Clinical trials: Artery Stenosis
Coronary Artery Disease, Postoperative Complications
Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Surgery
This study evaluates the efficacy and safety of single dose preoperative ferric carboxymaltose in the prevention of postoperative infections and blood transfusions in patients scheduled for cardiac surgery.
- Conditions
- Coronary Artery Disease, Postoperative Complications, Aortic Valve Stenosis, Mitral Valve Disease
- Trial name
- PREFER-CABG (NCT03574311)
- Testing
- Ferric carboxymaltose, Physiological saline
- Where
- Finland
- Volunteers
- 210 people
- Sponsor
- Turku University Hospital
Cardiovascular Diseases, Myocardial Ischemia
Cohort Study of Heart Rate Variability
To examine factors affecting heart rate variability (HRV) and the role of HRV in heart disease. Specifically, to examine the role of HRV: as a predictor of fatal and nonfatal ischemic heart disease over a six year follow-up of…
- Conditions
- Cardiovascular Diseases, Myocardial Ischemia, Carotid Stenosis, Hypertension
- Trial name
- NCT00005399
- Testing
- No interventions
- Volunteers
- 111,654 people
- Sponsor
- University of North Carolina, Chapel Hill
Carotid Artery Diseases
MicroNet-covered Stent System for Stroke Prevention in All Comer Carotid Revascularization
All-comer study of unselected patients suitable for carotid artery revascularization to evaluate the feasibility, efficacy and safety of first line endovascular revasculariztion using MicroNet covered stent (CGuard™) in the…
- Trial name
- PARADIGM-EXT (NCT04271033)
- Testing
- Carotid Artery Stenting
- Where
- Poland
- Volunteers
- 550 people
- Sponsor
- John Paul II Hospital, Krakow
Peripheral Arterial Disease, Iliac Artery Stenosis
SOLARIS Peripheral PMCF Trial
The objective of this clinical investigation is to evaluate, in a controlled setting, the long-term (up to 12 months) safety and efficacy of the Solaris Vascular Stent Graft (Scitech) in clinical settings when used according to…
- Conditions
- Peripheral Arterial Disease, Iliac Artery Stenosis, Common Femoral Artery Stenosis
- Trial name
- NCT04299906
- Testing
- Solaris Vascular Stent Graft
- Where
- 10 sites in Germany, Italy and 1 more
- Volunteers
- 70 people
- Sponsor
- Dr. Sabrina Overhagen
Plaque, Atherosclerotic, Carotid Artery Plaque
Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke Risk
Stroke is a leading cause of death and disability in the United States and around the world. The goal of this work is to develop and test a noninvasive ultrasound-based imaging technology to better identify patients at high risk…
- Conditions
- Plaque, Atherosclerotic, Carotid Artery Plaque, Carotid Stenosis
- Trial name
- NCT04063709
- Testing
- Acoustic Radiation Force Impulse (ARFI) ultrasound
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of North Carolina, Chapel Hill
Occlusion and Stenosis of Unspecified Cerebral Artery
Prevention for the Restenosis of Intracranial Artery Stent Implantation Treated With Herbal Medicine C117
Prevention for the Restenosis of Intracranial artery Stent Implantation Treated with herbal medicine C117--PRISIT Trial
- Trial name
- PRISIT (NCT03008798)
- Testing
- Herbal Medicine C-117
- Volunteers
- 180 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Coronary Disease, Coronary Artery Disease
Safety and Efficacy of the ZoMaxx™ Drug-Eluting Stent System in Coronary Arteries
The purpose of this study is to demonstrate the safety and efficacy of the ZoMaxx drug-eluting stent in patients with blockage of native coronary arteries.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- ZoMaxx™ I (NCT00148356)
- Testing
- ZoMaxx™ Drug-Eluting Coronary Stent System, TAXUS™ EXPRESS2™ Paclitaxel Eluting Coronary Stent System
- Where
- 29 sites in Australia, Belgium and 8 more
- Volunteers
- 401 people
- Sponsor
- Abbott Medical Devices
Ischemic Stroke, Vertebral Artery Stenosis
Drug-eluting Stenting Versus Medical Treatment for Extracranial Vertebral Artery Stenosis
Posterior circulation stroke accounts for 20% of all ischemic stroke. Approximately one quarter of posterior circulation strokes are due to stenosis in the vertebral artery and basilar artery.
- Trial name
- VISTA (NCT05885932)
- Testing
- Drug-eluting stenting plus aspirin and clopidogrel or ticagrelor, Aspirin and clopidogrel or ticagrelor, mono anti-platelet therapy
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Xuanwu Hospital, Beijing
Carotid Stenoses
Stroke and Panorama - Analyzing Carotid Endocalcifications (SPACE)
The odontological radiology method Panorama is known to be able to spot calcifications in the area of the carotid arteries. The calcifications could be carotid stenoses which is affiliated with an increased risk of stroke.
