Clinical trials: Arthroplasties, Replacement
Hip Osteoarthritis, Hip Arthroplasty Replacement
Virtual Reality for Intraoperative Anxiolysis and Postoperative Agitation in Elderely Hip Arthroplasty Patients
This study evaluates the effectiveness of Virtual Reality (VR) as a non-pharmacological intervention to reduce intraoperative anxiety and postoperative agitation in elderly patients undergoing elective hip arthroplasty under…
- Conditions
- Hip Osteoarthritis, Hip Arthroplasty Replacement, Emergence Delirium, Anesthesia, Emergence Agitation
- Trial name
- VR (NCT07705451)
- Testing
- immersive virtual reality, standard sedation
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Osteoarthritis, Knee
Alignment Comparison Between TruMatch™ Personalized Solutions and Conventional Total Knee Replacement Instrumentation
This investigation is intended to provide clinical information about alignment using TruMatch™ and to compare the results to a conventional total knee replacement.
- Trial name
- NCT01108237
- Testing
- TruMatch™ Personalized Solutions, Total Knee Arthroplasty with Conventional Instrumentation.
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- DePuy Orthopaedics
Total Knee Replacement
The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty
The purpose of this study is to explore the acceptability and feasibility of weighted blankets in total knee replacement (TKR) patients.
- Trial name
- NCT07219329
- Testing
- Weighted Blanket
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Osteoarthritis
Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement
This single-blind, randomized, controlled trial is designed to test the effect of an intensive, 16 week exercise rehabilitation program (progressive resistance training + functional mobility training) vs.
- Trial name
- TWEAK (NCT02628795)
- Testing
- PRT + FM, Usual Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Total Joint Replacement Surgery
A Rehabilitation Tool to Determine Patient's Stay in Hospital After Joint Replacement
This is the research study of a rehabilitation tool that informs, guides and empowers clinicians to care for their patients. We hope to learn ways to improve patient outcomes, reduce costs and increase value to the healthcare…
- Trial name
- NCT03776357
- Testing
- VERA clinic
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Derek Amanatullah
Arthroplasty
Efficacy and Safety Study of 4975 in Patients Undergoing Total Hip Replacement
Evaluate the efficacy, safety and tolerability of a single intraoperative dose of 4975 in patients undergoing total hip replacement
- Trial name
- NCT00683267
- Testing
- 4975, highly purified capsaicin
- Where
- 10 sites in United States
- Volunteers
- 118 people
- Sponsor
- Anesiva, Inc.
Osteoarthritis, Hip Infection
Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement
Infection remains one of the most difficult-to-treat complications of total hip arthroplasty. The gold standard treatment is two-stage removal of the prosthesis with later replacement of permanent implants.The first stage…
- Conditions
- Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation
- Trial name
- SPACERHIP (NCT01373099)
- Testing
- Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Rush University Medical Center
Drainage
Evaluating the Effectiveness of 2 Surgical Skin Preparation Methods in Reducing Surgical Wound Drainage After Total Hip or Knee Replacement
Surgical skin complications can be costly and could contribute to extended in-patient stay following total joint replacement or even the need for re-admission.
- Trial name
- NCT01097135
- Testing
- Duraprep Surgical Solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Rothman Institute Orthopaedics
Knee Pain Arthritis
Serum Levels of Bupivacaine in Autotransfusion Drains Following Total Joint Arthroplasty
The purpose of this study is to quantify the total blood serum levels of bupivacaine in OrthoPAT® collected blood 2 hours and 5 hours postoperatively.
- Trial name
- NCT02276040
- Testing
- periarticular bupivicaine and liposomal bupivicaine
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Avascular Necrosis of Hip
THRA_hematologic Variables
Total hip replacement arthroplasty is a surgery having intra- and postoperative substantial blood loss. The investigators will investigate the relationship between the various hematologic variables and postoperative bleeding…
- Trial name
- NCT01521858
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Bundang Hospital
Arthroplasties, Knee Replacement
Impact of Component Design and Fixation in Total Knee Arthroplasty
The purpose of this study is to determine implant design and determine if method of fixation cemented versus cementless results in different bone loss patterns.
