Clinical trials: Arthritis, Degenerative
Knee Osteoarthritis
Efficacy of Non-animal Chondroitin Sulphate for Overweight Subjects With Knee Ostoarthritis.
Knee osteoarthritis (OA) is predicted to become the fourth leading cause of disability worldwide by 2020. and is estimated to affect more than 40 million people in Europe and 4 million people in Italy.
- Trial name
- NACSKO (NCT03731793)
- Testing
- Non-Animal Chondroitin Sulphate
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Pain
Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain
The purpose of the study is to evaluate the efficacy and safety of OraVescent fentanyl treatment compared to placebo treatment monthly over a 12-week treatment period in alleviating breakthrough pain (BTP) in opioid-tolerant…
- Trial name
- NCT00343733
- Testing
- OraVescent Fentanyl
- Where
- 21 sites in United States
- Volunteers
- 120 people
- Sponsor
- Cephalon
Post-traumatic Osteoarthritis, Unspecified Ankle and Foot, Localized, Primary Osteoarthritis of the Ankle and/or Foot
Prospective Subtalar, Double, or Triple Arthrodesis Study With CCS Screws
The objective of this study is to prospectively evaluate the mid-term results and intraoperative and postoperative complication rate in patients who underwent double or triple arthrodesis using CCS screws.
- Trial name
- NCT02619838
- Testing
- Aptus CCS 5.0 or/and 7.0 screws
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Osteoarthritis, Knee, Muscle Weakness
PB125, Osteoarthritis, Pain, Mobility, and Energetics
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important regulator in the body. It controls how well cells protect themselves against stress.
- Conditions
- Osteoarthritis, Knee, Muscle Weakness, Pain, Joint
- Trial name
- NCT04638387
- Testing
- PB125
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Colorado State University
Bilateral Total Knee Arthroplasty, Gonarthrosis; Primary, Bilateral
Bilateral Simultaneous Total Knee Arthroplasty for Bilateral Gonarthrosis
The effects of two-team and single-team simultaneous bilateral total knee arthroplasty (SBA) on peri- and postoperative complications are not clear.
- Trial name
- NCT04299516
- Testing
- Two-team simultaneous bilateral total knee arthroplasty, Single-team simultaneous bilateral total knee arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 246 people
- Sponsor
- Bezmialem Vakif University
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Knee Chondropathy, Osteoarthritis, Knee
Platelet-rich Plasma vs Viscosupplementation in the Treatment of Knee Articular Degenerative Pathology
The investigators hypothesized that intra-articular injections of Platelet-rich Plasma (PRP) to treat knee degenerative articular cartilage pathology could determine pain relief and recovery of knee function with overall clinical…
- Trial name
- PRP2009 (NCT01670578)
- Testing
- PRP, Hyaluronic acid
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis
African American Preference for Knee Replacement: A Patient-Centered Intervention
A randomized, controlled design will be utilized to examine and compare the effectiveness of the proposed educational intervention, which includes an educational decision aid with attention control on select key patient-centered…
- Trial name
- ACTION (NCT01851785)
- Testing
- Decision Aid (DA) Intervention
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- University of Pennsylvania
Osteoarthritis of the Knee
Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee
The purpose of this study is to compare the efficacy of celecoxib versus placebo in delaying the onset of pain and improving walking function in subjects with knee Osteoarthritis
- Trial name
- NCT00597415
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center
Osteoarthritis of the Knee
KineSpring® System Patient Preference Study
The primary objectives of the survey are to obtain patient preference information that can be useful during the benefit-risk assessment of the KineSpring System.
- Trial name
- NCT02934672
- Testing
- Survey
- Volunteers
- 323 people
- Sponsor
- Moximed
Osteoarthritis
Health and Risk Factors in Patients With Hip and Knee Osteoarthritis
Hip and knee osteoarthritis is one of the leading causes of global disability. There is no cure for the disease, but research and guidelines recommends that patients with osteoarthritis, early after the diagnosis, receive…
- Trial name
- NCT03438630
- Where
- Sweden
- Volunteers
- 288,276 people
- Sponsor
- Vastra Gotaland Region
Medial Compartment Osteoarthritis, Genu Varum
TO Plate Fixation vs. External Fixator Comparison (HTO Plate vs. ExFix Study)
This study aims to compare the efficacy, accuracy, and functional outcomes of two different surgical stabilization techniques for medial opening wedge high tibial osteotomy (HTO) in patients with varus deformity and medial…
- Conditions
- Medial Compartment Osteoarthritis, Genu Varum, Varus Deformity, High Tibial Osteotomy
- Trial name
- NCT07220434
- Testing
- Medial HTO Locking Plate, Self-Adjusting HTO External Fixator
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Muhammed Cagatay Engin
Osteoarthritis of Multiple Joints
Probiotic for Osteoarthritis
The gut microbiome appears to be a significant contributor to musculoskeletal health and disease. Microbiome composition and its functional implications have been associated with prevention of bone loss and/or reducing fracture…
- Trial name
- NCT03985709
- Testing
- Probiotic product
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Osteoarthritis of Knee
Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency
This study investigates the effectiveness of two treatments-genicular nerve radiofrequency ablation and pulsed radiofrequency-in reducing pain and improving function in osteoarthritis patients.
- Trial name
- GRFT-PRF (NCT06894147)
- Testing
- Genicular nerve pulse radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis, Knee
Probiotic Supplements in Osteoarthritis
The current study aims to evaluate the effectiveness of adding probiotics to the standard of care in improving OA patient-related outcomes such as pain, stiffness, and physical activity.
- Trial name
- NCT07364578
- Testing
- Probiotic Formula, Control
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- Beni-Suef University
Healthy Volunteers
A Pilot Open-Label Crossover Bioavailability Study of Celecoxib in Healthy Volunteers
A pharmacokinetic study in healthy volunteers to determine the relative bioavailability of three formulations of celecoxib to the approved formulation.
- Trial name
- NCT00813241
- Testing
- celecoxib reference formulation, celecoxib test formulation A1, celecoxib test formulation B2
- Where
- Singapore
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
KOA
A Study of [89Zr]-Oxine-NCR100 Injection for the Cellular Distribution
This clinical study is to evaluate the biodistribution of [89Zr]-Oxine-NCR100 injection in subjects with knee osteoarthritis after local injection and the kinetic behavior characteristics of zirconium-labeled cells at the…
- Trial name
- Distribution (NCT07139431)
- Testing
- NCR100
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Osteoarthritis
Functional Outcome in Two Types of Total Knee Replacement Surgery for People With Osteoarthritis
When performing total knee replacement surgery, the surgeon has a choice as to which type of surgical technique to use. The standard technique at the Royal Infirmary in Edinburgh is the so-called 'medial parapatellar' exposure.
- Trial name
- NCT01576445
- Testing
- Mid-vastus approach, medial parapatellar approach
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Margaret University
Knee Osteoarthritis, Total Knee Arthroplasty
Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance
The investigators hypothesized that intraoperative opioid consumption would be different between remimazolam and propofol if the ANI-guided remifentanil continuous infusion rate was adjusted when the depth of anesthesia was…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Remimazolam
- Trial name
- NCT05322902
- Testing
- remimazolam group, propofol group
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Gangnam Severance Hospital
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma