Clinical trials: Arthritis, Unspecified
Rheumatoid Arthritis
Efficacy and Safety Study of BMS-986142 in Patients With Moderate to Severe Rheumatoid Arthritis
The purpose of this study is to determine whether the study drug, BMS-986142, is safe and effective in treating moderate to severe rheumatoid arthritis in subjects with an inadequate response to methotrexate or methotrexate and…
- Trial name
- NCT02638948
- Testing
- BMS-986142, Methotrexate
- Where
- 104 sites in United States, Argentina and 15 more
- Volunteers
- 508 people
- Sponsor
- Bristol-Myers Squibb
Knee Osteoarthritis
The Bone Cement Penetration in Medial Fixed-bearing Unicompartmental Knee Arthroplasty
During Medial Fixed-bearing Unicompartmental Knee Arthroplasty, pulsed lavage combined with moderate pressurization achieves deeper cement penetration into cancellous bone than manual rinsing, optimizing the bone-cement-implant…
- Trial name
- NCT07866378
- Testing
- unicompartmental knee arthroplasty
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Tianjin Union Medical Center
Hip Osteoarthritis, Osteoarthritis
Development and Evaluation of a Web Based Decision Aid for Patients With Hip Osteoarthritis
The main goal of this study is assess the effectiveness of a PtDA for patients with hip osteoarthritis
- Trial name
- NCT04241978
- Testing
- Patient Decision Aid (PtDA), Brochure with general information about osteoarthritis
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Servicio Canario de Salud
Knee Osteoarthritis (Knee OA)
Comparison of SVF Injection With and Without Microfracture in Moderate Knee Osteoarthritis
This prospective, randomized controlled clinical trial aims to evaluate the clinical and radiological effects of combining stromal vascular fraction (SVF) therapy with arthroscopic microfracture in patients with knee…
- Trial name
- NCT07112885
- Testing
- Arthroscopic Microfracture Combined with Autologous SVF Injection, Arthroscopic Debridement Followed by Autologous SVF Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Osteoarthritis, Knee, Psychological Disorder
Total Knee Arthroplasty Combined With Psychological Intervention for Patients With Psychological Disorders
Objective To evaluate the incidence of psychological problems in total knee arthroplasty (TKA) patients and examine whether perioperative psychological intervention can improve the outcomes of and patient satisfaction with TKA.
- Conditions
- Osteoarthritis, Knee, Psychological Disorder, Psychological Intervention, Satisfaction
- Trial name
- NCT03715608
- Testing
- Psychological Intervention
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Osteoarthritis, Knee
The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis
The aim of EFEX-OA-02 is to explore how running, cycling, exercise simulation and resting acutely influence collagen and proteoglycan homeostasis in OA, as reflected by changes in collagen and proteoglycan levels in urine and…
- Trial name
- EFEX-OA-02 (NCT04542668)
- Testing
- Cycling then running, Running then cycling, Inotropy
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Nordic Bioscience A/S
Knee Osteoarthritis, Effusion Synovial
Methotrexate in the Treatment of Advanced Knee Osteoarthritis With Effusion-synovitis
This multicentre randomized placebo-controlled clinical trial aims to evaluate whether methotrexate (MTX) has effects of relieving symptoms and reducing inflammation on advanced knee osteoarthritis (OA) with inflammatory…
- Conditions
- Knee Osteoarthritis, Effusion Synovial, Knee Pain
- Trial name
- NCT03815448
- Testing
- Methotrexate
- Where
- 11 sites in China
- Volunteers
- 215 people
- Sponsor
- Zhujiang Hospital
Arthritis, Psoriatic
Study of the Safety and Efficacy of Adalimumab in Subjects With Moderate to Severely Active Psoriatic Arthritis Subjects With Inadequate Response to Disease Modifying Anti-Rheumatic Drug Therapy
Multicenter Study of the Safety and Efficacy of Adalimumab in Subjects with Moderate to Severely Active Psoriatic Arthritis Subjects with Inadequate Response to Disease Modifying anti-Rheumatic Drug Therapy
- Trial name
- NCT00646178
- Testing
- adalimumab
- Volunteers
- 102 people
- Sponsor
- Abbott
Total Knee Arthroplasty, Osteoarthritis
Kinematic and Mechanical Alignment Randomized Trial
Knee replacement surgery is the second most common surgery in Canada. People who have very painful knee arthritis usually receive a knee replacement where the surgeon aims to make everyone's knee as straight as possible (called…
- Trial name
- KMART (NCT06787417)
- Testing
- Restricted Kinematically-aligned Arthroplasty, Mechanically-Aligned Arthroplasty
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- McMaster University
Niu Bang Zi Pill, Rheumatoid Arthritis
The Efficacy of the Traditional Chinese Medicine Niubang Pill Combined With Methotrexate on Active Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory autoimmune disease that results in the destruction of joints, connective tissues, muscle, tendons and fibrous tissue.
