Clinical trials: Arthropathy of Knee
Osteoarthritis, Knee
Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis
In this, prospective, double-blind study, patients with mild to moderate symptomatic knee osteoarthritis will be randomized to receive either a series of leukocyte poor, platelet-rich plasma or hyaluronic acid injections under…
- Trial name
- HA vs PRP (NCT02588872)
- Testing
- Platelet-rich Plasma (PRP), Hyaluronic Acid
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee
Intra-articular Injection of MSC-derived Exosomes in Knee Osteoarthritis (ExoOA-1)
The study aim to evaluate safety of exosomes (sEVs) from allogeneic mesenchymal stromal cells delivered by an intra-articular injection in the knee of patients with mild to moderate symptomatic osteoarthritis.
- Trial name
- ExoOA-1 (NCT05060107)
- Testing
- Exosomes (sEVs)
- Volunteers
- 10 people
- Sponsor
- Francisco Espinoza
Osteoarthritis, Knee, Quadriceps Muscle Atrophy
Efficacy of the Aussie Current in Patients With Knee Osteoarthritis.
Introduction: Osteoarthritis (OA) of the knee is a musculoskeletal disorder and is associated with significant implications related to public health and socioeconomic factors resulting in leave from work.
- Trial name
- NCT05355922
- Testing
- Electrical electrostimulation of the quadriceps muscle
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Osteoarthritis, Knee, Knee Osteoarthritis
2 Weekly Intra-articular Hyaluronan Knee Injections, Given 1 wk. Apart, of HYMOVIS Combined With Physical Exercise Program (PEP) Compared to PEP Alone, in Relatively Young, Active Population of Subjects With Patellofemoral Osteoarthritis (PFOA) and/or Tibiofemoral Osteoarthritis (TFOA)
Knee osteoarthritis (OA) is among the most common causes of musculoskeletal pain and disability. At present, there is no cure for OA.
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Patellofemoral Osteoarthritis
- Trial name
- NCT03281837
- Testing
- HYMOVIS plus Physical Exercise Program (PEP), Physical Exercise Program (PEP) alone
- Where
- 10 sites in United States
- Volunteers
- 148 people
- Sponsor
- Fidia Pharma USA Inc.
Knee Osteoarthritis, Muscle Tightness
Effects of Dynamic Soft Tissue Mobilization in Reducing Hamstring Tightness in Knee Osteoarthritis
The objective of this randomized control trial is to evaluate the effectiveness of dynamic soft tissue mobilization in comparison with the proprioceptive neuromuscular facilitation (hold-relax) technique in reducing hamstring…
- Conditions
- Knee Osteoarthritis, Muscle Tightness, Range of Motion, Dynamic Stretching
- Trial name
- NCT04925895
- Testing
- Dynamic soft tissue mobilization, Proprioceptive neuromuscular facilitation stretching, Cryotherapy
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Dow University of Health Sciences
Osteoarthritis, Knee, Osteo Arthritis Knee
OrthoCor Advanced Trial for Knee Osteoarthritis
The objective of this clinical trial is to show that PEMF therapy, heat, recovery metrics, and compliance data provided by the OrthoCor Advanced System improves pain and quality of life for patients with osteoarthritis.
- Trial name
- NCT06475677
- Testing
- OrthoCor Advanced System
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Caerus Corporation
Osteoarthritis, Knee
The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee
A clinical study to measure the effects of injection-site cooling on pain experienced after knee injections of capsaicin in healthy subjects and in patients with knee osteoarthritis.
- Trial name
- NCT03472677
- Testing
- Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), Capsaicin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Chronic Low Back Pain, Diabetic Peripheral Neuropathy
MR(Magnetic Resonance) Imaging of Neurotransmitters in Chronic Pain
This study is designed to assess: Hypothesis #1: That there is a significant central pain component in a distinct subset of patients diagnosed with knee osteoarthritis(KOA), Chronic low back pain(CLBP), painful diabetic…
- Conditions
- Chronic Low Back Pain, Diabetic Peripheral Neuropathy, Knee Osteoarthritis
- Trial name
- NCT01620775
- Testing
- MRIs, Pain testing
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pain Syndrome, Pain, Chronic
Validity, Reliability and Responsiveness of Pain Sensitization Questionnaire
The aim of this study was to translate the Pain Sensitivity Questionnaire, which was developed to determine the level of pain sensitivity of individuals, to Turkish and to evaluate the validity and reliability of the Turkish…
- Conditions
- Pain Syndrome, Pain, Chronic, Knee Osteoarthritis
- Trial name
- NCT04162730
- Testing
- Pressure pain threshold and behavioural data
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Acibadem University
Osteoarthritis of the Knee
Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis
Osteoarthritis (OA) is one of the most common joint diseases that is considered a chronic degenerative disorder. There is no effective therapy available today.
