Clinical trials: Arthropathy of Knee
DVT, Osteoarthritis
Does Thinning the Blood During Surgery Prevent Blood Clots Following Total Knee Replacement Surgery
The goal of this study is to prevent blood clots from forming during surgery and a few days after total knee replacement surgery.
- Trial name
- NCT00253851
- Testing
- unfractionated heparin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Knee Osteoarthritis
Observation of the Clinical Efficacy of Two Surgical Procedures for Varus Knee Osteoarthritis
The purpose of this study is to conduct a prospective randomized controlled trial to compare the effects between two surgical procedures in the treatment of varus knee osteoarthritis.The hypothesis was that there would be no…
- Trial name
- NCT05382429
- Testing
- OWHTO, CWHTO
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Osteoarthritis of the Knee, Pain
A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee
The primary objective of the study is to evaluate the efficacy of REGN5069 compared to placebo in patients with pain due to radiographically-confirmed OA of the knee who have a history of inadequate joint pain relief or…
- Trial name
- NCT03956550
- Testing
- REGN5069
- Where
- 12 sites in United States, Georgia and 3 more
- Volunteers
- 259 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Acute and Chronic Pain
Acute Effect of Inferential Therapy (IFT) and Short Wave Diathermy (SWD) on Balance in Subjects With Knee Pain
Background: The Y balance test is a dynamic test that requires strength, flexibility, and proprioception. It is a measure of dynamic balance that provides a significant challenge to athletes and physically active individuals.
- Trial name
- IFT & SWD (NCT04148768)
- Testing
- Inferential therapy, short wave diathermy
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- King Khalid University
Osteoarthritis, Knee, Osteoarthritis, Hip
Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee
The primary objective of the study is to evaluate the effect of fasinumab compared to placebo on peripheral nerves in participants with pain due to Osteoarthritis (OA) of the hip or knee.
- Trial name
- NCT03691974
- Testing
- Fasinumab
- Where
- 47 sites in United States, Poland and 1 more
- Volunteers
- 180 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis, Knee
Calypso Knee System Clinical Sub-study, OUS Continued Evaluation
Calypso Knee System Clinical Study, OUS for subjects with symptomatic osteoarthritis of the medial compartment of the knee. The sub-study will achieve continued evaluation of the safety and clinical effectiveness of the Calypso…
- Trial name
- NCT04548882
- Testing
- Calypso Knee System
- Sponsor
- Moximed
Arthritis Knee, Anesthesia
Prediction Model of Acute Postoperative Pain in Bilateral Total Knee Replacement Arthroplasty Patient
This study aims to predict risk factors of acute postoperative pain of the patients undergoing Total Knee Replacement Arthroplasty(TKRA).
- Conditions
- Arthritis Knee, Anesthesia, Arthropathy of Knee
- Trial name
- NCT03765723
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Osteoarthritis of the Knee, Type 2 Diabetes Mellitus
Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes
The purpose of this study was to compare the effects of FX006 and Triamcinolone Acetonide Injectable Suspension, United States Pharmacopeia (USP) (referred to as TCA IR in the protocol) on blood glucose (BG) in patients with…
- Trial name
- NCT02762370
- Testing
- FX006 32 mg, TCA IR 40 mg
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis
Pivotal Study to Evaluate Efficacy and Safety of SP5M002 Inj. as Compared to Synovian Inj. in Patients With Mild to Moderate Knee Osteoarthritis
This is a randomized, double-blind, multicenter, Active Controlled, pivotal clinical trial to assess the efficacy and safety of the novel hexamethylenediamine (HMDA) cross-linked hyaluronate intra-articular injection (SP5M002)…
- Trial name
- NCT06399042
- Testing
- SP5M002 inj, Synovian inj
- Where
- 16 sites in South Korea
- Volunteers
- 297 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Knee Osteoarthritis, Bone; Deformity, Congenital
COREV 2.0 PMCF-Study on Manual and Navigated Revision Knee Patients
The Columbus® Revision endoprosthetic system is bearing the CE-mark. This means that within the scope of this observational study the patient will not be subjected to any additional stressful, study-related medical examinations…
- Conditions
- Knee Osteoarthritis, Bone; Deformity, Congenital, Prosthesis Failure, Prosthesis-Related Infections
- Trial name
- COREV (NCT05113303)
- Testing
- Navigated Revision Total Knee Arthroplasty, Manual Revision Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Knee Osteoarthritis
Effectiveness of Inertial Sensors vs the Conventional Technique for the Execution of the Bone Resections in Primary TKA
Comparison of surgical technique for the execution of bone resections in total knee arthroplasty. Used technique are: a non-invasive extramedullary technique (EM technique) based on the use of inertial sensors for cutting guides…
- Trial name
- NCT04242303
- Testing
- Total knee replacement
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Injury, Knee Osteoarthritis
Monitoring Of Helsingborg Acute Knee Injuries (MOHAK)
Using magnetic resonance imaging (MRI), laboratory analyses and patient reported outcomes, the overall aim of this study is to investigate structural injuries and biochemical alterations in the acutely injured knee and to relate…
- Trial name
- NCT01382173
- Where
- Sweden
- Volunteers
- 192 people
- Sponsor
- Lund University
Osteoarthritis, Knee
Treatment of Osteoarthritis With Autologous, Microfragmented Adipose Tissue.
