Clinical trials: Arthritis, Unspecified
Total Hip Replacement, Coxarthrosis
Comparison of the Use of Conventional Ancillary Reaming and Single-use Ancillary Reaming Material in Total Hip Replacement
The main objective of the study is to compare the use of single-use ancillary reaming material during total hip replacement and conventional reusable ancillary reaming material.
- Trial name
- LUUC (NCT04903860)
- Testing
- total hip replacement with single use ancillary, total hip replacement with conventional ancillary
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Knee Osteoarthritis; Insomnia; Cervical Spondylosis; Chronic Low Back Pain; Allergic Rhinitis
Validating Blinding Maintenance of a Sham-Sensitization Control Design for Sensitization Acupuncture Trials
This study is the clinical validation component of a broader research program developing a randomized controlled trial (RCT) comparing sensitization acupuncture (an individualized technique in which treatment points are selected…
- Trial name
- NCT07868224
- Testing
- Sensitization Acupuncture, Traditional Acupuncture
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Spondylitis, Ankylosing
A Study of CC-99677 in Participants With Active Ankylosing Spondylitis
This study is designed to learn about response to CC-99677 treatment by measuring signs and symptoms of Ankylosing Spondylitis (AS), objective measures of disease activity, quality of life assessments, pharmacokinetics, safety…
- Trial name
- AS SpA axSpA (NCT04947579)
- Testing
- CC-99677
- Where
- 63 sites in United States, China and 6 more
- Volunteers
- 167 people
- Sponsor
- Celgene
Osteoarthritis, Pain
fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study
Painful osteoarthritis (OA) is the 4th largest cause of disability in the UK. Preoperative temporal summation, a measure of central pain facilitation, has been shown to predict postoperative pain after total knee replacement…
- Conditions
- Osteoarthritis, Pain, Postoperative Pain, Surgery
- Trial name
- NCT03126279
- Testing
- Total Knee Replacement Surgery
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Rheumatoid Arthritis
Study in Subjects With Rheumatoid Arthritis to Evaluate the Effect of a Single Dose of Olokizumab on the Pharmacokinetics of Substrates for CYP1A2, CYP2C9, CYP2C19 and CYP3A4
Olokizumab (OKZ) has been shown to reverse the inhibitory effect of IL-6 on the activity of Cytochrome P450 (CYP450) isozymes CYP1A2, CYP2B6, CYP2C9, CYP2C19, and CYP3A4/5 in vitro.
- Trial name
- NCT04246762
- Testing
- Olokizumab, Omeprazole, Caffeine
- Where
- 2 sites in Bulgaria, Moldova
- Volunteers
- 17 people
- Sponsor
- R-Pharm International, LLC
Rheumatoid Arthritis
An Observational Study to Assess the Real-World Effectiveness of Upadacitinib in Adult Participants With Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. RA can reduce the ability to perform everyday tasks.
- Trial name
- ENDEAVOUR (NCT05170646)
- Where
- 15 sites in United Kingdom
- Volunteers
- 97 people
- Sponsor
- AbbVie
Rheumatoid Arthritis
An Observational Study of Glucocorticoid Use in Patients With Rheumatoid Arthritis on Treatment With RoActemra/Actemra (Tocilizumab)
This observational study will evaluate the glucocorticoid sparing effect after 12 months of treatment with RoActemra/Actemra (tocilizumab) in patients with rheumatoid arthritis.
- Trial name
- NCT01392001
- Where
- 116 sites in France
- Volunteers
- 322 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
"Effect of Vitamin E (α-Tocopherol) on Clinical Activity and Inflammation in Rheumatoid Arthritis"
The objective of this clinical trial is to determine whether α-tocopherol (vitamin E) supplementation decreases inflammation and clinical activity in patients with rheumatoid arthritis (RA).The main questions to be answered are…
- Trial name
- VitE in RA (NCT06915701)
- Testing
- Will take vitamin E 800mg/day
- Where
- 2 sites in Mexico
- Volunteers
- 46 people
- Sponsor
- University of Guadalajara
Inflammatory Rheumatism
HIIT for Inflammatory Rheumatic Disease: Man vs Machine
The purpose of this study is to compare two modes of delivering high-intensity interval training (HIIT) in a population with inflammatory rheumatic disease over 10 weeks.
- Trial name
- NCT04649528
- Testing
- Effective endurance 4x4 training - Supervised, Effective endurance 4x4 training - APP
- Where
- Norway
- Volunteers
- 49 people
- Sponsor
- Molde University College
Rheumatoid Arthritis
Examination of the Effectiveness of Diffusion Weighted Magnetic Resonance Imaging for Identifying Poor Prognosis in Patients With Rheumatoid Arthritis
Diffusion Weighted Imaging (DWI) MRI will assist in differentiating poor prognosis bone oedema more effectively than traditional T2 weighted MRI in patients with early Rheumatoid Arthritis (RA).