- Trial name
- SPACE (NCT00514644)
- Testing
- Carotid ultrasound examination, Panorama examination
- Where
- Sweden
- Volunteers
- 266 people
- Sponsor
- Umeå University
Ischemic Stroke, TIA
Probucol for Symptomatic Intracranial and Extracranial Artery Stenosis
This study is a multicenter, double-blind, placebo-controlled, randomized clinical trial that aims to evaluate the efficacy of probucol on the reduction of the risk of recurrent stroke in patients with symptomatic intracranial or…
- Trial name
- NCT06225752
- Testing
- Probucol
- Where
- China
- Volunteers
- 5,452 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Atherosclerosis, Stroke
Carotid Revascularization Endarterectomy Versus Stenting Trial
The purpose of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is to compare the relatively new procedure of stent-assisted carotid angioplasty (CAS) to the traditional and accepted surgical approach of…
- Conditions
- Atherosclerosis, Stroke, Carotid Stenosis, Cerebral Infarction
- Trial name
- CREST (NCT00004732)
- Testing
- Carotid Endarterectomy (CEA), Carotid Artery Stenting (CAS)
- Where
- 115 sites in United States, Canada
- Volunteers
- 2,502 people
- Sponsor
- Rutgers, The State University of New Jersey
Aortic Valve Stenosis, Mitral Regurgitation
Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions
Prospective, single-arm, observational study with invasive coronary physiology measurements before and after transcatheter left-sided valvular intervention.
- Conditions
- Aortic Valve Stenosis, Mitral Regurgitation, Coronary Artery Disease, Fractional Flow Reserve
- Trial name
- POTUS (NCT05374733)
- Testing
- Coronary Physiology assessment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Coronary Artery Disease, Arterial Stiffness, Blood Pressure
Expanded Studies on the SCAPIS Stockholm Reexamination Cohort
The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018.
- Conditions
- Coronary Artery Disease, Arterial Stiffness, Blood Pressure, AORTIC VALVE DISEASES, Mitral Valve Stenosis and/or Insufficiency
- Trial name
- SCAPIS-ReEx (NCT07476703)
- Testing
- Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography
- Where
- Sweden
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Carotid Artery Stenosis
PROximal Protection VErsus NON-Protection in Carotid Artery Stenting
To compare the incidence of new ischemic brain injury detected with magnetic resonance imaging (MRI) after carotid artery stenting in patients treated with and without proximal cerebral protection (Gore Flow Reversal System).
- Trial name
- PROVENON (NCT01331473)
- Testing
- Carotid Artery Stenting with Proximal Protection, Carotid Artery Stenting without Protection
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Universität des Saarlandes
Radiation-induced Carotid Artery Stenosis
Carotid Revascularization for Radiation Induced Carotid Artery Stenosis
Cervical radiotherapy (RT) has greatly reduced the mortality of patients with malignant head and neck tumors, which, however, causes a higher risk of carotid artery stenosis, namely, radiation-induced carotid artery stenosis…
- Trial name
- CRICS (NCT05134246)
- Testing
- Carotid endarterectomy (CEA), Carotid artery stenting (CAS)
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- Xuanwu Hospital, Beijing
Stenosis, Carotid, Stroke
Deoxyhemoglobin Concentration Changes and Cerebral Perfusion Imaging
To investigate a new method to rapidly modulate pulmonary venous hemoglobin oxygen saturation to enable the use of deoxyhemoglobin concentration in arterial blood as an intra-arterial MRI contrast agent for cerebral tissue…
- Conditions
- Stenosis, Carotid, Stroke, Neurovascular Disorder
- Trial name
- NCT04537611
- Testing
- dHb contrast and gadolinium contrast imaging
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Clopidogrel, Poor Metabolism of, Carotid Stenosis
Multicentric Study on Clopidogrel Resistance in DAPT for CAS (MULTI-RESCLOSA)
Spontaneous prospective observational multicentre pharmacological study that aims to evaluate whether, from a statistical point of view, there is a significant difference between the use of Ticagrelor in "non-responders" patients…
- Trial name
- NCT05566301
- Testing
- Clopidogrel, Ticagrelor
- Where
- Italy
- Volunteers
- 1,140 people
- Sponsor
- IRCCS Policlinico S. Donato
Carotid Stenosis
Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients
Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism.
- Trial name
- MASCADI (NCT03202823)
- Testing
- blood samples, recover samples of atheromatous plaque
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Arteriovenous Access Fistula Stenosis
Paclitaxel for the Treatment of Distal Radial Artery Arteriovenous Access Fistula Stenosis (PaciFIST-2)
The objective of this study is to evaluate the safety and effectiveness of the use of intravascular paclitaxel, in addition to standard therapy, for the treatment of arteriovenous dialysis access fistula stenosis.
- Trial name
- PaciFIST-2 (NCT02040454)
- Testing
- Paclitaxel, Standard Therapy
- Where
- United States
- Sponsor
- Englewood Hospital and Medical Center
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