Clinical trials: Arthroplasty
Arthropathy of Hip, Arthropathy of Knee
Tranexamic Acid Dosing for Total Joint Arthroplasty
The purpose of this study is to determine the effect of increasing doses of tranexamic acid (TXA) on limiting blood loss during total knee and total hip arthroplasty as defined by a change in hemoglobin from pre-operative…
- Trial name
- NCT02584725
- Testing
- Tranexamic Acid
- Volunteers
- 84 people
- Sponsor
- Columbia University
Shoulder Injuries
IO Vancomycin in TSA
The purpose of this study is to compare two different antibiotic regimens and techniques during total shoulder arthroplasty. Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic…
- Trial name
- NCT05831774
- Testing
- Intervention - Intraosseous (IO) administration of vancomycin, Control - Standard IV administration of vancomycin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The Methodist Hospital Research Institute
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Knee Kinematics for Subjects With Zimmer-Biomet Posterior Cruciate Retaining or Posterior Stabilizing Total Knee Arthroplasty
25 subjects implanted with a Zimmer-Biomet Posterior Cruciate Retaining (PCR) total knee arthroplasty (TKA) and 25 subjects implanted with a Zimmer-Biomet Posterior Stabilizing (PS) TKA will be asked to perform stepping up and…
- Trial name
- PCR PS TKA (NCT04103515)
- Testing
- Zimmer-Biomet Posterior Cruciate Retaining total knee arthroplasty, Zimmer-Biomet Posterior Stabilizing total knee arthroplasty
- Where
- 3 sites in United States, France
- Volunteers
- 50 people
- Sponsor
- The University of Tennessee, Knoxville
Knee Pain Arthritis
Serum Levels of Bupivacaine in Autotransfusion Drains Following Total Joint Arthroplasty
The purpose of this study is to quantify the total blood serum levels of bupivacaine in OrthoPAT® collected blood 2 hours and 5 hours postoperatively.
- Trial name
- NCT02276040
- Testing
- periarticular bupivicaine and liposomal bupivicaine
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Osteoarthritis, Hip Arthropathy
Topical Tranexamic Acid (TXA) in Joint Arthroplasty
The objective of this study is to evaluate the efficacy of topical tranexamic acid (TXA) in decreasing blood loss following both shoulder arthroplasty and primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Hip Arthropathy, Shoulder Arthropathy
- Trial name
- NCT01937559
- Testing
- Tranexamic acid (TXA), Normal saline
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- The Hawkins Foundation
Arthropathy of Hip Joint, Osteoarthritis, Hip
Opioid Free and Therapy Minimized Advantages Using HANA Table for Total Hip Arthroplasty
To prove that anterior approach total hip arthroplasty using the HANA table can be performed with little, if any, need for opioids using a combination of education, optimized pre op and post op pain protocols and optimized…
- Trial name
- NCT03790306
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- St. Elizabeth Medical Center, Utica, NY
Osteoarthritis, Rheumatoid Arthritis
Robotic Arm Assisted Total Knee Arthroplasty
The Investigation will be conducted as a single-submission, multi-center study with approval from and in compliance of the Western Institutional Review Board (WIRB).
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis
- Trial name
- NCT02058069
- Testing
- Robotic Arm Assisted Total Knee Arthroplasty
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- MAKO Surgical Corp.
Arthroplasty, Replacement, Knee
Music Therapy Versus Control for Total Knee Arthroplasty
For millennia, people have listened to and enjoyed music for entertainment, as a distraction from daily troubles, and as a means to relax and relieve stress.
- Trial name
- NCT03569397
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Alabama at Birmingham
Shoulder Arthroplasty
A Post-Market Clinical Evaluation of the ReUnion TSA System
This investigation is a prospective, multicenter clinical investigation. It is anticipated that a total of one hundred (100) subjects will be enrolled at approximately 4-7 sites.
- Trial name
- NCT03858517
- Testing
- ReUnion TSA System
- Where
- 3 sites in United States
- Volunteers
- 51 people
- Sponsor
- Stryker Trauma and Extremities
Total Hip Arthroplasty (THA)
A Safety Follow Up Study in Australian Subjects Implanted With the SMF Short Modular Femoral Stem Hip System
This is a prospective, single arm, sequential enrolment study to collect relevant clinical and radiological data in approximately 26 subjects, at one site in Australia, who have been implanted with the SMF Short Modular Femoral…
- Trial name
- NCT03646513
- Testing
- SMF Short Modular Femoral Hip System
- Where
- Australia
- Volunteers
- 4 people
- Sponsor
- Smith & Nephew, Inc.
