Clinical trials: Arthritis, Septic
Bone Infection, Septic Arthritis
BonE and Joint Infections - Simplifying Treatment in Children Trial
This is a multi- centre trial of children with bone and joint infections (BJIs) at eleven major paediatric hospitals in Australia, New Zealand and Ireland.
- Conditions
- Bone Infection, Septic Arthritis, Bone and Joint Infection, Osteomyelitis
- Trial name
- BEST (NCT04538053)
- Testing
- Oral cefalexin only, IV cefazolin or IV flucloxacillin followed by oral cefalexin
- Where
- 11 sites in Australia, Ireland and 1 more
- Volunteers
- 214 people
- Sponsor
- Murdoch Childrens Research Institute
Osteoarthritis, Rheumatoid Arthritis
Ankle Joint Replacement Outcomes Study
This post market outcome study will look at the therapeutic results of the Salto Talaris Anatomic ankle prosthesis. The study population will consist of patients who will undergo an ankle arthroplasty procedure with a Salto…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Septic Arthritis
- Trial name
- NCT00503438
- Testing
- Salto Talaris Ankle
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Smith & Nephew, Inc.
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA)
Chinese Spondyloarthritis Inception Cohort (CESPIC)
The Chinese Spondyloarthritis Inception cohort (CESPIC) was started 2000 as a prospective, longitudinal, multicentre, nationwide study in China on patients with early SpA including ankylosing spondylitis (AS, also known as…
- Conditions
- Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA), Non-radiographic Axial Spondyloarthritis (Nr-axSpA), Axial Psoriatic Arthritis (axPsA), Acute Anterior Uveitis (AAU)
- Trial name
- CESPIC (NCT05960864)
- Testing
- Celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Southwest Hospital, China
Septic Arthritis
Short 3-week Antibiotic Treatment Versus 6 Weeks in Adults With Septic Arthritis of Native Joint
In France, the incidence of native joint infections is about 10 per 100 000 person-years, most commonly caused by S.aureus followed by b-haemolytic streptococci.
- Trial name
- SHASAR (NCT03716921)
- Testing
- Short antibiotics treatment
- Where
- 31 sites in France
- Volunteers
- 332 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Arthritis
Diagnostic Criteria for Septic Arthritis
Septic arthritis (SA) is a rare but highly disabling disease. The ideal diagnosis criteria is not well established. There is an urgent need to establish golden standard for diagnosis.
- Trial name
- NCT05790434
- Testing
- Laboratory test, History taking and physical examination, biopsy
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Joint Effusion
Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis
To study the diagnostic performance of infrared spectroscopy on fresh synovial fluids in early septic arthritis diagnosis in patients with acute joint effusion
- Trial name
- SYNOFRESH (NCT04004962)
- Testing
- Infrared spectroscopy
- Where
- 6 sites in France
- Volunteers
- 360 people
- Sponsor
- Rennes University Hospital
Diarrheal Disease, Infectious, Gastrointestinal Disease
Phase 1 Trial for Safety, Tolerability, and Immunogenicity of a Live, Attenuated, Oral Shigella/ETEC Combination Vaccine to Healthy Adults
This is a Phase 1 dose escalating study to assess the safety, tolerability, and immunogenicity of ShigETEC, a live, attenuated Shigella/ETEC combination vaccine given orally to healthy European adults 18 to 45 years of age.
- Conditions
- Diarrheal Disease, Infectious, Gastrointestinal Disease, Reactive Arthritis
- Trial name
- NCT05409196
- Testing
- ShigETEC live, attenuated, oral vaccine
- Where
- Hungary
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Eveliqure Biotechnologies GmbH
Arthritis, Reactive, Reiter Disease
Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria
Reactive arthritis, also known as Reiter's syndrome, is a form of arthritis that occurs as a reaction to an infection elsewhere in the body. It is characterized by inflammation of the joints, tendons, urogenital tract, and eyes.
- Trial name
- NCT00351273
- Testing
- Doxycycline and Rifampin, Azithromycin and Rifampin
- Where
- 3 sites in United States, Canada
- Volunteers
- 42 people
- Sponsor
- University of South Florida
Travelers' Diarrhea, Functional Bowel Disorders
Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD
The purpose of this study is to develop evidence on the relative efficacy of 2 rifaximin chemoprophylaxis regimens for the prevention of Travelers' Diarrhea (TD) in a deployed setting.
- Conditions
- Travelers' Diarrhea, Functional Bowel Disorders, Reactive Arthritis
- Trial name
- NCT02498301
- Testing
- Rifaximin
- Where
- 6 sites in United States, Kenya
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Inflammatory Disease, Rheumatoid Arthritis
Vaccination Perception in Inflammatory Conditions - Flu, Pneumonia and COVID-19
People with inflammatory diseases are often treated with medications that act to suppress the immune-system, increasing the risk of catching infections.
