Clinical trials: Arthritis, Rheumatoid (RA)
Rheumatoid Arthritis（RA）
Infliximab and Classic DMARDs in the Rheumatoid Arthritis Patients
A prospective, multi-centric, cohort study to observe the efficacy difference between intensive classic DMARDs and Infliximab(IFX) with methotrexate(MTX) treatment in sever rheumatoid arthritis(RA) 28 joints disease activity…
- Trial name
- INNOVATION (NCT01915537)
- Testing
- Infliximab group, Classic DMARDs treatment group
- Where
- 3 sites in China
- Volunteers
- 170 people
- Sponsor
- Zhang, Xiao, M.D.
Rheumatoid Arthritis
Observational Safety Study of Rituximab in Patients Diagnosed With Rheumatoid Arthritis (RA) Who Did Not Respond Adequately to TNF-alpha Blocker
This multi-center, observational, retrospective-prospective cohort study will investigate the safety of rituximab (MabThera) by collecting data from daily clinical practice on the use of rituximab and its relative clinical…
- Trial name
- NCT02322801
- Where
- 54 sites in Italy
- Volunteers
- 209 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Multicenter, Post-marketing, Non-interventional, Observational Study in RA Patients Treated With RoActemra/Actemra (Tocilizumab)
This non-interventional study will observe the usage and efficacy of RoActemra/Actemra in patients with rheumatoid arthritis (RA) who have recently begun treatment.
- Trial name
- NCT02101307
- Where
- 25 sites in China
- Volunteers
- 400 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion and Intra-Articular Injection for RA
This trial will study the safety and efficacy of intravenous infusion and intra-articular injection of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Rheumatoid Arthritis
- Trial name
- NCT05003934
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Rheumatoid Arthritis
A Study Comparing Infusion Rates of Tocilizumab in Patients With Moderate to Severe Rheumatoid Arthritis
This 2 arm study will compare the incidence of tocilizumab-related infusion reactions, using 2 different infusion times, in patients with moderate to severe rheumatoid arthritis who have shown an inadequate response to DMARDs…
- Trial name
- NCT00887341
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 24 sites in Spain
- Volunteers
- 76 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
A Non-Interventional Study Evaluating Rheumatoid Arthritis Participants Treated With Tocilizumab (RoActemra/Actemra)
This non-interventional study evaluated the use and efficacy of tocilizumab (RoActemra/Actemra) in participants with moderate to severe rheumatoid arthritis.
- Trial name
- NCT01671059
- Where
- 8 sites in Serbia
- Volunteers
- 80 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
A Post-marketing Study on the Safety of Abatacept Treatment in Denmark Using the Danish Database
The purpose of this study is to expand on the ongoing post-marketing monitoring of abatacept to include all participants with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with abatacept captured in Danish…
- Trial name
- DANBIO (NCT05421442)
- Where
- United States
- Volunteers
- 38,396 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
Rheumatoid Arthritis Comorbidity: Bone Health in Men and African Americans
The objective of the proposed study is to assess bone health and determinants of bone health among select subpopulations of rheumatoid arthritis patients.
- Trial name
- NCT00595894
- Where
- United States
- Volunteers
- 1,745 people
- Sponsor
- University of Nebraska
Rheumatoid Arthritis
Effect of Proactive Therapeutic Drug Monitoring on Maintenance of Sustained Disease Control in Adults With Rheumatoid Arthritis on a Subcutaneous TNF Inhibitor: The Rheumatoid Arthritis Therapeutic DRUg Monitoring Trial (RA-DRUM)
The goal of this clinical trial is to compare therapeutic drug monitoring (TDM) versus Standard of care in patients with rheumatoid arthritis treated with a subcutaneous tumor necrosis factor inhibitor (adalimumab).
- Trial name
- RA-DRUM (NCT06440629)
- Testing
- Therapeutic drug monitoring (TDM) of adalimumab
- Where
- 22 sites in Austria, Italy and 4 more
- Volunteers
- 387 people
- Sponsor
- Diakonhjemmet Hospital
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Decoy Receptor 3 (DcR3) Polymorphisms in Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE)
Although SLE and RA are correlated with genetic predisposing factors such as human leukocyte antigen (HLA) class II, both diseases and other genetic factors might have contributed to the development of dysregulated lymphocyte…
- Trial name
- NCT00172666
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Rheumatoid Arthritis
A Study to Investigate the Effectiveness of an Education Support Program on Medication Adherence in Italian Real Life Rheumatoid Arthritis (RA) Patients Treated With Subcutaneous (SC) Abatacept
The primary objective of this study is to investigate whether an Educational Supported Program (ESP), including tight control procedures implemented through patient home care, has positive impact in terms of better adherence to…
- Trial name
- TIGHT (NCT03188081)
- Where
- Italy
- Volunteers
- 171 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis (RA, Chronic Pain
Integrative AI-Based Multiomic and Neurophysiological Profiling of Chronic Pain in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease in which pain remains the most prominent and burdensome symptom from the patient's perspective.
