Clinical trials: Arthritis Knee
Knee Osteoarthritis
Clinical Investigation to Compare the Safety and Efficacy of Cellular Matrix to Those of Ostenil® Plus and to Those of PRP Only
Platelet-rich plasma (PRP) is an autologous product prepared from the patient's own blood, representing a powerful source of platelet-derived growth factors, particularly useful in the field of regenerative medicine.
- Trial name
- NCT02964143
- Testing
- Cellular Matrix / A-CP HA, Ostenil® Plus, RegenKit-BCT-1
- Volunteers
- 306 people
- Sponsor
- Regen Lab SA
KNEE OSTEOARTHRITIS
Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis
This study is a randomized, double-blind clinical trial in a Chinese population
- Trial name
- NCT05324163
- Testing
- X0002 Spray, Celecoxib capsules
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Jiangsu XinChen-Techfields Pharma Co., LTD.
Osteoarthritis, Knee
A Study of the Construct Validity of Community Walking Speed Data Collected Remotely With the Canary canturioTM te Tibial Extension
The purpose of this study is to determine the construct validity of the Canary Tibial Extension's measure of self-selected community walking speed.
- Trial name
- NCT05539326
- Testing
- Performance Clinical Outcome Test
- Where
- 6 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Canary Medical
Knee Osteoarthritis
A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study
A multicenter, randomized, double-blind, parallel-group, placebo-controlled, and active-drug, 12-week, multicenter clinical study.
- Trial name
- SAVE (NCT03936192)
- Testing
- glucosamine sulphate 1500mg and meloxicam 15mg, Glucosamine sulfate 1500mg and chondroitin sulfate 1200mg
- Sponsor
- Eurofarma Laboratorios S.A.
Osteoarthritis, Knee, Rheumatoid Arthritis
A Comparison of Two Surgical Techniques Using the Unity Knee™ Total Knee System
A comparison of two Unity Knee™ tissue-balancing techniques by analysing the results from X-rays and patient questionnaires.
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Post-Traumatic Osteoarthritis of Knee, Varus Deformity, Not Elsewhere Classified, Knee
- Trial name
- NCT03511144
- Testing
- Unity Knee™ TKR using measured resection, Unity Knee™ TKR using ligament balancing
- Sponsor
- Corin
Osteoarthritis
Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly
The primary objective is to compare buprenorphine transdermal delivery system (BTDS) with standard- treatment in subjects with osteoarthritis (OA).
- Trial name
- NCT00324038
- Testing
- Buprenorphine, Codeine paracetamol
- Where
- United Kingdom
- Volunteers
- 219 people
- Sponsor
- Napp Pharmaceuticals Limited
Osteoarthritis, Knee
Impact of Noninvasive Targeted Pulsed Electromagnetic Field (tPEMF) on Opioid Use, Pain, and Joint Function Following Total Knee Arthroplasty
The purpose of this study is to determine the effectiveness of pulsed radio frequency (PRF), a type of electromagnetic field treatment with the Ivivi Torino II for reducing post-operative narcotic use in patients recovering from…
- Trial name
- NCT01475604
- Testing
- Ivivi Torino II
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Amp Orthopedics, Inc.
Osteoarthritis
Safety, Tolerability and Pharmacokinetics of SAR113945 Following Intra-articular Administration in Patients With Knee Osteoarthritis
Primary Objective: Assess the safety and tolerability of single intra-articular doses of SAR113945 in patients with knee osteoarthritis.
- Trial name
- NCT01113333
- Testing
- SAR113945
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Sanofi
Knee Osteoarthritis
Oxford UKA and HTO Post-market Clinical Study
The purpose of this study is to compare the performance and safety of medial UKA and HTO in the treatment of AMOA in term of functional outcome, radiographic assessment, range of motion, postoperative complications, revision rate…
- Trial name
- NCT04518111
- Where
- China
- Volunteers
- 370 people
- Sponsor
- Zimmer Biomet
Knee Arthritis, Osteoarthritis
A Single-Center Phase 1 Study of ceAF for Knee Osteoarthritis (KOA)
Approximately 25 participants aged 18-70 years, with knee pain rated 4-7 on a 10-point visual analogue scale (VAS) and a disease duration of 6 months to 10 years, will be enrolled. The study has two parts.
- Trial name
- KOA (NCT07902128)
- Testing
- Animal early embryo extract
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Anhui HygeianCells BioMedical Co., Ltd.