- Trial name
- NCT03272178
- Testing
- Depuy total knee implant, Triathlon total knee implant
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Washington University School of Medicine
Osteoarthritis, Knee
Is Non Surgical CaRE Using Treat to Target Multimodal meDIcal Strategies aBLE to Delay or Avoid Total Knee Replacement?
Knee is the most common site of osteoarthritis. Treatment of knee osteoarthritis starts with a full course of medical therapy, followed by surgery to replace the knee with a prosthesis if this strategy fails, or in advanced…
- Trial name
- INCREDIBLE (NCT06643845)
- Testing
- arthroplasty, Medical and non-medical treatments
- Where
- 21 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Brest
Osteoarthritis
Outcomes Following Total Knee Arthroplasty
The purpose of this investigation is to determine both patient-reported and performance-based outcomes, specifically muscle function and kinematic/kinetic outcomes, between four different surgical total knee prostheses in…
- Trial name
- NCT02364011
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Utah
Joint Replacement
MCJR Joint Replacement Clinical Outcomes Database
The purpose of this research study is to develop a database of information regarding the diagnosis, treatment, and outcome of participants who have had a joint replacement.
- Trial name
- NCT03328611
- Testing
- Hip and Knee Joint Replacement
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Midwest Center for Joint Replacement
Venous Thromboembolism
A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement (TKR) surgery.
- Trial name
- ROXI-VTE II (NCT06454630)
- Testing
- REGN7508, Enoxaparin
- Where
- 14 sites in Bulgaria, Hungary and 3 more
- Volunteers
- 179 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis, Knee
Functional Outcome and Analgesia in TKA: Radiofrequency vs Continuous Adductor Canal Block
This randomized, double blind controlled trial is designed to investigate the potential benefits of radiofrequency in terms of analgesia and functional outcome, compared to the conventional continuous adductor canal block, for…
- Trial name
- NCT02680392
- Testing
- Pulsed and Continuous Radiofrequency, Continuous Adductor Canal Block
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Surgery, Cholecystectomy, Laparoscopic
Benefits of 'Repeat Back' Protocols Within A Computer-Based Informed Consent Program
This is a VA Merit Review Study involving 7 VA medical centers participating in a parallel group randomized trial comparing "repeat back" versus standard electronic consent for 4 common elective surgical procedures (total hip…
- Conditions
- Surgery, Cholecystectomy, Laparoscopic, Prostatectomy, Arthroplasty, Replacement, Hip
- Trial name
- NCT00288899
- Testing
- Enhanced surgical iMedConsent process (with "repeat back"), standard surgical iMedConsent process
- Where
- 7 sites in United States
- Volunteers
- 575 people
- Sponsor
- VA Office of Research and Development
Pain, Postoperative, Opioid Overdose
Ultrasound-guided PENG Block in Total Hip Replacement
This randomized controlled study will be carried out on 60 adult patients undergoing primary total hip replacement in Tanta University Hospitals.
- Trial name
- NCT04984109
- Testing
- Real PENG block
- Where
- Egypt
- Volunteers
- 71 people
- Sponsor
- Tanta University
Knee Osteoarthritis, Degenerative Joint Disease of the Knee
Patient Outcomes Following Kinematic and Functional Alignment in Robotic-Assisted Total Knee Arthroplasty With Randomized Insert Types
This study aims to evaluate patient outcomes following robotic-assisted total knee arthroplasty using the VELYS system. Patients undergoing surgery will receive either kinematic alignment or functional alignment as determined by…
- Trial name
- VELYS RCT (NCT07533188)
- Testing
- Medial Stabilized Insert, Cruciate Retaining Insert
- Where
- Singapore
- Volunteers
- 240 people
- Sponsor
- Singapore General Hospital
Arthroplasty, Replacement, Knee, Proprioception
The Comparison of Proprioception and Gait Function Among Different Rotational Designs in Knee Arthroplasty
The symptoms of knee osteoarthritis include knee joint pain, impaired proprioception, and etc. Knee arthroplasty is commonly recommended for the patient with severe knee osteoarthritis to relieve pain and regain function.
- Conditions
- Arthroplasty, Replacement, Knee, Proprioception, Gait, Balance
- Trial name
- NCT05219396
- Testing
- Knee arthroplasty
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- China Medical University Hospital
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