Clinical trials: Arthritis Knee
Osteoarthritis, Knee
Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium Therapy for Osteoartrithis
This study aims to compare the efficacy of Umbilical Cord Mesenchymal Stem Cell and secretome between arthroscopy and without arthroscopy intervention in OA patients.
- Trial name
- OA (NCT04314661)
- Testing
- Arthroscopy with Mesenchymal Stem Cells + Secretome + Secretome, Arthroscopy with Secretome + Mesenchymal Stem Cells + Secretome, Non Arthroscopy with Mesenchymal Stem Cells + Secretome + Secretome
- Where
- Indonesia
- Volunteers
- 31 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Osteoarthritis Pain of the Knee
A Study to Evaluate the Analgesic Efficacy and Safety of VM902A in Subjects With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the analgesic efficacy, safety, and tolerability of VM902A twice daily compared to placebo in subjects with moderate to severe chronic pain due to OA of the knee.
- Trial name
- NCT02847702
- Testing
- VM902A 200-mg Capsules, VM902A 400-mg Capsules, Naproxen 500-mg Capsules
- Where
- 31 sites in United States
- Volunteers
- 75 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis
Study Evaluating rhMBP-2/CPM in Open Wedge Osteotomies
To assess the feasibility of using rhBMP-2/CPM in OWO as a surgical model for pharmacodynamic studies, with assessment of the following parameters: Injecting the desired volume of rhBMP-2/CPM within the defect Conducting…
- Trial name
- NCT00243295
- Testing
- rhBMP-2/CPM
- Volunteers
- 6 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Osteoarthritis, Knee
HKT-500-US12 In Adult Patients With OA Knee Pain
The objective of this study is to characterize the analgesic properties of single dose study of HKT-500 in subjects with pain caused by mild to moderate OA of the knee
- Trial name
- NCT00647231
- Testing
- HKT-500 Topical Patch
- Where
- 29 sites in United States
- Volunteers
- 300 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Osteoarthritis, Knee
Treatment of Knee Osteoarthritis With PAAG-OA
This is a multi-center, randomized, double-blind clinical investigation to compare the effectiveness of intra-articular polyacrylamide hydrogel (PAAG-OA) and a hyaluronic acid, Synvisc-One to induce symptomatic benefit in…
- Trial name
- ROSA (NCT04045431)
- Testing
- PAAG-OA, Synvisc-One
- Where
- 3 sites in Denmark
- Volunteers
- 238 people
- Sponsor
- Contura
Osteoarthritis
Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn®
LT-NS001 is a prodrug of Naproxen, which is inactive as a cox inhibitor while intact and is rapidly metabolized to Naproxen once absorbed.
- Trial name
- NCT01063920
- Testing
- LT-NS001, Naprosyn®
- Where
- 65 sites in United States
- Volunteers
- 534 people
- Sponsor
- Logical Therapeutics
Degenerative Joint Disease, Osteoarthritis
PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.
The objective of this clinical study is to evaluate the operative performance of the PEAK PlasmaBlade 4.0 during total knee replacement; to monitor and record post-operative pain, activity level, narcotic consumption, adverse…
- Trial name
- PRECISE (NCT01081886)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Medtronic Surgical Technologies
Osteoarthritis (OA)
Safety, Tolerability and Preliminary Efficacy of Multiple Intra-articular Injections of LRX712 in Patients With Knee OA
This study explored the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity of articular cartilage.
- Trial name
- NCT04097379
- Testing
- LRX712
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis
A Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 in Subjects With Mild to Moderate Patello-Femoral Osteoarthritis Involving Both Knees
This one-year study is designed to investigate the safety and efficacy of TPX-100, a 23-amino acid chondrogenic peptide, delivered by intra-articular injection, in regeneration of knee cartilage in subjects with bilateral…
- Trial name
- NCT01925261
- Testing
- TPX-100 50mg, TPX-100 100mg, TPX-100 200mg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- OrthoTrophix, Inc
Osteoarthritis, Knee, Osteoarthritis, Hip
A Long Term Study of the Safety of Tanezumab When Administered By Subcutaneous Injections
This study will investigate the safety of three fixed dose levels of tanezumab (2.5 mg, 5 mg, and 10 mg) administered at an 8-week interval by subcutaneous injection multiple (7) times during the study treatment period.
