Clinical trials: Arthritis, Degenerative
Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)
This is a multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of intra-articular administration of PTP-001 (MOTYS) for the treatment of knee osteoarthritis.
- Trial name
- MOTION-P (NCT07219771)
- Testing
- PTP-01
- Where
- 18 sites in United States, Australia
- Volunteers
- 300 people
- Sponsor
- Doron Therapeutics Inc.
Joint Health
A Decentralized Clinical Study Evaluating the Effectiveness of Two Different Doses of MyCondro™ on Physical Mobility and Joint Health
This study evaluates the effect of two different doses of a consumer-grade product, MyCondro™, on individuals experiencing mobility issues related to knee osteoarthritis.
- Trial name
- NCT07493239
- Testing
- MyCondro 300mg, MyCondro 600mg
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Elbow Joint Destruction, Post-traumatic Lesions
Clinical Outcomes Study of the Nexel Total Elbow
The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.
- Conditions
- Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis
- Trial name
- NCT02469662
- Testing
- Nexel Total Elbow
- Where
- 11 sites in United States, Australia and 6 more
- Volunteers
- 134 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee / Osteoarthritis, Hip
Efficacy and Safety of MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain
The objective of this study is to verify the superiority of 16 weeks of MT-5547 treatment to placebo, as evidenced by the WOMAC pain score (the efficacy outcome measure), in patients with osteoarthritis of the knee or hip.
- Trial name
- NCT03245008
- Testing
- MT-5547
- Where
- 27 sites in Japan
- Volunteers
- 626 people
- Sponsor
- Tanabe Pharma Corporation
Osteoarthritis, Knee
Investigating the Effect of Deep Sea Krill Oil Supplementation in Osteoarthritis of the Knee
To evaluate the effectiveness of 4 g Swisse High Strength Deep Sea Krill Oil (Superba BOOST) daily on pain reduction in adults with mild to moderate osteoarthritis of the knee compared to placebo over a 6 month period.
- Trial name
- NCT03483090
- Testing
- Swisse High Strength Deep Sea Krill Oil
- Where
- 4 sites in Australia
- Volunteers
- 235 people
- Sponsor
- Swisse Wellness Pty Ltd
Osteoarthritis, Knee, Rheumatoid Arthritis of Knee
Evaluation of The Safety And Performance of The Freedom Total Knee® System With The PEEK-OPTIMA Femoral Component
Prospective, multi-centre, non-comparative, post-market surveillance clinical study
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis of Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT03224689
- Testing
- PEEK-Optima Femoral Component
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Maxx Orthopedics Inc
Osteoarthritis, Arthritis
A Multi-centre, Prospective Surveillance to Assess Mid-term Performance of the Mpact Cup
This is a multi-centre, prospective post marketing surveillance study to assess mid-term performance of the Mpact cup in subjects requiring primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT02196818
- Testing
- Mpact Acetabular Shell
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Knee Osteoarthritis
Efficacy of Dehydrated Cell and Protein Concentrate Versus Corticosteroid
To compare the efficacy of Ascent injection versus corticosteroid injection in treating knee osteoarthritis.
- Trial name
- NCT03710005
- Testing
- Ascent, Standard
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- StimLabs
Osteoarthritis
Clinical Trial of Allogenic Adipose Tissue-Derived Mesenchymal Progenitor Cells Therapy for Knee Osteoarthritis
Evaluate the safety and efficacy of Allogenic Adipose Tissue-Derived Mesenchymal Progenitor Cells Therapy for Knee Osteoarthritis.
- Trial name
- NCT02641860
- Testing
- Mesenchymal progenitor cells
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Shanghai AbelZeta Ltd.
Osteoarthritis, Knee
A Study of LY2828360 in Patients With Osteoarthritic Knee Pain
To investigate the safety, efficacy and pharmacokinetics of single daily oral dose of LY2828360 in male and female subjects with osteoarthritic knee pain
- Trial name
- NCT01319929
- Testing
- LY2828360
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis, Avascular Necrosis
Comprehensive Nano - Post Market Clinical Follow-Up Study
This data collection project is intended to provide clinical outcomes data to engineering, marketing as well as fulfill the post market surveillance requirements of various regulatory authorities.
