Clinical trials: Arthritis, Rheumatoid
Rheumatoid Arthritis
DF(Oat Bran) Intervention on Inflammation, Intestinal Flora, Disease Activity and Quality of Life in Patients With RA
The goal of this clinical trial is to test in Rheumatoid arthritis. The main question it aims to answer are: To verify the effect of dietary fiber supplementation on reducing the level of inflammation; To verify the effect of…
- Trial name
- NCT06322784
- Testing
- Oat bran (dietary fiber)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shenzhen People's Hospital
Arthritis, Rheumatoid, Syndrome, Metabolic
An Exploratory Clinical Study on Autophagy During Fasting
Autophagy is considered one of the key molecular mechanisms for the broad preventive and therapeutic effects of periodic fasting.
- Conditions
- Arthritis, Rheumatoid, Syndrome, Metabolic, Healthy
- Trial name
- NCT04739852
- Testing
- Fasting
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Osteoarthritis, Hip, Osteonecrosis of Femoral Head
Squeaking in Ceramic-on-Ceramic Total Hip Arthroplasty Using Delta TT Cup
This study will evaluate clinical outcome on patients who undergo ceramic on ceramic (CoC) bearing total hip arthroplasty (THA) using Delta TT cup.
- Conditions
- Osteoarthritis, Hip, Osteonecrosis of Femoral Head, Femoral Neck Fractures, Rheumatoid Arthritis of Hip
- Trial name
- NCT04594564
- Testing
- Total hip arthroplasty with Delta TT cup
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Seoul National University Hospital
Rheumatoid Arthritis
Association of Fear of Falling and Physical Activity in Rheumatoid Arthritis Comparison Before and After Biological Therapy
Primary Objective: To identify the prevalence and severity of the fear of falling in a rheumatoid population Secondary Objectives: To explore the effect the treatment with biological agents has on fear of falling and physical…
- Trial name
- NCT01071863
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Rheumatoid Arthritis
Very Early Versus Delayed Etanercept in Patients With RA
The main aim of the study is to determine whether TNFi instituted as first-line therapy in early RA confers better outcomes (clinical, structural and immunological) compared to delayed TNFi start; implying particular dominance of…
- Trial name
- VEDERA (NCT02433184)
- Testing
- Etanercept, Methotrexate, Sulfasalazine
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Leeds
Rheumatoid Arthritis
A Study To Evaluate The Safety And Efficacy Of Tofacitinib Modified Release Tablets Compared To Tofacitinib Immediate Release Tablets In Adult Patients With Rheumatoid Arthritis
This is a 12 week study that will evaluate the efficacy and safety of the 11 mg tofacitinib modified release tablet taken once a day in patients with rheumatoid arthritis who continue taking methotrexate.
- Trial name
- NCT02281552
- Testing
- Tofacitinib
- Where
- 36 sites in Japan
- Volunteers
- 209 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
A Phase I/III Study to Evaluate Efficacy, PK and Safety Between CT-P13 SC and CT-P13 IV in Patients With Active RA
This is a Phase I/III Study to Evaluate Efficacy, Pharmacokinetics and Safety between CT-P13 SC and CT-P13 IV in Patients with Active Rheumatoid Arthritis (RA).
- Trial name
- NCT03147248
- Testing
- CT-P13
- Where
- South Korea
- Volunteers
- 407 people
- Sponsor
- Celltrion
Inflammation, Rheumatoid Arthritis
A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Methotrexate
This trial is conducted in Europe, North America and South America. The aim of this trial is to investigate the clinical efficacy of NNC0109-0012, a human monoclonal antibody, compared to placebo when administered as weekly…
- Trial name
- NCT01636843
- Testing
- NNC0109-0012
- Where
- 139 sites in United States, Argentina and 12 more
- Volunteers
- 298 people
- Sponsor
- Novo Nordisk A/S
Rheumatoid Arthritis
A Study of Safety and Effectiveness of Golimumab in Participants With Active Rheumatoid Arthritis Despite Methotrexate Therapy
The purpose of this study is to assess the clinical effectiveness and safety of golimumab intravenous (IV) infusions every 12 weeks with or without Methotrexate (MTX), compared with MTX alone, in patients with active rheumatoid…
- Trial name
- NCT00361335
- Testing
- Golimumab, Methotrexate
- Where
- 72 sites in United States, Argentina and 13 more
- Volunteers
- 643 people
- Sponsor
- Centocor, Inc.
