Clinical trials: Arthroplasties, Replacement
Total Joint Replacement Surgery, Postoperative Nausea and Vomiting
Aromatherapy in Reducing PONV for Total Joint Replacement Patients
This study investigates the effectiveness of aromatherapy in reducing postoperative nausea and vomiting (PONV) among patients undergoing total joint replacement surgery, as these complications can lead to patient discomfort and…
- Trial name
- RCT PONV (NCT07281885)
- Testing
- Aromatherapy patches, Control (Standard treatment)
- Where
- Hong Kong
- Volunteers
- 159 people
- Sponsor
- Hong Kong Buddhist Hospital
Knee Osteoarthritis
Bespoke vs Standard Instrumentation in TKR
Total knee replacement (TKR) is an established treatment for knee osteoarthritis and leads to a satisfactory outcome in over 75% of patients.
- Trial name
- NCT02845206
- Testing
- Patient specific cutting blocks, Conventional cutting blocks
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- NHS Lothian
Arthroplasty Complications, Muscle Weakness
Achilles Tendon for the Treatment of Gluteus Medius Insufficiency
Residual limping after total hip arthroplasty is a serious complication that lacks effective treatment. The purpose of this study is to evaluate a surgical treatment for residual limping and compare its results with non-surgical…
- Conditions
- Arthroplasty Complications, Muscle Weakness, Muscle Atrophy, Muscle Tear
- Trial name
- HLS (NCT05206838)
- Testing
- Surgical reconstruction of gluteus medius with Achilles tendon allograft
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Sahlgrenska University Hospital
Osteoarthritis, Knee
A Single Time-Point Study to Evaluate the ConforMIS iTotal (PS) Knee Replacement System Versus Off-the-Shelf
This study is designed to compare outcome data for patients who have recently undergone surgery with the iTotal® Posterior Stabilizing (PS) Knee Replacement System (hereafter referred to as the "iTotal") versus those who have…
- Trial name
- NCT03146819
- Testing
- iTotal PS Knee Replacement System, Off-the-Shelf Knee Replacement System
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Restor3D
Arthroplasty, Replacement, Knee, Total Knee Replacement
X-3 Polyethylene Survival Outcomes Study
The goal of this clinical trial is to compare two types of polyethylene (Stryker Orthopaedics N2Vac and their X3 polyethylene) prostheses that are used in total knee replacements.
- Trial name
- NCT00493792
- Testing
- X3 Polyethylene, N2Vac Polyethylene
- Where
- 3 sites in United States
- Volunteers
- 518 people
- Sponsor
- Mayo Clinic
Postoperative Pain, Delirium
Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery
Pain, confusion, and breaks in normal sleep cycles have been challenges commonly faced by patients after undergoing joint surgeries.
- Conditions
- Postoperative Pain, Delirium, Confusion, Sleep
- Trial name
- NCT01505465
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Arthroplasty, Replacement, Knee
Wearable Sensors for Monitoring Recovery After Total Knee Arthroplasty
The goal of this observational study is to investigate the potential of wearable sensors for monitoring the postoperative recovery of patients after TKA.
- Trial name
- NCT05992064
- Testing
- Measuring gait
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aalborg University Hospital
Total Hip Replacement
Digital Healthcare App After Total Hip Arthroplasty
This study examines the effectiveness of rehabilitation after hip replacement surgery using a specialised app called Akina Cloud. Medical professionals at the Schulthess Clinic will provide detailed information about the study.
- Trial name
- NCT06409312
- Testing
- Akina Cloud
- Volunteers
- 20 people
- Sponsor
- Schulthess Klinik
Postoperative Pain
Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia
This is a Phase 2b, randomized, double-blind, saline placebo- and active-controlled, multicenter study in subjects undergoing primary unilateral total knee arthroplasty (TKA) to evaluate the analgesic efficacy, safety, and…
- Trial name
- NCT03015532
- Testing
- HTX-011, Bupivicaine HCl, Ropivacaine
- Where
- 24 sites in United States
- Volunteers
- 285 people
- Sponsor
- Heron Therapeutics
Knee Arthroplasty, Total
Manual Lymphatic Drainage Following Total Knee Arthroplasty Surgery
The purpose of this study is to evaluate the efficiency of manual lymphatic drainage to decrease the swelling of the knee after total knee replacement surgery
- Trial name
- NCT00711711
- Testing
- Manual lymphatic drainage, relaxation
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Haute Ecole de Santé Vaud
Hypnosis, Perioperative Care
Hypnosis for Symptom Management in Elective Orthopedic Surgery
The purpose of the study is to determine if teaching self-hypnosis techniques to patients prior to knee replacement surgery will decrease their pain medication requirements, pain medication side-effects, length of stay in the…
- Conditions
- Hypnosis, Perioperative Care, Knee Arthroplasty, Total, Postoperative Pain
- Trial name
- NCT03308071
- Testing
- Hypnosis
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Stanford University
Obstructive Sleep Apnea
A Pilot Study of Biomarkers in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is common and is a risk factor for postoperative complications, including respiratory and cardiac events and delirium.
