Clinical trials: Arthritis Knee
Pain, Activities of Daily Living
A Double-blind, Randomized, Parallel Group, Fase III Comparative Study With Rose Hip Powder Powder and Placebo Given to Patients With Mild to Moderate Osteoarthritis in the Knee or/and Hip
The trial is an investigator-initiated, double-blind, randomized, placebo-controlled phase III study. After the patient has receiving information about the study and after given written informed consent, the patient will be…
- Conditions
- Pain, Activities of Daily Living, Quality of Life
- Trial name
- NCT01459939
- Testing
- Rose-hip powder capsules
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hyben Vital ApS
Osteoarthritis
Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant
A better understanding of knee joint kinematics is important to explain the premature polyethylene wear failures within total knee arthroplasties (TKAs) and to help design a prosthesis that most closely approximates the normal…
- Trial name
- NCT01717001
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Restor3D
Osteoarthritis, Knee, Joint Instability
Combined Prospective and Retrospective Post-Market Follow Up of the 'BPK-S Integration' UC as Primary Implant in the Variant CoCr
Patients who received a total knee endoprosthesis BPK-S Integration between 2011 and 2013 will be invited to participate in this PMCF study provided sufficient source data documentation is available regarding preoperative…
- Trial name
- NCT03406637
- Testing
- BPK-S Integration
- Where
- 2 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Peter Brehm GmbH
Osteoarthritis of Knee
A Phase 1/2a Study to Evaluate Single Intraarticular Injections of 3 Dose Levels of SYN321 and Placebo in Patients With Symptomatic Knee Osteoarthritis
This is a, phase 1/2a trial, to assess the safety, tolerability, systemic exposure as well as preliminary efficacy following a single intra-articular injection of 3 dose levels of SYN321 in patients with symptomatic knee…
- Trial name
- NCT06989645
- Testing
- SYN321
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Synartro AB
Osteoarthritis, Knee
JOURNEY™ II CR Total Knee System
The purpose of this study is to evaluate the safety and effectiveness of the JOURNEY™ II CR Total Knee System in subjects with degenerative joint disease (DJD) requiring primary total knee replacement.
- Trial name
- NCT02440672
- Testing
- JOURNEY™ II CR Total Knee System (J II CR TKS)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Knee
Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium Therapy for Osteoartrithis
This study aims to compare the efficacy of Umbilical Cord Mesenchymal Stem Cell and secretome between arthroscopy and without arthroscopy intervention in OA patients.
- Trial name
- OA (NCT04314661)
- Testing
- Arthroscopy with Mesenchymal Stem Cells + Secretome + Secretome, Arthroscopy with Secretome + Mesenchymal Stem Cells + Secretome, Non Arthroscopy with Mesenchymal Stem Cells + Secretome + Secretome
- Where
- Indonesia
- Volunteers
- 31 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Osteoarthritis of Knee
RCT on the Performance and Safety of LightForce® Therapy Lasers on Knee Osteoarthritis Pain Reduction (SPARK)
DJO UK Ltd (ENOVIS) is conducting this study to assess the effectiveness of LightForce® Therapy Lasers on pain reduction in subjects with unilateral or bilateral knee osteoarthritis.
- Trial name
- SPARK (NCT06654739)
- Testing
- Laser therapy + physiotherapy/exercise protocol
- Where
- 7 sites in France, Italy and 1 more
- Volunteers
- 64 people
- Sponsor
- DJO UK Ltd
Osteoarthritis of the Knee
A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthritis Pain
Phase 1 will evaluate the safety of 3 intra-articular injections of Ampion™ administered 2 weeks apart to adults with osteoarthritis of the knee.
- Trial name
- NCT02184156
- Testing
- 4 mL injection of Ampion
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Osteoarthritis, Osteoarthritis, Hip
A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain
The purpose of this study is to compare the safety and effectiveness of different doses of JNJ-42160443 with placebo in the treatment of chronic, moderate to severe knee or hip pain in patients with a diagnosis of osteoarthritis.
- Conditions
- Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Pain
- Trial name
- NCT00973141
- Testing
- JNJ-42160443
- Where
- 77 sites in United States, Canada and 2 more
- Volunteers
- 467 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Osteoarthritis, Knee
Phase 2B Clinical Study of Chondrogen for Treatment of Knee Osteoarthritis
Primary osteoarthritis is a debilitating disease characterized by extensive damage to the joints and excruciating pain leading to loss of activity and depression.
