Clinical trials: Artery Stenosis
Cerebrovascular Disorders
Neuroprotective and Cardioprotective Effects Of Palm Vitamin E Tocotrienols
The purpose of the study is to assess the neuroprotective, anti atherogenic and hepatoprotective properties of tocotrienols (palm vitamin E) supplementation as determined by white matter lesion load on serial magnetic resonance…
- Trial name
- NCT00753532
- Where
- Malaysia
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Coronary Artery Stenosis
FFR and Inducible Myocardial Ischemia During Adenosine Stress Testing
This is a prospective, single center study involving 150 patients with stable coronary artery disease undergoing coronary angiography for chest pain evaluation.
- Trial name
- NCT04401657
- Testing
- Fractional flow reserve with adenosine stress testing
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Asan Medical Center
Arterial Hypertension, Chronic Kidney Disease, Primary Aldosteronism
Kidney Stiffness Measured by Ultrasound in Patients With High Blood Pressure and Healthy Volunteers
High blood pressure (hypertension) is a leading cause of kidney damage, but detecting early kidney changes remains challenging with currently available tools.
- Conditions
- Arterial Hypertension, Chronic Kidney Disease, Primary Aldosteronism, Arterial Stenosis
- Trial name
- K-STRESS (NCT07914075)
- Where
- Italy
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Padova
Restenosis, Coronary, Left Main Coronary Artery Disease
PCI vs. CABG in UPLM-ISR
Left main (LM) coronary artery disease is associated with high morbidity and mortality owing to the large myocardial territory at risk for ischemia.
- Conditions
- Restenosis, Coronary, Left Main Coronary Artery Disease, PTCA Left Main Artery Complications
- Trial name
- LM-DRAGON (NCT04968977)
- Testing
- PCI vs. CABG
- Where
- 11 sites in Italy, Poland
- Volunteers
- 305 people
- Sponsor
- Medical University of Silesia
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Chronic Coronary Syndrome
Drug-Coated Balloon Versus Drug-Eluting Stent for Treatment of De-Novo Coronary Lesions in Patients With High Bleeding Risk-2
A prospective, multi-center, open-label, randomized controlled, and superiority trial. The trial will compare clinical outcomes between discontinuation of antiplatelet agent and continuation of antiplatelet agent in HBR patients…
- Trial name
- DCB-HBR-2 (NCT06742931)
- Testing
- Discontinuation of antiplatelet agent group, Continuation of antiplatelet agent group
- Where
- 18 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Carotid Stenosis, Femoral Arterial Stenosis
Use of Amplified Sound Signal to Identify Presence of Carotid and Femoral Stenosis
The purpose of the study is to test a new amplified stethoscope(AudioDoc) that can detect the presence of bruit by using an acoustic signal to represent the bruit.
- Conditions
- Carotid Stenosis, Femoral Arterial Stenosis, Carotid Bruit Asymptomatic, Carotid Murmur
- Trial name
- NCT01599195
- Testing
- AudioDoc
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Albert Einstein Healthcare Network
Hypertension, Atherosclerosis
Renal Artery Calcium and Hypertension
CT of the abdomen is a very common examination performed for various indications.One of the common findings is vascular calcifications including calcifications of the renal arteries.Calcifications in the carotid arteries and…
- Trial name
- NCT00388869
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Carotid Stenosis
Risk Prediction Model for Cerebrovascular Events in Carotid Artery Stenosis
Atherosclerotic carotid artery stenosis is a major cause of stroke, and early identification of high-risk patients combined with surgical intervention can significantly reduce stroke risk.
- Trial name
- NCT06452173
- Testing
- Plasma, carotid high-resolution magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Intra-operative Hypotension, Carotid Stenosis
Effect of Blood Pressure on rSO2 in Carotid Endarterectomy (CEA)
Carotid endarterectomy (CEA) is the recommended treatment for symptomatic high degree stenosis of the internal carotid artery (ICA).
- Trial name
- NCT01451294
- Testing
- Administration of phenylephrine, Administration of ephedrine
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- G.J. de Borst
Aortic Stenosis
Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure
The primary purpose of this study is to observe reduced access site complications in patients with heavily calcified common femoral arteries requiring Transcatheter Aortic Valve Replacement (TAVR)
- Trial name
- NCT07205068
- Testing
- Shockwave M5 IVL Catheter, Modified Seldinger Technique
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Coronary Artery Disease, Bypass Graft Stenosis
Impact of Cholesterol Level on Long-term Coronary Bypass Graft Patency
This single-centre cross-sectional study aims to ascertain the impact of dyslipidemia on long-term graft patency after coronary artery bypass grafting (CABG).
