Clinical trials: Arthritis (Knee)
Osteoarthritis, Revision Arthroplasty
Pro Osteon Bone Void Filler Study
This study was designed to observe the outcomes of Pro Osteon according to its cleared indications for use.
- Trial name
- PO (NCT00858598)
- Sponsor
- Zimmer Biomet
Osteoarthritis, Osteoarthritis Knee Pain
Clinical Trial of Type II Collagen vs. Sodium Hyaluronate Intra-articular Injection in Knee Osteoarthritis
The purpose of this clinical trial is to evaluate the efficacy and safety of CartiSave compared with sodium hyaluronate in patients with knee pain.
- Conditions
- Osteoarthritis, Osteoarthritis Knee Pain, Knee Arthritis
- Trial name
- CartiSave (NCT07907926)
- Testing
- CartiSave, Hyalforte Injection
- Where
- 4 sites in South Korea
- Volunteers
- 117 people
- Sponsor
- ATEMs
Arthritis Ankle, Arthritis Knee
Investigation of Growth Hormone and Platelet-Rich Plasma on Joint Health
This clinical study will evaluate the efficacy and safety of intra-articular (IA) recombinant human growth hormone (rhGH; somatropin) combined with platelet-rich plasma (PRP) in adults with treatment-resistant knee and ankle…
- Trial name
- NCT06907121
- Testing
- Intra-Articular Injection of Growth Hormone and Platelet-Rich Plasma
- Where
- Australia
- Volunteers
- 192 people
- Sponsor
- Integrant Pty Ltd
Osteoarthritis (OA) of the Knee
2ccPA Study in Patients With Symptomatic Knee Osteoarthritis
This clinical trial is designed to determine safety and tolerability as well as the MTD of a single-dose 2ccPA and PK data in symptomatic knee OA.
- Trial name
- NCT04229394
- Testing
- 2ccPA
- Where
- 5 sites in Taiwan
- Volunteers
- 40 people
- Sponsor
- Orient Europharma Co., Ltd.
Osteoarthritis
The Influence Of a Natural Anti-Inflammatory Product On Levels Of Inflammatory Markers In Cases With Osteoarthritis Of Knee
This is a randomized, placebo controlled study. The first subject is expected to be enrolled in July 2014, and the last subject is expected to complete the study by July 2015.
- Trial name
- NCT02333084
- Testing
- PRN Joint Health Formula, PRN Flex Omega Benefits® combination
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Physician Recommended Nutriceuticals
Osteoarthritis Knee
Mesenchymal Stem Cell Treatment for Primary Osteoarthritis Knee
The purpose of this study is to evaluate the safety and preliminary efficacy of autologous adipose-derived mesenchymal stem cells (ADMSCs) treatment for patients with primary osteoarthritis knee.
- Trial name
- NCT02544802
- Testing
- Adipose-Derived Mesenchymal Stem Cells
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- Steminent Biotherapeutics Inc.
Osteoarthritis, Pain Intensity Assessment
A Study to Evaluate 90-Day Safety of Tapentadol(CG5503) Immediate Release (IR) or Oxycodone Immediate Release in Patients With Chronic Pain
The purpose of this study is to evaluate the safety of CG5503 base Immediate Release(IR) 50 mg or 100 mg taken every 4 to 6 hours as needed over the long-term exposure of 90 days in patients who have chronic pain.
- Conditions
- Osteoarthritis, Pain Intensity Assessment, Arthralgia, Sciatica
- Trial name
- NCT00364546
- Testing
- CG 5503;tapentadol
- Volunteers
- 877 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis
A Retrospective Study of the iTotal CR Knee Replacement System
This study involves retrospective collection of data regarding the first approximately 100 iTotal Knee Replacement System surgeries and their short term outcomes at a small set of centers throughout the US.
- Trial name
- NCT01564654
- Testing
- iTotal KRS
- Where
- 4 sites in United States
- Volunteers
- 89 people
- Sponsor
- Restor3D
Knee Osteoarthritis
A Study on Visco-antalgic Intra-articular Administration in Symptomatic Knee Osteoarthritis
Osteoarthritis (OA) is the most common joint disease affecting millions of people around the world, for which there is unfortunately no cure.
- Trial name
- NCT02740231
- Testing
- JTA-004 intra-articular injection, Reference product intra-articular injection
- Volunteers
- 173 people
- Sponsor
- Bone Therapeutics S.A
Osteoarthritis of the Knee
Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee
The purpose of this trial is to investigate the efficacy and safety of OLT1177 Gel in subjects with moderate to severe pain associated with osteoarthritis of the knee following cessation of pain therapy.
- Trial name
- NCT01768975
- Testing
- OLT1177 Gel
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Olatec Therapeutics, Inc.
Osteoarthritis, Knee, Pain
Osteoarthritis of the Knee Pain Study Using a CBD and THC Sublingual Tablet
This study is a prospective Phase 2, drug controlled, open-label study to evaluate the safety and efficacy of Pure Green sublingual tablets for the treatment of pain associated with osteoarthritis of the knee.
- Trial name
- NCT04195269
- Testing
- Test Article
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pure Green
Osteoarthritis, Knee
Air Barrier System for the Reduction of Airborne Colony Forming Units During Total Knee Arthroplasty
This objective of this study is to determine whether the Air Barrier System device reduces airborne colony-forming units (e.g., bacteria) present at a surgery site during total knee arthroplasty surgeries.
- Trial name
- NCT03473405
- Testing
- Air Barrier System, Control
- Volunteers
- 40 people
- Sponsor
- Nimbic Systems, LLC
Osteoarthritis, Avascular Necrosis
A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System
The purpose of this study is to collect information on complications and survivorship of patients implanted with the Oxford™ Meniscal Unicompartmental Knee System at multiple sites in the United States.
- Trial name
- NCT00578994
- Testing
- Oxford® Meniscal Unicompartmental Knee System
- Where
- 6 sites in United States
- Volunteers
- 388 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthritis, Hip, Osteoarthritis, Knee
Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee.
Tanezumab is a monoclonal antibody that binds to and inhibits the actions of nerve growth factor (NGF). The Nerve Growth Factor Inhibitor (NGFI) class may offer an important breakthrough in the treatment of chronic pain and is…
- Trial name
- NCT02709486
- Testing
- Tanezumab
- Where
- 148 sites in Austria, Bulgaria and 13 more
- Volunteers
- 849 people
- Sponsor
- Pfizer
Osteoarthritis
Registry of Celution Device for the Processing of Adipose Derived Regenerative Cells (ADRCs) to Treat Osteoarthritis
This registry study will compile information from patients that are scheduled to receive or have received Adipose Derived Regenerative Cells (ADRCs) prepared by the Celution device to treat osteoarthritis in the knee.
- Trial name
- RELIEVE (NCT02736110)
- Sponsor
- Cytori Therapeutics
Osteoarthritis of the Knee
A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System
This study is designed to observe the long term clinical outcomes of patient-specific knee arthroplasty in patients with osteoarthritis.
- Trial name
- NCT01820650
- Testing
- iTotal G2 CR Knee Replacement System
- Where
- 9 sites in United States
- Volunteers
- 359 people
- Sponsor
- Restor3D
Knee Osteoarthritis
Laser Cell Therapy for Knee Cartilage Repair
Laser pulsed energy will be delivered over an optical fiber to create channels into damaged cartilage of the knee or knees. The channels have a diameter of approximately 100 microns or less and an approximate depth of 1…
- Trial name
- NCT04001361
- Testing
- Laser Cell Therapy
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Endocellutions
Knee Osteoarthritis
A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
This one-year study is designed to investigate the safety and efficacy of TPX-100, a 23-amino acid chondrogenic peptide, delivered by intra-articular injection, in regeneration of knee cartilage in subjects with bilateral…
- Trial name
- NCT01925261
- Testing
- TPX-100 50mg, TPX-100 100mg, TPX-100 200mg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- OrthoTrophix, Inc
Participants With Obesity and Knee Osteoarthritis
A Trial of Ribupatide Injection in Participants With Obesity and Knee Osteoarthritis
The study is being conducted to evaluate the efficacy and safety of Ribupatide Injection in participants with obesity and knee osteoarthritis, and to explore its improvement on knee joint structure.
- Trial name
- NCT07709910
- Testing
- Ribupatide Injection
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Osteoarthritis, Knee, Osteoarthritis, Hip
Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip
The objective of this exploratory study is to evaluate the cellular and connective tissue composition of joints from patients with Osteoarthritis (OA) who have been treated with fasinumab, compared with those treated with placebo…
- Trial name
- NCT03949673
- Testing
- Fasinumab, Naproxen, Diclofenac
- Where
- 15 sites in United States, Poland and 1 more
- Volunteers
- 23 people
- Sponsor
- Regeneron Pharmaceuticals