Femoral Neck Disease
A Study of Ropivacaine Complex Methylene Blue Fascia Iliaca Compartment Block on Analgesia in Patients Undergoing Hip Arthroplasty
Total hip arthroplasty is currently the most effective method for treating hip joint lesions and improving quality of life, but postoperative severe pain is not conducive to rapid recovery of patients.
- Trial name
- NCT06284941
- Testing
- Ropivacaine combined with methylene blue for iliac fascia block
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Wang wanxia
Total Knee Replacement
Bone Wax Use for Hemostasis During Primary Unilateral Total Knee Arthroplasty
The purpose of this study is to assess whether the application of bone wax to exposed cancellous bone, after the cemented implants are in place, will provide superior hemostasis in total knee arthroplasty (TKA) patients compared…
- Trial name
- NCT04992052
- Testing
- Bone wax
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Northwell Health
Blood Loss, Hip Arthritis
TXA vs. Amicar in Total Knee and Hip Arthroplasty
The purpose of this study is to determine the relative effectiveness of two drug agents, Tranexamic acid (TXA) and aminocaproic acid (Amicar), that act through a similar mechanism of action.
- Conditions
- Blood Loss, Hip Arthritis, Knee Arthritis
- Trial name
- NCT02030821
- Testing
- Amicar, TXA
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Duke University
Postoperative Pain
Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement
The objectives in this study are to evaluate: (1) efficacy of buprenorphine transdermal system (BTDS, Butrans™) on postoperative pain following total knee replacement surgery; (2) the impact of BTDS on functional rehabilitative…
- Trial name
- NCT00403234
- Testing
- Buprenorphine transdermal patch
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Purdue Pharma LP
Pain
Liposomal Bupivacaine Versus Standard Bupivacaine in the Adductor Canal for Total Knee Arthroplasty
Study will evaluate the effect of liposomal bupivacaine versus standard bupivacaine on physical therapy measures and pain scores as well as opiate consumption.
- Trial name
- NCT03182933
- Testing
- Peripheral Nerve Blockade, 10 meter walk test on post-operative day 1, In person and over the phone questionnaire
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Wisconsin, Madison
Hip Arthroplasty, Osteoarthritis
Minimally Invasive Surgery of the Hip Versus Standard Approach
The purpose of this study is to determine if there is a difference in terms of length of hospital stay and post-operative outcomes between patients whose total hip replacement surgery is performed with a minimally invasive versus…
- Trial name
- NCT00261040
- Testing
- Minimally Invasive Surgery, Standard Surgery
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoarthritis of Hip
The Viability of Short Stems in Total Hip Arthroplasty
The purpose of this study is to determine the viability of short femoral stems as an alternative to standard-length stems in total hip arthroplasty.
- Trial name
- NCT02577822
- Testing
- Taperloc standard length stem, Taperloc short length stem
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Hip Arthropathy
Assessment of the Safety and the Performance of the SAGITTA EVL R Stems in Hip Arthroplasties
Total hip arthroplasty is the preferred treatment for hip disease (primary or secondary osteoarthritis, osteonecrosis, for example) and femoral neck fractures.
- Trial name
- NCT05153473
- Testing
- Total Hip Arthroplasty Revision
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Societe dEtude, de Recherche et de Fabrication
Shoulder Arthroplasty
Interscalene Block With Liposomal Bupivacaine vs. Interscalene Block With Bupivacaine and Adjuvants
The purpose of this study is to determine whether the use of plain bupivacaine with common adjuvants for interscalene block (ISB) provides non-inferior analgesic results compared to the use of liposomal bupivacaine for ISB, in…
- Trial name
- NCT03845894
- Testing
- Liposomal bupivacaine, Bupivacaine with adjuvants
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pain
A Study to Characterize Diclofenac's Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty
The purpose of this study is to evaluate the exposure of diclofenac in the plasma and in the knee joint following topical administration of DDEA gel 4 gram (g) applied twice daily for 7 days.
- Trial name
- NCT03497039
- Testing
- Diclofenac Diethylamine (DDEA) gel
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline