Clinical trials: Arthroplasty
Prosthetic Arthroplasties
Prosthetic Arthroplasties in Weight-bearing Shoulders
Repeated transfers and wheelchair propulsion in patients with neurological deficit of the lower limbs leads to a major mechanical overload of the upper limbs, especially on shoulders, the "weight-bearing" shoulder.
- Trial name
- NCT04418050
- Testing
- Shoulder arthroplasty
- Where
- France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Montpellier
Total Hip Arthroplasty (THA)
Alexis O-Ring and Charnley Retrievers and Its Effect on Contamination on Total Hip Arthroplasty
Randomized, prospective, single-blind clinical trial comparing two static wound retractors - the Charnley retractor and the Alexis O-Ring retractor - in primary total hip arthroplasty (THA).
- Trial name
- NCT07621250
- Testing
- Alexis O-Ring Wound Retractor, Charnley Retractor
- Where
- Spain
- Volunteers
- 144 people
- Sponsor
- Hospital del Mar
Arthroplasty, Replacement, Knee
The Association of Gait Kinematics, Instability and Patient Reported Outcomes in Patients With Total Knee Replacement
It is unclear why 20% of patients with total knee replacements (TKR) are dissatisfied. Few studies have specifically assessed the way people walk ('gait') with an 'unhappy' or unstable knee or following re-do ('revision') TKR…
- Trial name
- NCT03896191
- Testing
- Revision TKR surgery, No intervention.
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Bath
Pulmonary Embolism
Genetic Markers of Patients With History of Pulmonary Embolism Post Total Joint Arthroplasty
This study seeks to uncover potential genetic determinants of pulmonary embolism (PE). Our translational goal is to ultimately identify certain genetic markers that will allow us to stratify patients in terms of their PE risk…
- Trial name
- NCT03275610
- Testing
- Blood sample
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Southern California
Osteoarthritis, Knee Injuries
Knee Osteoarthritis in the Region of Norrbotten
The goal of this observational study is to assess the prevalence of radiographic knee osteoarthritis and to report medium and long term functional outcomes secondary to tibia plateau fractures.
- Conditions
- Osteoarthritis, Knee Injuries, Knee Osteoarthritis, Tibial Plateau Fractures
- Trial name
- KORN (NCT06451510)
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Umeå University
Total Joint Arthroplasty
Utility of Indwelling Catheter in Orthopaedic Patients Receiving Spinal Anesthesia
A study measuring utility of indwelling bladder catheter placement in orthopaedic surgical patients receiving spinal anesthesia. Study will track clinical outcomes, patient satisfaction and cost efficacy.
- Trial name
- NCT01577823
- Testing
- Foley Catheter
- Where
- United States
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthritis, Knee
The Comparison of Anterior Knee Pain in Patella With or Without Denervation in Medial Unicompartmental Knee Arthroplasty
the present study will conduct to assess anterior knee pain and complications after medial UKA with or without patella denervation in medial compartment arthritis and severe lateral facet patellofemoral arthritis patients.
- Trial name
- NCT03676179
- Testing
- patella denervation, patella non-denervation
- Where
- Thailand
- Volunteers
- 66 people
- Sponsor
- Ramathibodi Hospital
Hip Arthroplasty, Knee Arthroplasty
Operative Hemodynamic Optimization Using the Plethysmographic Variability Index During Orthopedic Surgery
The purpose of this study is to determine whether an operative hemodynamic optimization using the plethysmographic variability index during orthopedic surgery could decrease the length of hospital stay and the postoperative…
- Conditions
- Hip Arthroplasty, Knee Arthroplasty, General Anesthesia
- Trial name
- OPVI (NCT02207296)
- Testing
- Plethysmographic variability index
- Where
- France
- Volunteers
- 440 people
- Sponsor
- University Hospital, Caen
Knee Osteoarthritis, Total Knee Arthroplasty
Improvement of Total Knee Arthroplasty Effectiveness Using Preoperative Prehabilitation
Total knee arthroplasty (TKA) is the most effective treatment for stage III-IV knee osteoarthritis (OA). However, up to 30% of patients remain dissatisfied due to periarticular functional insufficiency, pain, and movement…
- Trial name
- TKA-PREHAB (NCT07790146)
- Testing
- Multimodal phenotype-based prehabilitation
- Where
- Russia
- Volunteers
- 64 people
- Sponsor
- Samara State Medical University
Knee Arthropathy
Effect of Pre-op Patient Education on Functional Outcomes After TKA
This study aims to evaluate the effect of preoperative patient education program on functional mobility, gait, postural control, and kinesiophobia level in subjects with TKA.
