Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis
Treatment for Subjects With Active Rheumatoid Arthritis (RA)
The purpose of this study is to assess the safety of etanercept liquid administered once weekly to subjects with RA.
- Trial name
- NCT00110903
- Testing
- Etanercept Liquid
- Sponsor
- Amgen
Rheumatoid Arthritis
Observational Real-world Evaluation of Cost of Infections of Rheumatoid Arthritis (RA) Patients on Biologics
To quantify the incremental cost of infections in patients treated with etanercept, adalimumab or infliximab versus abatacept.
- Trial name
- NCT01166620
- Volunteers
- 4,000 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Nerve Block of the Proximal Interphalangeal Joints PIPs in Rheumatoid Arthritis (RA) Patients: a Prospective Pilot Study
Researchers will include 83 rheumatoid arthritis patients (either early or established) diagnosed after 2010 ACR/EULAR criteria with bilateral hand arthritis aged 18 or above.
- Trial name
- NCT04130178
- Testing
- Nerve block, Saline injection
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Sohag University
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)
PREVENER is a randomized, open-label, multicenter, phase IV clinical trial designed to evaluate the efficacy and safety of a carotid ultrasound-based strategy for the primary prevention of cardiovascular events in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondy, Systemic Lupus Erythematosus (SLE)
- Trial name
- PREVENER (NCT07611747)
- Testing
- Carotid Ultrasound, High-intensity lipid-lowering therapy, Standard care according to ESC 2021 guidelines
- Where
- 17 sites in Spain
- Volunteers
- 1,944 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Rheumatoid Arthritis
A Long-Term Extension Study of WA22762 and NA25220 of Subcutaneous (SC) Tocilizumab (TCZ) in Moderate to Severe Rheumatoid Arthritis (RA)
This open-label extension study will evaluate the long-term safety and efficacy of SC TCZ in participants with moderate to severe RA who have completed the 97-week WA22762 (NCT01194414) or 96-week NA25220 (NCT01232569) core…
- Trial name
- NCT01662063
- Testing
- Tocilizumab
- Where
- 79 sites in United States, Puerto Rico
- Volunteers
- 218 people
- Sponsor
- Genentech, Inc.
RA - Rheumatoid Arthritis
Pentacam Study of the Cornea in RA Patients
To evaluate the effect of rheumatoid arthritis (RA) activity on the corneal densitometry, corneal curvature (CC), central corneal thickness (CCT), and lens densitometry by Pentacam and compared these parameters with those of…
- Trial name
- NCT05241639
- Testing
- Pentacam
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Rheumatoid Arthritis
Observation of Treatment With Certolizumab Pegol in Daily Practice
This is an observational, non-interventional, non-comparative, post-authorization safety study to evaluate efficacy and long-term safety of Cimzia in adult patients with RA in need of treatment with a biological product.
- Trial name
- FasT (NCT01069419)
- Where
- 163 sites in Germany
- Volunteers
- 1,117 people
- Sponsor
- UCB Pharma GmbH
Rheumatoid Arthritis (RA)
Comparison of Oral Administration of a JAK Inhibitor in Rheumatoid Arthritis
The aim of this study is to offer patients two treatment options: morning or evening administration of a JAK inhibitor prescribed within the framework of its marketing authorization, according to the EULAR response.
- Trial name
- JAK-INHI (NCT07674134)
- Where
- Monaco
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Princesse Grace
Rheumatoid Arthritis
Safety of TofAcitinib in Routine Care Patients With Rheumatoid Arthritis (STAR-RA)-Cancer Endpoints
There are two main aims of this study. First aim is to compare the risk of composite cancer outcomes, between patients treated with tofacitinib and patients treated with TNF inhibitors (TNFi) for rheumatoid arthritis (RA) among…
- Trial name
- STAR-RA-Cancer (NCT04798287)
- Testing
- Tofacitinib, TNF Inhibitor
- Where
- United States
- Volunteers
- 105,711 people
- Sponsor
- Brigham and Women's Hospital
Rheumatoid Arthritis
A Study of LY3090106 in Healthy Participants and Participants With Rheumatoid Arthritis (RA)
The main purpose of this study is to evaluate the safety of the study drug known as LY3090106 in healthy participants and in participants with RA who are having an inadequate response to methotrexate (MTX).
- Trial name
- NCT01925157
- Testing
- LY3090106 - SQ, LY3090106 - IV
- Where
- 4 sites in Bulgaria, Moldova and 2 more
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Premature Endothelial Dysfunction, Rheumatoid Arthritis
Exploratory Trial to Evaluate Premature Endothelial Dysfunction in Early Rheumatoid Arthritis(RA)Compared to Patients With Established RA, and Normal Subjects
Premature Endothelial Dysfunction is present in patients with early rheumatoid arthritis.
