Clinical trials: Arthroplasty, Replacement
Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC)
The KinematX Midcarpal Total Wrist Arthroplasty Registry
The goal of this observational study is to learn about functional and patient reported outcomes in patient undergoing total wrist replacement with the KinematX total wrist replacement study.
- Conditions
- Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC), Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC), Carpal Tunnel Syndrome (CTS)
- Trial name
- NCT05719935
- Testing
- KinematX total wrist arthroplasty system
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Extremity Medical
Knee Osteoarthritis
Minimally Invasive Knee Replacement Outcomes (MIKRO) Study
The purpose of this study is to evaluate and compare the clinical, radiographic (x-ray) and cost effectiveness outcomes (cost relative to risks and benefits) of two different minimally invasive knee joint replacement surgical…
- Trial name
- MIKRO (NCT00633113)
- Testing
- MPPA, SV
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Total Hip Arthroplasty (THA)
Impact of Rehabilitation Therapy Using Strength and Blood Flow Restriction Training on Muscular Fitness and Regeneration After Elective Hip Replacement
In the present project, the framework conditions of outpatient rehabilitation at the Bonn Center for Outpatient Rehabilitation will now be used to prove whether sports science-controlled strength and BFR training has a similar…
- Trial name
- NCT07043127
- Testing
- BFR
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bonn
Deep Vein Thrombosis, Venous
Rosuvastatin for Preventing Deep Vein Thrombosis
Deep vein thrombosis (DVT)is devastating disease which influencing the mortality and morbidity of patients at-risk like those undergoing orthopedic surgery.
- Conditions
- Deep Vein Thrombosis, Venous, Thrombosis, Prevention
- Trial name
- STOP-DVT (NCT01021488)
- Testing
- Rosuvastatin 20mg/d for 14days, enoxaparin only
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Hallym University Medical Center
Knee Arthroplasty, Knee Arthroplasty, Total
Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty
To evaluate the progression on patients suffering from end stage OA whilst being on the waiting list for TKR
- Conditions
- Knee Arthroplasty, Knee Arthroplasty, Total, Knee Replacement, Total, Replacement, Total Knee
- Trial name
- TKA HRQoL (NCT03492320)
- Testing
- Health Quality of Life Questionnaire Assessment
- Volunteers
- 127 people
- Sponsor
- Dr. Ho Ki Wai
Hip or Knee Replacement
'M'-Technique, Guided Imagery, or Standard of Care on Anxiety and Pain Pre- & Post-operatively in Elective Joint Replacement Patients
In the M-TIJRP protocol the investigators will utilize two Integrative Medicine modalities in a randomized, controlled study using either the 'M'-Technique® developed by Jane Buckle, PhD or Diane L.
- Trial name
- M•TIJRP (NCT01874379)
- Testing
- 'M'-Technique®, Guided Imagery, Standard of Care
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Saint Clare's Health System
ARTHROPLASTY, REPLACEMENT; ANESTHESIA
Postspinal Hypotension and Cardiac Performance in the Elderly
Patients, scheduled for elective arthroplasty were monitored with Lithium Dilution Cardiac Output monitor (LiDCOplus™) before and 45 minutes after spinal anesthesia.
- Trial name
- NCT02978066
- Testing
- Spinal anaesthesia
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Intraoperative Bleeding, Post-operative Bleeding
Study to Compare the Addition of Floseal to Our Standard of Care to Control Post Operative Bleeding in TKR
The purpose of this study is to compare Floseal to our standard of care (SOC) to decrease intraoperative and immediate post-operative bleeding.
- Trial name
- NCT01891461
- Testing
- Floseal
- Where
- Canada
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Arthroplasty, Replacement, Knee, Anesthesia, Conduction
Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery
This study will prospectively investigate the efficacy of Adductor canal block with periarticular infiltration Vs Adductor canal block, Periarticluar infiltration and Sensory posterior articular nerve of the knee block in…
- Conditions
- Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Acute Pain
- Trial name
- NCT04290442
- Testing
- adductor canal block, SPANK, Ropivacaine
- Where
- United States
- Sponsor
- Bruce Ben-David
Lumbar Degenerative Disc Disease, Lower Back Pain
Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine
Investigate the potential of tissue grafting that includes human mesenchymal stem cells in the repair and potential stabilization of the degenerative Lumbar disk and facet joint denovo and at the time of surgical reconstruction.
