Clinical trials: Arthropathy of Knee
Osteoarthritis of the Knee
Evaluation of Amniotic Fluid Product in Knee Osteoarthritis
A study evaluating Amniotic Fluid compared to a Saline Placebo Injection in the treatment of subjects with osteoarthritic (OA) knee pain
- Trial name
- NCT02768155
- Testing
- Amniotic Fluid 4.0ml dose, Amniotic Fluid 2.0ml dose
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- MiMedx Group, Inc.
Osteoarthritis of the Knee, Total Knee Replacement
Prophecy Guide Outcomes in Total Knee Replacement Surgery
This project aims to assess two different techniques used to position the knee replacement implant during surgery. The patients will be randomised to receive either the following: 1.
- Trial name
- NCT01163708
- Testing
- Prophecy Technique, Navigation System
- Where
- 2 sites in Australia
- Volunteers
- 188 people
- Sponsor
- Global Orthopaedic Technology
Arthritis, Obesity & Overweight
GLP-1s in Hip and Knee Arthroplasty
The number of people living with hip and knee arthritis continues to grow. A large amount of these people are also overweight and diagnosed with obesity.
- Conditions
- Arthritis, Obesity & Overweight, GLP - 1
- Trial name
- NCT07755085
- Testing
- GLP-1 Receptor Agonists + Behavioral modification
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis, Knee
PFC Sigma Fixed and Mobile Knee Study
The primary objective of this investigation is to evaluate the performance (in terms of post-operative active range of motion at one year) of the P.F.C. Sigma and P.F.C.
- Trial name
- NCT00208325
- Testing
- P.F.C Sigma Fixed Bearing total knee system, P.F.C Sigma RP Mobile Bearing knee system
- Where
- 4 sites in United Kingdom
- Volunteers
- 754 people
- Sponsor
- DePuy International
Osteoarthritis
Identification of Biochemical and Biomechanical Markers for Cartilage Degeneration in the Knee Joint (IBBM-CKJ)
The association between varus malalignment and dynamic knee loading / adduction moment and progression of knee joint cartilage degeneration in the lateral compartment is unclear and has not been studied in detail before.
- Trial name
- IBBM-CKJ (NCT02555514)
- Volunteers
- 100 people
- Sponsor
- Dr. Jan Siewe
Osteoarthritis, Knee
Efficacy and Safety of Intraarticular Sodium Hyaluronate Single Injection in Patients With Osteoarthritis of the Knee
A Phase III, prospective, multicentre, non-controlled, with consecutive participant enrollment in order to evaluate the efficacy, safety and duration of the effects of the viscosupplementation with a preparation of sodium…
- Trial name
- NCT03852914
- Testing
- Sodium hyaluronate 2%
- Where
- 10 sites in Spain
- Volunteers
- 93 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Osteoarthritis (OA) of the Knee
Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty
Participants are being invited to take part in a research study about pain control after total knee replacement surgery (also called total knee arthroplasty or TKA).
- Trial name
- NCT07775248
- Testing
- Periarticular Injection, Adductor Canal Block, Bupivacaine-Meloxicam
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
Osteoarthritis, Knee
Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis
To assess if there are any differences among platelet-rich plasma, hyaluronic acid, and corticosteroid knee intra-articular injection regarding function and pain.
- Trial name
- NCT04980105
- Testing
- Platelet-rich plasma, Hyaluronic acid, Methylprednisolone acetate injectable suspension (DEPO-MEDROL®)
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- University of Wasit
Knee Osteoarthritis
Bespoke vs Standard Instrumentation in TKR
Total knee replacements are operations that are offered to patients who have severe arthritis pain that is affecting daily activities that is no longer controlled with painkillers.
