Clinical trials: Arthroplasty
Arthritis
Evaluation of Implant Fixation in Reverse Total Shoulder Arthroplasty
Reverse total shoulder replacement surgery (RTSA) is performed for individuals with advanced arthritis of the shoulder who also have tears in their rotator cuff muscles.
- Trial name
- NCT02305966
- Testing
- surgery, 0.8 mm diameter Tantalum marker beads
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee
Antibiotic Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty
Introduction: The current evidence on the efficacy of Antibiotic Loaded Bone Cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient.
- Trial name
- ALBA (NCT04135170)
- Testing
- ALBC vs plain bone cement
- Where
- Norway
- Volunteers
- 9,172 people, healthy volunteers welcome
- Sponsor
- The Norwegian Arthroplasty Register
Knee Arthroplasty, Total, Robotic Surgical Procedures
ROSA® Knee System V1.5 Pilot Study
This pilot study seeks to evaluate the initial safety and usability of new features for the ROSA® Knee System, v1.5 and plan design modifications as needed. The primary objectives will be assessed by measuring: 1.
- Conditions
- Knee Arthroplasty, Total, Robotic Surgical Procedures, Joint Diseases, Knee Osteoarthritis
- Trial name
- NCT07009912
- Testing
- Total Knee Arthroplasty
- Where
- New Zealand
- Volunteers
- 40 people
- Sponsor
- Zimmer Biomet
Arthroplasty, Replacement
ORIGIN® vs. VANGUARD® PS Observational Study
The study objective is to assess patient satisfaction after the surgery with a patient match CE marked implant (ORIGIN®) versus off-the-shelf (VANGUARD PS) device, and to document the clinical and device performance outcomes of…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT04728542
- Testing
- ORIGIN PS System, VANGUARD PS System
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Symbios Orthopedie SA
Knee Osteoarthritis, Knee Arthroplasty
Evaluation of Fixation Achievable in Revision Total Knee Arthroplasty Implementing Latest-Generation Implant Technology
This is a prospective randomized control trial that aims to investigate fixation of implants after revision total knee replacement.
- Trial name
- NCT03276351
- Testing
- Long-Stemmed with Hybrid Fixation, Short-Stemmed with Augmented Fixation
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Total Knee Arthroplasty Secondary to Osteoarthritis, 18 Years and Older
Preoperative Genicular Radiofrequency and Functional Outcomes After Total Knee Arthroplasty
Knee osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage wear, leading to pain, stiffness, and joint swelling.
- Trial name
- NCT07727551
- Testing
- Radiofrequency ablation of the genicular nerve, 42 degrees Celsius for 120 seconds
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- Anesthesiology department Iris South Hospitals
Postoperative Pain Following Knee Arthroplasty
Evaluating Suzetrigine for Pain Control Following TKA
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine works to treat pain after total knee replacement surgery in adults. It will also learn about the safety of suzetrigine.
- Trial name
- NCT07357376
- Testing
- Suzetrigine
- Volunteers
- 210 people
- Sponsor
- AdventHealth
Knee Arthroplasty, Hip Arthroplasty
Fast-track Rehabilitation After Total Knee or Hip Arthroplasty
In the last years, a lot of surgical fast track programs (SFTP) have been created and developed. This is due to the steady growing number of interventions on knee and hip; after the surgical treatment, a period of physical…
- Trial name
- NCT03035435
- Testing
- fast-track rehabilitation, standard care rehabilitation
- Volunteers
- 58 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Chronic Knee Pain, Osteoarthritis, Knee
Radiofrequency For Chronic Knee Pain Post-Arthroplasty
Chronic knee osteoarthritis (OA) is one of the most common diseases with increasing prevalence in advanced age. Knee OA results in movement restriction, sleep disturbance, and disability.
- Trial name
- DEFIANT (NCT02931435)
- Testing
- Nerve Block with Radiofrequency Ablation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Randall Brewer, MD, CPI
Arthroplasty, Osteoarthritis, Knee
The Effects of Prehabilitative Exercise on Functional Recovery Following Total Knee Arthroplasty
The primary aim of this study is to determine the effects of pre-surgery exercise known as Prehabilitation, on functional outcomes for patients following Total Knee Arthroplasty (TKA) surgery.
