Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis
Patients With Rheumatoid Arthritis (RA) Treated With Rituximab in Kuopio University Hospital
One centre follow-up study on safety and efficacy of treatment with rituximab among patients with RA during 4 year period. Basic data is collected for the national register of biologicals.
- Trial name
- KuoRituxi1 (NCT00854321)
- Testing
- rituximab, rituximab, observational study amon patients with active RA
- Where
- Finland
- Volunteers
- 49 people
- Sponsor
- Kuopio University Hospital
Rheumatoid Arthritis
Evaluating Efficacy and Safety of Etanercept 50 mg Twice Weekly (BIW) in Rheumatoid Arthritis (RA) Subjects Who Are Sub-Optimal Responders to Etanercept 50 mg Once Weekly (QW)
The purpose of this study objective will be to evaluate the efficacy and safety of etanercept 50 mg BIW in RA subjects who showed a sub-optimal response to standard dose etanercept (50 mg QW) and concomitant methotrexate therapy.
- Trial name
- NCT00115219
- Testing
- Etanercept
- Volunteers
- 200 people
- Sponsor
- Amgen
Rheumatoid Arthritis
A Study of the Safety and Pharmacokinetics of PRO283698 in Patients With Rheumatoid Arthritis
This is a Phase I multicenter study that will be conducted in the United States and Europe.
- Trial name
- NCT00888745
- Testing
- PRO283698
- Where
- 12 sites in United States, Hungary
- Volunteers
- 65 people
- Sponsor
- Genentech, Inc.
Rheumatoid Arthritis, Insomnia
Cognitive Behavioural Therapy for Insomnia on Sleep in Rheumatoid Arthritis.
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory joint disease that attacks peripheral joints and posterior tissues.
- Trial name
- NCT03766100
- Testing
- Cognitive behavioural therapy (CBT-i)
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Bente Appel Esbensen
Rheumatoid Arthritis
Safety of Splenic Stimulation for RA
This study will evaluate the safety and tolerability of stimulating the splenic neurovascular bundle (NVB) with the Galvani System, which consists of a lead, implantable pulse generator, external components and accessories.
- Trial name
- NCT04955899
- Testing
- Active Stimulation
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 5 people
- Sponsor
- Galvani Bioelectronics
Arthritis (E.G., Degenerative Joint Disease (DJD), Osteoarthritis, and Rheumatoid Arthritis (RA))
A Prospective, Pre-market, Multi-center Study of Insignia Hip Stem in THA to Determine Implant Survivorship and PROMS.
The purpose of this study is to evaluate the survivorship (revision rates) and patient reported outcomes (PROMs) following implantation of the Insignia hip stem in patients undergoing cementless total hip replacement surgery…
- Trial name
- NCT06108934
- Testing
- Hip stem prosthesis
- Where
- Australia
- Volunteers
- 313 people
- Sponsor
- Stryker Australia Pty Ltd.
Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA)
A Study of BEN301 Injection in theTreatment of Autoimmune Diseases
The study aims to investigate the safety, tolerability, and preliminary clinical efficacy of BEN301 Injection in patients with autoimmune diseases.
- Conditions
- Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA), Sjogren's Syndrome (SS), Idiopathic Inflammatory Myopathies(IIM)
- Trial name
- NCT07527936
- Testing
- Single administration of 1x10^8 viable CD4+ CAR+ Foxp3+ cells., Single administration of 3x10^8 viable CD4+ CAR+ Foxp3+ cells.
- Where
- China
- Volunteers
- 24 people
- Sponsor
- RenJi Hospital
Rheumatoid Arthritis (RA)
The Effects of Kinesiophobia and Proprioception on Disability and Function in Rheumatoid Hand
This is a cross-sectional study aimed at examining the effects of kinesiophobia and proprioception on disability and function in the rheumatoid hand, compared to healthy controls.
- Trial name
- NCT07141927
- Testing
- Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Rheumatoid Arthritis
The Effect of Adalimumab Plus Methotrexate (MTX) Versus Placebo Plus MTX on Cartilage in (RA) Patients
This study aims to compare longitudinally the effect of adalimumab plus methotrexate (MTX) versus MTX monotherapy on cartilage GAG content, reflected by Delayed Gadolinium-enhanced magnetic resonance imaging of cartilage…
- Trial name
- NCT02150473
- Testing
- Adalimumab
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Rheumatoid Arthritis (RA)
A Phase IIa Study of JAB-8263 in Patients With Active Rheumatoid Arthritis
This study is an open-label, multi-center Phase IIa study. The study is divided into two phases. The first phase is a safety exploration phase.
- Trial name
- JAB-8263 (NCT07684157)
- Testing
- JAB-8263
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Jacobio Pharmaceuticals Co., Ltd.
