Clinical trials: Arthritis of the Knee Joint
Knee Osteoarthritis
Allogenic Adipose Tissue-Derived Mesenchymal Progenitor Cells for the Treatment of Knee Osteoarthritis
Evaluate the efficacy and safety of Allogenic Adipose Tissue-Derived Mesenchymal Progenitor Cells Therapy
- Trial name
- NCT04208646
- Testing
- Mesenchymal progenitor cells, No mesenchymal progenitor cells
- Where
- 7 sites in China
- Volunteers
- 106 people
- Sponsor
- Shanghai AbelZeta Ltd.
Knee Osteoarthritis
MultiCenter IDE Study of the PEEK-OPTIMA™ Femoral Component vs a CoCr Alloy TKA Femoral Component of Similar Design
The purpose of this investigational device exemption (IDE) study is to monitor the performance (safety and efficacy) of the Maxx Orthopedics, Freedom Total Knee® System, with a femoral component of similar design, manufactured…
- Trial name
- NCT06627673
- Testing
- Total Knee Arthroplasty
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Maxx Orthopedics Inc
Knee Osteoarthritis
A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
This phase 2 study is a placebo-controlled, double-blind, parallel group study of four concentrations of SM04690 (0.03, 0.07, 0.15, and 0.23 mg per 2 mL injection) injected intraarticularly (IA) into the target knee joint of…
- Trial name
- NCT03122860
- Testing
- SM04690
- Where
- 74 sites in United States
- Volunteers
- 700 people
- Sponsor
- Biosplice Therapeutics, Inc.
Gonarthrosis
Evaluation of the Effectiveness of a Muscular Strengthening Protocol With an Instrumented Orthosis for Gonarthrosis Patients
The management of knee osteoarthritis via a physical activity protocol for rehabilitation has convincing results. However, the effectiveness of these protocols could be improved with a connected instrumented knee brace with an…
- Trial name
- NCT04225182
- Testing
- traditional rehabilitation protocol, with instrumented Orthosis
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Knee Osteoarthritis
Evaluation of the Prognostic Value of Biological Markers, Coll2-1 and Coll2-1NO2 in Patients With Symptomatic Knee Osteoarthritis
The purposes of this study are to assess the prognostic value of serum and urinary biomarkers Coll2-1 and Coll2-1NO2 at baseline, and their change over the first year, on the progression of knee osteoarthritis MRI scores at 12…
- Trial name
- PRODIGE (NCT02070224)
- Testing
- Serum and urine samples collections, Imaging (x-rays and MRI)
- Where
- 2 sites in Belgium, France
- Volunteers
- 120 people
- Sponsor
- Artialis
Osteoarthritis, Knee
Efficacy and Safety of Single, Low-dose Dexamethasone in Patients After Total Knee Arthroplasty
This study was conducted to determine the efficacy of an additional preemptive, single, low-dose dexamethasone in terms of incidence and severity of postoperative nausea/vomiting (PONV), pain level, and the safety in terms of…
- Trial name
- NCT01612702
- Testing
- Dexamethasone
- Where
- South Korea
- Volunteers
- 291 people
- Sponsor
- Tae Kyun Kim
Knee Osteoarthritis
The Effect of Elastic Bandage Compression on Pain and Function in Individuals With Knee Osteoarthritis
Introduction and Purpose: Compression is a tactile stimulus that can reduce the perception of pain by stimulating tactile skin receptors and the speed of nerve conduction.
- Trial name
- NCT04724902
- Testing
- Elastic bandage compression
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Universidade Federal de Sao Carlos
Knee Osteoarthritis, Knee Pain Chronic
The Effect of PEMF for Patients With Knee OA
Health care costs are increasing alarmingly, which will impose an overwhelming economic burden to an aging society like that of Hong Kong.
- Trial name
- NCT05548712
- Testing
- Pulse Electromagnetic Field
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Knee Arthritis, Osteoarthritis
Muscle Recovery After Total Knee Arthroplasty
Total knee arthroplasty (TKA) surgery is a common procedure performed to reduce pain, improve function, and enhance the quality of life in patients with end-stage knee osteoarthritis.
