Clinical trials: Arthritis;Inflammatory
Knee Osteoarthritis
Efficacy of Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis.
Knee osteoarthritis (OA) causes patients considerable joint pain and leads to instability, reduced range of motion, and functional limitations.
- Trial name
- NCT03379168
- Testing
- Microfragmented Adipose Tissue (Lipogems), Corticosteroid injection, Saline
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Dustin L. Richter, MD
Osteoarthritis, Knee
A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA
The purpose of the study was to find out if the investigational treatment named QUC398 had beneficial effects on osteoarthritis (OA) knee pain and knee cartilage, and if it was safe and tolerated.
- Trial name
- NCT05462990
- Testing
- QUC398
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 101 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis
Synvisc-One for Younger, Active Patients With Osteoarthritis
This study aims to study use of viscosupplementation as a treatment of pain for young individuals who are active. Typically viscosupplementation is considered an intervention for knee osteoarthritis often for older patients who…
- Trial name
- SYNVISC-ONE (NCT01625013)
- Testing
- Synvisc-One (G-F 20)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Anthony Luke
Psoriatic Arthritis, Work Productivity
To Observe the Impacts of Anti-Tumor Necrosis Factor (TNF) Effectiveness on Improvement in Work Place and Household Productivity for Patients With Psoriatic Arthritis (PsA)
This post marketing observational study is designed to provide the initial data on work impairment of PsA patients in Turkey, as well as changes in work impairment, life quality and clinical response during treatment with…
- Trial name
- NCT02028169
- Volunteers
- 120 people
- Sponsor
- AbbVie
Osteoarthritis
A Retrospective Study of the iTotal CR Knee Replacement System
This study involves retrospective collection of data regarding the first approximately 100 iTotal Knee Replacement System surgeries and their short term outcomes at a small set of centers throughout the US.
- Trial name
- NCT01564654
- Testing
- iTotal KRS
- Where
- 4 sites in United States
- Volunteers
- 89 people
- Sponsor
- Restor3D
Psoriatic Arthritis, Axial Spondyloarthritis
Study of Efficacy and Safety of Secukinumab in Psoriatic Arthritis and Axial Spondyloarthritis Patients With Active Enthesitis Including One Achilles Tendon Site
The purpose of this study was to demonstrate efficacy, including effects on inflammation by magnetic resonance imaging (MRI) assessments, of secukinumab on Achilles tendon enthesitis for up to 1 year with a primary focus at Week…
- Conditions
- Psoriatic Arthritis, Axial Spondyloarthritis, Enthesitis
- Trial name
- ACHILLES (NCT02771210)
- Testing
- Secukinumab
- Where
- 55 sites in Bulgaria, Czechia and 6 more
- Volunteers
- 204 people
- Sponsor
- Novartis Pharmaceuticals
Hallux Rigidus
Surgical Treatment for Great Toe Arthritis
After potential subjects determine that they would like surgical treatment of their great toe arthritis, study staff will approach them about the study.
- Trial name
- NCT03935880
- Testing
- Cartiva Implant, Cheilectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Osteoarthritis, Rheumatoid Arthritis
The 3DKnee™ System: A Post-Market Study
The purpose of this study is to evaluate the survivorship and efficacy of the Encore 3DKnee™ system in a group of patients who will receive the 3DKnee™ as a primary (first) orthopedic implant in the knee.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post Traumatic Arthritis, Varus Deformity
- Trial name
- NCT00764673
- Testing
- 3DKnee
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Encore Medical, L.P.
Juvenile Idiopathic Arthritis
An Extension Study to WA19977 in Patients With Active Polyarticular-Course Juvenile Idiopathic Arthritis
This long-term, interventional, open-label extension study will evaluate the safety and efficacy of RoActemra/Actemra (tocilizumab) in patients from Poland and Russia with polyarticular-course juvenile idiopathic arthritis who…
- Trial name
- NCT01575769
- Testing
- RoActemra/Actemra (tocilizumab)
- Where
- 11 sites in Poland, Russia
- Volunteers
- 41 people
- Sponsor
- Hoffmann-La Roche
Osteoarthritis
Safety of Buprenorphine Transdermal Patch (BTDS) in Osteoarthritis Pain: a 52-Week Extension Phase
The purpose of this phase is to evaluate the long-term safety and tolerability of BTDS. Qualified subjects are started on BTDS 5 and the dose may be titrated, if necessary, to a maximum of BTDS 20 to achieve stable pain control.
