Clinical trials: Arthritis, Unspecified
Knee Arthritis, Hip Arthritis
Preoperative Pain Threshold and Rapid Recover Programs
To investigate the association between grip strength and preoperative pain threshold as measured by pressure algometer and validated pain outcome surveys.
- Trial name
- NCT02740738
- Testing
- Wagner Pain Algometer, Dynamometer
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Early Rheumatoid Arthritis
Power Doppler in Hand Joints of Early RA Patients
It is a prospective case-control study with women diagnosed early rheumatoid arthritis. Three therapeutic failures were considered: failure 1 - to the first Disease-modifying antirheumatic drugs (DMARDs) (methotrexate); failure 2…
- Trial name
- NCT04752748
- Testing
- Drug protocol
- Volunteers
- 48 people
- Sponsor
- Federal University of São Paulo
Arthroplasty, Replacement, Knee
Evaluation of Triathlon - A New Total Knee Prosthesis System - Triathlon PA vs. Triathlon Pressfit
The objective is to investigate the Clinical, Radiographic, Roentgen Stereophotogrammetric behaviour and patient outcome when using the Triathlon total knee prosthesis in a prospective randomized clinical trial.
- Trial name
- TriathlonRSA (NCT03198533)
- Testing
- Triathlon PA, Triathlon Pressfit
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Stryker Orthopaedics
Osteo Arthritis Knee
Intra-articular Injection of UC-MSC Exosome in Knee Osteoarthritis
The study aim to evaluate safety of exosomes (sEVs) from allogeneic mesenchymal stromal cells delivered by an intra-articular injection in the knee of patients with mild to moderate symptomatic osteoarthritis.
- Trial name
- EXO-OA01 (NCT06431152)
- Testing
- UC-MSC sEV
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Universidad de los Andes, Chile
Rheumatoid Arthritis
Develop Biomarkers for Assessing RA Joint Erosion
With the current therapeutic focus in rheumatoid arthritis (RA) shifting from symptom control to actual disease modification there is a growing demand for more objective and sensitive ways to evaluate structural damage in the…
- Trial name
- NCT00154947
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Rhematoid Arthritis
An Efficacy And Safety Study Evaluating Tofacitinib With And Without Methotrexate Compared To Adalimumab With Methotrexate
To assess the efficacy of tofacitinib monotherapy or tofacitinib with methotrexate as compared to adalimumab with methotrexate. To compare the efficacy of tofacitinib monotherapy compared to tofacitinib combined with…
- Trial name
- ORAL STRATEGY (NCT02187055)
- Testing
- Tofacitinib with methotrexate, Tofacitinib without methotrexate, Adalimumab with methotrexate
- Where
- 215 sites in United States, Argentina and 23 more
- Volunteers
- 1,152 people
- Sponsor
- Pfizer
Knee Osteoarthritis
SVF Therapy for Human Knee Osteoarthritis
The purpose of the study is to asses the safety and efficacy of SVF for treatment of knee osteoarthritis, and establish a novel method to provide 3D MRI imaging for human knee cartilage to qualitatively and quantitatively…
- Trial name
- NCT05019378
- Testing
- SVF treatment
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Osteoarthritis, Knee, Physical Inactivity
Effect of Structured Exercise in Patients With Knee Osteoarthritis
The aim of this randomized controlled trial is to evaluate the effect of Nordic walking and inspiratory muscle training (IMT) on cardiopulmonary function in patients with knee osteoarthritis (OA).
- Trial name
- NCT06084949
- Testing
- Nordic walking or inspiratory muscle training
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Rheumatoid Arthritis
A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs
The study objective of Period 1 (Day 1 to Week 24) is to compare the safety and efficacy of upadacitinib 30 mg once daily (QD) and 15 mg QD versus placebo for the treatment of signs and symptoms of participants with moderately to…
- Trial name
- SELECT-BEYOND (NCT02706847)
- Testing
- Upadacitinib
- Where
- 188 sites in United States, Australia and 25 more
- Volunteers
- 499 people
- Sponsor
- AbbVie
Knee Osteoarthritis, Total Knee Replacement
Knee Arthroplasty Activity Trial
Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA).
- Trial name
- KArAT (NCT04107649)
- Testing
- Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives, Wrist based activity tracker wear, Basic Study Activities
- Where
- 5 sites in United States
- Volunteers
- 600 people
- Sponsor
- Brigham and Women's Hospital
Hip and Knee Osteoarthritis
Recovery After Fast Track THA / TKA
The development and implementation of "fast-track" principles in total knee and hip arthroplasty have resulted in early recovery and rehabilitation alongside a reduced length of hospital stay.