- Trial name
- NCT06096792
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Hacettepe University
Osteoarthritis
An Investigation of ReNu™ Knee Injection in Patients With Osteoarthritis
This is a Prospective, Randomized study evaluating the efficacy of ReNu for the treatment of Kellgren-Lawrence grade 2 or 3 osteoarthritis.
- Trial name
- NCT02318511
- Testing
- Knee injection, ReNu amniotic allograft, Hyaluronic Acid
- Where
- 12 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NuTech Medical, Inc
Osteo Arthritis Knee
Cartilage Adaptation and Response to Interleukins and Exercise
This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.
- Trial name
- CARTILEX (NCT03410745)
- Testing
- Exercise.
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Bispebjerg Hospital
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Degenerative Arthritis, Knee Osteoarthritis
Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Comared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients.
The purpose of this study is to evaluate the efficacy and safety of intra-articular injection of autologous adipose tissue derived mesenchymal stem cells compared after high tibial osteotomy to negative control in the…
- Trial name
- NCT03000712
- Testing
- Autologous Adipose Tissue derived MSCs 1x10^8cells/3ml
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- R-Bio
Osteoarthritis of the Knee
Measures of Pain Relevant to Knee Osteoarthritis
The aim is to improve understanding of the assessment of pain experience in patients with osteoarthritis (OA) of the knee. The current study will be divided into two parts.
- Trial name
- NCT01310257
- Testing
- Questionnaires
- Where
- 3 sites in United Kingdom
- Volunteers
- 448 people
- Sponsor
- University of Nottingham
Osteoarthritis of Knee
Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis Patients
The goal of this clinical trial is to to clarify which is the best dose of administration, to select a dose and to confirm the therapeutic efficacy of clodronate in patients with painful knee osteoarthritis (OA).
- Trial name
- NCT06263517
- Testing
- Clodronate
- Where
- 11 sites in Italy
- Volunteers
- 296 people
- Sponsor
- SPA Società Prodotti Antibiotici S.p.A.
Osteoarthritis, Knee
Human Growth Hormone Injections in the Knee Joint to Treat Osteoarthritis
The goal of this clinical trial is to learn if growth hormone injections can be used to treat osteoarthritis (OA) in the knee. Human studies have shown that repeated injections of human growth hormone leads to the production of…
- Trial name
- NCT06354023
- Testing
- Recombinant human growth hormone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- John Sledge
Hip Osteoarthritis, Knee Osteoarthritis
Shared Decision Making in Patients With Osteoarthritis of the Hip and Knee
Total joint arthroplasty (TJA) is an effective procedure for reducing pain and improving function in patients with disabling osteoarthritis (OA) of the hip or knee.
- Trial name
- SDM (NCT01492257)
- Testing
- Shared Decision Making Intervention
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Francisco
Arthritis Knee
Comparing Pain and Kinematic Outcomes of Two Gait-Modifying Shoe Interventions
This study involves the use of a newly designed shoe device for knee arthritis patients that may help reduce knee pain and improve function.
- Trial name
- NCT03760380
- Testing
- Sole 1 - Neutral, Sole 1 - Offset, Sole 2 - Neutral
- Sponsor
- University of Florida
Osteo Arthritis Knee, Platelet-rich Plasma
Platelet Rich Plasma for Knee Osteoarthritis
This study aimed to analyze the effect of platelet-rich plasma (PRP) on knee osteoarthritis. Eligible patients will undertake arthroscopic knee surgery plus intraoperative PRP and also receive second look surgery and…
- Trial name
- NCT03197441
- Testing
- Platelet-rich plasma
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- Pei-Yuan Lee, MD
Osteo Arthritis of the Knee
Research Title: Long Term Functional Outcome of a Single Hyaluronic Acid Injection in Improving Symptoms and Function in Patients With Knee Osteoarthritis - A Single-Arm Open-Label Study (DIART ONE).
This study aims to evaluate the effectiveness of a single HA injection in improving pain, function, and quality of life in patients with knee OA over a 12-month period.
- Trial name
- NCT07736781
- Testing
- Hyaluronic Acid (HA)
- Where
- Malaysia
- Volunteers
- 62 people
- Sponsor
- Universiti Sains Malaysia
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