Clinical trials: Arthroplasty
Knee Osteoarthritis, Knee Rheumatism
Does Adding an Additional Numbing Medication Injection in the Thigh Help With Pain Control After Knee Replacement Surgery?
One common anesthetic that is performed for total knee replacement surgery is spinal anesthesia with an adductor canal regional block, which involves injecting numbing medication in the thigh region for pain control after…
- Trial name
- NCT03326999
- Testing
- Obturator nerve regional block, Adductor canal regional block, Saline
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Arthroplasty Complications
Evaluation of Noise Induced by Ceramic-ceramic Friction Torques of Total Hip Prostheses With Customized Femoral Stem
Evaluation of noise induced by ceramic-ceramic friction torques of total hip prostheses with customized femoral stem. Retrospective and prospective multicentric study.
- Trial name
- ATHENS (NCT05014932)
- Where
- France
- Volunteers
- 531 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Osteoarthrosis
Effect of Methylprednisolone on Orthostatic Intolerance and Heart Rate Variability in Hip-arthroplasty Patients
The study evaluates the pathophysiological effects of a single dose Methylprednisolone administered prior to total hip-arthroplasty (THA) surgery.
- Trial name
- NCT02445898
- Testing
- Methylprednisolone, Isotonic Sodium Chloride
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteoarthritis
A Clinical Investigation of the Oxford® Partial Knee System
The purpose of this prospective data collection is to document the performance and clinical outcomes of the Oxford® Partial Knee System.
- Trial name
- NCT00699257
- Volunteers
- 85 people
- Sponsor
- Biomet Orthopedics, LLC
Arthritis, Failure of Total Hip
A Validated Necrosis Assay to Determine the Need for Revision Surgery in Metal-on-metal Total Hip Arthroplasty
The purpose of the study is to develop a biomarker assay to be used as a diagnostic tool for adverse local tissue reaction, or tissue necrosis, in a metal on metal total hip replacement.
- Trial name
- NCT02208271
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Knee Osteoarthritis
The Post-operative Effect of Applying Drainage on Total Knee Arthroplasty
This multicenter clinical trial aims to investigate the exact effect of drainage use for osteoarthritis patients in total knee arthroplasty (TKA) on post-operative performance.
- Trial name
- NCT03365271
- Testing
- drainage, non-drainage
- Volunteers
- 100 people
- Sponsor
- Peking University People's Hospital
Total Knee Arthroplasty, Postoperative Recovery
Effects of Different Bispectral Index Target Depths on Early Postoperative Recovery Quality in Elderly Patients Undergoing Total Knee Arthroplasty
This is a prospective, single-center, randomized, double-blind controlled trial. The purpose of this study is to determine whether depth-controlled anesthesia with ciprofol guided by Bispectral Index (BIS) can improve early…
- Trial name
- NCT07906457
- Testing
- BIS-guided light-depth anesthesia management (BIS target 50-65), BIS-guided deep-depth anesthesia management (BIS target 35-50)
- Where
- China
- Volunteers
- 130 people
- Sponsor
- General Hospital of Ningxia Medical University
Total Hip Arthroplasty
Quadratus Lumborum Block in Total Hip Arthroplasty - Effect on Analgesia and Early Physiotherapy
Currently there is no consensus on the optimal peripheral nerve block for Total Hip Arthroplasty (THA). Furthermore, there is a gap in the literature in regard to the efficacy of Quadratus Lumborum Block (QLB) for Total Hip…
- Trial name
- NCT03945630
- Testing
- anterior Quadratus Lumborum Block, Standard of Care
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Medical University of Gdansk
Knee Osteoarthritis
Race and Preference for Knee Replacement: A Patient-Centered Intervention
A randomized, controlled design will be utilized to examine and compare the effectiveness of the proposed educational intervention, which includes a combination of an educational decision aid and motivational interviewing with…
- Trial name
- REPAIR (NCT02413411)
- Testing
- DA/MI Intervention, an educational program (an NIH-developed booklet)
- Where
- United States
- Volunteers
- 493 people
- Sponsor
- University of Pennsylvania
Ankle Osteoarthritis
Comparison of Customized and Standard Total Ankle Prostheses
The objective of this study is to compare primary total ankle replacement (TAR) performed with a customized procedure (prostheses customized for each patient based on his or her ankle morphology reconstructed from tomographic…
- Trial name
- NCT06193057
- Testing
- Total ankle arthroplasty
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Istituto Ortopedico Rizzoli
Arthrofibrosis
Losartan Use to Mitigate Arthrofibrosis Following Total Join Arthroplasty
Recent research has focused on methods to mitigate scar tissue formation and arthrofibrosis following surgery in hopes that patients may attain maximal range of motion goals, avoid manipulation and secondary surgery (i.e.
