Clinical trials: Arthritis, Degenerative
Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the hip.
- Trial name
- NCT02844764
- Testing
- [StroMed + platelet rich plasma (PRP)]
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- VivaTech International, Inc.
Unilateral Knee Osteoarthritis
Durolane Compared to Saline in Patients With Unilateral Knee Osteoarthritis
This was a study that compared Durolane injections to saline injections in the treatment of unilateral osteoarthritis of the knee.
- Trial name
- NCT01806207
- Testing
- Durolane injection, Saline injection
- Where
- United Kingdom
- Volunteers
- 218 people
- Sponsor
- Galderma R&D
Arthritis, Rheumatoid, Osteoarthritis
12-Week No-Rofecoxib Plus Aspirin Endoscopy Study (0782-003)
This study will look at the incidence of gastric and/or duodenal ulcers in patients with osteoarthritis or rheumatoid arthritis in four different treatment groups (a) MK0782 21 mg plus enteric-coated aspirin, (b) MK0782 42 mg…
- Trial name
- NCT00543465
- Testing
- MK0782
- Volunteers
- 49 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis, Osteoarthritis
A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the Pinnacle™ Cup with a ceramic-on-ceramic bearing combination in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872222
- Testing
- Pinnacle™ Acetabular System
- Where
- Czechia
- Volunteers
- 98 people
- Sponsor
- DePuy International
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Clinical Evaluation of Vanguard DD RP
This is a single cohort, prospective study of performance and safety of the Vanguard Deep Dish Rotating Platform (DD RP) cementless fixation with the goal to acquire clinical outcomes data and evaluate the performance of the…
- Conditions
- Knee Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT04076202
- Testing
- Cementless Vanguard DD RP
- Where
- Austria
- Volunteers
- 113 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Evaluation of the Latella Knee Implant System for Medial Osteoarthritis Pain Reduction (Latella-2 Study)
The objective of the Latella-2 study is to demonstrate the safety and efficacy of the Latella Knee Implant System for the reduction of medial osteoarthritis knee pain.
- Trial name
- NCT02343705
- Testing
- Latella Knee Implant System
- Where
- 12 sites in Netherlands, Spain and 1 more
- Volunteers
- 67 people
- Sponsor
- Cotera, Inc.
Osteoarthritis, Knee
Efficacy and Safety of PG-530742 in the Treatment of Mild to Moderate Knee Osteoarthritis
Matrix metalloproteinases (MMPs) have been implicated in the cartilage degradation. PG-530742 inhibits some MMPs, potentially limiting cartilage degradation and disease progression.
- Trial name
- NCT00041756
- Testing
- PG-530742, 50 mg PG-530742, 100 mg PG-530742
- Where
- 23 sites in Hungary, United Kingdom
- Volunteers
- 395 people
- Sponsor
- Procter and Gamble
Osteoarthritis
Study Evaluating rhMBP-2/CPM in Open Wedge Osteotomies
To assess the feasibility of using rhBMP-2/CPM in OWO as a surgical model for pharmacodynamic studies, with assessment of the following parameters: Injecting the desired volume of rhBMP-2/CPM within the defect Conducting…
- Trial name
- NCT00243295
- Testing
- rhBMP-2/CPM
- Volunteers
- 6 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Osteoarthitis
Clinical Trial to Assess the Safety and Efficacy of Intra-articular Injection Collagen Versus Hyaluronic Acid on Knee Osteoarthritis
This study was designed to assess the efficacy for pain relief, functional improvement, and safety of intra-articular collagen injections compared to hyaluronic acid injections for knee osteoarthritis.
- Trial name
- NCT07511777
- Testing
- CartiZol, Synovian inj.
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Cellontech Co., Ltd.
Osteoarthritis
To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee
The purpose of this study was to determine whether, in patients with mild to moderate knee osteoarthritis, canakinumab is safe and tolerable when injected intra-articularly.
- Trial name
- NCT01160822
- Testing
- Canakinumab, Naproxen
- Where
- 13 sites in United States, Finland and 2 more
- Volunteers
- 169 people
- Sponsor
- Novartis Pharmaceuticals
Non-inflammatory Joint Diseases
Metal on Metal Versus Ceramic on Metal Hip Replacement
The purpose of this study is to compare the performance of artificial hips with metal heads and metal sockets to artificial hips with ceramic heads articulating with metal socket components.
