Clinical trials: Arthritis, Unspecified
Rheumatoid Arthritis
Phase 2, Multicenter, Open-Label Extension Study With ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12-963 Study
This is a Phase 2, multicenter, 24-week OLE study to assess the safety and tolerability of ABT-122 in participants with rheumatoid arthritis (RA) who had had an inadequate response to methotrexate (MTX) therapy and who completed…
- Trial name
- NCT02433340
- Testing
- ABT-122
- Volunteers
- 158 people
- Sponsor
- AbbVie
Hip Fracture, Osteoarthritis
Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery
The purpose of this study is to determine the effects of two postoperative interventions designed to preserve muscle protein after major hip or knee surgery.
- Conditions
- Hip Fracture, Osteoarthritis, Femur Head Necrosis
- Trial name
- NCT00393848
- Testing
- Essential amino acid supplement, Ketoconazole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Arkansas
Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refractory autoimmune diseases (Breakfree-1).
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy, Systemic Sclerosis, Rheumatoid Arthritis
- Trial name
- NCT05869955
- Testing
- CC-97540, Fludarabine, Cyclophosphamide
- Where
- 46 sites in United States, Belgium and 4 more
- Volunteers
- 270 people
- Sponsor
- Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
SARS-Cov-2 Infection, Rheumatoid Arthritis
Deciphering a Specific Signature of the Immunosenescence Induced in COVID-19+ Patients Versus Rheumatoid Arthritis Patients
Immune aging or immunosenescence is characterized by a loss of T cell clonal diversity and a contraction of naïve T cells with proliferative capacity associated with the functional impairment of many others immune cells as well…
- Trial name
- SENO-COVID (NCT04880720)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Juvenile Idiopathic Arthritis, Inflammatory Bowel Diseases
Transition to Adulthood Through Coaching and Empowerment
Pediatric patients with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease who are preparing to transition into adult care face many unique challenges, and, to date, there is no comprehensive and implementable model of…
- Trial name
- TRACE (NCT05570617)
- Testing
- Transition Coach Intervention, Standard of Care- Youth Transition Roadmap
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- McMaster University
Osteoarthritis
Clinical Trial on the Efficacy and Safety of ALT001 in Osteoarthritis
This clinical trial will focus on the core efficacy endpoints including relief of pain intensity, improvement of joint motor function and enhancement of quality of life in patients.
- Trial name
- NCT07404891
- Testing
- ALT001
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Knee Osteoarthritis
Cartilage Recovery in Adults With Knee Osteorthritis by Mesenchymal Cell Therapy: Randomized Trial of Radiologic and Clinical Outcomes
The treatment of osteoarthritis (OA) of the knee remains still controversial. Despite that fact advanced stages with symptomatic and functional improvement are obtained with total knee replacement, however, there is no treatment…
- Trial name
- INMUNOCEM-OA (NCT05936060)
- Testing
- INMUNOCEM
- Volunteers
- 32 people
- Sponsor
- GUSTAVO SALGUERO
Hip Osteoarthritis
Exercise Therapy and Patient Education for Individuals With Hip Osteoarthritis of the Hip. A Case-Control Study
To identify differences between patients with OA of the hip in an early stage and a healthy control group. Hypothesis 1.1 There are significant differences between patients with OA of the hip in an early stage and a healthy…
- Trial name
- NCT00319124
- Where
- Norway
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
HIP AND KNEE OSTEOARTHRITIS
Prepare II - Predictive Model Training and External Validation
The general aim of the project is training and testing a predictive model of inpatient rehabilitation stay after hip and knee replacement for osteoarthritis.
- Trial name
- NCT07304323
- Testing
- Functional rehabilitation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Total Knee Arthroplasty, Knee Osteoarthritis
Gait in Fixed Or Rotating Cementless Total Knee Arthroplasties
The number of patients requiring knee replacements is increasing every year due to the combination of an aging population, increased patient expectancy, and rising levels of obesity.
