Clinical trials: Arthritis Knee
Osteoarthritis, Knee
A Study to Assess the Efficacy and Safety of AXS-02 in Subjects With Knee OA Associated With Bone Marrow Lesions
This is a randomized, double-blind, placebo-controlled, 24-week study to evaluate the efficacy and safety of AXS-02 in subjects with knee osteoarthritis associated with bone marrow lesions.
- Trial name
- COAST-1 (NCT02746068)
- Testing
- AXS-02
- Where
- 61 sites in United States, Australia
- Volunteers
- 346 people
- Sponsor
- Axsome Therapeutics, Inc.
Osteoarthritis
Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement
The main purpose of the study is to find out if, after 4 weeks of dosing, signs of the investigational drug AGG-523, or its effects, can be measured in urine, blood, or the knee joint.
- Trial name
- NCT00454298
- Testing
- AGG-523 (Aggrecanase Inhibitor)
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Pain, Joint Pain
Evaluation of the Antalgic Effect of Puressentiel Joints and Muscles - Gel on Joint Pain of the Knee
This clinical trial aims to evaluate the antalgic effect of Puressentiel Joints and Muscles - Gel with 14 essential oils for 12 weeks on knee joint pain in 45 patients suffering from chronic pain related to arthritis of the knee.
- Trial name
- EVAPURGEL (NCT04736563)
- Testing
- Joint and muscle gel Puressentiel
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Marco Pacchioni
Osteoarthritis of the Knee
To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients of the Knee
This is a randomized, double-blind study to compare the efficacy and safety of LAYLA tablet and CENATONE tablet in the treatment of osteoarthritis of the knee.
- Trial name
- NCT02049606
- Testing
- LAYLA tablet, CENATONE tablet
- Where
- 6 sites in South Korea
- Volunteers
- 134 people
- Sponsor
- PMG Pharm Co., Ltd
Severe Knee Pain, Severe Knee Disability
Zimmer POLAR Persona - TKA (EMEA Study)
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona knee implants used in primary total knee arthroplasty. The assessment will include: 1.
- Conditions
- Severe Knee Pain, Severe Knee Disability, Osteoarthritis, Rheumatoid Arthritis
- Trial name
- NCT02337244
- Testing
- Zimmer Persona Total Knee System
- Where
- 12 sites in Austria, France and 4 more
- Volunteers
- 777 people
- Sponsor
- Zimmer, GmbH
Osteoarthritis, Knee
Safety Study of a Long-Acting Injectable Steroid to Treat Knee Osteoarthritis
The main purpose of this study is to understand the pharmacokinetics of EP-104IAR and to determine whether it is safe to use in patients with osteoarthritis (OA) of the knee.
- Trial name
- STEPUP (NCT02609126)
- Testing
- EP-104IAR, Vehicle
- Where
- 3 sites in Canada
- Volunteers
- 32 people
- Sponsor
- Eupraxia Pharmaceuticals Inc.
Primary Knee Osteoarthritis
Intra-Articular Allocetra in Patients With Primary Knee Osteoarthritis
This is a multicenter, randomized, double-blind, placebo-controlled, Phase IIb study to evaluate intra-articular (IA) injections of Allocetra in participants with moderate-to-severe age related symptomatic primary knee…
- Trial name
- NCT07580716
- Testing
- Allocetra
- Where
- 17 sites in United States, Denmark and 1 more
- Volunteers
- 182 people
- Sponsor
- Enlivex Therapeutics Ltd.
Osteoarthritis
Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)
The purpose of this phase III study is to Evaluate the Efficacy and Safety of Oral Salmon Calcitonin in the Treatment of Patients with Osteoarthritis of the Knee
- Trial name
- NCT00704847
- Testing
- Oral Salmon Calcitonin
- Where
- 18 sites in United States, Belgium and 8 more
- Volunteers
- 1,030 people
- Sponsor
- Nordic Bioscience A/S
Osteoarthritis, Knee
Extract of Curcuma Longa Complexed With Phosphatidilcholine(Motore®)in the Treatment of Adults With Knee Osteoarthritis
Prospective, multicenter, phase IV, open, randomized, parallel, controlled, in which 288 (two hundred and eighty-eight) participants of both sexes, aged between 40 and 75 years will be randomly allocated to one of two treatment…
- Trial name
- NCT02409381
- Testing
- Motore, Alivium
- Where
- Brazil
- Volunteers
- 288 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Osteoarthritis, Knee
Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200
This is a study of an over-the-counter, capsaicin-based (0.25%) topical analgesic for management of osteoarthritis knee pain meeting the US Food and Drug Administration's (FDAs) Tentative Final Monograph (TFM) guidance for…
- Trial name
- NCT03124407
- Testing
- Capsaicin Topical Solution, Drug product vehicle
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Propella Therapeutics
Osteoarthritis, Osteo Arthritis Knee
A Study to Assess Efficacy of Supporting Properties and Safety of ARTNEO in Patients With Knee Osteoarthritis
The goal of the interventional study is to assess the effectiveness of the supporting properties and safety of the dietary supplement ARTNEO (ARTNEO®), capsules with an average weight of 585 mg, in patients with osteoarthritis of…
- Conditions
- Osteoarthritis, Osteo Arthritis Knee, Osteoarthritis, Knee
- Trial name
- NCT06032442
- Testing
- ARTNEO, Artra
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- NPO Petrovax
Osteoarthritis
Efficacy and Safety of RTX-GRT7039 in Adult Subjects With Knee Osteoarthritis
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of repeated injections of RTX-GRT7039 versus placebo in patients who have pain associated with…
- Trial name
- NCT05248386
- Testing
- RTX-GRT7039
- Where
- 103 sites in Canada, Czechia and 7 more
- Volunteers
- 469 people
- Sponsor
- Grünenthal GmbH
Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease
PMCF Study on the Safety, Performance and Clinical Benefits Data of the NexGen TM Augmentation Patella
The study is a single-center, retrospective and prospective, non-randomized, non-controlled and consecutive series post-market study.