- Trial name
- NCT03166865
- Testing
- Umbilical-cord mesenchymal stromal cells (UC-MSCs), Hyaluronic acid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Liaocheng People's Hospital
Osteoarthritis of the Knee, Type 2 Diabetes Mellitus
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
The purpose of this study was to compare the effects of FX006 and Triamcinolone Acetonide Injectable Suspension, United States Pharmacopeia (USP) (referred to as TCA IR in the protocol) on blood glucose (BG) in patients with…
- Trial name
- NCT02762370
- Testing
- FX006 32 mg, TCA IR 40 mg
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Hemovac Drain Removal on Early Outcomes After Total Knee Arthroplasty
This study aims to evaluate whether the timing of Hemovac drain removal affects early clinical outcomes after primary total knee arthroplasty (TKA).
- Trial name
- NCT07342894
- Where
- Turkey (Türkiye)
- Volunteers
- 207 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis Pain of the Knee
A Study to Evaluate the Analgesic Efficacy and Safety of VM902A in Subjects With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the analgesic efficacy, safety, and tolerability of VM902A twice daily compared to placebo in subjects with moderate to severe chronic pain due to OA of the knee.
- Trial name
- NCT02847702
- Testing
- VM902A 200-mg Capsules, VM902A 400-mg Capsules, Naproxen 500-mg Capsules
- Where
- 31 sites in United States
- Volunteers
- 75 people
- Sponsor
- Purdue Pharma LP
Knee Osteoarthritis
Staged Versus Simultaneous Bilateral Knee Arthroplasty
The purpose of this study is to assist surgeons and patients in answering the question "Should I have both knees replaced at the same time, or should I just do one and wait to do the second one?"
- Trial name
- NCT03564730
- Testing
- Simultaneous Knee Arthroplasty (UKA), Staged Knee Arthroplasty (UKA)
- Where
- 8 sites in Canada
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Innovation Centre
Knee Osteoarthritis
Autologous Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis
Knee osteoarthritis (OA) is characterized by loss of cartilage leading to instability, reduced range of motion, and functional limitations.
- Trial name
- NCT03788265
- Testing
- Lipogems
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Degenerative Joint Disease
Journey II BCS EU Observational Trial
Post-market study to confirm the safety and efficacy of the Journey II BCS knee prosthesis.
- Trial name
- NCT02211794
- Testing
- data collection
- Where
- 5 sites in Belgium, Italy and 3 more
- Volunteers
- 179 people
- Sponsor
- Smith & Nephew Orthopaedics AG
Osteo Arthritis Knee, Knee Osteoarthritis
Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Methods
This is a prospective, randomized, controlled study. The purpose of this study is to assess functional and clinical changes among patients with symptomatic knee OA treated with intra-articular injections of autologous adipose…
- Conditions
- Osteo Arthritis Knee, Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT04321629
- Testing
- autologous adipose tissue transfer, PRP injections
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Rehasport Clinic
Osteoarthritis, Rheumatoid Arthritis
6 Week Open-label Trial With Lumiracoxib 200mg o.d. in Primary Knee Osteoarthritis or Rheumatoid Arthritis
This study tested the safety, tolerability and efficacy of lumiracoxib - a COX-2 inhibitor- in patients with primary knee osteoarthritis or rheumatoid arthritis.
- Trial name
- NCT00170872
- Testing
- Lumiracoxib
- Volunteers
- 135 people
- Sponsor
- Novartis
Knee Osteoarthritis
Early Outcomes of MAKO Medial Unicompartmental Knee Arthroplasty
To determine if robotically-assisted UKA results in more consistent and improved component positioning and better patient reported outcome scores compared to manual TKA and MAKO TKA.
- Trial name
- NCT05736601
- Testing
- focus motion knee brace
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Washington University School of Medicine
Osteoarthritis, Knee, Knee Pain
The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis
This is a non-surgical trial comparing the clinical and functional outcomes of patients with osteoarthritis treated with Intra-articular injection of Micro Fragmented Adipose Tissue versus conventional therapy of intra-articular…
- Trial name
- NCT03467919
- Testing
- Micro Fragmented Adipose Tissue, Corticosteroid injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
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