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Revision
- Trial name
- NCT03423953
- Testing
- Comprehensive Nano
- Where
- 5 sites in Austria, Canada and 2 more
- Volunteers
- 194 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Study to Investigate the Mechanism of Action of an Oral Enzyme Treatment With Bromelain, Trypsin and Rutoside Versus Placebo in Subjects With OsTeoarthritis
The purpose of this study is to evaluate the pharmacodynamic profile of an oral enzyme treatment with Bromelain, Trypsin and Rutoside in subjects with osteoarthritis.
- Trial name
- WobeSmart (NCT05038410)
- Testing
- Wobenzym®
- Where
- 5 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Mucos Pharma GmbH & Co. KG
Osteoarthritis, Knee
SI-613 Study for Knee Osteoarthritis
The objective of the study is to evaluate the efficacy and safety of intra-articular injections of SI-613 compared with placebo for knee OA.
- Trial name
- NCT03209362
- Testing
- SI-613
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Seikagaku Corporation
Knee Osteoarthritis
A Prospective Study to Evaluate the iTotal Knee and iPoly XE Tibial Inserts
This study is designed to evaluate the clinical outcomes of subjects who have recently undergone surgery with the iTotal® Cruciate Retaining (CR) Total Knee Replacement System (KRS) who have also had iPoly XE Tibial Inserts…
- Trial name
- NCT03289754
- Testing
- iPoly XE tibial insert with ConforMIS iTotal KRS
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Restor3D
Joint Disease
Autologous Plasma Rich in Growth Factors (PRGF) Treating the Symptomatic Knee OA
The purpose of this study is to evaluate the efficacy and safety of PRGF infiltrations in the treatment of knee osteoarthritis.
- Trial name
- NCT00782197
- Testing
- PRGF Intraarticular injection, Hyaluronic Acid Intraarticular injection
- Where
- 3 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Biotechnology Institute IMASD
Osteoarthritis, Inflammatory Arthritis
Gender Solutions Natural Knee Post-Market Study
This is a prospective multicenter study of the Gender Solutions Natural Knee Flex System when used in primary total knee arthroplasty.
- Conditions
- Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT01463566
- Testing
- Zimmer Gender(R) Solutions(TM) Natural-Knee(R) Flex System
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee, Osteoarthritis
Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthritis Of The Knee
The goal of this Phase 1 study is to investigate the safety of CYT-108, our experimental recombinant protease inhibitor drug candidate for osteoarthritis, in a population of patients suffering from osteoarthritis of the knee.
- Trial name
- NCT06263270
- Testing
- CYT-108, a recombinant protease inhibitor, Phosphate Buffered Saline (PBS)
- Where
- 3 sites in Australia
- Volunteers
- 19 people
- Sponsor
- Cytonics Corporation
Joint Diseases
EVOLUTION® Revision STEMMED CS Post Market Clinical Follow-up Study Protocol
MicroPort (MPO) is conducting this PMCF study to evaluate the safety and effectiveness of its EVOLUTION® Revision Tibial System and EVOLUTION® Revision STEMMED CS Femur with the EVOLUTION® MP CS Tibial Insert.
- Trial name
- NCT06142669
- Testing
- EVOLUTION® Revision Tibial System and EVOLUTION® Stemmed CS Femur with the EVOLUTION® MP CS Tibial Insert
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- MicroPort Orthopedics Inc.
Osteoarthritis
Magnitude of Osteoarthritis disadVantage on pEoples liveS
Estimate the prevalence of self-reported osteoarthritis and its characterization in adults over 45 years of age: Characterization of self-reported patients with OA (socio-demographic, comorbidities, VAS for intensity of pain)…
- Trial name
- MOVES (NCT01423097)
- Where
- Portugal
- Volunteers
- 1,015 people
- Sponsor
- AstraZeneca
Osteoarthritis, Knee
The Comparison of HYAJOINT Plus and Hyalgan Hyaluronan Supplement for Knee Osteoarthritis Pain
The aim of this study was to compare single injection HYAJOINT Plus Synovial Fluid Supplement used on the single and repeat treatment of knee osteoarthritis that has the same safety and effectiveness as three-injection…
- Trial name
- NCT03643588
- Testing
- HYAJOINT Plus, Hyalgan
- Volunteers
- 140 people
- Sponsor
- SciVision Biotech Inc.
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