- Conditions
- Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease, Functional Deformity, Revision Total Knee Arthroplasty
- Trial name
- NCT05253976
- Where
- Switzerland
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee
Robotic-Assisted Versus Conventional Total Knee Arthroplasty With Virtual Home-Based Rehabilitation
The goal of this clinical trial is to learn whether robotic-assisted total knee replacement improves recovery compared with conventional total knee replacement in adults with knee osteoarthritis when both groups follow the same…
- Trial name
- R-TKR VCare (NCT07716267)
- Testing
- Robotic-assisted Total Knee Arthroplasty, Conventional Total Knee Arthroplasty, Hybrid Virtually-Assisted Peri-operative Rehabilitation Program
- Volunteers
- 60 people
- Sponsor
- Mark Hurworth
Osteo Arthritis Knee
Prospective Observational Study of Pain Evolution in Patients With Primary Knee Osteoarthritis Treated With Pronolis® HD
Prospective observational study of 6 months of follow-up, of national and multicenter scope with medical device with CE marking and according to the usual clinical practice.
- Trial name
- NO-DOLOR (NCT04196764)
- Where
- Spain
- Volunteers
- 188 people
- Sponsor
- Procare Health Iberia S.L.
Osteoarthritis of Knee
Assessment of the Safety and Efficacy of 3VM1001 Cream for Treatment of Chronic Pain Caused by Knee Osteoarthritis.
3VM1001 is a topical cream that may be useful for the treatment of chronic osteoarthritis of the knee. This proof of concept study is a randomized, placebo-controlled, double-blind study to compare treatment with 3VM1001 cream to…
- Trial name
- NCT02332148
- Testing
- 3VM1001
- Volunteers
- 50 people
- Sponsor
- CDA Research Group, Inc.
Gonarthrosis
Real-life Assessment of the Safety and Performance of the SYNOVIUM HCS Device
Patients who are to benefit from an injection of SYNOVIUM HCS as part of their care will be offered to participate in this study. Patients will need to sign a consent form to participate.
- Trial name
- YNOVIUM (NCT06087705)
- Testing
- Intra-articular injection of hyaluronic acid
- Where
- France
- Volunteers
- 134 people
- Sponsor
- LCA Pharmaceutical
Osteoarthritis Knee
Mesenchymal Stem Cell Treatment for Primary Osteoarthritis Knee
The purpose of this study is to evaluate the safety and preliminary efficacy of autologous adipose-derived mesenchymal stem cells (ADMSCs) treatment for patients with primary osteoarthritis knee.
- Trial name
- NCT02544802
- Testing
- Adipose-Derived Mesenchymal Stem Cells
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- Steminent Biotherapeutics Inc.
Osteoarthritis
A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain
CE-224535 is a new medication being developed as an analgesic and anti-inflammatory agent for the treatment of the signs and symptoms of osteoarthritis (OA).
- Trial name
- NCT00418782
- Testing
- naproxen, CE-224535
- Where
- 46 sites in United States
- Volunteers
- 212 people
- Sponsor
- Pfizer
Osteoarthritis
Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee
Primary Objective: To assess the efficacy of a single intraarticular dose of GZ389988 compared to placebo for relief of knee pain in patients with osteoarthritis (OA) of the knee.
- Trial name
- NCT02845271
- Testing
- GZ389988, acetaminophen or paracetamol, fixed combination of paracetamol + codeine
- Where
- 2 sites in Germany
- Volunteers
- 104 people
- Sponsor
- Genzyme, a Sanofi Company
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