Clinical trials: Arthroplasty
Osteoarthritis, Arthritis
A Multi-centre, Prospective Surveillance to Assess Mid-term Performance of the Mpact Cup
This is a multi-centre, prospective post marketing surveillance study to assess mid-term performance of the Mpact cup in subjects requiring primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT02196818
- Testing
- Mpact Acetabular Shell
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Pain
Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty
This is a Phase 4, multicenter, randomized, double-blind, controlled trial in approximately 140 adult subjects undergoing primary unilateral TKA under spinal anesthesia with bupivacaine HCl (10-15 mg).
- Trial name
- NCT02713490
- Testing
- EXPAREL, Bupivacaine
- Where
- 17 sites in United States
- Volunteers
- 140 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Glenohumeral Joint Degeneration
Comparing The Outcome of Large-Diameter vs Small-Diameter Glenospheres in Primary Reverse Shoulder Arthroplasty
The study will compare the outcome of primary reverse shoulder arthroplasty using the Stryker ReUnion System with implantation of either a large (40 mm) or a small (36 mm) glenosphere with either a +2 mm or a +6 mm offset.
- Trial name
- NCT02768597
- Testing
- ReUnion System with a Large-Diameter Glenosphere +2 mm offset, ReUnion System with a Small-Diameter Glenosphere +2 mm offset, ReUnion System with a Large-Diameter Glenosphere +6 mm offset
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Mayo Clinic
Opioid Tolerance, Opioid Naive, Opioid Exposure
Opioid Induced Loss of Local Anesthetic Potency in Patients Undergoing Total Knee Arthroplasty
Peripheral nerve blocks with local anesthetics (LAs) have become an integral part of postoperative pain management particularly for patients undergoing major limb procedures such as such as Total Knee Arthroplasty (TKA).
- Trial name
- NCT03294174
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Total Knee Arthroplasty
IO Vancomycin Administration in TKA
This is a prospective, single-center, open-label study evaluating systemic vancomycin levels following preoperative intraosseous administration in patients undergoing primary unilateral total knee arthroplasty.
- Trial name
- IO Vanco (NCT07633418)
- Testing
- Intraosseous Vamcomycin Administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Arthritis Knee, Arthroplasty
Robotic Assisted Knee Arthroplasty - Retain the Anterior Cruciate Ligament or Not
The goal of this clinical trial is to compare the function of the knee after retaining or sacrificing the anterior cruciate ligament in robotic assisted knee arthroplasty.
- Conditions
- Arthritis Knee, Arthroplasty, Gait Analysis
- Trial name
- NCT06264999
- Testing
- Journey II CR, Journey II XR
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Arthropathy of Knee, Analgesia
Fascia Iliaca Compartment Block and IPACK Block in Total Knee Arthroplasty
The investigators sought to compare the effectiveness of postoperative pain control between the standard intravenous multimodal analgesia procedure used in managing patients undergoing total knee surgery, who experience severe…
- Trial name
- NCT06125067
- Testing
- no peripheral block, Fascia Iliaca Compartment Block, iPACK Block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Pain, Chronic, Back Pain
Back Pain and Arthroplasty in Orthopedists
The relationship between arthroplasty and low back pain in orthopedists will be evaluated.
- Trial name
- NCT04505332
- Testing
- arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Uludag University
Arthritis, Traumatic Arthritis
Hydrogel Coating to Reduce Post-surgical Infection After Joint Arthroplasty
The goal of this randomized, controlled, monocentric, single-blind, 2-arm, feasibility clinical investigation is to evaluate the safety of MectaShield hydrogel coating and to capture its preliminary clinical performance in the…
- Conditions
- Arthritis, Traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT05679232
- Testing
- Hydrogel coating, Control
- Where
- Austria
- Volunteers
- 56 people
- Sponsor
- Medacta International SA
Osteoarthritis
Formal vs. Home-Based Physical Therapy After Unicompartmental Knee Arthroplasty
To determine whether home-based physical therapy (HBPT) is not clinically inferior to formal outpatient physical therapy (OPT) after hospital discharge of patients undergoing a unicompartmental knee arthroplasty (UKA).
