Clinical trials: Arthritis, Inflammatory
Rheumatoid Arthritis (RA)
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of SHR-3045 in Healthy Subjects
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single-dose subcutaneous injection of SHR-3045 in healthy subjects.
- Trial name
- NCT07200596
- Testing
- SHR-3045 Injection
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Osteoarthritis
A 2 Week Blinded Study For Pain Due To Arthritis Of The Knee
The primary aim is to assess if PF-00592379 is able to reduce pain in patients with osteoarthritis of the knee.
- Trial name
- NCT00483977
- Testing
- Oxycodone, PF-000592379
- Where
- 21 sites in United States
- Volunteers
- 113 people
- Sponsor
- Pfizer
Rheumatoid Arthritis (RA)
A Phase IIa Study of JAB-8263 in Patients With Active Rheumatoid Arthritis
This study is an open-label, multi-center Phase IIa study. The study is divided into two phases. The first phase is a safety exploration phase.
- Trial name
- JAB-8263 (NCT07684157)
- Testing
- JAB-8263
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
Rheumatoid Arthritis
Exposure Study Comparing 3 Routes of Methotrexate (MTX) Administration
Pharmacokinetics (PK) study
- Trial name
- NCT01737944
- Testing
- Methotrexate (MTX)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Antares Pharma Inc.
Rheumatoid Arthritis
A Study to Evaluate the Efficacy and Safety of ASP1707 in Postmenopausal Female Patients With Rheumatoid Arthritis Taking Methotrexate
The objective of this study is to evaluate the efficacy, pharmacokinetics, pharmacodynamics and safety of ASP1707 in combination with MTX in postmenopausal female patients with RA.
- Trial name
- NCT02884635
- Testing
- ASP1707, Methotrexate
- Where
- 27 sites in Japan
- Volunteers
- 72 people
- Sponsor
- Astellas Pharma Inc
Arthritis
A Pharmacokinetic (PK) Study Evaluating Naproxen and Esomeprazole Plasma Levels
A pharmacokinetic study evaluating naproxen and esomeprazole blood levels in 4 treatments, each containing one or both components.
- Trial name
- NCT00749385
- Testing
- PN 400, EC naproxen plus EC esomeprazole, EC naproxen
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- POZEN
Rheumatoid Arthritis (RA)
Safety and Efficacy of TollB-001 Tablets in Moderate to Severe Rheumatoid Arthritis
The goal of this study is to evaluate the safety, pharmacokinetic (PK) characteristics, and preliminary efficacy of a new oral chemical drug in : adults aged 18-70 years (male or female) with moderate to severe active rheumatoid…
- Trial name
- NCT07408024
- Testing
- TollB-001
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Toll Biotech Co. Ltd. (Beijing)
Arthritis, Juvenile
A Study of Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis
The purpose of this study is to evaluate the pharmacokinetics (PK), efficacy, safety and immunogenicity of ustekinumab and guselkumab in active juvenile psoriatic arthritis (jPsA).
- Trial name
- PSUMMIT-Jr (NCT05083182)
- Testing
- Ustekinumab, Guselkumab
- Where
- 50 sites in United States, Argentina and 8 more
- Volunteers
- 48 people
- Sponsor
- Janssen Research & Development, LLC
Ankylosing Spondyloarthritis
Study of Apremilast to Treat Subjects With Active Ankylosing Spondylitis
Apremilast is a new, orally available, small molecule drug that specifically inhibits phosphodiesterase 4 (PDE4), an enzyme that modulates inflammatory cytokines.
- Trial name
- POSTURE (NCT01583374)
- Testing
- Apremilast tablet 20 mg, Apremilast tablet 30 mg BID
- Where
- 103 sites in United States, Australia and 16 more
- Volunteers
- 490 people
- Sponsor
- Amgen
Venous Thromboses, Venous Thromboembolism
The Risk of Venous Thromboembolism in Systemic Inflammatory Disorders: a United Kingdom (UK) Matched Cohort Study
Blood clots occurring in the legs and in the lungs are relatively common; they occur in around 3 in a 1000 people per year. They can cause disability and are also potentially life threatening.
