Clinical trials: Arthropathy of Knee
Knee Osteoarthritis
Study to Evaluate the Iovera° Device for Temporary Relief From Knee Pain
This purpose of this study is to evaluate the effectiveness and safety of the iovera° device for the temporary reduction of pain associated with knee osteoarthritis.
- Trial name
- NCT02260921
- Testing
- iovera°
- Where
- 17 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Hip Osteoarthritis, Knee Osteoarthritis
Determining the Impact of a Physiotherapist-led Primary Care Model for Hip and Knee Pain - A Cluster Trial
This is a cluster randomized controlled trial to to evaluate the individual and health system impacts of implementing a new physiotherapist-led primary care model for hip and knee pain in Canada.
- Trial name
- NCT06358521
- Testing
- Physiotherapist-led primary care model for hip and knee pain, Usual physician-led primary care model for hip and knee pain
- Where
- Canada
- Volunteers
- 647 people, healthy volunteers welcome
- Sponsor
- Queen's University
Osteoarthritis, Knee, Epigenetic Disorder
Exercise on microRNA in Osteoarthritis
The present study is a prospective cohort study. This study will be conducted to determine the change in miRNA levels with exercise in knee Osteoarthritis (OA) patients.
- Conditions
- Osteoarthritis, Knee, Epigenetic Disorder, Quality of Life, Depression
- Trial name
- NCT05869630
- Testing
- Exercise Programme, Experiments
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Knee Osteoarthritis
To Evaluate the Optimum Dose of Platelet Rich Plasma in Knee Osteoarthritis and Compare Efficacy With Hyaluronic Acid
Randomized, Double-blind, 12-month, placebo-controlled study was conducted on 100 outpatients . Intervention platelet rich plasma( PRP) prepared from 60 ml of blood by adding novel step of filtration to manual centrifuge step to…
- Trial name
- NCT04198467
- Testing
- Platelet rich plasma, Hyaluronic Acid
- Volunteers
- 100 people
- Sponsor
- Dr. Himanshu Bansal Foundation
Knee Arthropathy
Persona Cohort Nordic Multicenter Study
In this project the investigators wish to: Evaluate intra-operative and postop complications, longer term survivorship and patient reported outcome measures (PROMs) following primary total knee replacement using Persona Total…
- Trial name
- NCT03495232
- Testing
- Zimmer Biomet Persona total knee system
- Where
- 4 sites in Denmark, France and 2 more
- Volunteers
- 700 people
- Sponsor
- Zimmer Biomet
Patellofemoral Pain Syndrome
Comparing the Outcome of Electrical Stimulation and Physical Therapy in Patellofemoral Pain Syndrome
The purpose of study is to evaluate the efficacy of the electrical muscle stimulation (EMS) device in patients with patellofemoral pain known as anterior knee pain. Usual treatment for it is physical therapy (PT).
- Trial name
- NCT03184545
- Testing
- EMS, Physical therapy
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Northwell Health
Knee Osteoarthritis
Amniotic Fluid Mesenchymal Stem Cells Developed for Chondrogenic Treatment (AFCC) Injection in Elderly Knee Osteoarthritis Patients
Amniotic fluid mesenchymal stem cells developed for chondrogenic treatment (AFCC) are used to treat elderly patients suffering from knee osteoarthritis (OA).
- Trial name
- NCT06386679
- Testing
- allogenic amniotic fluid mesenchymal stem cell
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Siriraj Hospital
Knee Osteoarthritis
Wearable LITUS Device for Osteoarthritis of the Knee: a Randomized Double-Blind Placebo-Controlled Trial
The purpose of this study is to measure the effectiveness of a wearable therapeutic ultrasound device in patients with stage I and stage II knee osteoarthritis.
- Trial name
- NCT02083861
- Testing
- Sam Ultrasonic Diathermy Device
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- ZetrOZ, Inc.
Knee Osteoarthrosis
Use of Wharton Jelly Derived Mesenchymal Stem Cells for Knee Osteoarthrosis
Wharton Jelly derived Mesenchymal Stem Cells (WJMSC) will be injected in patients diagnosed with Knee osteoarthrosis
- Trial name
- NCT02963727
- Testing
- Wharton Jelly derived mesenchymal stem cell
- Where
- Jordan
- Volunteers
- 10 people
- Sponsor
- Hanan Jafar
Anterior Knee Pain Syndrome
10-year Follow-up After Tibial Tubercle Transposition
Patellofemoral pain is a common complaint especially in young adults. It can be caused by patellar maltracking. Part of this is a patella alta.