- Trial name
- NCT04520945
- Testing
- Chondrogen
- Where
- Malaysia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meluha Life Sciences SDN BHD
Osteoarthritis
Efficacy & Safety Study Evaluating Natural Eggshell Membrane (NEM) in the Treatment of Osteoarthritis
The purpose of this study is to evaluate the effectiveness of Natural Eggshell Membrane (NEM) for the relief of pain and stiffness associated with moderate osteoarthritis of the knee and to compare the effectiveness of NEM to…
- Trial name
- OPTION (NCT00750477)
- Testing
- NEM
- Where
- 3 sites in United States
- Volunteers
- 67 people
- Sponsor
- ESM Technologies, LLC
Osteoarthritis, Knee, Osteoarthritis, Hip
Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip
The objective of this exploratory study is to evaluate the cellular and connective tissue composition of joints from patients with Osteoarthritis (OA) who have been treated with fasinumab, compared with those treated with placebo…
- Trial name
- NCT03949673
- Testing
- Fasinumab, Naproxen, Diclofenac
- Where
- 15 sites in United States, Poland and 1 more
- Volunteers
- 23 people
- Sponsor
- Regeneron Pharmaceuticals
Total Knee Replacement
Qualitative Interviews With Healthcare Professionals
PLANNING PHASE- Qualitative interviews with Healthcare Professionals to assist in the development of a new Patient Reported Outcome Measure (PROM) to assess patient's emotional wellbeing, and perceptions of Total Knee Replacement…
- Trial name
- NCT05597046
- Testing
- Interview
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Invibio Ltd
Knee Osteoarthritis
TreatMent Of Knee osTeoarthritis wIth chONdroitin Sulfate - the OA MOTION Study
The goal of this phase III study is to evaluate the efficacy, safety, and tolerability of chondroitin sulfate 800 mg oral tablets versus placebo in the treatment of subjects with pain due to knee OA (osteoarthritis).
- Trial name
- MOTION (NCT05632783)
- Testing
- Chondroitin Sulfate Sodium
- Sponsor
- IBSA Institut Biochimique SA
Osteoarthritis, Degenerative Arthritis
Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT Setting
The primary objective of the study is to determine how the short-term outcome of subjects implanted with the JOURNEY™ II BCS Total Knee System compares to subjects implanted with other PS total knee systems, and to determine if…
- Conditions
- Osteoarthritis, Degenerative Arthritis, Traumatic Arthritis
- Trial name
- NCT02820766
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Smith & Nephew, Inc.
Primary Osteoarthritis, Rheumatoid Arthritis
TC-A Registration Study
This is a prospective, randomized, multicenter clinical study to compare the safety and efficacy of TC-A PS total knee system with TC-PLUS Solution PS total knee system in Chinese subjects.
- Conditions
- Primary Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT02139345
- Testing
- TC-A PS Total Knee Replacement System, TC-PLUS Solution PS Total Knee Replacement System
- Where
- 4 sites in China
- Volunteers
- 162 people
- Sponsor
- Smith & Nephew Medical (Shanghai) Ltd
Osteoarthritis
Minimally Invasive Total Knee Replacement - Navigated Versus Non-navigated Study
The primary objective of this investigation is to compare the precision of long leg alignment achieved by the two types of procedure.
- Trial name
- NCT00733330
- Testing
- Either P.F.C. Sigma or L.C.S. Complete knee replacement using the conventional surgical approach and manual surgical technique, Either P.F.C. Sigma or L.C.S. Complete knee replacement using minimally invasive surgical approach and computer navigation
- Where
- 5 sites in United States, Australia and 1 more
- Volunteers
- 86 people
- Sponsor
- DePuy International
Knee Osteoarthritis
Cellular Matrix Device for the Treatment of Mild to Moderate Knee Osteoarthritis
This is a non-inferiority study on 190 patients to evaluate whether a treatment based on the combination of autologous platelet-rich plasma and hyaluronic acid obtained with Cellular Matrix represents a therapeutic advantage to…
- Trial name
- NCT03328728
- Testing
- Cellular Matrix / A-CP HA Kit, Synvisc-One
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Regen Lab SA
Osteoarthritis, Knee
Study of Intra-articular Injections vs Placebo in Patients With Pain From Osteoarthritis of the Knee
The aim of this study is to evaluate the effectiveness and safety of a combined Traumeel® / Zeel® injection against placebo (saline) in patients with moderate-to-severe pain associated with osteoarthritis of the knee.
- Trial name
- MOZArT (NCT01887678)
- Testing
- Traumeel® / Zeel® Injectable Solution
- Where
- 30 sites in United States
- Volunteers
- 287 people
- Sponsor
- Biologische Heilmittel Heel GmbH
Hyaluronic Acid
ArtiAid® Plus for Knee Osteoarthritis: A Post-market Study
The goal of this open-label, post-market clinical follow-up study is to demonstrate the safety and performance of ArtiAid® Plus Intra-articular Injection in patients with knee osteoarthritis(OA).
- Trial name
- NCT05881317
- Testing
- ArtiAid® Plus Intra-articular Injection
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- Maxigen Biotech Inc.
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