- Trial name
- SPHERE (NCT05579951)
- Testing
- Patient specific instrumentation, Conventional
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- Manchester University NHS Foundation Trust
Osteoarthritis
Collaborative Model of Care Between Orthopaedics and Allied Healthcare Professionals Trial (CONnACT)
Osteoarthritis knee is the leading cause of chronic disability among older adults. Our current model of care is doctor-centric and inefficient leading to suboptimal use of allied health intervention for effective lifestyle and…
- Trial name
- NCT03809975
- Testing
- Multidisciplinary Community Program, Current model of care
- Where
- 2 sites in Singapore
- Volunteers
- 114 people
- Sponsor
- Tan Tock Seng Hospital
Knee Osteoarthritis
Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections
This study aims to compare the effects of hyaluronic acid injection and platelet rich plasma injection in terms of pain, physical function and femoral cartilage thickness in short term treatment in patients with knee…
- Trial name
- NCT03761472
- Testing
- Hyaluronic acid injection, Platelet-rich plasma injection
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Knee Osteoarthritis
Combination of PRP and XLHA Prepared With RegenMatrix Medical Device To Treat Moderate to Severe Knee Osteoarthritis
In this clinical trial the investigator assess the safety and efficacy of a single injection of a combination of cross-linked hyaluronic acid (HA) with autologous platelet-rich plasma (PRP) obtained with the RegenMatrix medical…
- Trial name
- NCT05727371
- Testing
- Regen Matrix-PRP-XLHA, Hylan G-F 20
- Where
- 13 sites in France
- Volunteers
- 280 people
- Sponsor
- RegenLab France SAS
Knee Osteoarthritis
Outcome of TKA Using Customized Cutting Block Compared With Conventional Intramedullary Cutting Guide
Customized cutting block and conventional cutting guide are both effective in improving accuracy and function of OA knee patients.
- Trial name
- NCT02128464
- Testing
- Patient specific cutting guides, Standard knee cutting guides
- Where
- Thailand
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Osteoarthritis of the Knee
Prospective Randomized Trial of Navigated and Conventional TKA
Evaluation of the component position and kinematics after navigated and conventional Total Knee Arthroplasty.
- Trial name
- NCT01022099
- Testing
- Implantation of a Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis, Knee
Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (United States)
To compare the efficacy and safety of celecoxib versus ibuprofen in subjects with osteoarthritis (OA) of the knee.
- Trial name
- NCT00620867
- Testing
- Ibuprofen, celecoxib
- Where
- 33 sites in United States
- Volunteers
- 393 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis, Knee
Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee
Safety \& Efficacy of FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to Osteoarthritis of the Knee.
- Trial name
- OA (NCT03441607)
- Testing
- mHACMb
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Applied Biologics, LLC
Osteoarthritis, Knee
A Long-Term Safety and Efficacy Study of Lorecivivint in Subjects With Osteoarthritis of the Knee
Study OA-07 was a randomized, double-blind, placebo-controlled, Phase 3, multicenter, 2-year clinical trial that enrolled subjects from the recently completed Study OA-11 (NCT03928184).
- Trial name
- NCT04520607
- Testing
- Lorecivivint
- Where
- 42 sites in United States
- Volunteers
- 276 people
- Sponsor
- Biosplice Therapeutics, Inc.
Arthropathy of Knee
How Many Dexamethasone Doses Should Be Given Perioperatively?
The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea…
- Trial name
- DEXA_PERIOP (NCT06715709)
- Testing
- Dexamethasone IV, Dexamethasone IV+Oral, Dexamethasone IV+Oral 2 Day
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Mayo Clinic
Obesity, Osteo Arthritis Knee
Group Education & Lifestyle Modification's Impact on Weight Loss & Quality Life of Patients with OA
Patients referred to Calgary's Alberta Hip \& Knee Clinic, while awaiting consultation with an orthopedic surgeon for hip or knee osteoarthritis, will be offered the opportunity to participate in a dietary counseling program with…
- Conditions
- Obesity, Osteo Arthritis Knee, Osteoarthritis, Hip
- Trial name
- NCT04439019
- Testing
- Lifestyle and dietary modification program
- Where
- Canada
- Sponsor
- Alberta Hip and Knee Clinic
Knee Osteoarthritis
Health Aid for Knee Osteoarthritis
Knee osteoarthritis is a common condition that can cause pain, stiffness, and difficulty with daily activities. Many patients interpret these symptoms as signs of ongoing joint damage, which can influence their expectations and…
- Trial name
- KOA-HAID (NCT07669532)
- Testing
- Health Aid, Decision Aid
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- David Ring
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.