Clinical trials: Arthritis, Degenerative
Osteoarthritis, Total Knee Arthroplasty
Use of Cold and Compression Therapy With Total Knee Replacement Patients
The purpose of the study is to evaluate the effectiveness of a device that delivers cold and intermittent compression as compared to ice and compressive wraps on patients who have undergone knee replacement.
- Trial name
- NCT00712816
- Testing
- Game Ready Injury Treatment System (CoolSystems Inc.), Ice with compressive bandages
- Where
- 11 sites in United States, Australia
- Volunteers
- 224 people
- Sponsor
- CoolSystems, Inc.
Osteoarthritis
Osteoarthritis Topical Treatment
This is a phase 2a clinical trial performed to evaluate the efficacy of a topical treatment of ibuprofen compared to the use of a placebo topical treatment. A multi-center, double-blinded, randomized placebo controlled study.
- Trial name
- ANTIPAIN (NCT01496326)
- Testing
- Ibuprofen
- Where
- 5 sites in Switzerland
- Volunteers
- 75 people
- Sponsor
- BioChemics, Inc.
Osteoarthritis, Knee, Osteoarthritis, Hip
Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip
The primary objective of this study is to evaluate the effectiveness of REGN475 compared to placebo in participants with pain due to osteoarthritis (OA) of the knee or hip and a history of inadequate joint pain relief or…
- Trial name
- NCT02447276
- Testing
- REGN475
- Where
- 72 sites in United States
- Volunteers
- 421 people
- Sponsor
- Regeneron Pharmaceuticals
Gastric Ulcer, Duodenal Ulcer
Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAID
The purpose of this study is to assess the efficacy of esomeprazole (D961H) 20 mg versus placebo once daily for up to 24 weeks of treatment involving patients with a history of gastric and/or duodenal ulcers receiving daily…
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Rheumatoid Arthritis, Osteoarthritis
- Trial name
- NCT00542789
- Testing
- Esomeprazole
- Where
- 39 sites in Japan
- Volunteers
- 343 people
- Sponsor
- AstraZeneca
Osteoarthritis, Knee
Study of SI000413 in Knee Osteoarthritis Patients
The purpose of this study is to evaluate efficacy and safety of SI000413 in patients with knee osteoarthritis by orally administration and to determine optimal dose.
- Trial name
- NCT01525758
- Testing
- SI000413, microcrystalline cellulose
- Where
- 3 sites in South Korea
- Volunteers
- 152 people
- Sponsor
- Dong-A Pharmaceutical Co., Ltd.
Knee Osteoarthritis
Clinical Investigation to Compare the Safety and Efficacy of Cellular Matrix to Those of Ostenil® Plus and to Those of PRP Only
Platelet-rich plasma (PRP) is an autologous product prepared from the patient's own blood, representing a powerful source of platelet-derived growth factors, particularly useful in the field of regenerative medicine.
- Trial name
- NCT02964143
- Testing
- Cellular Matrix / A-CP HA, Ostenil® Plus, RegenKit-BCT-1
- Volunteers
- 306 people
- Sponsor
- Regen Lab SA
Osteoarthritis, Knee
Efficacy and Safety of G001 in Patients With Osteoarthritis (OA) of the Knee
Phase 2 multicenter, double-blind, randomized, parallel-group, vehicle-controlled study to evaluate the efficacy, safety, and local tolerability of G001 topical gel compared to matching Vehicle topical gel in patients with…
- Trial name
- NCT05007808
- Testing
- G001 Topical Gel, Vehicle
- Where
- 10 sites in Canada
- Volunteers
- 210 people
- Sponsor
- BUZZZ Pharmaceuticals Limited
Meniscus; Degeneration, Knee Osteoarthritis
NUsurface Implant Registry
The purpose of this active post-market surveillance clinical registry study is to further characterize the therapeutic effect, the long-term safety and effectiveness of the NUsurface® meniscus implant in the real-world…
- Conditions
- Meniscus; Degeneration, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NIR (NCT03953846)
- Where
- 6 sites in Belgium, Germany and 2 more
- Volunteers
- 36 people
- Sponsor
- Phoenix Kinetics
Osteoarthritis, Rheumatoid Arthritis
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501, a fixed-dose combination oral tablet of 800 mg ibuprofen and 26.6 mg famotidine for patients that require long-term NSAID treatment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- NCT00984815
- Testing
- HZT-501
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Moderate Pain in Knee Osteoarthritis, Severe Pain in Knee Osteoarthritis
A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis
Primary Objective: To explore the effectiveness of different doses of HRS-2129 in the treatment of patients with moderate to severe pain in knee osteoarthritis.