- Trial name
- NCT00208494
- Testing
- Total Hip Replacement
- Where
- 9 sites in United States, Canada
- Volunteers
- 392 people
- Sponsor
- DePuy Orthopaedics
Degenerative Joint Disease of the Hip
A Prospective, Multicenter, Single Arm Feasibility Study of the Safety and Performance of GRADION™ Hip Total Cartilage Replacement (TCR)™ in the Treatment of Degenerative Joint Disease of the Hip
This is a prospective, multicenter, single arm feasibility study of the safety and performance of the GRADION™ Hip Total Cartilage Replacement (TCR)™ in patients who require cartilage replacement.
- Trial name
- NCT01982266
- Testing
- GRADION™ Hip Total Cartilage Replacement (TCR)™
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Biomimedica, Inc
Knee Osteoarthritis
Effectiveness of Two Hyaluronic Acids in Osteoarthritis of the Knee
The purpose of this study is to assess whether a single injection hyaluronic acid (HA) product is not inferior to a 3 injection HA product at 24 weeks (6 months), in terms of effectiveness in reducing pain when walking in…
- Trial name
- NCT01543737
- Testing
- 3ml hyaluronic acid (DUROLANE), 2ml hyaluronic acid, (HYALGAN)
- Where
- 17 sites in France, Monaco
- Volunteers
- 290 people
- Sponsor
- Bioventus LLC
Osteoarthritis
Efficacy and Safety of Intraarticular Injections of Hyalgan in the Treatment of Osteoarthritis of the Knee
Evaluate the efficacy and safety of Hyalgan, at a dose of 20mg/2ml administered as 5 intraarticular injections at weekly intervals, for the sustained relief of pain and amelioration of joint dysfunction in patients of OA of the…
- Trial name
- NCT01319461
- Testing
- Hyalgan, sterile normal saline
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Med Pharma Co., Ltd.
Osteoarthritis of Hip
ArCom® and ArComXL® Polyethylene Data Collection
The purpose of this prospective clinical data-collection is to document the performance, clinical outcomes, and wear rates of ArCom® and ArComXL® Polyethylene.
- Trial name
- NCT00565786
- Testing
- ArCom® Polyethylene, ArComXL® Polyethylene
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis, Post-traumatic Osteoarthritis
Establish Implant Accuracy With X-PSI Knee System
The goal of this study is to establish the accuracy of the new X-PSI Knee System guides by analyzing early postoperative (4-6 weeks) imaging data with regards to the mechanical alignment and compare them with preoperative…
- Trial name
- X-PSI (NCT03275246)
- Testing
- X-PSI Knee System
- Where
- 4 sites in Germany, Netherlands and 1 more
- Volunteers
- 8 people
- Sponsor
- Zimmer, GmbH
Knee Osteoarthritis
Assessment of Efficacy of a Single Intra-articular Injection of HYALUBRIX 60 in Knee Osteoarthritis
The purpose of this study is to evaluate the effect of one single intra-articular (IA) injection of HYALUBRIX 60® plus physical exercise program (PEP) in terms of pain reduction, compared to PEP alone, in patients with knee…
- Trial name
- NCT06113783
- Testing
- HYALUBRIX 60
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis of the Lumbar Spine, Pain, Back
A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis of the Lumbar Spine
This is a Phase 3, Multicenter, Randomized, 22 Week, Double-Blind, Placebo Controlled and 3-Week, Open-Label Study to Evaluate the Efficacy and Safety of X0002 Spray in relief of the signs and symptoms of Subjects with…
- Trial name
- NCT03110523
- Testing
- X0002
- Sponsor
- Techfields Pharma Co. Ltd
Osteoarthritis, Knee
A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee OA pain.
- Trial name
- NCT06917404
- Testing
- Pentosan Polysulfate Sodium twice weekly
- Where
- 57 sites in United States, Australia and 2 more
- Volunteers
- 466 people
- Sponsor
- Paradigm Biopharmaceuticals Ltd.
Knee Osteoarthritis
sAfety PerfoRmance chitOsan osteOarthritis ViscosupplEmentation
KIO014 is an innovative chitosan-based biomaterial intended for synovial fluid viscosupplementation indicated for the symptomatic treatment of knee osteoarthritis (OA).
- Trial name
- APROOVE (NCT03679208)
- Testing
- Investigational device coded KIO014, Durolane(r) as control device
- Volunteers
- 100 people
- Sponsor
- Kiomed Pharma