Clinical trials: Arthropathy of Knee
Knee Osteoarthritis, Total Knee Arthroplasty
Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance
The investigators hypothesized that intraoperative opioid consumption would be different between remimazolam and propofol if the ANI-guided remifentanil continuous infusion rate was adjusted when the depth of anesthesia was…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Remimazolam
- Trial name
- NCT05322902
- Testing
- remimazolam group, propofol group
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Gangnam Severance Hospital
Osteoarthritis, Hip, Osteoarthritis, Knee
A Safety and Effectiveness Study of Acetaminophen (4000 mg/Day) and Naproxen (750 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee
The purpose of this study is to compare the long-term safety and effectiveness of acetaminophen (4000 mg per day) and naproxen (750 mg per day) in the treatment of osteoarthritis of the hip or knee.
- Trial name
- NCT00240773
- Testing
- acetaminophen, naproxen
- Volunteers
- 581 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Total Knee Arthroplasty
Clinical Study of Patellar Resurfacing and Non-resurfacing in Total Knee Arthroplasty
The literature regarding resurfacing of the patella in total knee arthroplasty has conflicting conclusions. This study assesses medium-term clinical results of total knee arthroplasties performed with and without the patellar…
- Trial name
- NCT03600922
- Testing
- the patella was resurfaced.
- Volunteers
- 66 people
- Sponsor
- Liaocheng People's Hospital
Knee Osteoarthritis (Knee OA)
Knee OsteoArthritis Long-term Assessment
The goal of this clinical study is to learn if Hydrogel OA 2% injection is safe and whether it works to improve symptoms of diagnosed knee osteoarthritis in adults when compared to Hyaluronic Acid (Durolane), a treatment that is…
- Trial name
- KOALA (NCT06839222)
- Testing
- Hydrogel OA 2%, Hyaluronic Acid (Durolane)
- Where
- 5 sites in Belgium
- Sponsor
- Allegro NV/SA
Gonarthrosis
Efficacy of Ultrasound-Guided Genicular Nerve Radiofrequency Ablation Therapy
The main symptom of knee osteoarthritis, which occurs after damage to the joint cartilage with age, is pain, but this symptom often becomes chronic.
- Trial name
- NCT06914960
- Testing
- 2-point Radiofrequency Ablation, 3-point Radiofrequency Ablation, 5-point Radiofrequency Ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Bengu Turemenogullari
Osteoarthritis of Knee
Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis
Primary aim: evaluate efficacy of intra-articular injection of etanercept for moderate and severe knee osteoarthritis. Second aim: investigate the potentiality of serum cytokines (TNF-α, Interleukin 1-α (IL1-α), IL1-β, matrix…
- Trial name
- EIAIETNKOA (NCT02722772)
- Testing
- Etanercept, Health education, exercise and diet guidance
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Necrosis of Femoral Head, Knee Osteoarthritis
MRI Maker of Perioperative Neurocognitive Disorder
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Lower Limb
- Trial name
- MRIPND (NCT03773627)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Knee Osteoarthritis, Aging
Effects of Specific Balance Training Prior TKR Surgery in the Early Postoperative Outcomes
Knee osteoarthritis is one of the most common pathologies in old people, and the leading cause of pain and disability. Symptoms include joint pain, stiffness, limited mobility, functional impairment and proprioceptive deficit.
- Trial name
- PRE_TKR_BLC (NCT02995668)
- Testing
- Strength-Function, Balance-Proprioception
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Valencia
Osteoarthritis, Knee
FibroFix Cartilage P Knee Implant Study
This is a multi-center first-in-human prospective clinical investigation to evaluate the safety and performance of the FibroFix™ Cartilage P Implant and Drill Set. The Implant is a medical device designed by Orthox Ltd.
- Trial name
- FFLEX (NCT05560490)
- Testing
- FibroFix Cartilage P Knee Implantation
- Where
- 2 sites in Hungary, United Kingdom
- Volunteers
- 2 people
- Sponsor
- Orthox Limited
Osteoarthritis, Knee
Safety of Intra-Articular Sc-rAAV2.5IL-1Ra in Subjects With Moderate Knee OA
This study seeks to determine the safety of three different doses of sc-rAAV2.5IL-1Ra delivered by intra-articular injection into one knee joint of patients with moderate OA of the knee.