- Trial name
- Cytokine OSA (NCT02325687)
- Testing
- Lumbar Puncture (Standard-of-Care)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Hypotension, Blood Pressure, Low
The Status of Autonomic Tone Before Tourniquet Deflation During Total Knee Replacement
This study evaluates the influences of the status of sympathovagal balance before tourniquet deflation on a decrease in arterial blood pressure following the deflation during total knee replacement arthroplasty
- Trial name
- NCT03408301
- Testing
- Tourniquet deflation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Daegu Catholic University Medical Center
Total Knee Arthroplasty
Biological Link Between Anxiety and Outcomes Post Knee Arthroplasty
This is a single-site, observational pilot study that aims to understand whether there is a biological explanation for why some patients with anxiety or depression experience poorer outcomes after total knee or hip replacement…
- Trial name
- NCT07102563
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Osteoarthritis of the Knee
Genicular Radiofrequency Ablation for Unilateral Knee Arthroplasty Pain Management
Three primary reasons prolong hospital stays following unilateral knee arthroplasty. Pain is the primary reason followed by opioid drowsiness and nausea/vomiting side effects.
- Trial name
- RFA (NCT02925442)
- Testing
- t-RFA, C-RFA, Control
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lyman Medical Research Foundation, Inc.
Osteoarthritis, Total Knee Replacement
Adductor Canal Block
The investigators aim to investigate whether the addition of a surgeon-administered adductor canal blockade to a multimodal periarticular injection cocktail provides additional pain relief for patients undergoing total knee…
- Trial name
- NCT04513145
- Testing
- Ropivacaine injection, Saline Injection, Total Knee Arthroplasty
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- OrthoCarolina Research Institute, Inc.
Arthroplasty, Replacement
Effectiveness of Pulsed Radiofrequency of the Saphenous Nerve in the Management of Knee Arthroplasty Pain
Approximately 40% of patients undergoing total knee arthroplasty develop acute to moderate post operative pain. Furthermore 20-30% develop chronic post operative pain.
- Conditions
- Arthroplasty, Replacement, Knee, Pain
- Trial name
- NCT03450681
- Testing
- Pulsed radiofrequency of the saphenous nerve before knee replacement surgery, Mock incision
- Volunteers
- 111 people
- Sponsor
- Fundación Santa Fe de Bogota
Arthroplasty Total Hip Replacement
The Relationship Between Operative and Radiologic Stem Version
Investigators prospectively evaluate the accuracy of intraoperative stem anteversion in 40consecutive total hip arthroplasties.
- Trial name
- NCT02552173
- Testing
- The Relationship Between Operative and Radiologic Stem Version
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Knee Osteoarthristis, Arthroplasty Replacement, Knee
Return to Sports After Knee Arthroplasty
The ability to return to sports after joint arthroplasty is increasingly becoming an important factor for patients in terms of their perceived quality of life.
- Trial name
- RTS (NCT07183475)
- Testing
- Return to sports test
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Arthroplasty Complications
Are Elastic Restraints Still Necessary in Improved Rehabilitation Programs After Hip and Knee Prosthetic Surgery?
Venous thrombosis and pulmonary embolism are considered serious and potentially preventable complications of hip and knee replacement surgery.
- Trial name
- NCT06563531
- Testing
- Pharmacological thromboprophylaxis and elastic compression, Pharmacological thromboprophylaxis without elastic compression
- Where
- France
- Volunteers
- 1,274 people
- Sponsor
- Clinique Pasteur Lanroze
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