- Trial name
- NCT03227120
- Testing
- Prehabilitation exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Total Knee Arthroplasty
Safety and Performance Study of the Legion Porous System in Total Knee Arthroplasty
The purpose of this research is to collect data on patients that had the Legion Porous HA Tibial Baseplates and/or the Legion Porous HA Femoral component implanted in the past.
- Trial name
- NCT03720782
- Testing
- LEGION Porous HA Tibial Baseplate and/or the LEGION Porous HA CR Femoral Component
- Where
- 2 sites in United States
- Volunteers
- 118 people
- Sponsor
- Smith & Nephew, Inc.
Arthrodesis, Degenerative Arthritis
INBONE Total Ankle Arthroplasty(TAA)Using Calcaneal Stem Fixation
The primary objective of this study is to evaluate the radiographic outcomes of Total Ankle Arthroplasty in patients having a calcaneal stem.
- Conditions
- Arthrodesis, Degenerative Arthritis, Rheumatoid Arthritis, Complications; Arthroplasty, Mechanical
- Trial name
- NCT01366989
- Testing
- Radiographic evaluation of previously implanted patients
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stryker Trauma and Extremities
Femoral Neck Fractures
Direct Anterior Approach for Femoral Neck Fractures
The primary objective is to examine if in patients with a dislocated femoral neck fracture who receive a total hip arthroplasty, direct anterior approach will give a better result in terms of mobilization, function and pain in…
- Trial name
- NCT03695497
- Testing
- Direct anterior approach, Direct Lateral Approach
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- Helse Møre og Romsdal HF
Gonarthrosis
Assessment of Patient Satisfaction After Arthroplasty: A Comparative Study by Implant Type
The main objective of this study is to evaluate the benefit of personalized prostheses compared to conventional prostheses on patient satisfaction 24 months after total knee arthroplasty.
- Trial name
- ESPACE (NCT04460989)
- Testing
- arthroplasty
- Where
- France
- Volunteers
- 480 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Joint Diseases, Arthritis Knee
Anterior Knee Pain in Mobile Bearing Versus Fixed Bearing in TKA
Osteoarthritis is the most common cause of chronic joint disease, and its incidence has increased due to the high average life expectancy, in addition to the high incidence of obesity.
- Conditions
- Joint Diseases, Arthritis Knee, Arthroplasty Complications
- Trial name
- NCT05696418
- Testing
- Total knee arthroplasty with a Mobile Bearing system., Total knee arthroplasty with a Fixed Bearing system.
- Where
- Syria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Damascus University
Distal Femur Fracture
Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)
Supracondylar femur periprosthetic fractures about a total knee arthroplasty (TKA) are a catastrophic and challenging complication of TKA and unfortunately are increasing in incidence.
- Trial name
- NCT05792189
- Testing
- Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Depression, Anxiety, Pain
Rational-emotional Behavioral Therapy (REBT) in Patients With Osteoarthritis and Concomitant Diseases Before Arthroplasty
The objective of this study was evaluation of the effectiveness of REBT on the emotional state of orthopedic patients with comorbidities before and after arthroplasty.
- Trial name
- REBT (NCT05971797)
- Testing
- REBT
- Where
- Russia
- Volunteers
- 95 people
- Sponsor
- Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
Knee Arthropathy, Return to Work
Determinants for Return to Work After Primary Knee Arthroplasty
The increase of end-stage osteoarthritis (OA) in an increasingly younger population is directly correlated with the rising incidence of obesity.
- Trial name
- RTW (NCT04665180)
- Testing
- Primary knee arthroplasty
- Where
- Belgium
- Volunteers
- 88 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoarthritis, Knee, Obesity
Weight Loss Intervention Before Total Knee Replacement
The purpose of this study is to compare the efficacy in a group of patients who must follow the current procedure for treatment of artificial knee, compared with a group of patients who must undergo an 8-week weight loss program…
- Trial name
- NCT01469403
- Testing
- 8 weeks weight loss program, Cambridge.
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- University of Aarhus
Osteoarthritis
14022 ATTUNE Cementless RP Clinical Performance Evaluation
The primary objective of this study is to examine the change from pre-operative baseline to two year postoperative functional performance improvement for the ATTUNE primary, cementless TKA RP system as measured with the KOOS…
- Trial name
- NCT02839850
- Testing
- Cementless Total Knee Arthroplasty
- Where
- 20 sites in United States, Austria and 7 more
- Volunteers
- 540 people
- Sponsor
- DePuy Orthopaedics
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