Clinical trials: Arthroplasty, Replacement
Knee Osteoarthritis
Bespoke vs Standard Instrumentation in TKR
Total knee replacement (TKR) is an established treatment for knee osteoarthritis and leads to a satisfactory outcome in over 75% of patients.
- Trial name
- NCT02845206
- Testing
- Patient specific cutting blocks, Conventional cutting blocks
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- NHS Lothian
Knee Replacement Surgery
The Effect of Nasal Continuous Positive Airway Pressure (N-CPAP) on Arterial pCO2 During Spinal Anesthesia
The proposed study intends to investigate several aspects of the respiratory effects of intravenous sedation of patients undergoing spinal anesthesia for knee replacement surgery.
- Trial name
- NCT01622647
- Testing
- Nasal Continuous Positive Airway Pressure (NCPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pediatrix
Arthroplasty, Replacement, Knee, Pain, Postoperative
Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study
The objective of this study is to see how pain management and its outcomes are effected when pharmacogenomic testing is used to determine patient specific pain medication and dosing.
- Trial name
- NCT02711592
- Testing
- Genetic Panel for Analgesics
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- TriHealth Inc.
Hip Replacement Arthroplasty
Stimulating Catheter for Lumbar Plexus Block: Better Postoperative Analgesia?
Stimulating catheters have been introduced to reduce the incidence of secondary failure after continuous peripheral nerve blocks, but they effectiveness over traditional nonstimulating catheters is still controversial.
- Trial name
- NCT02162121
- Testing
- Continuous lumbar plexus: stimulating catheter, Spinal Anesthesia, Local anesthetic infusion
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- ASST Gaetano Pini-CTO
Degenerative Arthritis, Rheumatoid Arthritis
Zimmer Trabecular Metal Total Ankle PMCF
The primary objective of this study is to obtain implant survivorship and clinical outcome data for commercially available Zimmer Trabecular Metal Total Ankle implants used in primary or revision total ankle arthroplasty.
- Conditions
- Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
- Trial name
- NCT02038140
- Testing
- Zimmer Trabecular Metal Total Ankle System
- Where
- 11 sites in United States, Canada and 4 more
- Volunteers
- 120 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
Efficacy of Intravenous Versus Topical Tranexamic Acid in Primary Total Hip Arthroplasty
Bleeding during and after total hip replacement surgery is a primary concern to the surgical and anaesthetic team. Tranexamic acid is a commonly-used drug that helps blood clotting and decreases surgical bleeding.
- Trial name
- TeACH-R (NCT02056444)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Arthroplasty, Replacement, Knee
Effect of Suction Drains in Total Knee Arthroplasty With Tranexamic Acid
Problem Suction drains during TKA present certain costs to the health system and requires additional nursing care. There is no clear evidence that supports their use, and no studies so far have compared blood loss in patients…
- Trial name
- NCT03145493
- Testing
- drainage
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Hip Replacement
Patient Outcomes Using HIP7 Software as Compared to Conventional THA
The study is designed to demonstrate how Hip7 software can lead to improved patient outcomes compared to conventional procedures with standard instrumentation for total hip arthroplasties (THA) surgery.
- Trial name
- NCT04989998
- Testing
- Hip7 Software on Kick/ CORI platforms, Conventional surgical procedures
- Sponsor
- Smith & Nephew Orthopaedics AG
Osteoarthritis, Knee
The Difference Between Rehabilitation With or Without Strength Training After Total Knee Replacement
Background and purpose: In the early phase after a total knee replacement (TKA), patients experience a decrease in leg muscle strength with up to about 80%.
- Trial name
- TKA (NCT01351831)
- Testing
- Rehabilitation with strength training, Rehabilitation without strength training
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Hip Osteoarthritis, Knee Osteoarthritis
Fit-Joints: Getting Fit for Hip or Knee Replacement
Osteoarthritis leads to reduced independence and quality of life. Total hip replacement is a successful and cost-effective surgical intervention to relieve pain and improve functioning in patients with osteoarthritis.