- Conditions
- Venous Thromboses, Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT03835780
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 266,890 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Knee Osteoarthritis
Pharmacokinetics of Imrecoxib in Subjects With Hepatic Insufficiency
This clinical research study will assess pharmacokinetics and the safety of Imrecoxib in patients with impaired hepatic function as compared to healthy volunteers.
- Trial name
- NCT02456688
- Testing
- Imrecoxib
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Osteoarthritis, Knee
A Controlled Surveillance of the Osteoarthritic Knee Microenvironment With Regenexx® SD Treatment
The primary objective of this study is to determine the levels of proteins and/or cellular components of the synovial fluid that are indicative of microenvironment phenotypes of the osteoarthritic knee compared to unilateral…
- Trial name
- NCT02370823
- Testing
- Regenexx SD
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Regenexx, LLC
Rheumatoid Arthritis
TL011 in Severe, Active Rheumatoid Arthritis Patients
The purpose of this study is to determine the safety and pharmacology of TL011 in patients with severe rheumatoid arthritis.
- Trial name
- NCT01123070
- Testing
- TL011, anti CD20, for the treatment of rheumatoid arthritis, MabThera infusions
- Where
- 18 sites in Czechia, Hungary and 3 more
- Volunteers
- 54 people
- Sponsor
- Teva Pharmaceutical Industries, Ltd.
Rheumatoid Arthritis
Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel)
This study is designed to evaluate the effectiveness of adding etanercept to disease modifying anti-rheumatic drug (DMARD) therapy in patients with moderately active Rheumatoid Arthritis (RA).
- Trial name
- NCT01313208
- Testing
- etanercept, DMARD Therapy
- Where
- 47 sites in United States, Canada
- Volunteers
- 210 people
- Sponsor
- Amgen
Bone Necrosis, Arthritis/Arthrosis
Prospective Clinical 5-year Follow-up of the LINK® Endo-Model® SL®
The objective of this study is to collect outcome information on patients requiring Total Knee Replacement (TKR) in primary or revision cases and therefore receiving the LINK® Endo-Model® SL® under routine conditions.
- Conditions
- Bone Necrosis, Arthritis/Arthrosis, Failure of Prosthetic Joint Implant
- Trial name
- NCT02367417
- Where
- 3 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Waldemar Link GmbH & Co. KG
Rheumatoid Arthritis (RA)
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)
Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function.
- Trial name
- NCT04888585
- Testing
- ABBV-154
- Where
- 220 sites in United States, Australia and 19 more
- Volunteers
- 473 people
- Sponsor
- AbbVie
Axial Spondylarthritis (axSpA), Psoriatic Arthritis (PsA)
Treatment Effectiveness in People With axSpA or PsA Starting Treatment With Bimekizumab, Risankizumab, Guselkumab, Upadacitinib, or a TNF Inhibitor
This observational study will target patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) who have started treatment with bimekizumab, upadacitinib, risankizumab, guselkumab, or a tumour necrosis…
- Trial name
- NCT07166315
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 700 people
- Sponsor
- Adelphi Real World
Medial Monocompartmental Osteoarthritis of the Knee
Position HTO Multicenter NIS
Evaluation of the Position HTO system in patients with unicompartmental medial arthrosis after open wedge high tibial osteotomy
- Trial name
- Position HTO (NCT00889304)
- Testing
- Position HTO system
- Where
- 5 sites in Germany
- Volunteers
- 221 people
- Sponsor
- Aesculap AG
Rheumatoid Arthritis
Prospective Observational Study of Filgotinib in Participants With Rheumatoid Arthritis in France
An observational study to describe the effectiveness, safety, and patient-reported outcomes (PROs) in participants with moderate to severe active rheumatoid arthritis (RA) in France receiving filgotinib in real-world setting.
- Trial name
- PARROTFISH (NCT05323591)
- Testing
- Filgotinib
- Where
- 17 sites in France
- Volunteers
- 155 people
- Sponsor
- Alfasigma S.p.A.
Ankle Arthritis, Foot Arthritis
Use of a Dynamic Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis
The purpose of this study is to determine the clinical efficacy of a novel dynamic compression intramedullary nail for tibiotalocalcaneal (TTC) arthrodesis.
- Trial name
- NCT03747952
- Testing
- Tibiotalocalcaneal arthrodesis, DynaNail
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- MedShape, Inc