- Conditions
- Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
- Trial name
- NCT02529566
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Hip Osteoarthritis, Knee Osteoarthritis
Fit-Joints: Getting Fit for Hip or Knee Replacement
Osteoarthritis leads to reduced independence and quality of life. Total hip replacement is a successful and cost-effective surgical intervention to relieve pain and improve functioning in patients with osteoarthritis.
- Trial name
- Fit-Joints (NCT02885337)
- Testing
- Multi-Modal Frailty Intervention, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- McMaster University
Metal Staple Removal After Total Knee Replacement
Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Lidocaine patch is a safe and effective topical anesthetic agent for removal of metal staples after total knee replacement
- Trial name
- NCT02812602
- Testing
- Lidocaine patch
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
TKA, THA
Binaural Beats for Postoperative Pain and Anxiety Reduction
To deliver a 30-minute binaural beats audio intervention in PACU and collect pain and anxiety outcomes immediately following surgery, and 4 hours following surgery completion in adults undergoing ambulatory total knee…
- Conditions
- TKA, THA, Anxiety, Binaural Beats
- Trial name
- NCT07437469
- Testing
- Binaural Beats Audio Intervention, Music of Choice
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Postoperative Pain
Comparison of the Efficacy of PENG Block in Combination With LFCN Block and Wound Infiltration
The ultrasound-guided approach for the blockade of articular branches of femoral and obturator nerves, pericapsular nerve group (PENG) block, is an effective method for postoperative analgesia in hip surgeries.
- Trial name
- NCT04681222
- Testing
- LFCN, Wound infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Derince Training and Research Hospital
DVT, Osteoarthritis
Does Thinning the Blood During Surgery Prevent Blood Clots Following Total Knee Replacement Surgery
The goal of this study is to prevent blood clots from forming during surgery and a few days after total knee replacement surgery.
- Trial name
- NCT00253851
- Testing
- unfractionated heparin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Total Knee Arthroplasty (Postoperative Pain)
Phase 2B Study Assessing Pain Relief After Replacement of the Knee
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty.
- Trial name
- SPARK2 (NCT06799845)
- Testing
- ATX101, bupivacaine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 226 people
- Sponsor
- Allay Therapeutics, Inc.
Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee
Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty
This study aims to compare the efficacy of different doses of glucocorticoids in local infiltration analgesia (LIA) during total knee arthroplasty (TKA) through a prospective single-center randomized controlled trial, and to…
- Conditions
- Adrenal Cortex Hormones, Arthroplasty, Replacement, Knee, Anesthesia, Local
- Trial name
- NCT07337772
- Testing
- LIA with different doses of Diprospan
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Knee Pain Chronic, Osteoarthritis
Cryoneurolysis for TKA - a Pilot Study
Total Knee Arthroplasty (TKA) is also known as a knee replacement. It is one of the most common orthopaedic (bone) surgeries performed and is usually very successful, but some people who have had a knee replacement feel pain that…
- Trial name
- NCT05286996
- Testing
- Iovera - Cryoneurolysis, Local anesthetic
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Total Hip Arthroplasty
Leg Length and Quality of Life After Total Hip Arthroplasty
This study used 3D reconstructions from the EOS biplanar radiographic imaging system to perform leg length measurements before and after THA (Total hip arthroplasty) on all included THA patients from 2015 to evaluate surgeon…
- Trial name
- EOS-PTH (NCT03437343)
- Testing
- Hip arthroplasty
- Volunteers
- 185 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Total Knee Replacement, Genicular Nerve Block
Genicular and Anterior Femoral Cutaneous Nerve Blocks for Total Knee Arthroplasty
The goal of this randomized controlled trial is to examine if there is a relationship between the addition of the genicular nerve block and anterior femoral cutaneous nerve block in providing analgesia and the use of oral and…
- Conditions
- Total Knee Replacement, Genicular Nerve Block, Opioid Use
- Trial name
- NCT05980546
- Testing
- Bupivacaine Injection, Dexamethasone injection, Fentanyl
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- Hospital for Special Surgery, New York