- Conditions
- Inflammatory Disease, Rheumatoid Arthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- OPINION (NCT05115370)
- Testing
- Semi-structured qualitative interview
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Acute Arthritis
Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF)
Septic arthritis is a frequent, potentially disabling and/or life-threatening disease. To diagnose a septic arthritis is a complex procedure, first because of numerous differential diagnoses (such as crystal arthritis), second…
- Trial name
- NOUBASST (NCT01010165)
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Grenoble
Arthritis, Infectious
Pro-calcitonin for Early Detection of Septic Arthritis
Background: Children presenting with non-traumatic joint pain require different treatment depending on the cause of pain. Septic arthritis, which results from a bacterial infection in the joint, often requires a surgical…
- Trial name
- NCT02085733
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Juvenile Idiopathic Arthritis, Arthritis, Septic
Rapid Diagnostic Test for Septic Arthritis
Diagnostic Validation Study of a Test Based on the Analysis of the Proteome by Mass Spectrometry for the Diagnosis of Septic Arthritis in Children Under 16 Years of Age
- Conditions
- Juvenile Idiopathic Arthritis, Arthritis, Septic, Arthritis, Unspecified
- Trial name
- TDR-Arthrite (NCT04460144)
- Testing
- Mass spectrometry
- Where
- France
- Volunteers
- 274 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Arthritis
Evaluation of the Efficacy of Corticosteroids in Septic Arthritis in Adults
Septic arthritis is a severe infection associated with significant morbidity and mortality. Despite eradication of the microorganisms, persistent inflammation may lead to substantial long-term functional joint sequelae.
- Trial name
- CORSAR (NCT07440238)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Health Care Associated Pneumonia, Osteomyelitis/Septic Arthritis
Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients
For more than fifty years, vancomycin has been cited as a nephrotoxic agent. Reports of vancomycin induced kidney injury (a.k.a vancomycin induced nephrotoxicity or VIN), have waxed and waned throughout the years for various…
- Conditions
- Health Care Associated Pneumonia, Osteomyelitis/Septic Arthritis, Endocarditis, Bacteremia
- Trial name
- STOP-NT (NCT01734694)
- Testing
- Vancomycin, Ceftaroline, Daptomycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Henry Ford Health System
Opioid Use Disorder, Bloodstream Infection
Retention and Re-Engagement in Treatment for Addiction Following Serious Injection Related Infections (RETAIN)
This project is a pilot study of an adapted intervention of an existing Opioid Use Disorder (OUD) treatment retention intervention called Recovery Management Checkups (RMC).
- Conditions
- Opioid Use Disorder, Bloodstream Infection, Osteomyelitis, Endocarditis
- Trial name
- RETAIN (NCT06489535)
- Testing
- RETAIN, Unrelated videos
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Septic Arthritis
The Predictive Role of C-reactive Protein to Albumin Ratio (CAR) in the Treatment of Septic Arthritis in Young Chlidren
Purpose: C-reactive protein to albumin ratio (CAR) has emerged as a novel marker of inflammation. However, almost no research has evaluated the role of CAR in septic arthritis (SA).
- Trial name
- NCT06241365
- Volunteers
- 82 people
- Sponsor
- wangxiaodong
Septic Arthritis, Gait Disorder, Sensorimotor
Clinical Utility of Exoskeleton Robot Training in Patients With Septic Arthritis After a Thermal Injury: A Case Report
Bone and/or joint infections, such as septic arthritis (SA), are rare, but delayed diagnosis or improper treatment can result in irreversible joint destruction.
- Trial name
- NCT05886166
- Testing
- robot assisted training
- Volunteers
- 2 people
- Sponsor
- Hangang Sacred Heart Hospital
Reactive Arthritis
Study of Long-Term Antibiotic Treatment in Reactive Arthritis
This is a randomized, double-blind, placebo-controlled trial of the effect of 3-month treatment with the combination of 200 mg ofloxacin twice daily and 150 mg roxithromycin twice daily on clinical course of recent-onset reactive…
- Trial name
- NCT00621387
- Testing
- ofloxacin and roxithromycin
- Where
- 2 sites in Finland
- Volunteers
- 56 people
- Sponsor
- University of Helsinki
Osteoarticular Infections
Molecular Microbiology in Osteo-arthritis Infection
Osteoarticular infections are painful and disabling diseases that require antimicrobial treatment adapted to the microorganisms implicated.
- Trial name
- MOLOS (NCT01193803)
- Testing
- Microbiological cultures and Molecular biology
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris