Clinical trials: Arthritis Knee
Knee Osteoarthritis
MultiCenter IDE Study of the PEEK-OPTIMA™ Femoral Component vs a CoCr Alloy TKA Femoral Component of Similar Design
The purpose of this investigational device exemption (IDE) study is to monitor the performance (safety and efficacy) of the Maxx Orthopedics, Freedom Total Knee® System, with a femoral component of similar design, manufactured…
- Trial name
- NCT06627673
- Testing
- Total Knee Arthroplasty
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Maxx Orthopedics Inc
Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee
JOURNEY II XR Safety and Effectiveness PMCF
This study was designed to demonstrate the safety and performance of the JOURNEY II XR total knee system by evaluating implant survival rates at 10 years using Kaplan-Meier analysis.
- Conditions
- Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis, Degenerative Arthritis Peripheral Joint
- Trial name
- NCT03136887
- Testing
- JOURNEY II XR Total Knee System
- Where
- 14 sites in United States
- Volunteers
- 176 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis of Knee
Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patients With Osteoarthritis of the Knee
A multicenter, randomized, double-blinded, parallel, active-controlled, phase IV clinical trial to evaluate the efficacy and safety of PlbCR and aceclofenac in the treatment of patients with osteoarthritis of the knee
- Trial name
- NCT02682524
- Testing
- Pelubiprofen CR 45mg tab., Aceclofenac 100mg tab.
- Where
- South Korea
- Volunteers
- 191 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Osteoarthritis of the Knee
Efficacy and Safety of 3 Different Dosage Regimens of Hyaluronic Acid in Patients With Knee Osteoarthritis (OA)
The main objective is the comparison of three different dosage regimens of hyaluronic acid in the treatment of osteoarthritis of the knee.
- Trial name
- NCT01290497
- Testing
- Hyaluronic acid 5 x 2.5 ml, Hyaluronic acid 1 x 5 ml, Hyaluronic acid 2 x 5 ml
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Hip Osteoarthritis, Knee Osteoarthritis
Efficacy of a Digital Biofeedback System for Home-based Rehabilitation After Total Joint Replacement
The study was designed to assess the efficacy of a home-based rehabilitation program using a digital kinematic biofeedback system after total hip or knee replacement. This is a single-arm prospective study.
- Trial name
- NCT03648060
- Testing
- Digital kinematic biofeedback system
- Where
- Portugal
- Volunteers
- 88 people
- Sponsor
- Sword Health, SA
Osteo Arthritis of the Knee
Lubricin-inspired Osteoarthritis Treatment: a Unique Solution
This goal of this open label study is to evaluate the safety and tolerability of a single intra-articular administration of ABR1 in adults with knee osteoarthritis with a KL grade from 2 to 4.
- Trial name
- LOTUS (NCT07611708)
- Testing
- ABR1
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Pleryon Therapeutics (Hangzhou) Limited
Osteoarthritis of the Knee
A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee
The purpose of this study is to assess the efficacy of a single dose level of gefapixant (AF-219/MK-7264) in subjects with moderate to severe pain associated with osteoarthritis (OA) of the knee compared with placebo after 4…
- Trial name
- NCT01554579
- Testing
- Gefapixant, Sugar Pill
- Where
- 34 sites in United States
- Volunteers
- 171 people
- Sponsor
- Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Osteoarthritis of the Knee, Chronic Lower Back Pain
A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee
The purpose of the study is to evaluate the analgesic efficacy of ASP7962 relative to placebo. This study will also evaluate the efficacy of ASP7962 relative to placebo on pain on walking, function and stiffness; the time course…
- Trial name
- OAK (NCT02611466)
- Testing
- ASP7962, Naproxen
- Where
- 34 sites in Belgium, Czechia and 4 more
- Volunteers
- 215 people
- Sponsor
- Astellas Pharma Europe B.V.
Osteo Arthritis of the Knee
A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee Osteoarthritis
The goal of this clinical trial is to test HL-01 in patients with knee osteoarthritis pain. The main question[s] it aims to answer are: Measure the change in average daily knee pain intensity scores from baseline to the end of…
- Trial name
- NCT07819461
- Testing
- Sodium hyaluronate solution - 3.36%, Sterile buffered solution
- Volunteers
- 704 people
- Sponsor
- IBSA Institut Biochimique SA
Osteoarthritis, Knee
Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee
This is an open-label study assessing the effect of the administration of a single intra-articular (IA) injection of FX006 32 mg on synovial volume in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT03529942
- Testing
- FX006 32 mg
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 129 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteo Arthritis Knee, Arthritis
Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
The purpose of this study is to assess the ability of long-duration low intensity therapeutic ultrasound (LITUS) to alleviate knee Osteoarthritis pain over a 24-week period.
