloons.
Retrospective analysis of data collected in an institutional database of coronary interventions with use of drug-eluting balloons, with a prospective follow-up for major adverse cardiovascular events and living status.
- Conditions
- Coronary Arterial Disease (CAD), Restenosis, Coronary, Bifurcation Coronary Disease
- Trial name
- EASY-DEB (NCT06972225)
- Testing
- DEB
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- Olivier F. Bertrand
Coronary Artery Stenosis
Observational Study to Evaluate Short and Long-term Safety of the ABSORB Scaffold
The German-Austrian ABSORB Register shall provide an analysis of acute and long-term safety as well as therapy outcomes of the ABSORB (trade mark) bioresorbable vascular scaffold system in patients suffering from coronary artery…
- Trial name
- GABI-R (NCT02066623)
- Testing
- ABSORB Scaffold
- Where
- 81 sites in Austria, Germany
- Volunteers
- 3,330 people
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Ischemic Stroke
Application of High-Resolution Magnetic Resonance Vessel Wall Imaging in Endovascular Treatment
Intracranial atherosclerotic disease (ICAD) is one of the most important causes of ischemic stroke and is also associated with some recurrent stroke.
- Trial name
- NCT07497152
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Shanghai East Hospital
Lower Limb Ischemia, Peripheral Arterial Disease
The PORTuguese Registry of Supera Supported Femoral-Fopliteal Revascularization (SupPORT Registry)
The SupPORT Registry aims at collecting real-world from Portuguese centers performing femoral-popliteal revascularization with Supera (r) implants. This is a prospective non-randomized non-controlled consecutive registry.
- Conditions
- Lower Limb Ischemia, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia, Chronic Limb Ischemia
- Trial name
- SupPORT regist (NCT06416644)
- Testing
- Supera Vasculomimetic Stent
- Where
- 15 sites in Portugal
- Volunteers
- 100 people
- Sponsor
- Hospital do Divino Espírito Santo de Ponta Delgada
Dysfunctional Arterial-venous Grafts
Atherectomy and Drug Coated Balloon for the Treatment of Arterio-Venous Graft Stenosis
This single-centre, single-arm, prospective study will enroll 30 subjects presenting with clinical and hemodynamic abnormalities in arteriovenous graft (AVG) in the arm.
- Trial name
- NCT04627051
- Testing
- Atherectomy and balloon angioplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Coronary Disease, Coronary Artery Disease
ABSORB Clinical Investigation, Cohort A (ABSORB A) Everolimus Eluting Coronary Stent System Clinical Investigation
Prospective, open-labeled First in Man Clinical Investigation enrolling patients with visually estimated nominal vessel diameter of 3.0 mm receiving a single 3.0 x 12 mm or 3.0 x 18 mm BVS EECSS containing 98 microgramme per cm²…
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- ABSORB A (NCT00300131)
- Testing
- Bioabsorbable Everolimus Eluting Coronary Stent
- Where
- 4 sites in Denmark, Netherlands and 2 more
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Carotid Stenosis, Ischemic Stroke
Comprehensive Assessment of Atherosclerotic Ischemic Stroke Risk and Development of a Prediction Model
This observational study was designed for the assessment of plaque vulnerability in patients with carotid atherosclerotic stenosis and the development of predictive models for the occurrence and recurrence of atherosclerotic…
- Trial name
- CAIS-pre (NCT06315153)
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Ischemic, Stenosis, Carotid
Impact of Significant Carotid Stenosis on Retinal Perfusion Measured Via Automated Retinal Oximetry
Background: Large vessel carotid stenosis represent significant cause of ischaemic stroke. Indication for surgical revascularisation treatment relies on severity stenosis and clinical symptoms.
- Trial name
- NCT06085612
- Testing
- Automated retinal oximetry
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Olomouc
Coronary Artery Disease
Outcome of FFR-guided Intervention Strategy
The investigator will evaluate the clinical outcomes of the patients in whom the treatment strategy for their coronary stenosis were determined by fractional flow reserve measurement.
- Trial name
- NCT01409577
- Where
- 2 sites in South Korea
- Volunteers
- 1,500 people
- Sponsor
- Seoul National University Hospital
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