Clinical trials: Arthropathy of Knee
Osteoarthritis, Knee
The Effect of Spironolactone on Pain in Older People With Osteoarthritis
This pilot study will obtain preliminary evidence on which to base sample size calculations for a future trial of whether spironolactone (an aldosterone blocker) reduces knee pain in older people with symptomatic OA knee when…
- Trial name
- SPIR-OA (NCT02046668)
- Testing
- spironolactone
- Where
- 2 sites in United Kingdom
- Volunteers
- 86 people
- Sponsor
- University of Dundee
Osteoarthritis
Visual Feedback Non-weight Bearing Exercise on the Elderly With Knee Osteoarthritis.
Degenerative knee arthritis is the most common chronic arthritis disease. Once the elderly suffer from this disease, it will accelerate the loss of body function and autonomy.
- Trial name
- NCT04919486
- Testing
- visual feedback with non-weight bearing exercise, elastic band exercise
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Osteo Arthritis Knee
Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals
This pilot study aims to investigate the viability of using a smartwatch-based electrodermal activity (EDA) sensor to capture enough EDA signal to quantitatively assess pain in osteoarthritis subjects and test the feasibility of…
- Trial name
- NCT06701461
- Testing
- Electrodermal Activity signal
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Knee Arthropathy
Fibrin Glue or Tranexamic Acid for Total Knee Arthroplasty
Objectives: a) Principal: To assess if the fibrin glue or the tranexamic acid reduce less than 20% the blood losses with respect to the habitual haemostasia in patients with arthroplasty total of knee.
- Trial name
- ATRHEMOS (NCT01306370)
- Testing
- Tranexamic Acid, Fibrin glue, Habitual haemostasis
- Where
- Spain
- Volunteers
- 172 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip
iPACK Block vs. Periarticular Infiltration for TKA Pain Control
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA).
- Trial name
- NCT07267650
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Turgutlu State Hospital
Osteoarthritis
Clinical Trial to Examine the Pain Relief of PH-797804 Alone Or With Naproxen in Subjects With Osteoarthritis of the Knee
PH-797804 is a potent inhibitor of inflammatory mediators that have a potential role in pain signalling following nerve injury and inflammation. Blocking such mediators may potentially have a therapeutic benefit by reducing pain.
- Trial name
- NCT01102660
- Testing
- PH-797804, Naproxen, Naproxen + PH-797804
- Where
- 26 sites in United States
- Volunteers
- 172 people
- Sponsor
- Pfizer
Pain, Osteo Arthritis Knee
Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee
This is a phase 2, randomized, double-blind, placebo-controlled trial of multiple doses and multiple administrations of LEVI-04 for the treatment of pain due to osteoarthritis of the knee.
- Conditions
- Pain, Osteo Arthritis Knee, Knee Osteoarthritis, Arthritis
- Trial name
- NCT05618782
- Testing
- LEVI-04
- Where
- 13 sites in Czechia, Denmark and 3 more
- Volunteers
- 518 people
- Sponsor
- Levicept
Knee Osteoarthritis (Mild to Moderate, Medial Compartment)
Enhancing Medial Knee Pain Rehabilitation : A Clinical Trial On The Effectiveness Of Blood Flow Restriction In Combination With Targeted Exercises For Adult With Varus Deformity
Medial knee pain is common in active adults with varus knee alignment and can limit daily and sports activities. Standard physiotherapy can reduce pain and improve function, but strength gains may be suboptimal when patients…
- Trial name
- NCT07283237
- Testing
- Targeted Exercise Program, Blood Flow Restriction (BFR) Training with Targeted Exercise Program
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Osteoarthritis of Knee
The Effect of Balneotherapy on Knee Osteoarthritis
Osteoarthritis (OA) is a chronic degenerative disease characterized by the breakdown and repair processes of the cartilage structure in synovial joints.
- Trial name
- Balneotherapy (NCT07008937)
- Testing
- Balneotherapy, home exercise program
- Volunteers
- 50 people
- Sponsor
- Ahi Evran University Education and Research Hospital
Osteoarthritis of the Knee
Intraarticular Ozone Therapy for Pain Control in Osteoarthritis of the Knee
The purpose of this study is to determine whether an intraarticular injection of Ozone into the knee joint is an effective therapy for pain control in patients with osteoarthritis of the knee.