- Trial name
- NCT06257537
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches
- Where
- 3 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Osteoarthritis, Hip, Arthritis
A Clinical Investigation of the M2a-Magnum™ Hip System
The purpose of this prospective clinical data collection is to document the performance and clinical outcomes of the M2a-Magnum™ Hip System
- Conditions
- Osteoarthritis, Hip, Arthritis, Rheumatoid Arthritis, Joint Disease
- Trial name
- NCT00698347
- Testing
- M2a-Magnum™ Hip System
- Volunteers
- 249 people
- Sponsor
- Biomet Orthopedics, LLC
Osteo Arthritis Knee, Total Knee Arthroplasty
Comparing Surgical and Economical Parameters of Total Knee Replacement.
Randomized study comparing surgical and economic parameter of Total Knee Arthroplasty performed using two different specific surgical techniques.
- Trial name
- NCT03427047
- Testing
- MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis (OA) of the Knee
INJECTABLE COLD ENERGY THERAPY FOR THE MANAGEMENT OF CHRONIC PAIN ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE
The goal of this clinical trial is to evaluate the effectiveness of Neural Ice for pain management associated with knee osteoarthritis in adults aged 22-80 years.
- Trial name
- ICE (NCT06700109)
- Testing
- Neural Ice, Triamcinolone acetate
- Where
- 15 sites in United States
- Volunteers
- 263 people
- Sponsor
- Brixton Biosciences, Inc.
Osteoarthritis, Knee
Delivra-Celecoxib 8% Cream and Osteoarthritis
The observation of the clinical use of the Delivra Celecoxib cream (8%) in the treatment of osteoarthritis of the knee. Observations will be made over 12 weeks of treatment.
- Trial name
- Del-Cel (NCT03882749)
- Where
- 3 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Delivra, Inc.
Knee Osteoarthritis
Safety, Tolerability and Pharmacokinetics of SAR113945 in Japanese Patients With Knee Osteoarthritis
Primary Objective: To assess the safety and tolerability of SAR113945 in Japanese patients with knee osteoarthritis after ascending single intra-articular doses Secondary Objective: To assess the pharmacokinetics of SAR113945 in…
- Trial name
- NCT01511549
- Testing
- SAR113945
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- Sanofi
Osteoarthritis, Knee
A Safety and Tolerability Study of UBX0101 in Patients With Osteoarthritis of the Knee
A study to evaluate safety, tolerability, and pharmacokinetics of a single intra-articular injection of UBX0101 in patients diagnosed with painful osteoarthritis of the knee.
- Trial name
- NCT03513016
- Testing
- UBX0101
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Unity Biotechnology, Inc.
Knee Osteoarthritis
Catabolic Marker Levels After Platelet Poor Plasma (PPP) Lavage
The purpose of this study is to understand how the components of osteoarthritic knee joint fluid (synovial fluid) change after lavage treatment with platelet poor plasma.
- Trial name
- PPP (NCT03120988)
- Testing
- Lavage with Platelet Poor Plasma (PPP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Regenexx, LLC
Osteoarthritis, Knee
The Impact of Procedural Awareness of Knee Injections for Osteoarthritis on Patient Perceptions of Effectiveness
The purpose of this study is to determine whether outcomes for patients receiving intra-articular platelet-rich plasma (PRP) injections for knee osteoarthritis are influenced by observation of the preparatory steps to the…
- Trial name
- NCT04111718
- Testing
- Platelet-rich plasma (PRP), Viewing of preparation
- Where
- Canada
- Volunteers
- 158 people
- Sponsor
- ArthroBiologix Inc.
Osteoarthritis of the Knee, Arthroplasty, Replacement, Knee
Flex Intramedullary Rod Study
The purpose of this study is to compare the effect of post-operative ROM between Flex IM rod and Rigid IM rod, to collect bone morphology of Japanese lower extremity and to research the incidence of overhung with Flex IM rod.
- Trial name
- NCT02543489
- Testing
- Flex IM rod
- Where
- 3 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Stryker Japan K.K.
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