- Trial name
- RA-PAIN-AI (NCT07769619)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Rheumatoid Arthritis
An Observational Study of Dosage Patterns in Routine Clinical Practice in Patients With Rheumatoid Arthritis (ACT-LIFE)
This observational study will evaluate the dosage patterns, safety and efficacy of RoActemra/Actemra (tocilizumab) in clinical practice in patients with moderate to severe rheumatoid arthritis who have not responded or are…
- Trial name
- NCT01338545
- Where
- 48 sites in United States, Spain
- Volunteers
- 400 people
- Sponsor
- Hoffmann-La Roche
Arthritis, Rheumatoid
A Long-term Safety Extension Study of Tocilizumab in Brazilian Participants With Rheumatoid Arthritis (RA) Who Completed the Studies ML21530 and MA21488
This multicenter, open-label, single-arm extension study will evaluate the long-term safety of tocilizumab (RoActemra/Actemra) in participants with RA.
- Trial name
- RITACT (NCT01715831)
- Testing
- DMARDs, Tocilizumab
- Where
- 9 sites in Brazil
- Volunteers
- 26 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis, Psoriatic Arthritis
Endothelial Function, Inflammatory Disease Activity, and Bone and Cartilage Markers in Rheumatic Patients: The Influence of Antirheumatic Treatment
The aim of this study is to examine the associations between inflammatory disease activity and endothelial function in rheumatoid arthritis (RA) and spondyloarthritis patients treated with methotrexate and Tumor Necrosis Factor…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Endothelial Dysfunction
- Trial name
- PSARA (NCT00902005)
- Where
- Norway
- Volunteers
- 145 people
- Sponsor
- Revmatismesykehuset AS
Rheumatoid Arthritis (RA)
Study of Tocilizumab in Combination With Methotrexate for Treatment of Moderate to Severe Rheumatoid Arthritis Patients
This is a Phase III study to evaluate efficacy and safety of Tocilizumab in patients with Rheumatoid Arthritis.
- Trial name
- NCT01258712
- Testing
- Tocilizumab + methotrexate(MTX)
- Where
- 12 sites in Taiwan
- Volunteers
- 86 people
- Sponsor
- Chugai Pharma Taiwan
Rheumatoid Arthritis (RA), Crohn's Disease (CD)
UCB Cimzia Pregnancy Follow-up Study
The purpose of this observational follow-up study is to collect data systematically on pregnancies and offspring of women who become pregnant while participating in a Certolizumab Pegol (CZP) study or whose pregnancies have…
- Conditions
- Rheumatoid Arthritis (RA), Crohn's Disease (CD), Psoriatic Arthritis (PsA), Axial Spondyloarthritis and Ankylosing Spondylitis
- Trial name
- NCT02775656
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Rheumatoid Arthritis
Tc 99m Tilmanocept Imaging for Early Prediction of Anti-TNFα Therapy Response in Moderate to Severe Active RA
This study will confirm the ability of Tc 99m tilmanocept imaging to predict clinical response in individuals with RA who are beginning anti-TNFα therapy.
- Trial name
- NCT05246280
- Testing
- TC99m-tilmanocept
- Where
- 13 sites in United States
- Volunteers
- 169 people
- Sponsor
- Navidea Biopharmaceuticals
Rheumatoid Arthritis
A Study of Retreatment With MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (RA)
This study will evaluate the efficacy and safety of various treatment and retreatment regimens of MabThera. All patients will receive concomitant methotrexate, 10-25mg once weekly either orally or parenterally.
- Trial name
- NCT00422383
- Testing
- rituximab [MabThera/Rituxan]
- Where
- 91 sites in Australia, Belgium and 16 more
- Volunteers
- 378 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Advanced Therapeutics in Rheumatoid Arthritis (RA)
This study will evaluate the retention rates of two advanced therapies, Tumour Necrosis Factor (TNF) and Janus kinase inhibitor (JAK) in the treatment of adults with Rheumatoid Arthritis (RA) over a two year period.
- Trial name
- NCT03976245
- Testing
- Etanercept, tofacitinib
- Where
- Canada
- Volunteers
- 144 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's