Rheumatoid Arthritis
Efficacy and Safety Study of MK0359 in Patients With Arthritis (0359-017)
Efficacy and Safety Study of MK0359 in Patients with Arthritis
- Trial name
- NCT00482417
- Testing
- MK0359
- Volunteers
- 11 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis
A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis
This study was designed to evaluate the safety of administering rituximab at a more rapid infusion rate in patients with moderate to severe rheumatoid arthritis who have had an inadequate response to biopharmaceuticals that treat…
- Trial name
- RATE-RA (NCT01382940)
- Testing
- rituximab, methotrexate, methylprednisolone
- Where
- 86 sites in United States
- Volunteers
- 351 people
- Sponsor
- Hoffmann-La Roche
Immune-Related Adverse Events, Lupus Erythematosus, Systemic
Interferon Signature in Anti-CTLA-4 and Anti-PD-1/PD-L1-Treated Cancer Patients Compared With Systemic Autoimmune Disease Patients
This study aims to identify a way to predict the side effects that some people with cancer experience when receiving immunotherapy.
- Conditions
- Immune-Related Adverse Events, Lupus Erythematosus, Systemic, Sjogren Syndrome, Systemic Sclerosis (SSc)
- Trial name
- INTER-AUTENTIC (NCT07249060)
- Testing
- Immune Checkpoint Inhibitors
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Hospital Universitario Araba
Type 2 Diabetes
Impact of Rheumatoid Arthritis on the Course of Type 2 Diabetes During a Longitudinal Follow-up of 5 Years
The purpose of this study is to determine whether patients with rheumatoid arthritis and type 2 diabetes experience a more severe disease course compared to control patients with osteoarthritis and type 2 diabetes
- Trial name
- INSPIRED (NCT02639988)
- Where
- France
- Volunteers
- 176 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis
A Moderate to Severe Rheumatoid Arthritis Study
The purpose of this study is to determine whether baricitinib 4 milligram (mg) once daily is superior to placebo in the treatment of participants with moderately to severely active Rheumatoid Arthritis (RA) who have had an…
- Trial name
- RA-BEACON (NCT01721044)
- Testing
- Baricitinib, cDMARD
- Where
- 103 sites in United States, Argentina and 20 more
- Volunteers
- 527 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
Promoting Engagement in Physical Activity in Early Rheumatoid Arthritis: Proof of Concept Study
People with rheumatoid arthritis have indicated that they would like better support to remain physically active following diagnosis and would welcome a physical activity programmes delivered outside of a secondary care setting by…
- Trial name
- PEPA-RA (NCT04321798)
- Testing
- Physical Activity
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of the West of England
Rheumatoid Arthritis
Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis
The purpose of the study is to assess the long-term safety, tolerability, and efficacy of repeated administration of adalimumab in adult Japanese subjects with rheumatoid arthritis.
- Trial name
- NCT00235833
- Testing
- adalimumab
- Where
- 7 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Abbott
Rheumatoid Arthritis
Assessment of the Effectiveness of IV and SC Abatacept (Orencia) Patient Alert Cards in Patients With Rheumatoid Arthritis in a Sample of EU Countries
The purpose of the study is to determine a) if the implementation of abatacept (Orencia®) patient alert card (PAC) resulted in effective understanding of key safety messages and b) if the degree of understanding of key safety…
- Trial name
- NCT02632890
- Where
- 36 sites in France, Germany and 3 more
- Volunteers
- 203 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Comparison of Two Etanercept Regimens (REUMATOCEPT® Versus ENBREL®) for Treatment of Rheumatoid Arthritis
This study is a comparison of safety and efficacy of two etanercept regimens (REUMATOCEPT® versus ENBREL®) for treatment of Rheumatoid Arthritis.
- Trial name
- NCT01394913
- Testing
- Reumatocept (etanercept), Enbrel (etanercept)
- Where
- Brazil
- Sponsor
- EMS
Arthritis, Rheumatoid
Topical Tripterygium Wilfordii Gel for Moderate Activity Rheumatoid Arthritis
Tripterygium wilfordii Hook F (TwHF), a traditional Chinese herb, is widely used in China for treating Rheumatoid Arthritis (RA), but limited only for elderly RA patients because of its reproductive system toxicity.
- Trial name
- NCT02818361
- Testing
- Topical tripterygium gel
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Rheumatoid Arthritis, Juvenile
A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Juvenile Rheumatoid Arthritis
The purpose of this study is to evaluate the effectiveness and safety of infliximab (Remicade) in patients with Juvenile Rheumatoid Arthritis (JRA).
- Trial name
- NCT00036374
- Testing
- Infliximab
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Centocor, Inc.