Clinical trials: Arthroplasty
Total Hip or Knee Arthroplasty
Transfusion Requirements in Orthopedic Surgery (PHASE 2)
The objective of our research program is to determine the transfusion threshold required to maximize functional recovery after major orthopedic surgery (total hip/knee replacement) in these, most often, elderly patient with…
- Trial name
- TRIOS (NCT00726349)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 305 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Blood Loss, Hip Arthritis
TXA vs. Amicar in Total Knee and Hip Arthroplasty
The purpose of this study is to determine the relative effectiveness of two drug agents, Tranexamic acid (TXA) and aminocaproic acid (Amicar), that act through a similar mechanism of action.
- Conditions
- Blood Loss, Hip Arthritis, Knee Arthritis
- Trial name
- NCT02030821
- Testing
- Amicar, TXA
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Duke University
Aseptic; Osteonecrosis, Hip Osteoarthritis
Radiographic Changes and Clinical Implications of Implantation of Shortened Uncemented Femoral Stems in THA
The hip prosthesis market is constantly growing with the number of prostheses reaching 949,000 in 2019. Along with this, there is also an increase in interest in short stems also called shortened stems.
- Trial name
- THA (NCT05666284)
- Where
- France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Strasbourg, France
Total Hip Arthroplasty (THA)
MFinity BE Pre-market Trial
The primary objective of this trial is to determine the implant survival at 1 year of follow up in a population of patients undergoing primary Total Hip Replacement with MFinity Collared Femoral stem and to test its…
- Trial name
- NCT07616895
- Testing
- Mfinity collared stem
- Volunteers
- 95 people
- Sponsor
- Medacta International SA
Norepinephrine, Glypressin, Tourniquet Deflation, Hypotension
Noradrenaline Versus Glypressin for Prevention of Hypotension After Deflation of Tourniquet in Knee Arthroplasty
Pneumatic tourniquet is usually used in orthopedic surgeries, as it helps to decrease operative bed bleeding, and thus, maintaining a clean and dry surgical field allowing easy and clear identification of the anatomical…
- Trial name
- NCT05774067
- Testing
- Saline, Norepinephrine, glypressin
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Tanta University
Osteoarthritis
Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement
This single-blind, randomized, controlled trial is designed to test the effect of an intensive, 16 week exercise rehabilitation program (progressive resistance training + functional mobility training) vs.
- Trial name
- TWEAK (NCT02628795)
- Testing
- PRT + FM, Usual Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Shoulder Osteoarthritis, Proximal Humeral Fracture
Individual Preoperative Planning for RSA
Degenerative diseases and traumatic injuries of the shoulder joint, lead to dysfunction of the arm. Arthroplasty has recently become an increasingly popular operation for severe damage to the shoulder joint.
- Conditions
- Shoulder Osteoarthritis, Proximal Humeral Fracture, Avascular Necrosis of Humerus
- Trial name
- NCT04762667
- Testing
- reverse shoulder arthroplasty
- Where
- Russia
- Volunteers
- 65 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Osteoarthritis, Hip, Blood Loss
Bipolar Sealer for Reduction of Blood Loss in Anterior Total Hip Arthroplasties
The overall objectives and purpose of this study is to show that the Smith and Nephew Werewolf Fastseal 6.0 Bipolar Sealer is an effective tool to aide the surgical team in providing significant hemostasis during anterior total…
- Trial name
- NCT05356637
- Testing
- Werewolf Fastseal 6.0
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- North Texas Medical Research Institute, PLLC
Knee Arthroplasty
Continuous Monitoring of Physiology and Self-reported Pain Score Amongst Post-surgical Knee Patients
The aim of this observational study is to assess whether patient reported pain levels correlate with a Pain Index derived from deviations in multivariate physiology biomarkers captured in real-world setting.
- Trial name
- ObservePAIN (NCT03789630)
- Testing
- Continuous physiology monitoring in ambulatory setting pre and post surgery
- Where
- Singapore
- Volunteers
- 55 people
- Sponsor
- Biofourmis Singapore Pte Ltd.
