Clinical trials: Arthritis Knee
Osteoarthritis, Rheumatoid Arthritis
6 Week Open-label Trial With Lumiracoxib 200mg o.d. in Primary Knee Osteoarthritis or Rheumatoid Arthritis
This study tested the safety, tolerability and efficacy of lumiracoxib - a COX-2 inhibitor- in patients with primary knee osteoarthritis or rheumatoid arthritis.
- Trial name
- NCT00170872
- Testing
- Lumiracoxib
- Volunteers
- 135 people
- Sponsor
- Novartis
Osteoarthritis, Inflammatory Arthritis
Gender Solutions Natural Knee Post-Market Study
This is a prospective multicenter study of the Gender Solutions Natural Knee Flex System when used in primary total knee arthroplasty.
- Conditions
- Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT01463566
- Testing
- Zimmer Gender(R) Solutions(TM) Natural-Knee(R) Flex System
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Knee Osteoarthritis and Balneotherapy
The goal of this clinical trial is to assess the efficacy of a 18-day balneotherapy program in the rheumatology indication in patients presented with knee osteoarthritis.
- Trial name
- ANGELLO (NCT05819437)
- Testing
- Balneotherapy program
- Where
- France
- Volunteers
- 173 people
- Sponsor
- CEN Biotech
Knee Osteoarthritis
Efficacy and Safety Study in Patients Suffering From Knee Osteoarthritis
The primary objective of this study is to compare a combination of hyaluronic acid and chondroitin sulfate (V0220) to Hyalgan® on pain relief in patients with symptomatic knee osteoarthritis (OA) over 24 weeks when administered…
- Trial name
- VESTA (NCT01469507)
- Testing
- Chondroitin sulfate and sodium hyaluronate, Hyaluronan
- Sponsor
- Pierre Fabre Medicament
Osteoarthritis
Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I
The objective of this study is to evaluate the efficacy and safety of TDS-943 (topical diclofenac spray) compared to oral celecoxib and placebo in subjects with osteoarthritis of the knee.
- Trial name
- NCT00546507
- Testing
- TDS-943 (topical diclofenac sodium 4% spray), celecoxib
- Where
- 43 sites in United States
- Volunteers
- 650 people
- Sponsor
- Mika Pharma GmbH
Osteoarthritis
Study Comparing Fit of the iTotal Versus Standard Total Knee Implants
This study compares intraoperative fit of the patient-specific iTotal knee replacement to other standard knee replacement implants
- Trial name
- NCT01861028
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Restor3D
Osteoarthritis
Trial to Assess Efficacy and Safety of Lacosamide in Subjects With Osteoarthritis of the Knee
The purpose of this trial is to evaluate the effectiveness, safety and tolerability of lacosamide (LCM) 400mg/day in treating the signs and symptoms of osteoarthritis of the knee.
- Trial name
- NCT00485472
- Testing
- lacosamide
- Where
- 26 sites in Czechia, Germany and 5 more
- Volunteers
- 194 people
- Sponsor
- UCB Pharma
Osteoarthritis of the Knee
A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee
The purpose of this research study is to investigate the safety and tolerability of OP-1 when it is injected into the knee joint of patients who have osteoarthritis on the knee.
- Trial name
- Knee OA (NCT00456157)
- Testing
- Intra-articular Injection of OP-1 to affected knee
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Stryker Biotech
Osteoarthritis, Knee
A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA
The purpose of the study was to find out if the investigational treatment named QUC398 had beneficial effects on osteoarthritis (OA) knee pain and knee cartilage, and if it was safe and tolerated.
- Trial name
- NCT05462990
- Testing
- QUC398
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 101 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Knee
A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients
This is a multicentre, open-label, one-arm Phase II extension study to evaluate the safety and tolerability of MIV-711 in patients with knee joint osteoarthritis (OA).
- Trial name
- NCT03037489
- Testing
- MIV-711
- Where
- 4 sites in Bulgaria, Georgia and 2 more
- Volunteers
- 50 people
- Sponsor
- Medivir
Knee Osteoarthritis
Evaluation of the Efficacy and Safety of Entelon Tab. 150mg in Patients With Osteoarthritis of Knee
This clinical trial is planned to prove Entelon tab. arm is not inferior to Celebrex cap. arm in terms of the efficacy and safety through the change of K-WOMAC's total score sum in patients with osteoarthritis of knee.