- Trial name
- NCT07351968
- Testing
- HRS-2129 Tablet, Celecoxib capsule
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Arthritis, Osteoarthritis
A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, in Patients With Rheumatoid Arthritis or Osteoarthritis
The purpose of this study is to assess the degree of pain control achieved by treatment with fentanyl, administered via adhesive patches applied to the skin ('transdermal system") in patients with rheumatoid arthritis or…
- Conditions
- Arthritis, Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT00524160
- Testing
- Fentanyl transdermal patch
- Volunteers
- 264 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Osteoarthritis, Hip, Rheumatoid Arthritis
A Clinical Investigation of the Balance® Microplasty™ Hip System
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Balance® Microplasty™ Hip System.
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis
- Trial name
- NCT00699088
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthritis, Knee
Oxford Partial Knee Comparative Instrument Pilot Study
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Oxford Partial Knee System using Signature Custom Guides and Conventional Instrumentation.
- Trial name
- NCT01410786
- Testing
- Conventional Instrumentation, Signature Custom Guides
- Where
- New Zealand
- Volunteers
- 35 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis, Hip Osteoarthritis
The Kaia Hip and Knee Pain Intervention for Self-management of the Pain in Patients With Osteoarthritis.
The study intervention provides an innovative way of making exercise training and other recommended lifestyle modifications as accessible as possible for knee and hip OA participants by introducing a home-based exercise training…
- Trial name
- PIVOT (NCT04615377)
- Testing
- Kaia hip and knee pain application, Treatment as usual
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Kaia Health Software
Osteoarthritis of the Knees
Determining the Optimal Dose of AD-211 in Patients With Osteoarthritis of the Knee
The purpose of this study is to determine the optimal dose of AD-211 in patients with osteoarthritis of the knee.
- Trial name
- NCT07550231
- Testing
- AD-211-L, AD-211-M, AD-211-H
- Volunteers
- 200 people
- Sponsor
- Addpharma Inc.
Osteoarthritis, Knee
JOURNEY™ II CR Total Knee System
The purpose of this study is to evaluate the safety and effectiveness of the JOURNEY™ II CR Total Knee System in subjects with degenerative joint disease (DJD) requiring primary total knee replacement.
- Trial name
- NCT02440672
- Testing
- JOURNEY™ II CR Total Knee System (J II CR TKS)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis,Knee
Celebrex Short Versus Long Therapy In Osteoarthritis Of The Knee
This is a phase III, multicentre, randomized, double blind, parallel-group, pilot study designed to compare a long term (12 weeks) versus a short term (2 weeks) treatment with celecoxib 200 mg/die in treatment and prevention of…
- Trial name
- NCT00137410
- Testing
- Celebrex
- Where
- 16 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Pfizer
Knee Arthritis Osteoarthritis
An Open-Label, Double-Treatment Group Study to Evaluate the Efficacy and Safety of Human Allogeneic Bone-Marrow- Derived Mesenchymal Stromal Cell Product StromaForte Compared With Hyaluronic Acid for the Treatment of Knee Osteoarthritis
StromaForte injection for knee OA
- Trial name
- NCT07542808
- Testing
- Mesenchymal Stem Cells (MSC), Hyaluronic Acid (HA)
- Where
- United Arab Emirates
- Volunteers
- 140 people
- Sponsor
- Cellcolabs Clinical SPV Limited
Osteoarthritis, Degenerative Arthritis
Pinnacle RSA Study
The primary objective is to establish the mean superior cup migration of the Pinnacle Acetabular Shell using model-based RSA over the first two years post-implantation.
- Trial name
- NCT04070989
- Testing
- THA
- Where
- 3 sites in Canada
- Volunteers
- 100 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
Safety, Efficacy and Acceptability of Flavocoxid (Limbrel)A Pilot Study
safety, efficacy and acceptability of Flavocoxid
- Trial name
- NCT00303017
- Testing
- flavocoxid, Naproxen
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Primus Pharmaceuticals
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