- Conditions
- Premature Endothelial Dysfunction, Rheumatoid Arthritis, Healthy
- Trial name
- NCT01499732
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Orrin M Troum, M.D. and Medical Associates
Ankylosing Spondylitis, Psoriatic Arthritis
Study Evaluating Epidemiology of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis in Australia
The study is a cross sectional, epidemiology study of disease severity for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis in four geographic regions in Australia (Illawarra, Sutherland, Hunter Urban and…
- Conditions
- Ankylosing Spondylitis, Psoriatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT00751387
- Where
- 4 sites in Australia
- Volunteers
- 559 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis
Effects of Tranilast on Pharmacokinetics of Methotrexate (MTX) in Patients With Rheumatoid Arthritis (RA)
The treatment of rheumatoid arthritis has improved considerably in recent years with the understanding that better outcomes can be achieved by optimising the dosage schedule of conventional drugs that suppress the inflammatory…
- Trial name
- NCT00717808
- Testing
- Tranilast
- Sponsor
- Imperial College London
Rheumatoid Arthritis
Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Not Responding.
The purpose of the study is to evaluate the effectiveness of two dosing regimens of fostamatinib compared to placebo, in patients with rheumatoid arthritis (RA) who are taking methotrexate but not responding.
- Trial name
- OSKIRA - 1 (NCT01197521)
- Testing
- fostamatinib
- Where
- 127 sites in United States, Argentina and 15 more
- Volunteers
- 923 people
- Sponsor
- AstraZeneca
Arthritis, Rheumatoid
Effectiveness of Bazedoxifene for Prevention of Glucocorticoid-induced Bone Loss in RA Patients
The purpose of this study is to study the effectiveness of bazedoxifene in preventing loss of bone mineral density (BMD) and trabecular bone score (TBS), and any fractures in postmenopausal rheumatoid arthritis (RA) patients…
- Trial name
- NCT02602704
- Testing
- Bazedoxifene, Calcium/Vit D
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Hanyang University
Rheumatoid Arthritis (RA), SSc-Systemic Sclerosis
Improving ILD Screening in Patients With RA and SSc Using EHR-Embedded CDS and PRO Tools
This is a quality improvement initiative that aims to find better ways to identify interstitial lung disease (ILD) early in people with rheumatoid arthritis (RA) or systemic sclerosis (SSc).
- Trial name
- ILD-QUI (NCT07849673)
- Testing
- EHR-Embedded CDS and PRO Tools Intervention
- Volunteers
- 800 people
- Sponsor
- Foundation for Advancing Science Technology Education and Research
Rheumatoid Arthritis
Impact of Anti-citrullinated Protein Antibody Status on Treatment Response and Treatment Persistence in Participants With Rheumatoid Arthritis (RA) Who Are Treated With Abatacept or Tumor Necrosis Factor Inhibitors in Australia
An observational study assessing the impact of anti-citrullinated antibody (ACPA) in rheumatoid arthritis (RA) participants who have received abatacept or tumour necrosis factor inhibitors (TNFi) from the Optimising Patient…
- Trial name
- NCT03663829
- Testing
- Non-Interventional
- Where
- Australia
- Volunteers
- 2,052 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
CD40L Antagonism in Rheumatoid Arthritis (RA)
The primary objective is to determine if the addition of a 12-week course of treatment with VIB4920 to TNFi treatment will result in improved clinical disease control in patients with RA who have had an inadequate response to a…
- Trial name
- CONTROL-RA (NCT05306353)
- Testing
- VIB4920 with TNFi, VIB4920 without TNFi
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis (RA)
A Study of Oral Upadacitinib Tablets to Assess Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Adult Participants With Moderate to Severe Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function.
- Trial name
- UPHOLD (NCT04497597)
- Where
- 263 sites in Argentina, Australia and 17 more
- Volunteers
- 1,532 people
- Sponsor
- AbbVie
Rheumatoid Arthritis, Interstitial Lung Disease
Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease
A study to identify patients with Rheumatoid Arthritis - Associated Interstitial Lung Disease (RA-ILD) that are at the highest risk for progression.
- Trial name
- MOUNTAIN (NCT06397677)
- Testing
- Research Testing Performed (Laboratory), Information Collected as Standard of Care, Research Testing Performed
- Where
- 4 sites in United States
- Volunteers
- 450 people
- Sponsor
- University of Colorado, Denver