The study is a blinded, multicenter, randomized, controlled trial with participants individually randomized to one of two parallel groups: 1.
- Trial name
- NCT03771989
- Testing
- autologous, micro-fragmented adipose tissue, Saline
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Hvidovre University Hospital
Joint Diseases, Knee
Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis
We believe we can demonstrate a link between the analgesic action of intra-articular injection of botulinum toxin and synovial inflammation by Dynamic Contrast Enhancement (DCE) perfusion Magnetic Resonance Imaging (MRI).
- Conditions
- Joint Diseases, Knee, Therapeutics, Magnetic Resonance Imaging
- Trial name
- TOXART (NCT03726788)
- Testing
- Botulinum Toxin Type A 100U, Botulinum Toxin Type A 200U, Triamcinolone Hexacetonide Inj Susp 20 MG/ML
- Where
- France
- Sponsor
- Lille Catholic University
Osteoarthritis, Arthralgia
Leeches for the Treatment of Knee Osteoarthritis
Previous studies have not addressed the question, whether or not a repeated leeching can supply symptomatic relief of osteoarthritic pain for extended periods of time.
- Trial name
- NCT00435773
- Testing
- Single Leeching, Repeated Leeching after 4 weeks
- Where
- Germany
- Volunteers
- 118 people
- Sponsor
- RWTH Aachen University
Osteo Arthritis Knee, Platelet-rich Plasma
Platelet Rich Plasma for Knee Osteoarthritis
This study aimed to analyze the effect of platelet-rich plasma (PRP) on knee osteoarthritis. Eligible patients will undertake arthroscopic knee surgery plus intraoperative PRP and also receive second look surgery and…
- Trial name
- NCT03197441
- Testing
- Platelet-rich plasma
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- Pei-Yuan Lee, MD
Osteoarthritis
Efficacy and Safety of RTX-GRT7039 in Adult Subjects With Knee Osteoarthritis
A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of repeated injections of RTX-GRT7039 versus placebo in patients who have pain associated with…
- Trial name
- NCT05248386
- Testing
- RTX-GRT7039
- Where
- 103 sites in Canada, Czechia and 7 more
- Volunteers
- 469 people
- Sponsor
- Grünenthal GmbH
Post-Traumatic Osteoarthritis of Knee, Knee Injuries
Changes in the Immunomodulatory Properties of Adipose Stromal Cells Due to Hemarthrosis After Knee Injury
The goal of this observational study is to gain insight in the natural course of pro-inflammatory factors and hemarthrosis in patients older than 18 with a recent knee trauma.
- Conditions
- Post-Traumatic Osteoarthritis of Knee, Knee Injuries, Hemarthrosis
- Trial name
- CASH (NCT05687331)
- Testing
- knee arthrocentesis, venipuncture, MRI-scan
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Non-inflammatory Degenerative Joint Disease
Journey™ UNI Post Market Clinical Follow-Up
This is a retrospective/prospective, open-label single cohort, multicenter study to collect relevant clinical data from 147 subjects with unicompartmental degeneration of the knee in whom the Journey UNI UKS was previously…
- Trial name
- Journey UNI (NCT03442231)
- Testing
- Journey UNI Unicompartmental Knee System
- Where
- 4 sites in United States, Canada
- Volunteers
- 147 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
Single Cutting Guides System for the Installation of a Total Knee Replacement
The knee prosthesis is a validated treatment for end-stage of knee osteoarthritis, and this intervention usually provides a significant improvement in the quality of life of patients.
- Trial name
- NCT02429245
- Testing
- Retrospective study
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France