- Trial name
- NCT01135524
- Testing
- Buprenorphine transdermal patch
- Where
- 89 sites in United States
- Volunteers
- 196 people
- Sponsor
- Purdue Pharma LP
Psoriatic Arthritis
Efficacy of Secukinumab Compared to Adalimumab in Patients With Psoriatic Arthritis
This was a randomized, double-blind, active controlled, multicenter, parallel-group study evaluating secukinumab monotherapy and adalimumab monotherapy in approximately 850 patients with active psoriatic arthritis (PsA) who are…
- Trial name
- EXCEED 1 (NCT02745080)
- Testing
- Secukinumab, Adalimumab
- Where
- 156 sites in United States, Australia and 24 more
- Volunteers
- 853 people
- Sponsor
- Novartis Pharmaceuticals
Pain, Osteoarthritis
A Two-Arm Study Comparing the Analgesic Efficacy and Safety of Tramadol HCl Once-a-Day Versus Placebo for the Treatment of Pain Due to Osteoarthritis
The purpose of this study is to compare the analgesic efficacy, safety and clinical benefit of Tramadol OAD tablets versus Placebo.
- Trial name
- NCT00833794
- Testing
- Tramadol Once a day
- Volunteers
- 1,028 people
- Sponsor
- Labopharm Inc.
Systemic Juvenile Idiopathic Arthritis (SJIA)
ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of Canakinumab
The purpose of this study was to evaluate the efficacy observed with canakinumab dose reduction in a subgroup of patients in the extension study CACZ885G2301E1.
- Trial name
- ß-SPECIFIC 4 (NCT02296424)
- Testing
- ACZ885 150 mg (Canakinumab)
- Where
- 50 sites in United States, Austria and 14 more
- Volunteers
- 182 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
Ultrasound Efficacy in Moderate Rheumatoid Arthritis
The objectives of this research study are to determine the frequency of low synovitis scores by ultrasound in patients with Rheumatoid Arthritis in moderate or high disease activity and to compare physician treatment…
- Trial name
- NCT04662359
- Testing
- Ultrasound Assessment
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Pennsylvania
Rheumatoid Arthritis
An Open-Label Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis
This open-label, single-arm study will evaluate the efficacy and safety of tocilizumab in patients with active moderate to severe rheumatoid arthritis.
- Trial name
- NCT01951170
- Testing
- Tocilizumab
- Where
- 10 sites in Australia
- Volunteers
- 52 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Inflammation and the Heart
Studies have shown that people with rheumatoid arthritis (RA) have a higher rate of heart disease than people that do not have RA. we believe this is caused by the inflammation produced by RA.
- Trial name
- NCT01589770
- Testing
- cardiac Magnetic Resonance imaging
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Osteoarthritis
Evaluating the Need for Pneumatic Compression Devices
For patients undergoing total hip and knee arthroplasty, does the use of Aspirin alone compared to using Aspirin along with a mobile compression device provide equivocal results for preventing Deep Vein Thrombosis (DVT) and…
- Trial name
- NCT02641080
- Testing
- Aspirin, Portable Compression Device
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Chronic Pain, Osteoarthritis of the Knee
Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee
The objective of this study is to determine the analgesic efficacy and safety of Buprenorphine Transdermal System (BTDS) 10 and 20 compared to placebo in opioid-naïve subjects with moderate to severe chronic pain due to…
- Trial name
- NCT00531427
- Testing
- Buprenorphine
- Where
- 87 sites in United States
- Volunteers
- 567 people
- Sponsor
- Purdue Pharma LP
Arthritis, Rheumatoid
Study To Evaluate The Response To Enbrel And The Impact Of Rheumatoid Factor(RF) And Anti-Cyclic Citrullinated Peptide(Anti-CCP) In Rheumatoid Arthritis(RA) Patients
This study is to evaluate available local data in Iraqi patients with rheumatoid arthritis on Enbrel treatment with regards to the impact of Rheumatoid factor and Anti-cyclic citrullinated peptide using data from the Baghdad…
- Trial name
- NCT04428424
- Testing
- Enbrel
- Where
- Iraq
- Volunteers
- 1,493 people
- Sponsor
- Pfizer
Osteoarthritis, Hip
3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
Spinal anesthesia is commonly utilized for hip replacement surgery. Different medications used for spinal anesthesia work for different lengths of time.
- Trial name
- NCT03948386
- Testing
- isobaric bupivacaine, hyperbaric bupivacaine, isobaric mepivacaine
- Where
- 2 sites in United States
- Volunteers
- 159 people
- Sponsor
- Thomas Jefferson University