- Trial name
- NCT05157464
- Testing
- Losartan
- Where
- United States
- Sponsor
- NYU Langone Health
Infection
Fructosamine as a Predictor of Surgical Outcomes in Total Joint Arthroplasty A Prospective Multi-center Study
A prospective multicenter study including all patients undergoing elective total hip (THA) or knee (TKA) arthroplasty (primary and revision).
- Trial name
- NCT03503019
- Volunteers
- 3,000 people
- Sponsor
- Rothman Institute Orthopaedics
Prosthetic Joint Infection
Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation
Study Type Prospective, single-arm, open-label, multicenter (3 to 5 sites), interventional trial. Primary Study Objective The objective of the study is to determine the safety profile of local antibiotic irrigation for the…
- Trial name
- NCT03721328
- Testing
- vancomycin hydrochloride and tobramycin sulfate
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Osteal Therapeutics, Inc.
Total Knee Arthroplasty (TKA)
Clinical Correlation of TKA Alignment and Native Knee Anatomy
Total knee arthroplasty (TKA) is still considered the treatment of choice for painful osteoarthritis. In the last decades neutral mechanical knee alignment in the coronal plane has been considered the gold standard.
- Trial name
- CAT (NCT05435092)
- Testing
- 3D-reconstruction CT
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- University Hospital, Basel, Switzerland
Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty
Perioperative Colchicine for TKA
This study is a prospective, randomized, double-blinded, placebo-controlled study of the drug colchicine in the acute postoperative period for patients who are undergoing a total knee arthroplasty (TKA).
- Conditions
- Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty, Perioperative Pain Control
- Trial name
- NCT06936709
- Testing
- Colchicine 1.8 mg + 0.6 mg
- Volunteers
- 75 people
- Sponsor
- Geisinger Clinic
Total Knee Arthroplasty
Effectiveness of a Femoral Block Following Total Knee Arthroplasty (TKA)
Hospital stays after total joint replacement surgery have been getting shorter over the past 10 years. This is mostly due to new ways to manage pain and early rehabilitation.
- Trial name
- NCT00659087
- Testing
- Femoral Block, Usual Care
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Edmonton Civic Employees Research Fund
Osteoarthritis, Hip
Prospective Evaluation of Fixation of the Prime Acetabular Cup
This is a prospective study to compare migration of the Microport Prime acetabular cup to a well-established acetabular cup design after total hip replacement.
- Trial name
- NCT04039984
- Testing
- Prime Cup
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Delirium, Hip Arthroplasty
Delirium, Intraoperative Cerebral Perfusion and EEG Abnormalities After Total Hip Arthroplasty
The overall objective of this study is to test for perturbations in intraoperative electroencephalogram (EEG) , cerebral blood flow (CBF), cerebral metabolic rate of oxygen consumption (CMRO2), oxygen extraction fraction (OEF)…
- Conditions
- Delirium, Hip Arthroplasty, Elderly
- Trial name
- NCT02818764
- Testing
- Blood Draw, Cerebral Spinal Fluid collection, Electroencephalogram
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Pennsylvania
Total Hip Arthroplasty
A Post Market Surveillance Study About the MONOCER Cup
Over the years, the use of large diameter femoral heads has become increasingly common in orthopaedics due to the decreased risk of dislocation due to increased jumping distance and range of motion.
- Trial name
- NCT05785364
- Testing
- Mpact 3D metal MONOCER cup
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- Medacta International SA
Total Knee Anthroplasty, Robotic Surgery
Early Clinical and Radiological Outcomes of a Novel Robotic TKA System
This study aimed to evaluate the early clinical and radiological outcomes of robot assisted total knee arthroplasty, and to determine the efficiency and safety of its bone resection and implant positioning of the novel robot…
- Trial name
- RA-TKA (NCT06638047)
- Testing
- robotic-assisted TKA, CI-TKA
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Peking University Third Hospital
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