Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis
Autologous Adipose-derived Stem Cells (AdMSCs) for Rheumatoid Arthritis
This is an investigational new drug clinical trial for combined Phase 1 dose escalation study and Phase 2a randomized, placebo controlled and double blinded study using intravenous injection of autologous adipose stem cells…
- Trial name
- NCT04170426
- Testing
- autologous adipose derived stem cells
- Volunteers
- 54 people
- Sponsor
- Celltex Therapeutics Corporation
Rheumatoid Arthritis
Role of Greyscale and Power Doppler Sonography in Therapy Monitoring in Early Rheumatoid Arthritis (RA)
The purpose of this study is to evaluate the role of musculoskeletal ultrasound and power Doppler in early therapy monitoring of rheumatoid arthritis patients.
- Trial name
- NCT00854243
- Volunteers
- 20 people
- Sponsor
- Cairo University
Early Rheumatoid Arthritis
Early RA MRI Early Intensive Treatment Study
To compare the effectiveness of two treatment strategies in early rheumatoid arthritis (ERA), namely the delayed usual care and early intensive care, in Hong Kong.
- Trial name
- NCT01762176
- Testing
- Protocolized intensive treatment, Usual care
- Where
- China
- Volunteers
- 163 people
- Sponsor
- Chinese University of Hong Kong
Rheumatoid Arthritis (RA)
A Study With Upadacitinib (ABT-494) in Subjects From China and Selected Countries With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs)
The study objectives of Period 1 of this study were to compare the efficacy, safety, and tolerability of upadacitinib versus placebo for the treatment of signs and symptoms of subjects from China and selected countries including…
- Trial name
- NCT02955212
- Testing
- Upadacitinib
- Where
- 43 sites in Brazil, China and 1 more
- Volunteers
- 338 people
- Sponsor
- AbbVie
Rheumatoid Arthritis (RA)
Comparison of Glucocorticoid Tapering Schedules in Rheumatoid Arthritis
This multicenter, randomized, controlled, single-blind prospective study aims to establish an evidence-based protocol for discontinuing long-term low-dose glucocorticoids in patients with rheumatoid arthritis (RA).
- Trial name
- NCT07227428
- Testing
- Prednisolone
- Volunteers
- 206 people
- Sponsor
- Seoul National University Hospital
Rheumatoid Arthritis
Validation Study of RA-INF-Dx, a Multigene Molecular Test Used to Predict Non-Response to INfliximab Therapy
Study Design \& Objectives: Multi-centre, non-interventional, open-label, non-comparative, prospective cohort study with a clinical follow-up between 12 and 14 weeks.
- Trial name
- PRINT (NCT01299545)
- Where
- 37 sites in Canada, France and 6 more
- Volunteers
- 123 people
- Sponsor
- TcLand Expression S.A.
Rheumatoid Arthritis
Observational Safety Study of Rituximab in Patients Diagnosed With Rheumatoid Arthritis (RA) Who Did Not Respond Adequately to TNF-alpha Blocker
This multi-center, observational, retrospective-prospective cohort study will investigate the safety of rituximab (MabThera) by collecting data from daily clinical practice on the use of rituximab and its relative clinical…
- Trial name
- NCT02322801
- Where
- 54 sites in Italy
- Volunteers
- 209 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Effect of a Thin Customized Insole in RA
50-90% of patients with RA reports foot problems and the metatarsophalangeal joints of the forefoot are most frequently afflicted.
- Trial name
- NCT02964156
- Testing
- Supersole, No intervention
- Volunteers
- 21 people
- Sponsor
- Revmatismesykehuset AS
Rheumatoid Arthritis
A Study Assessing the Efficacy and Safety of Sarilumab Added to MTX in Japanese Patients With Moderately to Severely Active Rheumatoid Arthritis (SARIL-RA-KAKEHASI)
Primary Objective: -To demonstrate that sarilumab added to methotrexate (MTX) reduce signs and symptoms of rheumatoid arthritis (RA) in Japanese RA participants with an inadequate response to MTX.
- Trial name
- NCT02293902
- Testing
- Sarilumab SAR153191 (REGN88), Methotrexate, Folic acid
- Where
- 96 sites in Japan
- Volunteers
- 243 people
- Sponsor
- Sanofi
Rheumatic Diseases, Rheumatoid Arthritis (RA)
Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy
The CARe RAiSE project represents a pioneering translational initiative aimed at advancing precision medicine in the treatment of autoimmune rheumatic diseases.
- Conditions
- Rheumatic Diseases, Rheumatoid Arthritis (RA), Giant Cell Arteritis (GCA), Psoriatic Arthritis (PsA)
- Trial name
- CARe RAiSE (NCT07150000)
- Testing
- Ex Vivo Assay
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Rheumatoid Arthritis
Imaging of Lymphatic Vessels in People With Rheumatoid Arthritis (RA)
Lymphatic transport was previously examined by these investigators using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) of the upper extremities.