Pain
Efficacy, Safety, and Pharmacokinetics of Brachial Plexus Block With EXPAREL in Shoulder Surgery
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study in 155 adult subjects undergoing primary unilateral total shoulder arthroplasty or rotator cuff repair with general anesthesia
- Trial name
- NCT02713230
- Testing
- bupivacaine liposome injectable suspension
- Where
- 20 sites in United States, Belgium and 1 more
- Volunteers
- 156 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Arthroplasty Complications
Evaluation of Metal-on-conventional-polyethylene vs Ceramic-on-ceramic Articulating Surfaces in Total Hip Arthroplasty
Polyethylene wear debris from metal-on-polyethylene articulations are one of the main causes of periprosthetic bone loss and non-infectious loosening in total hip arthroplasty.
- Trial name
- NCT03692364
- Testing
- Ceramic-on-ceramic uncemented hip arthroplasty, Metal-on-polyethylene uncemented total hip arthroplasty
- Volunteers
- 104 people
- Sponsor
- Sahlgrenska University Hospital
Osteo Arthritis Knee
Utilization of a Knee Brace With Extension Swing
The purpose of this research is to help determine if use of the Guardian brace during prehab and post-op rehab after TKA can help improve functional outcomes and reduce the incidence of post-operative flexion contractures which…
- Trial name
- NCT05179044
- Testing
- Guardian Sport Rehabilitator knee brace
- Where
- United States
- Sponsor
- NYU Langone Health
Osteoarthritis, Hip, Rheumatoid Arthritis
A Clinical Investigation of the Balance® Microplasty™ Hip System
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Balance® Microplasty™ Hip System.
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis
- Trial name
- NCT00699088
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthritis, Hip, Arthropathy of Hip
Evaluation of Cemented and Cementless Fixation of Dual-mobility Hip Prosthesis in Elderly Patients With Osteoarthritis
The aim of this project is to investigate prosthesis fixation in the bone, respectively cemented and uncemented operation method of Avantage® dual-mobility acetabular cup in elderly patients, wear of the plastic in dual-mobility…
- Trial name
- NCT02404727
- Testing
- cup fixation, Avantage® Cup
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Thumb Osteoarthritis
Variable Immobilization Protocol for Arthroplasty of the Carpometacarpal Joint of the Thumb
Thumb carpometacarpal (CMC) osteoarthritis (OA) is common, seen frequently in middle-aged and elderly women. While a variety of surgical treatments have been described with none superior to any other, there is no consensus on the…
- Trial name
- NCT04828954
- Testing
- Immobilization for 2-weeks postoperative, Immobilization for 6-weeks postoperative
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Chicago
Rotator Cuff Tear Arthropathy, Post Operative Pain
Effect of Radiofrequency of Suprascapular Nerve in Shoulder Reverse Arthroplasty
The purpuse of this study is to asses if the pulsed radiofrecuency of the supraescapular nerve and accesory nerve have the same or superior efectivity controlling the acute postoperative pain than interscalenic braquial plexus…
- Trial name
- NCT05785572
- Testing
- supraescapular nerve radiofrequency, interescalenic braquial plexus
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Hospital Universitario Virgen Macarena
Osteoarthritis (OA) of the Knee
Photographic Evidence on Total Knee Arthroplasty Outcomes
Historically, total knee arthroplasty (TKA) has been performed to restore knee range of motion and relieve pain, with postoperative rehabilitation focused on helping patients regain mobility and function.
- Trial name
- NCT07223359
- Testing
- Photographic Evidence of Postoperative Knee Range of Motion, Standard Postoperative Care
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Loyola University
Knee Arthroplasty
Active Versus Passive Motion Device Following Knee Replacement Surgery
The purpose of this study is to determine how well an active motion device, Camoped, works compared to a continuous passive motion device, CPM, for rehabilitation after partial or total knee replacement.
- Trial name
- NCT02339831
- Testing
- CAMOPED, CPM passive motion device
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Knee Osteoarthritis, Arthroplasty, Replacement, Knee
Implementation of Indication Criteria for Total Knee Replacement in Osteoarthritis (Value-based TKR)
The aim of this trial is to investigate the effect of a medical decision aid (EKIT-Tool) on decision quality for knee arthroplasty.
- Trial name
- NCT04837053
- Testing
- Digital decision aid for physicians and patients, Routine care
- Where
- Germany
- Volunteers
- 1,092 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis, Rheumatoid Arthritis
Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System
Prospective, multi-center clinical study to evaluate the clinical outcomes of the posterior stabilized design of the LCS® Complete Mobile-bearing Total Knee System
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Juvenile Arthritis
- Trial name
- NCT00487565
- Testing
- Total knee arthroplasty
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- DePuy Orthopaedics
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