- Trial name
- NCT03230942
- Testing
- Pre-operative education, Pos-operative rehabilitation
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of the State of Santa Catarina
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain
Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery
SPRINT PNS System will be offered to patients with postoperative knee pain following primary unilateral total knee arthroplasty (TKA) who meet eligibility criteria and consistent with established coverage policy.
- Conditions
- Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery
- Trial name
- NCT04670042
- Testing
- SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
- Where
- United States
- Sponsor
- Stanford University
Total Hip Replacement, Patient-Reported Outcomes
Patient Scores and Functional Tests After Hip Surgery
This study aims to explore how well patient self-assessments reflect their actual physical performance following hip replacement surgery.
- Trial name
- NCT07048041
- Testing
- Functional Assessment Battery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ordu University
Pain, Postoperative, Arthroplasty, Replacement, Knee
Reducing Postoperative Side Effect of Pregabalin
The purpose of this study was to determine 1) if pregabalin, when given 37.5 mg twice on the day before surgery, would be effective in reducing the early postoperative side effects including dizziness, nausea, vomiting and…
- Conditions
- Pain, Postoperative, Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
- Trial name
- NCT04599894
- Testing
- 37.5mg Pregabalin + 75mg Pregabalin, 75mg Pregabalin
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The First Hospital of Jilin University
Spinal Induced Hypotension, Elderly
Norepinephrine Versus Phenylephrine for Preventing Spinal Anesthesia Induced Hypotension in Elderly
Various regimens were used for prevention of hypotension; most of these regimens included the use of vasopressors. Ephedrine is commonly used vasopressor for management and prophylaxis of hypotension; however, ephedrine is…
- Trial name
- NCT04195321
- Testing
- Norepinephrine, phenylephrine
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Kasr El Aini Hospital
Total Hip Arthroplasty
The Clinical Outcomes After Direct Anterior Approach and Microposterior Approach for Total Hip Arthroplasty
Background The direct anterior approach (DAA) and micro-posterior approach (micro-PA) for total hip arthroplasty (THA) become popular approaches due to their fast recovery and good clinical outcomes.
- Trial name
- NCT03210844
- Testing
- Surgical approaches of total hip arthroplasty
- Where
- Taiwan
- Volunteers
- 141 people
- Sponsor
- National Taiwan University Hospital
Prosthetic Joint Infection (PJI)
A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants
This is a Phase 2b, randomized, controlled, open-label clinical study evaluating the efficacy, safety, and local PK profiles of TNP-2092 administered via IA injection on a background of antibiotic treatment in participants with…
- Trial name
- NCT07858916
- Testing
- TNP-2092 for injection, Vancomycin Hydrochloride for Injection, Oral antibiotics
- Where
- China
- Volunteers
- 40 people
- Sponsor
- TenNor Therapeutics (Zhongshan) Limited
Postoperative Urinary Retention, Total Hip Arthroplasty
RCT Foley Catheter Study for Elective TJA
Urinary retention is a known complication following surgical procedures, with a theoretical increased risk in patients receiving neuraxial anesthesia due to a decreased ability to sense bladder distension.
- Conditions
- Postoperative Urinary Retention, Total Hip Arthroplasty, Total Knee Arthroplasty
- Trial name
- NCT05428020
- Testing
- Indwelling foley catheter, No foley catheter
- Where
- United States
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
HIP AND KNEE OSTEOARTHRITIS
Prepare II - Predictive Model Training and External Validation
The general aim of the project is training and testing a predictive model of inpatient rehabilitation stay after hip and knee replacement for osteoarthritis.
- Trial name
- NCT07304323
- Testing
- Functional rehabilitation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteoarthritis, Deep Venous Thrombosis
Exercise and Cycle Ergometry Post TKA - A Randomized Controlled Trial
The purpose of this investigation is to examine the effect of, and improve patient compliance and motivation following total knee arthroplasty; to determine the efficacy of two post-surgical exercise programs on knee pain…
- Trial name
- NCT02265523
- Testing
- Cycle ergometer
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Lakehead University
Pain
Local Continuous Wound Infusion of Anesthetics in the Management of Post-operative Pain After Total Hip Arthroplasty.
The combination of subarachnoid anaesthesia (SAB) and continuous local wound infiltration (LCWI) with a consistent amount of local anaesthetics could prevent central sensitization through an additive or synergistic effect because…
- Trial name
- NCT02728310
- Testing
- Levobupivacaine, Saline
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- San Salvatore Hospital of L'Aquila
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