Osteoarthritis of Knee
A Phase 1/2a Study to Evaluate Single Intraarticular Injections of 3 Dose Levels of SYN321 and Placebo in Patients With Symptomatic Knee Osteoarthritis
This is a, phase 1/2a trial, to assess the safety, tolerability, systemic exposure as well as preliminary efficacy following a single intra-articular injection of 3 dose levels of SYN321 in patients with symptomatic knee…
- Trial name
- NCT06989645
- Testing
- SYN321
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Synartro AB
Ankle Sprain, Back Pain
Counterpain PXM Versus Diclofenac Versus Piroxicam
The goal of this clinical trial is to learn if a gel containing Piroxicam plus Counterirritant (warming/cooling ingredients) is as effective and safe as two other common anti-inflammatory gels for treating acute muscle, bone, and…
- Conditions
- Ankle Sprain, Back Pain, Osteoarthritis (OA) of the Knee, Tennis Elbow
- Trial name
- NCT07475663
- Testing
- Piroxicam plus Counterirritant (brand name Counterpain® PXM)., Diclofenac Sodium 10 mg (Brand Name Hotin® DCL), Piroxicam 0.5% (Brand name Pirofel® gel)
- Where
- Indonesia
- Volunteers
- 180 people
- Sponsor
- Taisho Pharmaceutical Indonesia
Osteoarthritis, Knee, Osteo Arthritis Knee
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical study is to determine if a single injection of 1 or more dose levels of adeno-associated virus (AAV) gene therapy (GNSC-001) is safe and tolerated compared to placebo in participants with painful…
- Conditions
- Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Osteoarthritis
- Trial name
- DONATELLO (NCT05835895)
- Testing
- GNSC-001, transient immune-modulation
- Where
- 9 sites in United States
- Volunteers
- 67 people
- Sponsor
- Genascence Corporation
Knee Osteoarthritis (Knee OA)
Study in Patients With Knee Osteoarthritis Treated by Embolization Using NBGM200
Study in patients with knee osteoarthritis treated by embolization using NBGM200
- Trial name
- NCT06930677
- Testing
- embolization therapy
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 72 people
- Sponsor
- Next Biomedical Co., Ltd.
Osteoarthritis, Knee, Knee Degenerative Disease
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells
In this prospective study we aim to evaluate the feasibility and safety of the implantation of 40 millions MSV in knees with osteoarthritis of grade II-IV (Kellgren and Lawrence).
- Conditions
- Osteoarthritis, Knee, Knee Degenerative Disease, Knee Osteoarthritis
- Trial name
- KDD&MSV (NCT01183728)
- Testing
- Autologous bone marrow mesenchymal stem cells (MSV)
- Where
- 2 sites in Spain
- Volunteers
- 12 people
- Sponsor
- Red de Terapia Celular
Osteoarthritis
Efficacy and Safety of Shinbaro Capsule
The purpose of this study is to evaluate the efficacy and safety of 'Shinbaro Capsule', a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee.
- Trial name
- NCT01535417
- Testing
- Shinbaro Capsule, Celebrex
- Volunteers
- 198 people
- Sponsor
- Green Cross Corporation
Osteoarthritis, Hip, Arthritis
A Clinical Investigation of the M2a-Magnum™ Hip System
The purpose of this prospective clinical data collection is to document the performance and clinical outcomes of the M2a-Magnum™ Hip System
- Conditions
- Osteoarthritis, Hip, Arthritis, Rheumatoid Arthritis, Joint Disease
- Trial name
- NCT00698347
- Testing
- M2a-Magnum™ Hip System
- Volunteers
- 249 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthritis, Knee
Intra-articular Polyacrylamide Hydrogel in the Treatment of Knee Osteoarthritis
1-year follow-up of a randomized controlled trial with open-label extension to assess the long-term efficacy and safety of Intra-articular HBISA Endoprosthesis of Synovial Fluid NOLTREX™ in Knee Osteoarthritis.
- Trial name
- NCT06523491
- Where
- 2 sites in Russia
- Volunteers
- 57 people
- Sponsor
- Research Centre BIOFORM
Osteoarthritis, Knee
Safety Study of TissueGene-C in Degenerative Joint Disease of the Knee
The study is being conducted to investigate the safety and activity of TissueGene-C injected into the knee joint of patients with chronic degenerative joint disease (DJD) who will be undergoing total knee replacement.
- Trial name
- TGC-03-01 (NCT00599248)
- Testing
- TissueGene-C
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Kolon TissueGene, Inc.
Joint Disease
Signature Versus Computer Assisted Surgery Study
The purpose of the data collection is to document the performance and clinical outcomes of the Vanguard Knee using Signature Custom Cutting Guides and Computer Assisted Surgery.
- Trial name
- NCT01256216
- Testing
- Total Knee Replacement with Vanguard Total Knee
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Zimmer Biomet
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