Clinical trials: Arthropathy of Knee
Hip Arthropathy, Knee Arthropathy
Cryoneurolysis in Patients Awaiting Total Hip and Knee Arthroplasty
During the COVID-19 pandemic, there was a drastic increase in surgical wait times across Canada, notably for patients awaiting total knee and hip arthroplasty.
- Trial name
- NCT06942078
- Testing
- Cryoneurolysis
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Knee Arthropathy, Allergic Reaction
Nickel Sensitivity
The purpose of this study is to compare clinical outcomes of patients with self reported nickel sensitivity undergoing primary total knee arthroplasty (TKA) with conventional, standard-of-care vs nickel-free implants.
- Trial name
- NCT04058743
- Testing
- TKA with nickel free components, TKA with standard cobalt chromium components
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rush University Medical Center
Knee Arthropathy
Post-Market Clinical Follow Up for Total Knee Arthroplasty System Madison
MADISON Total Knee Prosthesis is intended to be used for total knee arthroplasty to reduce pain and restore joint mobility of the knee.
- Trial name
- 2022-07 (NCT06120023)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Societe dEtude, de Recherche et de Fabrication
Knee Disease, Knee Osteoarthritis
Ultrasound Guıded Adductor Canal Block vs Perıcapsular Nerve Group Block in Knee Artroplasty
Knee arthroplasty surgery numbers are increasing depending on joint deformities and cartilage degenerations. Severe postoperative pain may occur in these patients due to surgery and the placed prosthesis.
- Conditions
- Knee Disease, Knee Osteoarthritis, Knee Arthropathy
- Trial name
- NCT06203483
- Testing
- Adductor canal block, PENG block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa City Hospital
Osteoarthritis, Knee, Joint Diseases
Comparative Study of Navigation-assisted OrthoPilot® Elite and Robotic-assisted MAKO® Total Knee Arthroplasty
Randomized, controlled, single center observational study to compare the safety and performance of navigation-assisted OrthoPilot Elite and robotic-assisted MAKO total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Joint Diseases, Rheumatoid Arthritis of Knee, Posttraumatic Arthropathy
- Trial name
- ORMAK (NCT05980442)
- Testing
- Navigated total knee arthroplasty, Robot assisted total knee arthroplasty
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Aesculap AG
Knee Arthropathy
Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty
This study is a prospective double-blind randomized controlled trial to evaluate the effect of extended oral TXA after primary total TKA on short-term and mid-term postoperative outcomes, including function, pain, and…
- Trial name
- NCT07494032
- Testing
- Tranexamic acid (TXA)
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- NYU Langone Health
Arthropathy of Knee
A Comparison Of Primary TKA Rehabilitation Using A Smart Orthotic Versus Outpatient Physical Therapy
This will be a prospective, randomized, noninferiority clinical trial comparing rehabilitation methods post-total knee arthroplasty (TKA).
- Trial name
- NCT04924205
- Testing
- FM2 Knee Brace
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Nicolas Noiseux, MD, MS, FRCSC
Knee Osteoarthritis, Knee Arthropathy
Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty
Knee replacement surgery can be performed in one of two ways. Traditionally the goal was for the new joint to be in a neutral position with respect to the femur (thigh bone). This is called Mechanical Alignment (MA).
- Trial name
- NCT06617871
- Testing
- Mechanical Alignment (MA), Kinematic Alignment (KA) Interventions:
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Northwestern University
Knee Arthropathy, Hip Arthropathy
Knee-hip Surgery Wait-list Support Program
This project will outline a pre-surgery support program that identifies risk factors related to poor surgical outcomes and recommends actions to improve these before surgery.
- Trial name
- NCT06575621
- Testing
- Support program
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Knee Arthropathy
Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Knee Surgery
Postoperative pain remains undertreated with inadequate analgesic options. Opioids have well-known limitations for both individuals and society; single-injection and continuous peripheral nerve blocks provide intense analgesia…
- Trial name
- NCT07336355
- Testing
- Percutaneous peripheral nerve stimulation
- Where
- United States
- Sponsor
- University of California, San Diego
Knee Arthropathy, Return to Work
Determinants for Return to Work After Primary Knee Arthroplasty
The increase of end-stage osteoarthritis (OA) in an increasingly younger population is directly correlated with the rising incidence of obesity.
