Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis
A Study of Ocrelizumab Compared to Placebo in Patients With Active Rheumatoid Arthritis Continuing Methotrexate Treatment (STAGE)
This study will evaluate the efficacy and safety of ocrelizumab, compared with placebo, in combination with methotrexate in patients with active rheumatoid arthritis who have had an inadequate response to methotrexate.
- Trial name
- STAGE (NCT00406419)
- Testing
- Methotrexate, ocrelizumab
- Where
- United States
- Volunteers
- 1,015 people
- Sponsor
- Genentech, Inc.
Rheumatoid Arthritis
A Study of P38 Inhibitor (4) in Patients With Active Rheumatoid Arthritis (RA) on Stable Methotrexate Therapy
This 6 arm study will evaluate the efficacy and safety of different doses of P38 Inhibitor (4) in patients with RA currently having an inadequate clinical response to methotrexate.
- Trial name
- NCT00316771
- Testing
- P38 Inhibitor (4) 150mg, P38 Inhibitor (4) 25mg, P38 Inhibitor (4) 300mg
- Where
- 114 sites in United States, Australia and 12 more
- Volunteers
- 374 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis (RA), Spondyloarthritis (SA)
Inflammatory Arthritis and Tango
The hypothesis is that pleasure brought by argentine tango practice would increase total physical activity of patients with chronic inflammatory arthritis.
- Trial name
- IATANGO (NCT03840785)
- Testing
- Argentine tango
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Clermont-Ferrand
Rheumatoid Arthritis
Anakinra (Kineret®) in Combination With Disease Modifying Anti-Rheumatic Drugs (DMARDS) in Subjects With Active Rheumatoid Arthritis (RA)
The purpose of this study is to evaluate the percentage of subjects in Australian clinical practice continuing treatment with Anakinra (Kineret®) at the end of study week 48 in subjects with active RA.
- Trial name
- NCT00117091
- Testing
- Anakinra (Kineret®)
- Sponsor
- Amgen
Rheumatoid Arthritis
Study to Evaluate Safety and Pharmacokinetics of GS-4059 (Tirabrutinib) in Healthy Volunteers and Participants With Rheumatoid Arthritis (RA)
This study will consist of two parts: Part A will evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of tirabrutinib in healthy participants.
- Trial name
- NCT02626026
- Testing
- Tirabrutinib
- Where
- 9 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathy (IIM)
Phase 1 Study of HBI0101 CAR-T in Refractory B-Cell Autoimmune Diseases
A Phase 1 study of HBI0101 BCMA-CART in B-Cell Mediated Autoimmune Rheumatic Diseases. The goal of the study is evaluation of safety and identification of the maximum HBI0101 CART dose that may be administered safely to patients…
- Conditions
- Systemic Sclerosis (SSc), Idiopathic Inflammatory Myopathy (IIM), Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE)
- Trial name
- NCT07085676
- Testing
- HBI0101 CART
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Polina Stepensky
Rheumatoid Arthritis
Assessment of 14-3-3 η (Eta) Protein Antibodies in the Serum of Rheumatoid Arthritis Patients and Its Relation to Atherosclerosis.
The aims of this study are: • To assess 14-3-3 η (eta) protein antibodies in the serum of rheumatoid arthritis patients and its relation to disease activity and severity.
- Trial name
- NCT04937140
- Testing
- 14-3-3 η (eta) protein antibodies in the serum of rheumatoid arthritis patients
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sohag University
Rheumatoid Arthritis (RA)
Discontinuation of Disease-modifying Anti-rheumatic Drugs (DMARDs) in Rheumatoid Arthritis Patients Also Using TNF Inhibitors
The goal is to investigate whether a strategy of attempting to discontinue of MTX or LEF (and restart when necessary) in RA patients treated with an optimal dose (allowed dose or lower, tapered to the maximum, or according to…
- Trial name
- DISCO (NCT07802678)
- Testing
- Strategy to attempt discontinuation of MTX or LEF (and restart when necessary), Continuation of MTX or LEF
- Where
- 4 sites in Netherlands
- Volunteers
- 202 people
- Sponsor
- Sint Maartenskliniek
Arthritis, Rheumatoid Arthritis (RA)
Dose Response of Exercise for Arthritis Management
The purpose of the study is to see examine the effects of 3 different levels of physical activity (45 minutes/week, 90 minutes/week, or 150 minutes/week) on arthritis symptoms.
- Conditions
- Arthritis, Rheumatoid Arthritis (RA), Gout, Fibromyalgia (FM)
- Trial name
- DREAM (NCT06880653)
- Testing
- DREAM Adaptive Intervention
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- University of South Carolina
Rheumatoid Arthritis
Characterize Patients With Moderately Active Rheumatoid Arthritis (RA)
1. To assess the baseline (i.e. RA therapy initiation) characteristics in a real-world setting across two moderate RA cohorts: a Test Group of patients newly exposed to etanercept (Enbrel) therapy and a Control Group of patients…
- Trial name
- NCT01557322
- Testing
- etanercept, methotrexate (MTX)
- Volunteers
- 1,754 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Study of MRA in Patients With Rheumatoid Arthritis (RA)
This is an open-label, extension, Phase II study to evaluate the long-term safety and efficacy of MRA in Patients with RA who were participated in Study MRA009JP.