- Trial name
- NCT05197530
- Testing
- Indocyanine green, MultiSpectral Imaging System
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Rheumatoid Arthritis
To Evaluate 1 Year Extension Study of the Efficacy and Safety of Tocilizumab in Patients With Moderate to Severe Rheumatoid Arthritis
The purpose of this study is to evaluate 1 year extension study of the efficacy and the safety during treatment tocilizumab in patients completing treatment CWP-TCZ301 study with moderate to severe active RA and an inadequate…
- Trial name
- NCT01256736
- Testing
- Tocilizumab, DMARDs
- Where
- South Korea
- Volunteers
- 89 people
- Sponsor
- JW Pharmaceutical
Rheumatoid Arthritis
Examination of Efficacy and Safety of Baricitinib in RA Patients
The aim of this study is to examine the efficacy and adverse events in the following 3 groups in rheumatoid arthritis patients: 1. Baricitinib treatment for 12 months 2. Biologics treatment for 12 months 3.
- Trial name
- NCT03755466
- Testing
- "Baricitinib", "olumiant®", "Biologics", Tofacitinib 5 MG [Xeljanz]
- Where
- Japan
- Volunteers
- 90 people
- Sponsor
- Shinshu University
Rheumatoid Arthritis (RA), Periodontitis
Effects of Nonsurgical Periodontal Treatment on GCF Calprotectin and IL-10 in Rheumatoid Arthritis
This study evaluates the relationship between rheumatoid arthritis and periodontal health and examines the effects of nonsurgical periodontal treatment on clinical periodontal findings and gingival crevicular fluid biomarkers.
- Conditions
- Rheumatoid Arthritis (RA), Periodontitis, Gingivitis
- Trial name
- NCT07844564
- Testing
- Non-surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Rheumatoid Arthritis (RA)
Complementary Herbal Approach to Rheumatoid Management Study (CHARMS)
Rheumatoid Arthritis (RA) is a chronic disease characterised by symmetric, polyarticular pain and swelling, involving small joints of the hands and feet.
- Trial name
- CHARMS (NCT07627893)
- Testing
- Shu Bi Ning (modified Si Miao Xiao Bi), Methotrexate
- Where
- Singapore
- Volunteers
- 132 people
- Sponsor
- Singapore General Hospital
Rheumatoid Arthritis
Observational Study of Tocilizumab in Participants With Rheumatoid Arthritis in Australia
This multi-center, observational study will evaluate the treatment patterns in clinical practice, efficacy and safety of tocilizumab in participants with rheumatoid arthritis (RA) who have had an inadequate response (or were…
- Trial name
- NCT01683604
- Testing
- Observational study
- Where
- 7 sites in Australia
- Volunteers
- 37 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
A Study of the Effects of RoActemra/Actemra (Tocilizumab) on Neutrophils in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Biologic and/or Non-biologic DMARDs.
This open-label, single arm study will assess the effect of RoActemra/Actemra (tocilizumab) on neutrophils and monitor safety and benefit-risk of RoActemra/Actemra treatment in patients with active rheumatoid arthritis who have…
- Trial name
- NCT01195272
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Hoffmann-La Roche
Arthritis, Rheumatoid
Efficacy and Safety of Valdecoxib and Naproxen in Treating the Signs and Symptoms of Rheumatoid Arthritis (RA) in a Severe Rheumatoid Arthritis Patients
The objectives of the study were to evaluate the efficacy, safety, and tolerability of valdecoxib 10 mg once daily (QD) or naproxen 500 mg twice daily (BID) versus placebo, and to assess the efficacy of valdecoxib 10 mg QD versus…
- Trial name
- NCT00650455
- Testing
- valdecoxib, naproxen
- Where
- 55 sites in United States, Canada
- Volunteers
- 489 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
A Study on the Prevalence of the Modified Citrullinated Vimentin Anti-body (Anti-MCV) in an Irish Rheumatoid Arthritis (RA) Population and to Assess the Impact of Anti-MCV and the Anti-cyclic-citrullinated Peptide Antibody (Anti-CCP) Status on the Management of Irish Patients With Early RA
A key challenge in the management of patients with Rheumatoid Arthritis (RA) is the early identification of patients that are at risk of developing a severe and destructive disease.
- Trial name
- NCT01078597
- Where
- 4 sites in Ireland
- Volunteers
- 35 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Rheumatoid Arthritis (RA)
A First-in-human Study of KT502 in Adult Participants With Rheumatoid Arthritis (RA)
This is a Phase 1, open-label, first-in-human study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of KT502 administered subcutaneously to participants with Rheumatoid Arthritis (RA).
- Trial name
- NCT07564154
- Testing
- KT502
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 27 people
- Sponsor
- Kali Therapeutics, Inc.