- Trial name
- TTTfollow-up (NCT05629754)
- Testing
- MRI, radiological assessment
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Centre for Orthopaedic Research Alkmaar
Hip Osteoarthritis, Knee Osteoarthritis
Face to Face or Digitally Delivered First-line Osteoarthritis Treatment?
This study will compare outcomes of two different delivery methods (Face-to-face and digitally) of first-line treatment for hip and knee osteoarthritis.
- Trial name
- NCT04836988
- Testing
- Three months of digitally delivered osteoarthritis treatment, Three months of face-to-face delivered osteoarthritis treatment
- Where
- Sweden
- Volunteers
- 6,946 people
- Sponsor
- Lund University
Pain, Osteoarthritis
APIC-CF Therapy for Mild to Moderate Osteoarthritis of the Knee
The mechanism of Osteoarthritis (OA) is complex, however the investigators know that cartilage breakdown follows changes in certain cells in the cartilage called chondrocytes, leading to proteases that break down cartilage.
- Trial name
- NCT02210468
- Testing
- APIC-CF, 4 cc, APIC-CF, 2 cc
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cytonics Corporation
Osteoarthritis, Knee, Osteoarthritis, Hip
Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee
The primary objective of the study is to evaluate the effect of fasinumab compared to placebo on peripheral nerves in participants with pain due to Osteoarthritis (OA) of the hip or knee.
- Trial name
- NCT03691974
- Testing
- Fasinumab
- Where
- 47 sites in United States, Poland and 1 more
- Volunteers
- 180 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis
Use of Autologous Adipose-Derived Stromal Vascular Fraction To Treat Osteoarthritis of Hip, Knee, Ankle, and Thumb Joints
This study will examine the safety and efficacy of autologous adipose-derived stromal vascular fraction (SVF) cells for treatment of hip, knee and thumb osteoarthritis (OA); monitoring adverse events and measuring pain, function…
- Trial name
- NCT03166410
- Testing
- Cell injection
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Texas Plastic Surgery
Knee Arthritis, Osteoarthritis
Platelet-Rich Plasma Composition and Clinical Effects in Knee Osteoarthritis
This is a prospective, observational cohort study involving 40 patients with primary knee osteoarthritis hospitalized in a rehabilitation hospital in Cluj-Napoca.
- Trial name
- NCT07558980
- Testing
- intra-articular administration of plasma rich in platelets (PRP)
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Knee Osteoarthritis, Pain
Anatomical Axis on X-Ray and Its Relationship With Pain and Kinesiophobia in Knee Osteoarthritis
Knee osteoarthritis is a common joint disease that causes pain, stiffness, and limitations in daily activities, especially in older adults.
- Conditions
- Knee Osteoarthritis, Pain, Kinesiophobia
- Trial name
- KOA-AXIS (NCT07168590)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Selim Sezikli
Knee Osteoarthritis
Prosthesis and Surgery Guide System for Personalized Total Knee Arthroplasty
The subject is planned to carry out the clinical trails of femoral condyle prosthesis, tibial tray prosthesis and meniscus prosthesis; At the same time, in order to achieve personalized precision bone resection, the clinical…
- Trial name
- NCT04963491
- Testing
- Personalized TKA prosthesis, Zimmer NexGen prostheses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Osteo Arthritis Knee
Effects of Retro-walking in Patients With Knee OA
Osteoarthritis is degenerative joint disease that cause deterioration of the articular cartilage and neighboring tissue and lead to osteophyte formation, weakening of surrounding muscles, ligamentous laxity and inflammation of…
- Trial name
- NCT06130774
- Testing
- Retro walking and conventional, conventional therapy
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Osteoarthritis
Comparison of a Minimally Invasive Technique for Total Knee Replacement to a Standard Technique
Comparison of a minimally invasive technique for total knee replacement to a standard technique
- Trial name
- NCT00175474
- Testing
- knee surgery
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- University of British Columbia
Osteoarthritis, OA Knee Pain
Open-label Extension Study Of RN624
Study RN624-CL007 is planned to be an open-label protocol to enroll subjects who have previously participated in Study No. RN624-CL006. In this study, subjects will receive RN624 on an open-label basis.
- Conditions
- Osteoarthritis, OA Knee Pain, Arthritis
- Trial name
- NCT00399490
- Testing
- RN624 (PF-04383119)
- Where
- 36 sites in United States
- Volunteers
- 287 people
- Sponsor
- Pfizer
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