- Trial name
- NCT02883998
- Testing
- Outpatient Physical Therapy, Home Base Physical Therapy
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Comparison of High Flex and Standard Rotating Platform Total Knee Arthroplasty (TKA)
The goal of this study is to determine if the rotating platform high flex design provides improved flexion compared to the standard rotating platform TKA.
- Trial name
- NCT01176292
- Testing
- Rotating Platform High-Flex Cruciate Substituting TKA, Rotating Platform Cruciate Substituting TKA
- Volunteers
- 142 people
- Sponsor
- Anderson Orthopaedic Research Institute
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
This study is intended to gather medium (5- to 7-years) and long-term (minimum 8- to 10-years) information regarding the performance and safety of the commercially available 36mm CERAMAX® Ceramic on Ceramic (COC) Total Hip System…
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Post-Traumatic Osteoarthritis of Hip
- Trial name
- COC36mmPAS (NCT02096198)
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- DePuy Orthopaedics
Arthritis Knee
Effectiveness of Client-centered Intervention in After Total Knee Arthroplasty
The current study was conducted to comparison of the Client-centered (CC) intervention with face-to-face (FF) and TR methods after Total Knee Arthroplasty (TKA).
- Trial name
- NCT04969432
- Testing
- Client-centered
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi
Arthroplasty, Replacement, Hip
Trident II Tritanium Acetabular Shell Outcomes Study
The purpose of this study is to review the performance and success rate of an FDA approved cementless hip replacement part called the Trident II Tritanium Acetabular Shell.
- Trial name
- NCT02999009
- Testing
- Trident II Tritanium Acetabular Shell
- Where
- 9 sites in United States
- Volunteers
- 383 people
- Sponsor
- Stryker Orthopaedics
Total Joint Arthroplasty
The Effect of Guided Imagery Technique on Anxiety, Pain, and Analgesic Use in Total Joint Arthroplasty Patients
This randomized controlled study will investigate the effects of guided imagery on preoperative anxiety and postoperative pain and analgesic consumption in patients undergoing total joint arthroplasty.
- Trial name
- NCT07194252
- Testing
- Guided imagery technique application
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Ankara Yildirim Beyazıt University
Degenerative Disc Disease
CHARITÉ™ Artificial Disc Compared to Anterior Interbody Fusion for Treatment of Degenerative Disc Disease
The study is designed to evaluate the safety and effectiveness of the CHARITE Artificial Disc compared to anterior lumbar interbody fusion for treatment of degenerative disc disease at one level of the lumbar spine (either L4/L5…
- Trial name
- NCT00215306
- Testing
- CHARITÉ Artificial Disc, Anterior Interbody Fusion with BAK Cage
- Volunteers
- 304 people
- Sponsor
- DePuy Spine
Osteoarthritis
Intra-articular Tranexamic Acid in the Reduction of Blood Transfusions in Primary Total Hip and Total Knee Arthroplasty
This is a randomized, double blinded, controlled trial in patients undergoing elective Total Knee Arthroplasty (TKA) and Total Hip Arthroplasty (THA).
- Trial name
- NCT02393963
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Innovation Centre
Distal Interphalangeal Arthroplasty, Distal Interphalangeal Arthrodesis
Outcomes of Motion-preserving Surgery and Arthrodesis at the Distal Interphalangeal (DIP) Joint
The objective of this project is to investigate the subjective and clinical outcome in patients at least one year after DIP arthroplasty and compare them to matched patients with an arthrodesis.
- Trial name
- NCT03074916
- Testing
- DIP arthroplasty or arthrodesis
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Schulthess Klinik
Postoperative Pain, Postoperative Nausea and Vomiting
High-Dose Steroid for Knee Arthroplasty Patients Expected to Have Postoperative Pain
The purpose of the Study is to test a higher dose of steroids(Dexamethasone) given just prior to surgery in the setting of Fast-Track Knee surgery with Arthroplasty in a group of expected High Pain Responders and the effect on…
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting, Knee Osteoarthritis, Perioperative/Postoperative Complications
- Trial name
- NCT03763734
- Testing
- Dexamethasone
- Where
- 2 sites in Denmark
- Volunteers
- 88 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
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