- Trial name
- NCT03173040
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Cui xuejun
Rheumatoid Arthritis, Autoimmune Rheumatologic Disease
COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases
People living with Systemic autoimmune rheumatic diseases (SARDs) face a new and urgent dilemma: immunosuppression increases risk for worse COVID-19 infection, yet an immune stimulation, such as vaccination, could re-activate…
- Conditions
- Rheumatoid Arthritis, Autoimmune Rheumatologic Disease, Systemic Lupus Erythematosus, Systemic Vasculitis
- Trial name
- COVBIRD (NCT05236491)
- Testing
- COVID-19 vaccine
- Where
- 2 sites in Canada
- Volunteers
- 287 people
- Sponsor
- Paul R Fortin
Hip Osteoarthritis
Comparison of the Effect of Intra Articular Steroid Injection and Pericapsular Nerve Group Block for Hip Osteoarthritis
The most common cause of hip joint dysfunction in the elderly is degenerative osteoarthritis of the hip. Innervation of the hip joint capsule is provided by the obturator nerve, the accessory obturator nerve, and the femoral…
- Trial name
- NCT05136248
- Testing
- intraarticular injection, peng block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Knee Osteoarthritis
The McKenzie System With Arthritic Knees: Do Some Knees Respond to Specific Exercise More Than General or no Exercise
The purpose of the study is to explore if a subgroup of people with osteoarthritic knees can be identified using the McKenzie System of Mechanical Diagnosis and Therapy.
- Trial name
- NCT01641874
- Testing
- Exercise, Evidence based exercise
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lumbar Spinal Stenosis
A Pivotal Study of a Facet Replacement System to Treat Spinal Stenosis
The purpose of this study is to determine if the ACADIA® Facet Replacement System is effective in the treatment of spinal stenosis.
- Trial name
- NCT00401518
- Testing
- Non-randomized ACADIA® Facet Replacement System, Randomized ACADIA® Facet Replacement System, Randomized Instrumented posterolateral fusion (PLF)
- Where
- 29 sites in United States, Puerto Rico
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Globus Medical Inc
Knee Osteoarthritis
The Effect of Reflexology and Knee Massage With Black Cumin Oil on Pain and Fatigue
In this study, black cumin extract oil was used in elderly individuals with Knee Osteoarthritis (OA). The effects of foot reflexology and knee massage on pain and fatigue symptoms.
- Trial name
- NCT06298760
- Testing
- Knee Massage With Black Cumin Oil Group:, Foot Reflexology Group With Black Cumin Oil
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Erzurum Technical University
Rheumatoid Arthritis
A Study of KD6005 in Healthy Participants and Participants With Rheumatoid Arthritis (RA)
This phase 1 study will consist of two parts: Phase 1a is a single-dose study, and will evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary pharmacodynamics (PD) in healthy participants.
- Trial name
- NCT06213259
- Testing
- KD6005
- Where
- China
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Shanghai Kanda Biotechnology Co., Ltd.
Osteoarthritis, Knee
Mechanics of Knee Bracing
The overall objective of this project is to determine whether the provision of a pneumatic knee brace in patients with medial knee osteoarthritis (OA) improves knee mechanics.
- Trial name
- NCT00823888
- Testing
- pneumatic brace
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The New England Baptist Hospital
Arthritis, Rheumatoid, Telerehabilitation
ELECTOR Treat-to-target Via Home-based Disease Activity Monitoring of Patients With Rheumatoid Arthritis
The aim of this study is to explore whether the effectiveness of home-based disease activity monitoring via a home-based (eHealth) intervention is superior to standard clinical disease activity assessment in obtaining and…
- Trial name
- NCT03428763
- Testing
- Homebased disease monitoring (eHealth), Standard clinical disease monitoring
- Where
- 2 sites in Czechia, Denmark
- Sponsor
- Frederiksberg University Hospital
Knee Osteoarthritis
Effectiveness and Safety of Embosphere Microspheres for Embolization of the Geniculate Artery for the Treatment of Pain With Known Moderate to Severe Knee Osteoarthritis
The purpose of this research study is to evaluate the effectiveness and safety of a permanent embolic (Embosphere Microspheres) for embolization of the geniculate artery for the treatment of moderate to severe knee osteoarthritis.
- Trial name
- NCT05112926
- Testing
- Embosphere Microspheres
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Miami
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