- Trial name
- NCT00144651
- Testing
- MRA(Tocilizumab)
- Volunteers
- 135 people
- Sponsor
- Chugai Pharmaceutical
Rheumatoid Arthritis
A Non-Interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis
This multi-center observational study will evaluate the use and efficacy of RoActemra/Actemra (tocilizumab) in patients with moderate to severe rheumatoid arthritis.
- Trial name
- NCT01670045
- Testing
- Tocilizumab
- Where
- 9 sites in Indonesia
- Volunteers
- 43 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis, Cardiovascular Disease
Study of Adalimumab to Lower Cardiovascular Risk in RA Patients With Well Controlled Joint Disease
Rheumatoid arthritis patients are at increased risk of cardiovascular disease because of systemic inflammation that can persist even in patients with well-controlled joint disease.
- Trial name
- NCT01893996
- Testing
- Adalimumab
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Jonathan Graf
Rheumatoid Arthritis, Cardiovascular Disease
Cardiovascular Outcomes in the VA's Rheumatoid Arthritis(VARA) Population
Rheumatoid arthritis (RA) is a symmetric, peripheral polyarthritis of uncertain etiology that can lead to joint deformity and destruction. However, the effects of RA are not confined simply to joint involvement.
- Conditions
- Rheumatoid Arthritis, Cardiovascular Disease, Coronary Disease
- Trial name
- NCT00431405
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Dallas VA Medical Center
Arthritis, Rheumatoid
COBRA-Slim With or Without Fast Access to TNF Blockade for Remission Induction in Early RA
In the Care in Rheumatoid Arthritis (CareRA) trial (NCT01172639) about 70% of early RA patients are in remission at the 2 year evaluation point independent of the combination scheme used.
- Trial name
- CareRA2020 (NCT03649061)
- Testing
- Etanercept 50 MG/ML, Leflunomide 10 milligram (MG)
- Where
- 19 sites in Belgium
- Volunteers
- 276 people
- Sponsor
- P. Verschueren
Arthritis, Rheumatoid
The Efficacy and Safety of Tofacitinib (TF) With Iguratimod (IGU) on RA
RA is a common autoimmune disease that causes joint damage.It is necessary to reach the standard as soon as possible and give effective drugs according to the patient's disease activity to avoid disability.
- Trial name
- NCT04928066
- Testing
- Iguratimod, Tofacitinib, Pred
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Rheumatoid Arthritis
Efficacy and Safety of Increased Dose of TA-650(Infliximab) in Patients With Rheumatoid Arthritis
The purpose of this study is to assess the efficacy, safety and pharmacokinetics of maintenance treatment with 3mg/kg, 6mg/kg or 10mg/kg of TA-650 in combination with methotrexate (MTX) after three infusions (weeks-0, 2, 6) of…
- Trial name
- NCT00691028
- Testing
- TA-650 3 mg/kg, TA-650 6 mg/kg, TA-650 10 mg/kg
- Volunteers
- 327 people
- Sponsor
- Tanabe Pharma Corporation
Rheumatoid Arthritis (RA)
Rehabilitation Exercise Intervention for Rheumatoid Arthritis Patients Using Artificial Intelligence-Based Exercise Prescription System
This is a single-center, randomized, parallel-controlled trial evaluating the efficacy and safety of an artificial intelligence-based exercise prescription system for rehabilitation in rheumatoid arthritis (RA) patients.
- Trial name
- NCT07246811
- Testing
- AI Exercise Prescription, education and basic joint mobility exercises, paper-based exercise prescription
- Where
- China
- Volunteers
- 147 people
- Sponsor
- Peking University Third Hospital
Rheumatoid Arthritis
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Measure Response to Etanercept in Rheumatoid Arthritis
The purpose of this study is to assess whether DCE-MRI can detect changes of active disease in rheumatoid arthritis (RA) patients after 4, 8 and 12 weeks of etanercept.
- Trial name
- NCT00361634
- Testing
- Etanercept
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 14 people
- Sponsor
- Amgen
Rheumatoid Arthritis
Ultrasound Neuroimmune Modulation in Adults With Rheumatoid Arthritis
This two-stage, multicenter clinical trial is designed to evaluate the feasibility, safety, and preliminary efficacy of splenic ultrasound stimulation to activate immune-neuromodulation (SUSTAIN) in patients with rheumatoid…
- Trial name
- SUSTAIN (NCT07293871)
- Testing
- Active treatment
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Surf Therapeutics