Clinical trials: Arthritis of Knee
Osteoarthritis Knee
Gel-One Treatment in Knee Osteoarthritis
The purpose of this study is to determine whether Gel-One demonstrates a superior effectiveness in osteoarthritis (OA) knee pain compared with phosphate buffered saline (PBS) injections.
- Trial name
- NCT01934218
- Testing
- Gel-One, PBS
- Where
- 41 sites in United States
- Volunteers
- 814 people
- Sponsor
- Seikagaku Corporation
Osteoarthritis
A Study to Determine the Performance of the Press Fit Condylar (P.F.C.) Sigma RP-F Knee System
The purpose of this study is to evaluate if the P.F.C. Sigma RPF knee accommodates functional stability with a post-operative passive range of motion of greater than 125° of flexion and to demonstrate that the range of motion…
- Trial name
- NCT00761410
- Testing
- P.F.C. Sigma RP-F Total Knee Replacement
- Where
- 8 sites in India, Japan and 5 more
- Volunteers
- 170 people
- Sponsor
- DePuy International
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Comparison of CoCr Alloy and TiN Coating in TKA
In the current prospective, randomized study, two different materials of the same total knee arthroplasty (TKA) system - cobalt-chromium (CoCr) and titanium-nitride (TiN) - are going to be compared with regards to postoperative…
- Trial name
- NCT04701359
- Testing
- TiN-alloy based total knee arthroplasty, CoCr-coating based total knee arthroplasty
- Where
- Austria
- Sponsor
- Medical University of Graz
Osteoarthritis, Knee
Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty
Our purpose of this study is to conduct a prospective randomized controlled trial to investigate the blood-conservation effect of this two topical hemostatic agents in primary TKA procedures in patients with a risk of…
- Trial name
- NCT02865174
- Testing
- Topical tranexamic acid, Floseal®, Enoxaparin
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Articular Cartilage Lesion of Knee
Study to Assess the Safety of Treatment of Articular Cartilage Lesions With CartiLife®
The purpose of this study is to assess the safety and efficacy of implanting bead-type autologous chondrocytes (CartiLife®) obtained by culturing expanded costal chondrocytes of the patient with a chondral defect in the knee.
- Trial name
- NCT03517046
- Testing
- CartiLife
- Volunteers
- 6 people
- Sponsor
- Biosolution Co., Ltd.
Knee Osteoarthritis (OA), Postoperative Pain
Effect of Adding a Biceps Femoris Short Head Block to Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is frequently associated with moderate to severe postoperative pain, which may delay mobilization, increase opioid consumption, and impair functional recovery.
- Trial name
- BiFeS-TKA (NCT07803887)
- Testing
- Ultrasound-Guided Adductor Canal Block, Ultrasound-Guided Biceps Femoris Short Head Block
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Antalya Training and Research Hospital
Knee Osteoarthritis
New Application of Buprenorphine Patch on Painful Knee Joint in Knee Osteoarthritis Patients
Osteoarthritis (OA) is already one of the most disabling diseases in developed countries. Intra-articular (IA) injection of opioid in joints has been widely studied for its simplicity, safety and efficacy.
- Trial name
- NCT03947125
- Testing
- Buprenorphine transdermal patch on knee joint
- Volunteers
- 200 people
- Sponsor
- Ajou University School of Medicine
Osteoarthritis, Knee
Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis
The purpose of this study is to evaluate whether the investigators can develop a computer algorithm to predict which individual patients will respond to injections of hyaluronic acid (HA) products for knee osteoarthritis.
- Trial name
- NCT01557868
- Testing
- hylan G-F 20, 1% sodium hyaluronate
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- American Orthopaedic Society for Sports Medicine
Osteoarthritis
Assessment of Conventional and Patient-specific Instrumentation in Total Knee Arthroplasty
This study will use a special type of x-ray called radiostereometric analysis (RSA) imaging to determine whether patient-specific instrumentation for total knee arthroplasty (replacement) has an effect on implant loosening…
- Trial name
- NCT02230215
- Testing
- Total Knee Arthroplasty with use of Visionaire Patient-Specific Instrumentation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Medial Knee Compartment Arthritis
Oxford Partial Knee Kinematics Gait Analysis Study
The objective of this study is to compare the effect on gait of unicompartmental knee arthroplasty (UKA), using the Oxford Partial Knee, versus normal knee.
- Trial name
- NCT01454908
- Testing
- Oxford Partial Knee
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The CORE Institute
Osteoarthritis, Knee
Calypso Knee System Clinical Study, OUS
A study to evaluate the safety and effectiveness of the Calypso Knee System when used in subjects with symptomatic osteoarthritis of the medial compartment of the knee.