- Trial name
- NCT00832312
- Testing
- ozone-oxygen mixture
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Ben-Gurion University of the Negev
Osteoarthritis, Knee, Breast Cancer
Assessment of 99mTc-NTP 15-5 Uptake on Cartilage, a New Proteoglycan Tracer
This study is a phase I clinical trial aimed to determine the recommended dose of 99mTc-NTP 15-5 to obtain the best tracer joints contrast on images without any toxicity.
- Trial name
- CARSPECT (NCT04481230)
- Testing
- 99mTc-NTP 15-5 at a diagnostic activity of 5 MBq/kg, 99mTc-NTP 15-5 at a diagnostic activity of 10 MBq/kg, 99mTc-NTP 15-5 at a diagnostic activity of 15 MBq/kg
- Where
- 2 sites in France
- Volunteers
- 6 people
- Sponsor
- Centre Jean Perrin
Osteoarthritis of the Knee
Triathlon PKR Study in Japan
The Purpose of this study is to evaluate compatibility of the Triathlon Partial Knee Replacement (PKR) with the Japanese population.
- Trial name
- NCT02552095
- Testing
- Triathlon PKR
- Where
- 5 sites in Japan
- Volunteers
- 63 people
- Sponsor
- Stryker Japan K.K.
Knee Osteoarthritis
Biomarkers and Knee Osteoarthritis
High joint load during walking has been linked to cartilage degradation. Biomarkers, found in the blood and urine, are protein fragments released after cartilage degradation characteristic of OA.
- Trial name
- NCT01241812
- Testing
- Lower limb muscle strengthening
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- University of British Columbia
Osteoarthritis, Sarcopenia
The Strong Brain Study
To evaluate operational aspects of studying pre to post surgery/hospitalization changes in the integrity of a major white matter pathways and how these contribute to reductions in the ability to produce forceful muscle…
- Trial name
- NCT02320864
- Testing
- Total knee replacement surgery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Florida
Arthropathy of Knee
How Many Dexamethasone Doses Should Be Given Perioperatively?
The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea…
- Trial name
- DEXA_PERIOP (NCT06715709)
- Testing
- Dexamethasone IV, Dexamethasone IV+Oral, Dexamethasone IV+Oral 2 Day
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Mayo Clinic
Gonarthrosis, Knee Osteoarthritis
Efficacy of Craniosacral Therapy in Patients With Gonarthrosis
This randomized controlled trial was designed to investigate the effects of craniosacral therapy on pain, heart rate variability, joint stiffness, physical function, quality of life, body image, kinesiophobia, and dynamic balance…
- Trial name
- NCT07372534
- Testing
- Craniosacral Therapy, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Ankara Yildirim Beyazıt University
Medial Compartment Knee Osteoarthritis
Effects of Lateral Wedge Insoles, Knee Taping on the Management of Knee Osteoarthritis
Knee osteoarthritis (OA) is a degenerative, progressive and wide spread disease, which may lead the patient to severe outcomes e.g. pain, loss of joint motion, inflexibility, disability and decreases the quality of life (QOL).
- Trial name
- NCT03848130
- Testing
- Mulligan Knee Taping with Home Exercises, Lateral wedge insoles with Home Exercises, Traditional Physiotherapy with Home Exercises
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Isra University
Pain Associated With Osteoarthritis of the Knee
A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis Knee Pain
This is a Phase 3, Multicenter, 22-Week, double-blind and 30-Week open label Study to Evaluate the Efficacy and Safety of X0002 Spray in relief of pain of subjects with Osteoarthritis of the Knee.
- Trial name
- NCT03081806
- Testing
- X0002
- Where
- 33 sites in United States
- Volunteers
- 399 people
- Sponsor
- Techfields Pharma Co. Ltd
Knee Osteoarthritis
A Study of NCR100 Injection for the Treatment of Knee Osteoarthritis（ KOA）
This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It contains two parts dose-escalating, and blind random study in adult KOA subjects.
- Trial name
- NCT06741098
- Testing
- NCR100, 0.9% Normal saline
- Volunteers
- 162 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Osteo Arthritis Knee, Osteoarthritis, Knee
OA Optimization Program Pilot Trial
Total joint replacement is a highly successful treatment option for people affected by severe osteoarthritis (OA), however, the mismatch between resources and demand for this surgery means that many patients face long wait times…
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis
- Trial name
- NCT05389371
- Testing
- Alberta Healthy Living Program, Alberta Obesity Centre Program, Osteoarthritis advice
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Calgary
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