- Trial name
- RTW (NCT04665180)
- Testing
- Primary knee arthroplasty
- Where
- Belgium
- Volunteers
- 88 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Arthropathy of Knee, Early Ambulation
Peripheral Nerve Blocks and Postoperative Pain and Mobilization After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is frequently associated with significant postoperative pain, which may delay early mobilization and negatively affect functional recovery.
- Conditions
- Arthropathy of Knee, Early Ambulation, Pain, Postoperative, Pain Management
- Trial name
- NCT07442123
- Testing
- Fascia Iliaca Plane Block, Adductor Canal Block + IPACK Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Knee Arthropathy, Recurrence
Evaluation of Outcomes of the Triathlon Hinge Knee (THK) System
This study is a prospectively and retrospectively enrolled, post-market, open-label, non-randomized, single institution evaluation of clinical outcomes of primary or revision knee surgery patients who meet the eligibility…
- Conditions
- Knee Arthropathy, Recurrence, Knee Infection
- Trial name
- Hinge (NCT06379321)
- Testing
- Triathlon Hinge Knee (THK) System
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- The Cleveland Clinic
Arthropathy of Knee, Replacement
Triathlon All-Polyethylene Tibia Outcomes Study
The purpose of this study is to evaluate the clinical functional results of the Triathlon All-Polyethylene Tibia Knee Device.
- Conditions
- Arthropathy of Knee, Replacement, Knee Arthritis
- Trial name
- APT (NCT04636190)
- Testing
- Triathlon All-Polyethylene Tibia Knee
- Where
- 6 sites in United States
- Volunteers
- 204 people
- Sponsor
- Stryker Orthopaedics
Degenerative Osteoarthritis, Rheumatoid Arthritis
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
Prospective, multinational pilot study for evaluation of the Pheno4U data platform in Total Knee Arthroplasty (TKA) patients
- Conditions
- Degenerative Osteoarthritis, Rheumatoid Arthritis, Posttraumatic Arthropathy, Chronic Instability of Knee
- Trial name
- Pheno4U Pilot (NCT05302934)
- Testing
- Pheno4U
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 600 people
- Sponsor
- Aesculap AG
Knee Arthropathy
Femoral BMD Change Following Cemented or Cementless Total Knee Arthroplasty
The purpose of this study is to examine femur bone mineral density (BMD) change before and after surgery in patients receiving cemented or cementless total knee arthroplasty (TKA). performed with manual or robotic methods.
- Trial name
- NCT06733597
- Testing
- Cement, Cementless, Manual Surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Knee Arthropathy, PJI
Incidence and Microbial Profiles of Periprosthetic Joint Infection After Total Knee Arthroplasty in Obese vs Non-Obese Patients
Importance: After a primary total knee arthroplasty (TKA), we anticipate that obese individuals are more likely to experience a of periprosthetic joint infection (PJI).
- Trial name
- NCT07398742
- Where
- Denmark
- Volunteers
- 101,299 people
- Sponsor
- Bispebjerg Hospital
Knee Arthropathy
Post-market Clinical Follow-up on the balanSys UNI Knee Prosthesis Implanted With a Spacer Block Surgical Technique
The purpose of the study is the evaluation of the clinical and radiological long-term performance of the balanSys UNI fix in a multicenter routine clinical setting.
- Trial name
- NCT04598568
- Testing
- balanSys UNI
- Volunteers
- 116 people
- Sponsor
- Mathys Ltd Bettlach
Arthropathy of Knee
How Many Dexamethasone Doses Should Be Given Perioperatively?
The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea…
- Trial name
- DEXA_PERIOP (NCT06715709)
- Testing
- Dexamethasone IV, Dexamethasone IV+Oral, Dexamethasone IV+Oral 2 Day
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Mayo Clinic
Knee Arthropathy
Physica TT Tibial Plate Follow up Study
This clinical study aims at evaluating clinical, radiographic, patient-reported outcomes of total knee arthroplasty with Physica TT Tibial Plate in combination with Physica Porous KR or Physica Porous PS up to 2 years after…
- Trial name
- NCT06337123
- Testing
- Device: Physica TT TIbial Plate and Physica Porous KR, Device: Physica TT TIbial Plate and Physica Porous PS
- Where
- 3 sites in Italy
- Volunteers
- 130 people
- Sponsor
- Limacorporate S.p.a