- Trial name
- NCT03838978
- Testing
- Calypso Knee System (Implantable Shock Absorber)
- Where
- 5 sites in Belgium, Poland
- Volunteers
- 81 people
- Sponsor
- Moximed
Knee Osteoarthritis
A Prospective, Randomized Study Comparing Cemented and Cementless Total Knee Replacement
The purpose of this study is to compare the the Nexgen knee replacement system using cementless fixation with the same system using cemented fixation.
- Trial name
- NCT01194817
- Testing
- High-Flexion Knee Replacement System using Cemented Fixation, High-Flexion Knee Replacement System using Cementless Fixation
- Volunteers
- 100 people
- Sponsor
- Anderson Orthopaedic Research Institute
Osteoarthrosis
E1K Intra Articular(IA) Treatment for Knee Osteoarthritis
The objective of this study is to evaluate the efficacy and safety of pain relief treatment on knee osteoarthritis when administered E1K or placebo in patients with knee osteoarthritis aged 40 to 70 to determine the optimal dose.
- Trial name
- NCT05697952
- Testing
- E1K 1,200 ㎍/joint, E1K 2,400 ㎍/joint
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Ensol Bioscience
Knee Osteoarthritis (Knee OA)
Effects of Core Stabilization Exercises in Female Patients With Gonarthrosis
Osteoarthritis (OA) is a non-inflammatory degenerative disease characterized by progressive deterioration of cartilage tissue, synovial membrane, and joint capsule, primarily affecting weight-bearing joints.
- Trial name
- NCT07482332
- Testing
- 10 days of conventional physiotherapy (Hot Pack, TENS, Ultrasound) and 6 weeks of routine knee exercises, Six weeks of core stabilization exercises.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cumhuriyet University
Osteoarthritis, Knee Arthritis
The Effect of Telerehabilitation-Based Exercise and Training on Outcome Measures in Patients With Knee Osteoarthritis
Video exercise component of the telerehabilitation would provide additional contribution to the patients. The aim of this study is to compare the effects of telerehabilitation-based exercise program and conventional (given on…
- Trial name
- NCT05209893
- Testing
- Telerehabilitation, Paper Based Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Ege University
Knee Osteoarthritis
Evaluation of a New Bi-Condylar Total Knee Prosthesis (TKP) With All-Ceramic Friction (The Forgotten Knee)
The results of TKP (Total Knee Prosthesis) are satisfactory but do not reach those of THP (Total Hip Prosthesis) in terms of indolence and function.
- Trial name
- ForgottenKne (NCT06592248)
- Testing
- Coc Knee
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoarthritis of the Knee
A Comparative Study of Knee Systems
The custom cutting guides personalized for each patient via pre-operative MRI will result in significantly faster intraoperative time with comparable knee alignment accuracy, cost, knee function, and patient satisfaction.
- Trial name
- Bake-Off (NCT01331278)
- Testing
- Total Knee Arthroplasty with Custom Cutting Blocks, Total Knee Arthroplasty via Computer Assisted Surgery
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Foundation for Southwest Orthopedic Research
Osteo Arthritis Knee
Effects of Closed and Open Kinetic Chain Exercises
Osteoarthritis (OA) is a heterogeneous pathology characterized by focal cartilage degeneration and the formation of new bone around the subchondral bone and joint, which is the disruption of balance between the processes of…
- Trial name
- NCT04186143
- Testing
- Closed Cinetic Chain Exercises, Open Kinetic Chain Exercises, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Hip Osteoarthritis, Knee Osteoarthritis
The Effects of Conventional Exercise Combined With Core Stabilization Exercise by Telerehabilitation in Patients With Hip and/or Knee Osteoarthritis
Age-related hip and knee osteoarthritis is the leading cause of pain and locomotor problems worldwide. There is no definitive solution in the treatment of hip and knee osteoarthritis.
- Trial name
- NCT05272748
- Testing
- Conventional Exercise + Core Stabilization Exercise, Conventional Exercise
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Saglik Bilimleri Universitesi
Osteo Arthritis Knee
Multi-modal Exercise Program in Older Aduls With Knee Osteoarthritis
Aim: To evaluate the short-term effects of a multi-modal exercise program on physical performance variables in older adults with knee osteoarthritis.
- Trial name
- MME-KOA (NCT03951506)
- Testing
- Multi-modal exercise program, Conventional treatment
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Cardenal Herrera University