- Conditions
- Coronary Artery Disease, Bypass Graft Stenosis, Dyslipidemias, Bypass Graft Occlusion
- Trial name
- NCT05393882
- Testing
- Computed tomography coronary angiogram
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Stenosis
Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease
The objective of this randomized study was to compare outcomes of imaging-and physiology-guided state-of-the-art percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in patients with diabetes and…
- Trial name
- DEFINE-DM (NCT05831085)
- Testing
- State-of-the-Art Percutaneous Coronary Intervention, standard CABG
- Where
- 39 sites in United States, Australia and 12 more
- Volunteers
- 1,500 people
- Sponsor
- Duk-Woo Park, MD
Coronary Artery Disease
Diastolic Hyperemia Free Index for Assessment of Moderate Coronary Stenoses
A total of 106 subjects will be enrolled at up to 3 sites. Initial enrollment will occur at Washington University only. After 15 subjects have been enrolled at the primary site and no serious adverse events or protocol events…
- Trial name
- DFRiFR (NCT04019535)
- Testing
- physiological assessment with Volcano Verrata pressure wire (iFR)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Washington University School of Medicine
Peripheral Arterial Disease, Stenosis
A Trail of Sperstent® Used for Residual Lesions of Femoropopliteal Arteries
This is a prospective, multi-center, randomized trial designed to investigate the efficacy and safety of Sperstent® peripheral spot stent system versus Everflex® self-expanding peripheral stent system in the endovascular…
- Conditions
- Peripheral Arterial Disease, Stenosis, Dissection
- Trial name
- SURF (NCT06539689)
- Testing
- Sperstent® peripheral spot stent system, Everflex® self-expanding peripheral stent system
- Where
- 12 sites in China
- Volunteers
- 240 people
- Sponsor
- FrontAce Scientific Co., Ltd
Diabetes, Hyperlipidemia
Diabetic Under 70 (Diabetics Below 70)
A screening project of diabetics with a very high cardiovascular risk (e.g. diabetes plus coronary heart disease) who already receive cholesterol-lowering therapy.
- Conditions
- Diabetes, Hyperlipidemia, Atherosclerosis
- Trial name
- NCT00516204
- Where
- Austria
- Volunteers
- 685 people
- Sponsor
- AstraZeneca
Aortic Valve Stenosis, Mitral Regurgitation
Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions
Prospective, single-arm, observational study with invasive coronary physiology measurements before and after transcatheter left-sided valvular intervention.
- Conditions
- Aortic Valve Stenosis, Mitral Regurgitation, Coronary Artery Disease, Fractional Flow Reserve
- Trial name
- POTUS (NCT05374733)
- Testing
- Coronary Physiology assessment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Chronic Total Occlusion of Coronary Artery
Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.
The objective of this study is to evaluate the safety and efficacy of the SoundBite™ Crossing System - Coronary (SCS-C) in a subject population with chronic coronary artery disease including Chronic Total Occlusion (CTO).
- Trial name
- ACTIVE (NCT03521804)
- Testing
- SoundBite™ Crossing System Active Wire 14
- Where
- 5 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- SoundBite Medical Solutions, Inc.
Coronary Artery Disease, Acute Myocardial Infarction
Collateral Circulation to LAD and Wellens Sign
Overall Aim Coronary artery disease significantly contributes to morbidity and mortality in the United States. Atherosclerotic disease can lead to stenosis of the coronary arteries and subsequent cardiac hypoperfusion.
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Acute Myocardial Infarction of Anterior Wall, Collateral Circulation, Any Site
- Trial name
- NCT03707626
- Testing
- Wellens Sign
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Coney Island Hospital, Brooklyn, NY
Coronary Artery Disease, Coronary Artery Stenosis
Disease Characteristics of IR-CAD: a Case-control Study
The present case-control study is designed to investigate the disease characteristics of IR-CAD by comparing the demographics, clinical features, lab results, imaging findings, and prior treatment between 20 patients with IR-CAD…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Coronary Artery Restenosis, Coronary Artery Disease Progression
- Trial name
- NCT06007248
- Testing
- Protocol-defined Examinations
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
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