- Trial name
- AAVIL-1Ra (NCT02790723)
- Testing
- sc-rAAV2.5IL-1Ra
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Hamstring Shortness, Patellofemoral Pain Syndrome
Effect of Specific Versus General Hamstring Stretch on Clinical Outcomes in Patellofemoral Pain Syndrome (PFPS)
This randomized, Single-blind, parallel-group trial will compare the effects of three hamstring stretching interventions-general hamstring Muscle Energy Technique (MET), medial hamstring MET, and lateral hamstring MET-each…
- Conditions
- Hamstring Shortness, Patellofemoral Pain Syndrome, Hamstring Flexibility, Patellofemoral Pain (PFPS)
- Trial name
- PFPS (NCT07013617)
- Testing
- Transcutaneous Electrical Nerve Stimulation Device, Strength exercises for lower limb, Hamstring Stretch Muscle Energy Technique(MET) (General )
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Osteoarthritis of the Knee
Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee
Subjects with chronic osteoarthritis of the knee will be assigned to receive an injection of either 1.2% sodium hyaluronate or buffered saline to evaluate its effectiveness and safety for 26 weeks.
- Trial name
- NCT00988091
- Testing
- 1.2% Sodium Hyaluronate, Buffered Saline
- Where
- 34 sites in United States
- Volunteers
- 596 people
- Sponsor
- Ferring Pharmaceuticals
Knee Osteoarthritis
Bracing to Treat Knee Osteoarthritis in Elderly
Background: Osteoarthritis (OA) is highly prevalent in the elderly, with the knee being the most commonly affected joint in this population. Knee braces are often used to prevent common problems in knees during daily activities.
- Trial name
- NCT02443974
- Testing
- Brace (Fisiotensor®), Sleeve (Fisiotensor®)
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis, Knee, Postoperative Pain
A Randomized Comparison of the Efficacy of the IPACK Block Versus the Popliteal Plexus Block for Posterior Knee Analgesia, in Patients Undergoing a Total Knee Arthroplasty and Receiving a Continuous Distal Femoral Triangle Block
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, including pain arising from the posterior aspect of the knee.
- Trial name
- NCT07876310
- Testing
- Ultrasound-Guided iPACK Block, Ultrasound-Guided Popliteal Plexus Block, Ultrasound-Guided Continuous Femoral Triangle Block
- Volunteers
- 136 people
- Sponsor
- Clinica Santa Maria
Synovial Diseases, Pigmented Villonodular Synovitis
Clinical Study of Magnetic Resonance Imaging and Deep Learning of Joint Synovial Disease
Through the high-throughput feature extraction of magnetic resonance images, the deep learning prediction model of joint synovial lesions is constructed used for the diagnosis, differential diagnosis and curative effect…
- Conditions
- Synovial Diseases, Pigmented Villonodular Synovitis, Gout, Rheumatoid Arthritis
- Trial name
- NCT04952896
- Testing
- Synovitis diagnosis
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Peking University Third Hospital
Osteoarthritis
Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (BTDS) (5, 10 and 20) in comparison to placebo transdermal system in subjects with moderate to severe…
- Trial name
- NCT00313846
- Testing
- Buprenorphine transdermal patch
- Where
- 44 sites in United States
- Volunteers
- 529 people
- Sponsor
- Purdue Pharma LP
Knee Osteoarthritis
Different Volumes of Durolane in Knee OA
The purpose of the study is to assess the safety and efficacy profiles of new single-injection volumes of Durolane in patients with knee OA.
- Trial name
- NCT01265459
- Testing
- Durolane 3 ml, Durolane 4,5 ml, Durolane 6 ml
- Where
- 3 sites in Sweden
- Volunteers
- 68 people
- Sponsor
- Galderma R&D
Osteoarthritis, Knee
Study of the KinexConnect Telerehabilitation System (KCTRS)
A randomized, single-blind study comparing telerehabilitation at home with continuous passive motion (CPM) and a tablet-based patient engagement application (KinexConnect) versus traditional outpatient physical therapy (PT)…
- Trial name
- KCTRS (NCT04191798)
- Testing
- Telerehabilitation using the KinexConnect system for rehabilitation after TKA., Traditional outpatient PT for rehabilitation after TKA.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kinex Medical Company, LLC
Knee Osteoarthritis
Platelet Rich Plasma and Neural Prolotherapy Injections in Treating Knee Osteoarthritis
Osteoarthritis (OA) of the knees is the most common degenerative disorder seen in a rehabilitation outpatient clinic. It is characterized by metabolic, biochemical, and structural changes in the articular cartilage and the…
- Trial name
- NCT04006314
- Testing
- Autologous platelet rich plasma and dextrose solution.
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Knee Arthropathy
Persistent Post Surgical Pain After Total Knee Arthroplasty
Patients undergone total knee replacement are randomized to receive a "fast track" regional anesthesia protocol or a "traditional" regional anesthesia continuous infusion by both a femoral and sciatic catheter to assess if this…
- Trial name
- NCT06182059
- Testing
- continuous peripheral nerve block
- Where
- Italy
- Volunteers
- 436 people
- Sponsor
- Policlinico di Monza SpA
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