- Trial name
- 0-21 (NCT02137655)
- Where
- 2 sites in Denmark
- Volunteers
- 112 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lipedema, Knee Osteoarthritis
The Effect of Lipedema on Knee Osteoarthritis
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context.
- Conditions
- Lipedema, Knee Osteoarthritis, Knee Acute and Chronic Pain, Knee
- Trial name
- NCT07575555
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Izmir Democracy University
Sjögren's Disease
A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease
To evaluate efficacy, safety, and tolerability of DDY391 up to 52 weeks in participants with Sjögren's disease (SjD) and to determine the dose response relationship of DDY391 in participants with SjD, to support dose selection…
- Trial name
- NCT07737743
- Testing
- DDY391
- Where
- 25 sites in United States, Australia and 4 more
- Volunteers
- 344 people
- Sponsor
- Novartis Pharmaceuticals
Osteo Arthritis Knee
Bone Marrow Versus Adipose Autologous Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
Mesenchymal stem cells (MSC) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation.
- Trial name
- NCT04351932
- Testing
- bone marrow mesenchymal stem cells, Adipose Mesenchymal stem cells, bone marrow & adipose mesenchymal stem cells injection
- Where
- Ecuador
- Volunteers
- 54 people
- Sponsor
- Universidad Catolica Santiago de Guayaquil
Osteoarthritis, Knee
An Evaluation of a Gender Specific Insole to Provide Relief From Knee Pain Due to Osteoarthritis or General Anterior Knee Pain in Male Subjects When Used in Foot Wear Over a Period of Four Weeks
The primary objective of this trial is to demonstrate the ability of a full length foam insole to provide relief from pain due to osteoarthritis of the knee or general knee pain when used in foot wear for a 4-week period of time.
- Trial name
- NCT03556787
- Testing
- BPI 1000013 (Dr Scholls Insole)
- Where
- 2 sites in United States
- Volunteers
- 89 people
- Sponsor
- Bayer
Osteoarthritis, Knee
Trial of Naproxen to Evaluate Various Methods of Measuring Analgesic Effect in Osteoarthritis Pain of the Knee
This study aims to evaluate various methods of measuring pain relief in subjects who have chronic OA of the knee. After a 1 week of wash-out from existing therapy, subjects will be treated in a blinded fashion for 1 week with…
- Trial name
- NCT01557816
- Testing
- Naproxen
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Analgesic Solutions
Rheumatoid Arthritis
A Randomized, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of F8IL10 (Dekavil) in Patients With Active RA Receiving MTX
A multicenter, randomized, parallel assignment, double blind, placebo-controlled, safety/efficacy phase II study of two different dosages of subcutaneous F8IL10 in patients with active rheumatoid arthritis receiving MTX.
- Trial name
- NCT02270632
- Testing
- F8IL10, MTX
- Where
- 8 sites in Germany, Italy and 1 more
- Volunteers
- 27 people
- Sponsor
- Philogen S.p.A.
Rheumatoid Arthritis
Study to Evaluate and Compare Safety and Pharmacokinetics of the HCP1004 and VIMOVO 500/20mg in Healthy Korean Male
The purpose of this study is to Evaluate and Compare Safety and Pharmacokinetics of the HCP1004 and VIMOVO 500/20mg in Healthy Korean Male
- Trial name
- NCT01688193
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Treatment, Osteoarthritis
Evaluate Safety & Efficacy of Condroflex in Subjects With OA
Primary Objective: To compare, after 12 weeks of double-blind treatment, the evolution of the improvement of pain (at rest and during / after exercise) in the questionnaire WOMAC (Western Ontario and McMaster Universities…
- Conditions
- Treatment, Osteoarthritis, Elderly
- Trial name
- ZD20108 (NCT00838487)
- Testing
- condroflex and exercise, sugar pill and exercise
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- Zodiac Produtos Farmaceuticos S.A.
Ankylosing Spondylitis
Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Ankylosing Spondylitis Who Have an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drug Therapy
The primary objective of this study is to evaluate the effect of filgotinib versus placebo on signs and symptoms of active ankylosing spondylitis (AS), evaluated by Assessment of SpondyloArthritis international Society 40%…
- Trial name
- SEALION1-IR (NCT04483687)
- Testing
- Filgotinib
- Sponsor
- Gilead Sciences
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