- Trial name
- Fit-Joints (NCT02885337)
- Testing
- Multi-Modal Frailty Intervention, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- McMaster University
Arthroplasty, Knee Replacement
Neurostimulation an Adjuvant Postoperative Analgesic in Total Knee Replacement (TKR) Surgeries
To study and evaluate the effect of using the Primary Relief PENS treatment as adjuvant analgesia for reducing pain in total knee replacement (TKR) patients.
- Trial name
- TKR (NCT05416294)
- Testing
- Primary Relief, Inactive Primary Relief
- Sponsor
- DyAnsys, Inc.
Spinal Anesthesia, Total Knee Arthroplasty
Low Dose Spinal Bupivacaine for Total Knee Replacement and Recovery Room Wait Time
This study plans to investigate whether a reduced dose of bupivacaine (a local anesthetic numbing drug) injected into the spinal space for a total knee replacement will result in a shorter time to discharge from the recovery room…
- Trial name
- NCT00537472
- Testing
- Low dose bupivicaine in spinal anesthetic, Standard dose bupivacaine in spinal anesthetic
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Queen's University
Osteoarthritis, Knee, Patellofemoral Knee Arthroplasty
Study of Knee Replacements for Patellofemoral Osteoarthritis
This is a randomized comparison of PFA and TKR in treatment of isolated patellofemoral osteoarthritis.
- Trial name
- PFA/TKR (NCT01326156)
- Testing
- Knee arthroplasty
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Postoperative Pain, Arthropathy of Knee
Comparison of Postoperative Pain in Primary Cemented Total Knee Arthroplasty With or Without Drain
The use of closed aspirative surgical drainage presents a truly questionable role in the field of orthopedic surgery. The pathophysiological mechanisms on which it acts have been widely theorized, as well as the disadvantages…
- Trial name
- NCT07175883
- Testing
- Redon drain
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Knee Arthroplasty
Clinical Outcomes of Knee Replacement
The objective of this study is to document the demographic and clinical characteristics and the long-term clinical outcomes of patients who require a robot assisted knee arthroplasty.
- Trial name
- NCT01705366
- Testing
- Non-MAKO® Robot Assisted Total Knee Arthroplasty, MAKO® Robot Assisted Medial Knee Arthroplasty, MAKO® Robot Assisted Medial and PF Knee Arthroplasty
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- Northwest Surgical Specialists, Vancouver
Knee Arthroplasty, Postoperative Pain
Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee Arthroplasty
This study is conducted to evaluate the effectiveness and safety of ketamine infusion for pain relief after knee replacement surgery.
- Conditions
- Knee Arthroplasty, Postoperative Pain, Pain Management, Analgesia
- Trial name
- KETARTHRO (NCT07059429)
- Testing
- Ketamine, Standard Analgesia
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Osteoarthritis, Hip
Celecoxib Versus Diclofenac In The Treatment Of Osteoarthritis Of The Hip
To determine if celecoxib 200 mg once daily is as effective as diclofenac 50 mg three times daily in the treatment of pain symptoms associated with osteoarthritis of the hip
- Trial name
- NCT00174317
- Testing
- Celecoxib, Diclofenac
- Where
- 44 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- Pfizer
Arthroplasty, Replacement
Wound Additives in Primary Total Joint Athroplasty
3 cohorts of total joint patient of 30 members each were randomized to receive PRP or Activated Collegen or no additive were studied for status of the wound at 6 weeks and recorded all complications, infections and reoperations.
- Trial name
- NCT03158623
- Testing
- Platelet Rich Plasma, Cellerate
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Salt Lake Orthopedic Clinic
Hip Replacement Arthroplasty
AMIStem-H Radiological Assessment
The purpose of this study is to evaluate radiological performance of the cementless femoral stem AMIStem H at 1 and 5-year follow-up.
- Trial name
- NCT03505580
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- Medacta International SA
Knee Osteoarthritis
Cognitive Muscular Therapy for People Awaiting Knee Joint Replacement
The primary aim will seek to understand whether Cognitive Muscular Therapy (CMT) could provide pain relief for people on a waiting list for joint replacement.
- Trial name
- NCT05801510
- Testing
- Cognitive Muscular Therapy for knee pain
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Salford