Clinical trials: Arthritis, Unspecified
Osteoporosis, Osteoarthritis
OSTEOMICS: Identifying Regulators of Bone Homeostasis
Diseases of bone associated with ageing, including osteoporosis (OP) and osteoarthritis (OA), reduce bone mass, bone strength and joint integrity.
- Conditions
- Osteoporosis, Osteoarthritis, Bone Diseases, Bone Fracture
- Trial name
- OSTEOMICS (NCT05732870)
- Testing
- Relevant orthopaedic surgery
- Where
- 8 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Relation Therapeutics
Hip Osteoarthritis
PENG Block and Delirium After Hip Arthroplasty
Postoperative delirium is a common and serious complication in older adults undergoing total hip arthroplasty, associated with prolonged hospitalization, increased morbidity, delayed rehabilitation, and long-term cognitive…
- Trial name
- NCT07449468
- Testing
- 0.2% ropivacaine
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Poznan University of Medical Sciences
Juvenile Psoriatic Arthritis, Enthesitis Related Arthritis
An Extension Study of Subcutaneous Secukinumab in Patients With Juvenile Psoriatic Arthritis (JPsA) and Enthesitis Related Arthritis (ERA)
Optional open label, roll over extension study to investigate the efficacy and safety of secukinumab treatment in Juvenile Idiopathic Arthritis (JIA) subtypes of Juvenile Psoriatic Arthritis (JPsA) and Enthesitis Related…
- Trial name
- NCT03769168
- Testing
- Secukinumab
- Where
- 23 sites in United States, Belgium and 7 more
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis
Diphenhydramine Ointment for Knee Osteoarthritis
The main purpose of this study is to evaluate whether recruitment rates are adequate to power a future RCT. The secondary aims are to obtain preliminary information about safety and efficacy of topical diphenhydramine 5% ointment…
- Trial name
- NCT05036174
- Testing
- Diphenhydramine 5%
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology
Rheumatoid Arthritis
Efficacy and Safety of Colquhounia Root Tablet in Patients With Rheumatoid Arthritis
This study is a multi-center, randomized, double-blinded, controlled trial with two parallel arms. The aim of the study is to evaluate whether Colquhounia Root Tablet combined with methotrexate (MTX) might be better than MTX…
- Trial name
- NCT05393050
- Testing
- Colquhounia Root Tablet, Methotrexate tablets
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Quan Jiang
Hand Osteoarthritis
Splinting to Treat Hand Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis and the hand is the most frequently affected site.Interphalangeal (IP) joints (the small joints of the fingers) are often involved causing pain, progressive loss of hand…
- Trial name
- SPLINTOA (NCT01249391)
- Testing
- Splinting
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Imperial College London
Osteoarthritis, Knee
Prospective Randomized Study of Cementless vs Cemented UKA
To evaluate the non-inferiority of the cementless Engage Partial Knee System compared to cemented Engage Partial knee System.
- Trial name
- NCT05377450
- Testing
- Engage Partial Knee
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- JIS Research Institute
Juvenile Idiopathic Arthritis (JIA), Childhood Rheumatic Diseases
Investigation of Catastrophizing of Pain Reported by Parents in JIA Patients
Juvenile idiopathic arthritis (JIA) is the primary rheumatic disease reported to affect the pediatric population. Research suggests that parents' thoughts and feelings about their child's pain, specifically with JIA diagnosis…
- Trial name
- NCT07185750
- Testing
- Questionnaire application for JIA cases and their parents
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Rheumatoid Arthritis
Effect Of CP-690,550 On The Pharmacokinetics Of Metformin In Healthy Volunteers
This study will evaluate the potential effect of CP 690,550 on the pharmacokinetics of metformin, a probe drug for organic cationic transport.
- Trial name
- NCT01405118
- Testing
- Metformin/CP-690,550
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rheumatoid Arthritis
Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies.
It is hypothesized that repository corticotropin injection in combination with other biologic agents will be able to provide relief of both rheumatoid arthritis and acute exacerbations of rheumatoid arthritis for patients with…
- Trial name
- NCT01966718
- Testing
- Repository corticotropin injection
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Arthritis Treatment Center, Maryland
Osteoarthritis (OA)
Empowered Relief Study
"Empowered Relief" (ER) Intervention was developed by Beth Darnall, PhD at what is now the Stanford Pain Relief Innovations Lab. Our design is a randomized 3-arm study with test treatment, active control, and placebo arms.