Rheumatoid Arthritis (RA)
Changes in MTX-PG Concentrations During Subcutaneous MTX Therapy in Patients With Rheumatoid Arthritis(COSMOS Study)
Methotrexate is known to exist intracellularly as methotrexate polyglutamate, which is formed by the addition of glutamic acid after absorption into the body.
- Trial name
- NCT06913907
- Testing
- Methotrexate (MTX)
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Keio University
Rheumatoid Arthritis
A Phase IV Study to Evaluate the Effect of Subcutaneous (SC) Tocilizumab Administered to Participants With Rheumatoid Arthritis (RA) Assessed Using Disease Activity Score (DAS28)
The purpose of this clinical trial is to prospectively evaluate RA activity using the assessment of change in DAS28 under local conditions in Slovakia in participants who are treated with subcutaneously administered tocilizumab…
- Trial name
- NCT02534311
- Testing
- Tocilizumab
- Where
- 5 sites in Slovakia
- Volunteers
- 60 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
A Randomized, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of F8IL10 (Dekavil) in Patients With Active RA Receiving MTX
A multicenter, randomized, parallel assignment, double blind, placebo-controlled, safety/efficacy phase II study of two different dosages of subcutaneous F8IL10 in patients with active rheumatoid arthritis receiving MTX.
- Trial name
- NCT02270632
- Testing
- F8IL10, MTX
- Where
- 8 sites in Germany, Italy and 1 more
- Volunteers
- 27 people
- Sponsor
- Philogen S.p.A.
Rheumatoid Arthritis
A Study Comparing CRx-102 Plus Disease-modifying Anti-rheumatic Drug (DMARD) Therapy to Placebo Plus DMARD Therapy in RA
This study was a Multicenter, Randomized, Blinded Study Comparing the Effect of CRx-102 Plus DMARD Therapy to that of Placebo Plus DMARD Therapy on Serum C Reactive Protein (CRP) and Cytokines in Subjects with Rheumatoid…
- Trial name
- NCT00747214
- Testing
- CRx-102, DMARD Therapy
- Volunteers
- 59 people
- Sponsor
- Zalicus
Rheumatoid Arthritis
Comparative Study (Double-Blind) of MRA for Rheumatoid Arthritis (RA)
The purpose of this study is to investigate the clinical efficacy and safety of MRA in a double-blind, parallel-group, controlled study using MRA or methotrexate (MTX) in rheumatoid arthritis (RA) patients with MTX administered.
- Trial name
- NCT00144521
- Testing
- MRA(Tocilizumab), MTX
- Volunteers
- 127 people
- Sponsor
- Chugai Pharmaceutical
Arthritis, Rheumatoid
Determine the Improvement in Activity Status/Quality of Life (QoL) of Patients With Rheumatoid Arthritis (RA) During Treatment With Lodotra (Prednisone)
Rheumatoid arthritis is the most common rheumatic disease with symptomatic morning stiffness which entails a quite essential restriction in the everyday life and in the life quality.
- Trial name
- LODOTRA (NCT01075711)
- Testing
- Prednisone
- Where
- Germany
- Volunteers
- 2,728 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Rheumatoid Arthritis
A Study to Evaluate the Safety, Tolerability, and Drug Levels of BMS-986454 in Participants With Rheumatoid Arthritis
The purpose of this study is to evaluate the safety, tolerability, and drug levels of BMS-986454 in participants with Rheumatoid Arthritis
- Trial name
- NCT07171983
- Testing
- BMS-986454
- Where
- 9 sites in India
- Volunteers
- 46 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis (RA)
Comparison of Oral Administration of a JAK Inhibitor in Rheumatoid Arthritis
The aim of this study is to offer patients two treatment options: morning or evening administration of a JAK inhibitor prescribed within the framework of its marketing authorization, according to the EULAR response.
- Trial name
- JAK-INHI (NCT07674134)
- Where
- Monaco
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Princesse Grace
Rheumatoid Arthritis
An Observational Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis And Inadequate Response Or Intolerance to a First Anti-TNF Alpha Therapy
This prospective, multi-center, observational study will evaluate the efficacy and the safety of MabThera (rituximab) in participants with rheumatoid arthritis who have not responded or have been intolerant to a first anti-TNF…
- Trial name
- NCT01592292
- Testing
- Rituximab, Adalimumab, Etanercept
- Where
- 15 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
A Study With CIT-013 in RA Patients
The goal of this clinical trial is to learn if CIT-013 works to treat rheumatoid arthritis in adults. It will also learn about the safety of CIT-013.
- Trial name
- Citydream (NCT06567470)
- Testing
- CIT-013 low dose, CIT-013 high dose, CIT-013 medium dose
- Where
- 20 sites in Belgium, Germany and 3 more
- Volunteers
- 96 people
- Sponsor
- Citryll BV