Clinical trials: Arthritis Knee
Osteoarthritis of the Knee
An Efficacy and Safety Study of Two Doses of Intra-Articular Ampion Injection for Pain of Osteoarthritis of the Knee
This study will evaluate the efficacy of two doses of Intra-Articular Injection of Ampion™ in Adults with pain due to osteoarthritis of the knee.
- Trial name
- NCT01839331
- Testing
- 4 mL injection of Ampion, 10 mL Injection of Ampion
- Volunteers
- 329 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Knee Pain, Chronic Osteoarthritis
ROSA Total Knee Investigational Testing Authorization Study
This is a prospective, single-center clinical study designed to facilitate the collection and evaluation of workflow efficiency, patient pain and function, and adverse event data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT03970629
- Testing
- PERSONA Total Knee
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Osteoarthritis of Knee
A Phase 1/2a Study to Evaluate Single Intraarticular Injections of 3 Dose Levels of SYN321 and Placebo in Patients With Symptomatic Knee Osteoarthritis
This is a, phase 1/2a trial, to assess the safety, tolerability, systemic exposure as well as preliminary efficacy following a single intra-articular injection of 3 dose levels of SYN321 in patients with symptomatic knee…
- Trial name
- NCT06989645
- Testing
- SYN321
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Synartro AB
Osteoarthritis
Efficacy & Safety Study Evaluating Natural Eggshell Membrane (NEM) in the Treatment of Osteoarthritis
The purpose of this study is to evaluate the effectiveness of Natural Eggshell Membrane (NEM) for the relief of pain and stiffness associated with moderate osteoarthritis of the knee and to compare the effectiveness of NEM to…
- Trial name
- OPTION (NCT00750477)
- Testing
- NEM
- Where
- 3 sites in United States
- Volunteers
- 67 people
- Sponsor
- ESM Technologies, LLC
Osteoarthritis, Osteo Arthritis Knee
Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis
The purpose of this study is to test safety and efficacy of study drug LY3526318 in for the treatment of knee pain due to with osteoarthritis (OA).
- Trial name
- NCT05080660
- Testing
- LY3526318
- Where
- 30 sites in United States, Puerto Rico
- Volunteers
- 160 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
To assess the safety and tolerability of orally-administered CR845 in patients with osteoarthritis (OA) of the hip or knee. The study drug is being tested to reduce OA pain, and will be taken twice a day for two weeks, with four…
- Trial name
- NCT02524197
- Testing
- CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Cara Therapeutics, Inc.
Knee Osteoarthritis, Disuse Atrophy
Effects of Kneehab 12-week Peri-operative Total Knee Arthroplasty
Determine the efficacy of neuromuscular electrical stimulation (NMES, Kneehab) in promoting accelerated recovery of quadriceps function in patients recovering from total knee arthroplasty (TKA) as measured by increases in…
- Trial name
- KneehabTKA (NCT01096524)
- Testing
- Standard Physiotherapy, Kneehab
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Bio-Medical Research, Ltd.
Osteoarthritis, Knee
Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium Therapy for Osteoartrithis
This study aims to compare the efficacy of Umbilical Cord Mesenchymal Stem Cell and secretome between arthroscopy and without arthroscopy intervention in OA patients.
- Trial name
- OA (NCT04314661)
- Testing
- Arthroscopy with Mesenchymal Stem Cells + Secretome + Secretome, Arthroscopy with Secretome + Mesenchymal Stem Cells + Secretome, Non Arthroscopy with Mesenchymal Stem Cells + Secretome + Secretome
- Where
- Indonesia
- Volunteers
- 31 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Osteoarthritis, Knee
An Exploratory Study of PRX167700 in Patients With Knee Osteoarthritis
This is an exploratory study to evaluate a new anti-inflammatory drug, PRX167700, in subjects with painful osteoarthritis of the knee.
- Trial name
- NCT01945346
- Testing
- PRX167700
- Where
- 5 sites in United Kingdom
- Volunteers
- 74 people
- Sponsor
- Proximagen Limited
Rheumatoid Arthritis, Traumatic Arthritis
3DKnee™ System vs. the MJS Knee System
The purpose of this study is to compare the survivorship and efficacy of the Encore 3DKnee™ system with that of the Encore MJS™ Knee System in a group of 600 patients for whom data collection is already under way.
- Conditions
- Rheumatoid Arthritis, Traumatic Arthritis, Joint Disease Secondary to Osteoarthritis
- Trial name
- NCT00764803
- Testing
- Encore 3DKnee™ system, Encore MJS™ Knee System
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Encore Medical, L.P.