- Trial name
- NCT00994890
- Testing
- Tanezumab 2.5 mg, Tanezumab 5 mg, Tanezumab 10 mg
- Where
- 100 sites in United States
- Volunteers
- 679 people
- Sponsor
- Pfizer
Knee Osteoarthritis
Cingal Study for Knee Osteoarthritis
The purpose of this study is to see if a single injection of Cingal into the knee provides safe relief of pain caused by osteoarthritis.
- Trial name
- NCT01891396
- Testing
- Hyaluronic Acid and TH (Cingal®), Hyaluronic Acid (Monovisc®), Saline
- Where
- 27 sites in Bulgaria, Canada and 3 more
- Volunteers
- 368 people
- Sponsor
- Anika Therapeutics, Inc.
Osteoarthritis, Knee, Chronic Pain
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA).
- Trial name
- OA07 (NCT07641517)
- Testing
- LY4065967
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 150 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis
Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells (GXCPC1) for Knee Osteoarthritis
The aim of the investigators study was to investigate the safety and efficacy of allogeneic ADSCs for the clinical treatment of knee osteoarthritis.
- Trial name
- NCT03943576
- Testing
- GXCPC1, HA
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Gwo Xi Stem Cell Applied Technology Co., Ltd.
Knee Osteoarthritis
To Assess Efficacy of Epiitalis on Knee Pain in Patients Suffering From Knee Osteoarthritis
Epiitalis is an ingredient of a currently marketed product named as Osteo-Restore, indicated for joint health.The present study is primarily planned to establish the role of Epiitalis as a single ingredient in the treatment of…
- Trial name
- NCT04117490
- Testing
- Epiitalis
- Where
- 8 sites in India
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteoarthritis
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Oral Doses of BI 1026706 in Male and Female Healthy Subjects and Patients With Osteoarthritis of the Knee
To investigate the safety and tolerability of BI 1026706 in male and female healthy subjects and osteoarthritis (OA) patients following oral administration of repeated rising doses To explore the pharmacokinetics after multiple…
- Trial name
- NCT02126826
- Testing
- BI 1026706
- Where
- Germany
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Osteoarthritis, Knee, Pain
New Hydroxyethyl Cellulose Hydrogel for the Treatment of the Pain of Knee Arthrosis
Prospective, multicenter study, unmasked, single-arm, to study the safety and efficacy of a new hydroxyethyl cellulose hydrogel for the treatment of the knee pain caused by osteoarthritis.
- Trial name
- PROMGEL-OA (NCT04061733)
- Testing
- Hydrogel injection
- Where
- 3 sites in Argentina
- Volunteers
- 50 people
- Sponsor
- Promedon
Knee Osteoarthritis
Assessment of the Efficacy of Andrographis Paniculata in Subjects With Mild to Moderate Osteoarthritis
This is a 12 weeks randomized, double-blind, placebo-controlled clinical study to assess the effect of Andrographis Paniculata at low dose of 300 mg/day and high dose of 600 mg/day in the study population in the age range of…
- Trial name
- A Paniculata (NCT03262792)
- Testing
- Andrographis Paniculata
- Where
- 4 sites in India
- Volunteers
- 108 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
Safety and Efficacy Study of GRT6005 in Patients With Osteoarthritis (OA) Knee Pain
The purpose of this study is to evaluate the safety and efficacy of GRT6005 compared to placebo in patients with moderate to severe chronic pain due to osteoarthritis (OA) of the knee.
- Trial name
- NCT01709214
- Testing
- Cebranopadol (GRT6005) Low-Dose Range, Cebranopadol (GRT6005) High-Dose Range, Oxycodone CR
- Where
- 83 sites in United States
- Volunteers
- 619 people
- Sponsor
- Tris Pharma, Inc.
Osteoarthritis
A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis
The purpose of this study is to compare the effectiveness of tramadol hydrochloride 37.5 milligram (mg) plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants…
- Trial name
- NCT00635349
- Testing
- Meloxicam, Aceclofenac, Tramadol Hydrochloride Plus Acetaminophen
- Volunteers
- 143 people
- Sponsor
- Janssen Korea, Ltd., Korea
Knee Osteoarthritis, Anterior Knee Pain
MORA Cure for Knee Osteoarthritis With Anterior Knee Pain
This prospective, multicenter, single-arm, sponsor-initiated pilot study will evaluate the clinical course and safety of MORA Cure in adults older than 50 years with knee osteoarthritis accompanied by anterior knee pain.
- Trial name
- Leave blank (NCT07769593)
- Testing
- MORA Cure
- Where
- 2 sites in South Korea
- Volunteers
- 44 people
- Sponsor
- EverEx Inc.
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