- Trial name
- NCT01482507
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Optimus Clinical Research
Axial Spondyloarthritis
Factors for the Onset and Course of Axial Spondylitis
In a research project, investigators want to study the course of the disease of axial spondylitis: the causes of disease onset, prognosis, and treatment effects.
- Trial name
- EISPA (NCT06594107)
- Where
- 2 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska Institutet
Fibromyalgia, Multiple Sclerosis
e-Mobile Tablet for People With Chronic Conditions
Maintaining a healthy diet and engaging in routine physical activity may help decrease severity of symptoms, prevent secondary conditions, and slow functional decline in people with disabling neuromusculoskeletal conditions.
- Conditions
- Fibromyalgia, Multiple Sclerosis, Osteoarthritis, Sjögren's Syndrome
- Trial name
- NCT02833311
- Testing
- Computer Tablet Group, Paper and Pencil Group, Contact Control Group
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Case Western Reserve University
Healthy Volunteers
A Dose-Block Randomized, Placebo Controlled (Double-blind), Active Controlled(Open-label), Dose-escalation Study
The study design of this trial is a Dose-Block Randomized, Placebo controlled (Double-blind), Active Controlled(Open-label), Dose-escalation.
- Trial name
- NCT02175056
- Testing
- HL2351, Kineret(Anakinra)
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Handok Inc.
Rheumatoid Arthritis
Effect of Roflumilast and Desloratadine as Add-On Therapy in Patients With Rheumatoid Arthritis
Rheumatoid arthritis is a chronic inflammatory disease that causes joint pain, swelling, and disability. Although standard disease-modifying antirheumatic drugs (DMARDs) are effective for many patients, some individuals continue…
- Trial name
- NCT07566351
- Testing
- Roflumilast, Desloratadine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Horus University
Osteoarthritis, Knee
Effect of Low Intensity Training Combined With Partial Restriction of Blood Flow in Individuals With Knee Osteoarthritis
Osteoarthritis (OA) is a chronic degenerative infection that presents clinical features such as pain and limited range of motion.
- Trial name
- NCT04819672
- Testing
- Low Intensity Training associated with Partial Blood Flow
- Volunteers
- 66 people
- Sponsor
- Universidade Federal do Ceara
Sjogren's Syndrome, Non-celiac Gluten Sensitivity
Wheat-free Diet in the Treatment of Sjogren's Syndrome
Recent data show that some foods can increase intestinal mucosa permeability and immune activation of subjects with gastrointestinal (GI) symptoms.
- Trial name
- NCT05644795
- Testing
- Wheat/milk free diet (W/MFD) group, Rice/turkey free diet (R/TFD) group
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Arthritis
ReCap Total Hip Resurfacing Prospective Data Collection
Prospective data collection on survivorship of ReCap Total Hip Resurfacing
- Trial name
- NCT00758472
- Testing
- ReCap Total Hip Resurfacing
- Where
- 2 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis, Osteoarthritis
Relative Bioavailability Study of Naproxen Delayed-Release Tablets (375 mg)
The purpose of this study is to demonstrate the relative bioavailability of Naproxen delayed-release tablets (375 mg).
- Trial name
- NCT00959439
- Testing
- Naproxen Delayed Release Tables, 375 (Gevena Pharmaceuticals, Inc.), Naproxen (EC-Narosyn) Delayed Release Tables, 375 (Syntex (USA), Inc.)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sandoz
Ankylosing Spondylitis (AS)
Integrated Traditional Chinese and Western Medicine for Ankylosing Spondylitis (AS): A Cohort Study Protocol Focusing on Spondyloarthritis Research Consortium of Canada (SPARCC) Scoring System
This study is a multicentre, ambidirectional, observational cohort study. The ambidirectional design incorporates both the collection of retrospective data from the three years prior to enrolment, and a prospective follow-up…
- Trial name
- NCT07509775
- Where
- China
- Volunteers
- 210 people
- Sponsor
- China-Japan Friendship Hospital
Systemic Lupus Erythematosus
The Therapeutic Value and Mechanism of Recombinant Human Interleukin-2 on Children With Rheumatic Diseases
The study aims to explore the therapeutic value and mechanism of Interleukin-2 on children with rheumatic diseases (Systemic Lupus Erythematosus, Primary Sjögren Syndrome, Juvenile Idiopathic Arthritis).
- Trial name
- SLE，pSS，JIA (NCT04397107)
- Testing
- IL-2
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
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