- Trial name
- NCT01768520
- Testing
- Enteron tab. 150mg(vitis vinifera extract 150mg) : twice daily for 12 weeks, Celebrex cap. (celecoxib 200mg) : once daily, for 12 weeks
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Osteoarthritis of the Knee
A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee
This study will test the effectiveness of CF101 in treating the symptoms of osteoarthritis (OA) of the knee. Eligible patients will be given either CF101 or matching placebo tablets and their symptoms will be evaluated over the…
- Trial name
- NCT00837291
- Testing
- CF101
- Where
- Israel
- Sponsor
- Can-Fite BioPharma
Knee Osteoarthritis, Traumatic Arthritis of Knee
Post Market Clinical Follow-Up Study for EVOLUTION® BIOFOAM® Tibia and EVOLUTION® CS/CR Porous Femur
MicroPort (MPO) is conducting this PMCF study to evaluate the safety and effectiveness of its EVOLUTION® BIOFOAM® Tibia and EVOLUTION® Cruciate Sacrificing/Cruciate Retaining (CS/CR) Porous Femur components, including EVOLUTION®…
- Conditions
- Knee Osteoarthritis, Traumatic Arthritis of Knee, Avascular Necrosis, Degenerative Joint Disease of Knee
- Trial name
- NCT04301622
- Testing
- Primary Knee implants
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- MicroPort Orthopedics Inc.
Knee Osteoarthritis
Assessment of Safety and Efficacy of ARTHRUM 2.5% for Treatment of Painful Osteoarthritis of the Knee
ARTHRUM 2.5% MONO-INJECTION as symptomatic treatment by joint injection extends the conservative therapeutic arsenal in Knee osteoarthritis.
- Trial name
- ART-ONE75 (NCT06228274)
- Testing
- ARTHRUM 2.5%
- Volunteers
- 218 people
- Sponsor
- LCA Pharmaceutical
Knee Osteoarthritis
Physica CR and Physica PS Clinical Trial
Type \& Design: Post-market, international, multicentre Prospective, parallel groups, open-label, baseline controlled Objectives: 1.
- Trial name
- NCT02766231
- Testing
- Physica CR, Physica PS
- Where
- 4 sites in Belgium, Italy and 1 more
- Volunteers
- 157 people
- Sponsor
- Limacorporate S.p.a
Knee Osteoarthritis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
- Trial name
- NCT06000410
- Testing
- Amniotic Suspension Allograft
- Where
- 41 sites in United States
- Volunteers
- 594 people
- Sponsor
- Organogenesis
Knee Osteoarthritis
Catabolic Marker Levels After Platelet Poor Plasma (PPP) Lavage
The purpose of this study is to understand how the components of osteoarthritic knee joint fluid (synovial fluid) change after lavage treatment with platelet poor plasma.
- Trial name
- PPP (NCT03120988)
- Testing
- Lavage with Platelet Poor Plasma (PPP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Regenexx, LLC
Pain, Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safety of CG5503 Prolonged Release (PR) in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
The purpose of this study is to evaluate whether tapentadol (CG5503) prolonged-release (PR) tablets at doses of 100-250 mg twice daily provide a better pain relief in patients with moderate to severe chronic pain due to…
- Trial name
- NCT00486811
- Testing
- Tapentadol ER (100 to 250 mg twice daily), Oxycodone CR (20 to 50 mg twice daily)
- Where
- 100 sites in Austria, Croatia and 11 more
- Volunteers
- 990 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis
Evaluation of a New Formulation Useful for the Osteoarthrosis Treatment
Abstract Kondrium, is a pharmaceutical composition for the treatment of osteoarthritis (OA). This study was designed to evaluate the efficacy and safety of kondrium in the treatment of OA of knee.
- Trial name
- EFO (NCT00977444)
- Testing
- kondrium, kondrium f, methyl prednisolone (corticosteroid)
- Where
- Mexico
- Volunteers
- 114 people
- Sponsor
- Nucitec
Osteoarthritis
Long-Term Study Of The Safety Of Tanezumab In Arthritis Patients
Tanezumab, administered for up to 1 1/2 years, reduces the pain of osteoarthritis without affecting how nerve impulses are transmitted in sensory nerves
- Trial name
- NCT00960804
- Testing
- Tanezumab
- Where
- 18 sites in United States
- Volunteers
- 21 people
- Sponsor
- Pfizer
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