Osteoarthritis of the Knee
Clinical Study of Umbilical Cord Tissue Mesenchymal Stem Cells (UC-MSC) for Treatment of Osteoarthritis
Allogeneic human umbilical cord tissue-derived stem cells injected intravenously (IV) once per day for 3 days or once intra-articularly are a safe and will induce a therapeutic effect in osteoarthritis (OA) patients.
- Trial name
- NCT02237846
- Testing
- Human umbilical cord tissue-derived mesenchymal stem cells
- Where
- Panama
- Sponsor
- Translational Biosciences
Osteoarthritis, Knee
An Intervention Study Evaluating the Effects of a Raspberry Leaf Extract in an Osteoarthritic Population.
A double-blind, randomized, placebo-controlled clinical study to evaluate the efficacy of raspberry extract to alleviate symptoms of osteoarthritis in the knee.
- Trial name
- NCT03703024
- Testing
- Raspberry Leaf Extract
- Where
- Ireland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Knee Osteoarthritis
Safety of Use and Efficacy of Pandora for Patients Suffering From Gonarthrosis (PANDORA2)
The knee osteoarthritis is a frequent degenerative condition that mainly affects subjects over 60, population often weakened by numerous comorbidities and concomitant treatments, justifying the development of new therapies.
- Trial name
- PANDORA2 (NCT05978180)
- Testing
- Medical Device : HO-1, Medical Device : HS-3, Medical Device : SINOVIAL® ONE
- Where
- 35 sites in France, Monaco
- Volunteers
- 252 people
- Sponsor
- Labrha
Knee Osteoarthritis
Study of Cingal™ for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide
This is a multi-center, randomized, double-blind, parallel group, active comparator controlled trial to evaluate the efficacy and safety of a single injection of Cingal for the relief of joint pain in subjects with OA of the knee.
- Trial name
- NCT03191903
- Testing
- Cingal, Monovisc, Triamcinolone Hexacetonide
- Where
- 19 sites in Hungary, Poland
- Volunteers
- 576 people
- Sponsor
- Anika Therapeutics, Inc.
Chronic Pain, Osteoarthritis
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release (PR) in participants suffering from severe chronic pain due to osteoarthritis of the knee…
- Trial name
- NCT00982280
- Testing
- Tapentadol PR
- Where
- 24 sites in Australia, Denmark and 4 more
- Volunteers
- 82 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis of Knee
Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis Patients
The goal of this clinical trial is to to clarify which is the best dose of administration, to select a dose and to confirm the therapeutic efficacy of clodronate in patients with painful knee osteoarthritis (OA).
- Trial name
- NCT06263517
- Testing
- Clodronate
- Where
- 11 sites in Italy
- Volunteers
- 296 people
- Sponsor
- SPA Società Prodotti Antibiotici S.p.A.
Osteoarthritis Knee
Gel-One Treatment in Knee Osteoarthritis
The purpose of this study is to determine whether Gel-One demonstrates a superior effectiveness in osteoarthritis (OA) knee pain compared with phosphate buffered saline (PBS) injections.
- Trial name
- NCT01934218
- Testing
- Gel-One, PBS
- Where
- 41 sites in United States
- Volunteers
- 814 people
- Sponsor
- Seikagaku Corporation
Osteoarthritis
Efficacy Study of PN400 (VIMOVO) Twice Daily and Celebrex Once Daily in Patients With Osteoarthritis
We will evaluate the efficacy of PN400 and an active comparator in patients that have Osteoarthritis of the knee.
- Trial name
- NCT00664560
- Testing
- PN 400 (VIMOVO), celebrex, Rescue Antacid
- Where
- United States
- Volunteers
- 614 people
- Sponsor
- POZEN
Osteoarthritis
A Study of Patients Treated With the Journey Deuce Bicompartmental Knee System
This is a prospective, multicenter, consecutive clinical study of the Journey Deuce Knee System and is intended to evaluate the safety and effectiveness of the new device.
- Trial name
- NCT01704326
- Where
- 4 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Osteoarthritis, Knee
A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthritis of the Knee
Objective: Identifying the dose of EVI-01 with the best clinical response, balancing the efficacy, safety, and tolerability of the investigational product.
- Trial name
- NCT05337540
- Testing
- EVI-01, Active comparator Synvisc-One
- Where
- 2 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Aptissen SA
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