- Trial name
- G-FORCE (NCT06483178)
- Testing
- Attune knee implant, Triathlon knee implant
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Belfast Health and Social Care Trust
Gout
Phase 2b/3 Study to Assess ABP-671 a Novel URAT1 Inhibitor in Participants With Gout
This is a multicenter, randomized, double-blind, Phase 2b/3 study to evaluate the efficacy and safety of ABP-671. Part 1 of the study will compare the efficacy and safety of different doses and regimens of ABP-671 with placebo…
- Trial name
- NCT05818085
- Testing
- ABP-671, Allopurinol
- Where
- 57 sites in United States, Australia and 3 more
- Volunteers
- 300 people
- Sponsor
- Atom Therapeutics Co., Ltd
Chronic Pain, Osteoarthritis
Effects of tDCS and tUS on Pain Perception in OA of the Knee
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with…
- Trial name
- NCT02330315
- Testing
- transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Spaulding Rehabilitation Hospital
Active Rheumatoid Arthritis
Study to Demonstrate Non-Inferior Efficacy and Safety of CinnoRA® Versus Humira® for Treatment of Active RA
The purpose of this study is to compare the efficacy and safety of adalimumab produced by CinnaGen company and AbbVie adalimumab in subjects with active Rheumatoid Arthritis.
- Trial name
- NCT03172325
- Testing
- Adalimumab, Methotrexate, Folic Acid
- Where
- 10 sites in Iran
- Volunteers
- 136 people
- Sponsor
- Cinnagen
Cardiovascular Diseases, Rheumatoid Arthritis
Comprehensive Assessment of Subclinical Atherosclerosis in Patients With Rheumatoid Arthritis
Cardiovascular disease is a leading cause for morbidity and mortality in general population. The incidence of cardiovascular disease and their poor outcome is well documented in a broad spectrum of connective tissue diseases…
- Conditions
- Cardiovascular Diseases, Rheumatoid Arthritis, Atherosclerosis, Coronary
- Trial name
- NCT03813017
- Volunteers
- 100 people
- Sponsor
- Ziv Hospital
Degenerative Hip Joint Disease, Post-traumatic Osteoarthritis
Safety and Performance Assessment of the SYMBOL Range of Medical Devices in Patients Underlying Total Hip Arthroplasty
The purpose of this post-market clinical follow up study is to assess the safety and effectiveness of the SYMBOL range of medical devices.
- Conditions
- Degenerative Hip Joint Disease, Post-traumatic Osteoarthritis, Hip Arthritis, Femoral Neck Fractures
- Trial name
- NCT05227924
- Testing
- Total hip arthroplasty (primary or revision)
- Where
- 9 sites in France
- Volunteers
- 747 people
- Sponsor
- Dedienne Sante S.A.S.
Rheumatoid Arthritis
A Long-term Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients With Rheumatoid Arthritis
This open-label, international multi-center extension study WA18695 was designed to assess the long term safety of tocilizumab in patients who had moderate to severe active rheumatoid arthritis (RA).
- Trial name
- NCT00721123
- Testing
- Tocilizumab
- Where
- 69 sites in Argentina, Australia and 15 more
- Volunteers
- 538 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis, Osteoarthritis of Hands
Home Based Computer Gaming Hand Exercise Regimen for People With Arthritis Affecting the Hands
The purpose of the study is to determine whether a novel computer gaming hand exercise regimen would improve hand function, decrease pain/ stiffness and be feasible in people with Rheumatoid arthritis or Osteoarthritis affecting…
- Trial name
- NCT01635582
- Testing
- Conventional hand exercise program, Computer gaming hand exercise regimen
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Manitoba
Osteoarthritis, Avascular Necrosis
Metal Ions in Ceramic on Metal Total Hip Arthroplasty
The investigators aim to measure the blood levels of certain metals in a group of patients all of whom have had a ceramic on metal total hip replacement.
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Developmental Dysplasia of the Hip
- Trial name
- COM (NCT01437124)
- Where
- United Kingdom
- Volunteers
- 83 people
- Sponsor
- Hussain Kazi
Knee Osteoarthritis
Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis
In recent years, the incidence rate and disability rate of osteoarthritis have continued to grow, and it has become a common chronic disease of elderly patients, second only to the "three highs", and poses a continuous threat to…
- Trial name
- NCT06463847
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Arthritis of the Knee Joint
Should my New Knee Rotate?
Total Knee Arthroplasty (TKA) is the surgical reconstruction of the knee joint in order to relieve pain, restore function and correct deformity.
- Trial name
- NCT02892838
- Testing
- mobile bearing knee system for total knee arthroplasty, fixed bearing total knee prosthesis
- Volunteers
- 106 people
- Sponsor
- Maastricht University Medical Center
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