- Trial name
- NCT07562750
- Testing
- Empowered Relief, "Self Management Strategies" handout
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Knee Osteoarthritis, Intra-Articular Injection
Innovative Tool to Analyse Synovial Fluid of Patients With Knee Ostearthritis After IA Injection of Synvisc-one®
The objective of this trial is to assess the clinical pertinence of an innovative analytical tool (SYNODIAG) to analyze the Synovial Fluid (SF) composition and guide the patient treatment in a Proof of Concept (PoC) study using…
- Trial name
- RESYF (NCT04321668)
- Testing
- Synvisc-One
- Where
- 3 sites in Belgium
- Volunteers
- 13 people
- Sponsor
- Pulsalys
Sjogren's Syndrome
Ro60 Expression in Macrophages in Sjogren's Disease
Context: The Ro60 protein associates with YRNAs (or RNYs) to form the RoRNP complex, which regulates RNA surveillance and maturation.
- Trial name
- RoMioSS (NCT06324968)
- Testing
- Positive serology for anti-SSA
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoarthritis
Using Web-based Tools to Facilitate Tailored Exercise for People With Osteoarthritis
The purpose of this pilot study is to assess the feasibility, acceptability, and potential effectiveness of identifying people with osteoarthritis (OA) who are interested in individualized exercise programs through a web-based…
- Trial name
- exercise/OA (NCT02404974)
- Testing
- exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Osteo Arthritis Knee
Black Seed Oil in Treatment of Osteoarthritis
Osteoarthritis is a continual illness of joints. We aim to investigate the effect of Nigella sativa oil in comparison with placebo on the reduction of osteoarthritis pain.
- Trial name
- NCT06029868
- Testing
- Black seed oil capsule
- Where
- Iran
- Volunteers
- 110 people
- Sponsor
- Ramsar international campus
Arthritis, Rheumatoid, Healthy
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effects of Multiple Rising Subcutaneous Doses of BI 655064 in Healthy Volunteers and in Rheumatoid Arthritis Patients With Prior Inadequate Response to Methotrexate Therapy
To evaluate the safety and tolerability of multiple doses of BI 655064 administered subcutaneously in healthy volunteers (HVs) and in rheumatoid arthritis (RA) patients.
- Trial name
- NCT01751776
- Testing
- BI 655064
- Where
- 25 sites in Czechia, Germany and 4 more
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Osteoarthritis
Enthesitis in Patients With Knee Osteoarthritis
The current study was conducted to estimate the prevalence of knee cap enthesitis in patients with knee osteoarthritis and its relation to knee function.
- Trial name
- NCT03897829
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University
Rheumatoid Arthritis
A Study of Subcutaneously Administered Tocilizumab in Patients With Rheumatoid Arthritis
This open-label randomized 2arm study will investigate the pharmacokinetics, pharmacodynamics, efficacy and safety of subcutaneously administered tocilizumab in patients with rheumatoid arthritis who have shown an inadequate…
- Trial name
- NCT00965653
- Testing
- folic acid, methotrexate, tocilizumab [RoActemra/Actemra]
- Where
- 7 sites in Canada, New Zealand and 1 more
- Volunteers
- 29 people
- Sponsor
- Hoffmann-La Roche
Hip Osteoarthritis, Short Stem Prosthesis
Subsidence of Short Stem THA With DORR Type C
Total hip arthroplasty (THA) is a widely accepted procedure for the treatment of end-stage hip osteoarthritis. Neck preserving short stems have gained popularity in recent years, as they aim to preserve proximal femoral bone…
- Conditions
- Hip Osteoarthritis, Short Stem Prosthesis, Total Hip Arthroplasty (THA)
- Trial name
- NCT06768541
- Testing
- THA using a short stem
- Where
- Austria
- Volunteers
- 108 people
- Sponsor
- Krankenhaus Barmherzige Schwestern Linz
Hallux Valgus, Hallux Limitus
The Hyalex MTP Study
The HYALEX SLALOM MTP Hemiarthroplasty System consists of a synthetic implant designed to replace the distal metatarsal surface of the great toe for treatment of arthritis .
- Conditions
- Hallux Valgus, Hallux Limitus, Hallux Rigidus
- Trial name
- NCT07538141
- Testing
- MTP Hemiarthroplasty
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Hyalex Orthopaedics, Inc.
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